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3.16 - 3700
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1.1
(6R,7R)-3-[(acetyloxy)methyl]-7-(hydroxyamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
1.59
(6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
1.38
(6R,7R)-3-[(acetyloxy)methyl]-7-[formyl(hydroxy)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
2.02 - 100
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
85.1 - 45000
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
7.01
(6R,7Z)-3-[(acetyloxy)methyl]-7-(hydroxyimino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
120
(6R,7Z)-7-(hydroxyimino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide
-
pH and temperature not specified in the publication
7.9
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
0.47
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
245
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
21.3
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
2.36
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
109
3-nitrophenyl (2S)-2-hydroxy-3-phenylpropanoate
pH not specified in the publication, temperature not specified in the publication
69
3-[[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]benzoic acid
pH not specified in the publication, temperature not specified in the publication
17.4
benzyl [[(2R)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
7.5
benzyl [[(2S)-2-hydroxy-2-phenylacetyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
120
benzyl [[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
55
benzyl [[(2S)-2-hydroxy-4-phenylbutanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
2.8
benzyl [[(2S)-2-hydroxypropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.067 - 18710
benzylpenicillin
230
biapenem
pH 7.0, 25°C
0.102 - 0.206
Bocillin-FL
7.18 - 3300
carbenicillin
5.48 - 3998.3
cefoperazone
270
cefpirome
pH 7.0, 30°C
0.014 - 25860
cephalothin
2.9
faropenem
pH 7.0, 30°C
0.18
moxalactam
pH 7.0, 25°C
30.73 - 12000
piperacillin
0.63
tebipenem
pH 6.5, 22°C, recombinant enzyme
6.6
temocillin
pH 7.0, 30°C
3.16
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
3700
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
2.02
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
100
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
85.1
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
45000
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
38
amoxicillin
30°C, pH not specified in the publication
43.96
amoxicillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
49.51
amoxicillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
272.7
amoxicillin
pH 8.0, 30°C, recombinant wild-type enzyme
1050
amoxicillin
pH and temperature not specified in the publication
36334.3
amoxicillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.056
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
1.15
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
3.3
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
8
ampicillin
30°C, pH not specified in the publication
12
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
13
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
14.1
ampicillin
pH 7.0, 25°C
19
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
34.96
ampicillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
36.23
ampicillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
71
ampicillin
pH 7.0, 25°C
120
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
122
ampicillin
pH 7.2, 25°C
380
ampicillin
pH 7.5, 37°C
630
ampicillin
pH 7.5, 30°C
880
ampicillin
pH 7.0, 30°C
900
ampicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
1008.4
ampicillin
pH 8.0, 30°C, recombinant wild-type enzyme
1200
ampicillin
pH 7.2, 25°C, recombinant enzyme
2300
ampicillin
pH 7.2, 25°C, recombinant enzyme
2400
ampicillin
pH 7.0, 30°C
2600
ampicillin
pH 7.2, 25°C, recombinant enzyme
2800
ampicillin
pH 7.2, 25°C, recombinant enzyme
2900
ampicillin
pH 7.2, 25°C, recombinant enzyme
3000
ampicillin
pH 7.2, 25°C, recombinant enzyme
4100
ampicillin
pH 7.2, 25°C, recombinant enzyme
4200
ampicillin
pH 7.0, 30°C
5578
ampicillin
-
pH and temperature not specified in the publication
5578
ampicillin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
6200
ampicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
7000
ampicillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
8100
ampicillin
pH not specified in the publication, 30°C, recombinant enzyme
17000
ampicillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
17000
ampicillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
29000
ampicillin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
