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Literature summary for 3.5.2.6 extracted from

  • Beceiro, A.; Dominguez, L.; Ribera, A.; Vila, J.; Molina, F.; Villanueva, R.; Eiros, J.M.; Bou, G.
    Molecular characterization of the gene encoding a new AmpC beta-lactamase in a clinical strain of acinetobacter genomic species 3 (2004), Antimicrob. Agents Chemother., 48, 1374-1378.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

Cloned(Commentary)

Cloned (Comment) Organism
-
 Acinetobacter pittii

Inhibitors

Inhibitors Comment Organism Structure
Sulbactam IC50: 0.013 mM Acinetobacter pittii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 cefoxitin
-
 Acinetobacter pittii
0.052
-
 cefuroxime
-
 Acinetobacter pittii
0.053
-
 ampicillin
-
 Acinetobacter pittii
0.1
-
 cephalothin
-
 Acinetobacter pittii

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE Acinetobacter pittii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Acinetobacter pittii noninducible ?
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter pittii Q7WZ37 clinical strain of genomic species 3
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.159
-
-
 Acinetobacter pittii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
 Acinetobacter pittii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cefoxitin + H2O
-
 Acinetobacter pittii (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefuroxime + H2O
-
 Acinetobacter pittii (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephalothin + H2O
-
 Acinetobacter pittii (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
additional information noninducible Acinetobacter pittii ?
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Acinetobacter pittii

Synonyms

Synonyms Comment Organism
AmpC beta-lactamase
-
 Acinetobacter pittii

pI Value

Organism Comment pI Value Maximum pI Value
Acinetobacter pittii
-
-
 9

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.013
-
 IC50: 0.013 mM Acinetobacter pittii Sulbactam