Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbapenem antibiotics | EDTA combined with carbapenems produces a significant PLIE on VIM-MBL-positive Pseudomonas aeruginosa strains | Pseudomonas aeruginosa | |
EDTA | EDTA combined with carbapenems produces a significant PLIE on VIM-MBL-positive Pseudomonas aeruginosa strains | Pseudomonas aeruginosa | |
additional information | MIC values, overview | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas aeruginosa | production of beta-lactamases is the main mechanism of resistance to beta-lactams in Gram-negative bacteria, the phenomenon of continuing suppression of bacterial growth after removal of beta-lactamase inhibitors is termed post-beta-lactamase inhibitor effect, PLIE. EDTA combined with carbapenems produces a significant PLIE on VIM-MBL-positive Pseudomonas aeruginosa strains | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
gene blaVIM | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | production of beta-lactamases is the main mechanism of resistance to beta-lactams in Gram-negative bacteria, the phenomenon of continuing suppression of bacterial growth after removal of beta-lactamase inhibitors is termed post-beta-lactamase inhibitor effect, PLIE. EDTA combined with carbapenems produces a significant PLIE on VIM-MBL-positive Pseudomonas aeruginosa strains | Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
metallo-beta-lactamase | - |
Pseudomonas aeruginosa |
VIM-metallo beta-lactamase | - |
Pseudomonas aeruginosa |