40
aztreonam
pH and temperature not specified in the publication
1200
aztreonam
pH 7.0, 30°C
0.067
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.53
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
13
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
25
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
57
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
80
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
130
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
150
benzylpenicillin
30°C, pH not specified in the publication
620
benzylpenicillin
pH 7.5, 30°C
1500
benzylpenicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
3100
benzylpenicillin
pH 7.0, 25°C
4762
benzylpenicillin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
6000
benzylpenicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
18710
benzylpenicillin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
0.102
Bocillin-FL
pH 8.0, 30°C, recombinant enzyme Y194F
0.206
Bocillin-FL
pH 8.0, 30°C, recombinant enzyme E193A
7.18
carbenicillin
pH 7.0, 25°C
470.1
carbenicillin
pH 8.0, 30°C, recombinant wild-type enzyme
3300
carbenicillin
pH 7.0, 25°C
1500
cefalotin
pH 7.2, 25°C, recombinant enzyme
1600
cefalotin
pH 7.2, 25°C, recombinant enzyme
1900
cefalotin
pH 7.2, 25°C, recombinant enzyme
2600
cefalotin
pH 7.2, 25°C, recombinant enzyme
4100
cefalotin
pH 7.2, 25°C, recombinant enzyme
4600
cefalotin
pH 7.2, 25°C, recombinant enzyme
6100
cefalotin
pH 7.2, 25°C, recombinant enzyme
3.1
cefazolin
pH 7.0, 30°C
4.6
cefazolin
pH 7.0, 30°C
531
cefazolin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
1242
cefazolin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
1.1
cefepime
pH 7.0, 30°C
3.16
cefepime
pH 7.0, 25°C
3.3
cefepime
pH 7.2, 37°C, recombinant enzyme
440
cefepime
pH 7.5, 30°C
1300
cefepime
pH 7.0, 30°C
1500
cefepime
pH 7.5, 37°C
5.48
cefoperazone
pH 7.5, 25°C, recombinant His-tagged mutant E162A
7.33
cefoperazone
pH 7.5, 25°C, recombinant His-tagged mutant E164A
3998.3
cefoperazone
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.88
cefotaxime
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
4.31
cefotaxime
pH 8.0, 30°C, recombinant wild-type enzyme
4.4
cefotaxime
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
10
cefotaxime
pH 7.0, 30°C
230
cefotaxime
pH 7.5, 30°C
260
cefotaxime
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
700
cefotaxime
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
900
cefotaxime
pH not specified in the publication, 30°C, recombinant enzyme
1200
cefotaxime
pH 7.0, 30°C
1600
cefotaxime
pH 7.5, 37°C
5250
cefotaxime
pH and temperature not specified in the publication
17000
cefotaxime
pH 7.0, 30°C
0.26
cefoxitin
pH 7.0, 30°C
0.32
cefoxitin
pH 7.0, 25°C
3.4
cefoxitin
pH 7.2, 37°C, recombinant enzyme
130
cefoxitin
pH 7.2, 25°C, recombinant enzyme
140
cefoxitin
pH 7.2, 25°C, recombinant enzyme
150
cefoxitin
pH 7.2, 25°C, recombinant enzyme
170
cefoxitin
pH 7.2, 25°C, recombinant enzyme
180
cefoxitin
pH 7.5, 30°C
180
cefoxitin
pH 7.2, 25°C, recombinant enzyme
220
cefoxitin
pH 7.2, 25°C, recombinant enzyme
230
cefoxitin
pH 7.2, 25°C, recombinant enzyme
2900
cefoxitin
pH 7.5, 37°C
35000
cefoxitin
pH 7.0, 30°C
2
ceftazidime
pH 7.2, 25°C
2.4
ceftazidime
pH 7.2, 37°C, recombinant enzyme
40
ceftazidime
pH and temperature not specified in the publication
180
ceftazidime
pH 7.2, 25°C, recombinant enzyme
200
ceftazidime
pH 7.2, 25°C, recombinant enzyme
210
ceftazidime
pH 7.2, 25°C, recombinant enzyme
230
ceftazidime
pH 7.2, 25°C, recombinant enzyme
260
ceftazidime
pH 7.2, 25°C, recombinant enzyme
600
ceftazidime
pH 7.5, 37°C
770
ceftazidime
pH 7.5, 30°C
920
ceftazidime
pH 7.0, 30°C
1800
ceftazidime
pH 7.0, 30°C
7
ceftriaxone
pH 7.0, 30°C
155.2
ceftriaxone
pH 8.0, 30°C, recombinant wild-type enzyme
0.2
cefuroxime
wild-type, pH 7.0, 22°C
11
cefuroxime
pH 7.2, 25°C
130
cefuroxime
pH 7.5, 30°C
160
cefuroxime
pH 7.2, 37°C, recombinant enzyme
2300
cefuroxime
pH 7.5, 37°C
3800
cefuroxime
pH 7.0, 30°C
6000
cefuroxime
pH 7.0, 25°C
6700
cefuroxime
pH 7.0, 30°C
11910
cefuroxime
pH and temperature not specified in the publication
8.81
cephalexin
pH 8.0, 30°C, recombinant wild-type enzyme
10
cephalexin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
28.6
cephalexin
-
pH 7.0, 25°C
9300
cephalexin
pH 7.0, 30°C
0.03
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
10
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
12
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
16
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
18
cephaloridine
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
23
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
180
cephaloridine
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
200
cephaloridine
-
pH and temperature not specified in the publication
200
cephaloridine
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
0.014
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.25
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
1
cephalothin
30°C, pH not specified in the publication
1.57
cephalothin
pH 8.0, 30°C, recombinant wild-type enzyme
1.89
cephalothin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
5
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
7.72
cephalothin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
14
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
20
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
35
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
120
cephalothin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
230
cephalothin
pH 7.0, 30°C
320
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
380
cephalothin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
400
cephalothin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
428
cephalothin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
470
cephalothin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
800
cephalothin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
900
cephalothin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
2511.1
cephalothin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
2739
cephalothin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
3100
cephalothin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
3600
cephalothin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
8900
cephalothin
pH not specified in the publication, 30°C, recombinant enzyme
10000
cephalothin
pH 7.0, 30°C
25860
cephalothin
pH and temperature not specified in the publication
810
cephalotin
pH 7.5, 37°C
4000
cephalotin
pH 7.5, 30°C
7900
cephalotin
pH 7.0, 30°C
36000
cephalotin
pH 7.0, 25°C
2
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
12
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
13
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
18
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
47
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
1000
Cloxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
2000
Cloxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
1.67
doripenem
pH 6.5, 22°C, recombinant enzyme
1700
doripenem
pH 7.2, 25°C, recombinant enzyme
1900
doripenem
pH 7.2, 25°C, recombinant enzyme
2000
doripenem
pH 7.2, 25°C, recombinant enzyme
4500
doripenem
pH 7.2, 25°C, recombinant enzyme
5400
doripenem
pH 7.2, 25°C, recombinant enzyme
6000
doripenem
pH 7.2, 25°C, recombinant enzyme
6800
doripenem
pH not specified in the publication, 30°C, recombinant enzyme
8600
doripenem
pH 7.2, 25°C, recombinant enzyme
1.3
ertapenem
pH 7.0, 30°C
1.67
ertapenem
pH 6.5, 22°C, recombinant enzyme
13
ertapenem
pH 7.2, 25°C
54
ertapenem
pH 7.2, 37°C, recombinant enzyme
250
ertapenem
pH 7.2, 37°C, recombinant enzyme, in presence of NaCl
2200
ertapenem
pH 7.5, 37°C
15000
ertapenem
pH not specified in the publication, 30°C, recombinant enzyme
3
Imipenem
30°C, pH not specified in the publication
8.5
Imipenem
pH 7.2, 37°C, recombinant enzyme
220
Imipenem
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
370
Imipenem
pH 7.0, 30°C
642
Imipenem
pH 7.0, 25°C
1000
Imipenem
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
1000
Imipenem
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
2200
Imipenem
pH 7.2, 25°C, recombinant enzyme
2300
Imipenem
pH 7.2, 25°C, recombinant enzyme
2400
Imipenem
pH 7.5, 30°C
2500
Imipenem
pH 7.5, 37°C
2900
Imipenem
pH 7.2, 25°C, recombinant enzyme
4100
Imipenem
pH 7.2, 25°C, recombinant enzyme
5800
Imipenem
pH 7.2, 25°C, recombinant enzyme
6000
Imipenem
pH not specified in the publication, 30°C, recombinant enzyme
7600
Imipenem
pH 7.2, 25°C, recombinant enzyme
9200
Imipenem
pH 7.2, 25°C, recombinant enzyme
23000
Imipenem
pH 7.0, 25°C
0.1
meropenem
30°C, pH not specified in the publication
0.3
meropenem
pH 6.5, 22°C, recombinant enzyme
1.4
meropenem
pH 7.5, 30°C
6.2
meropenem
pH 7.0, 30°C
19
meropenem
pH 7.2, 25°C
91.6
meropenem
pH 7.2, 37°C, recombinant enzyme
140
meropenem
pH 7.5, 37°C
505
meropenem
pH 7.0, 25°C
875
meropenem
pH 7.0, 25°C
2600
meropenem
pH 7.2, 25°C, recombinant enzyme
4100
meropenem
pH 7.2, 25°C, recombinant enzyme
4200
meropenem
pH 7.2, 25°C, recombinant enzyme
4300
meropenem
pH 7.2, 25°C, recombinant enzyme
4900
meropenem
pH 7.2, 25°C, recombinant enzyme
5200
meropenem
pH 7.2, 25°C, recombinant enzyme
7400
meropenem
pH 7.2, 25°C, recombinant enzyme
14000
meropenem
pH not specified in the publication, 30°C, recombinant enzyme
0.21
nitrocefin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.3
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.57
nitrocefin
pH 7.0, 25°C
0.66
nitrocefin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
1.48
nitrocefin
pH 8.0, 30°C, recombinant wild-type enzyme
5.5
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
30
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
40
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
100
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
130
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
130
nitrocefin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
190
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
1000
nitrocefin
pH 7.2, 37°C, recombinant enzyme
1400
nitrocefin
pH 7.0, 30°C
3100
nitrocefin
pH 7.2, 25°C, recombinant enzyme
5000
nitrocefin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
5600
nitrocefin
pH 7.2, 25°C, recombinant enzyme
5900
nitrocefin
pH 7.2, 25°C, recombinant enzyme
6100
nitrocefin
pH 7.5, 30°C
6100
nitrocefin
pH 7.2, 25°C, recombinant enzyme
6300
nitrocefin
pH 7.2, 25°C, recombinant enzyme
7500
nitrocefin
pH 7.2, 25°C, recombinant enzyme
7700
nitrocefin
pH 7.0, 30°C
8700
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
10000
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
10450
nitrocefin
-
pH and temperature not specified in the publication
10450
nitrocefin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
10900
nitrocefin
pH 7.2, 25°C, recombinant enzyme
11000
nitrocefin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
13000
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
31000
nitrocefin
pH 7.0, 25°C
52000
nitrocefin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
170000
nitrocefin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
2
Oxacillin
30°C, pH not specified in the publication
4.2
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
16
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
17.5
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
40
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
53
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
61.6
Oxacillin
pH 8.0, 30°C, recombinant wild-type enzyme
130
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
700
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
1400
Oxacillin
pH 7.0, 30°C
3000
Oxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
3000
Oxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
18610
Oxacillin
-
pH and temperature not specified in the publication
18610
Oxacillin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
100
panipenem
pH 7.0, 30°C
4900
panipenem
pH not specified in the publication, 30°C, recombinant enzyme
29
penicillin G
mutant E166C, pH 7.0, 22°C
40
penicillin G
mutant E166C, carrying 6-bromoacetyl-2-dimethylaminonaphthalene label, pH 7.0, 22°C
210
penicillin G
-
mutant R61H/E64H/43H, 25°C, pH not specified in the publication
437
penicillin G
-
mutant M182T/T195S/A224V, 25°C, pH not specified in the publication
809
penicillin G
-
pH 7.0, 25°C
950
penicillin G
-
wild-type, 25°C, pH not specified in the publication
3870
penicillin G
pH and temperature not specified in the publication
8238.8
penicillin G
pH 8.0, 30°C, recombinant wild-type enzyme
14000
penicillin G
pH 7.0, 30°C
34000
penicillin G
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
54000
penicillin G
wild-type, pH 7.0, 22°C
30.73
piperacillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
44.17
piperacillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
46
piperacillin
pH 7.2, 25°C
80
piperacillin
30°C, pH not specified in the publication
170
piperacillin
pH not specified in the publication, 30°C, recombinant enzyme
1140
piperacillin
pH and temperature not specified in the publication
1753.2
piperacillin
pH 8.0, 30°C, recombinant wild-type enzyme
1900
piperacillin
pH 7.5, 37°C
2700
piperacillin
pH 7.0, 30°C
3300
piperacillin
pH 7.0, 30°C
3400
piperacillin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
3500
piperacillin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
4000
piperacillin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
9000
piperacillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
11672.4
piperacillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
12000
piperacillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
5
ticarcillin
30°C, pH not specified in the publication
150
ticarcillin
pH 7.5, 30°C
217.4
ticarcillin
pH 8.0, 30°C, recombinant wild-type enzyme
360
ticarcillin
pH and temperature not specified in the publication
390
ticarcillin
pH not specified in the publication, 30°C, recombinant enzyme
1800
ticarcillin
pH 7.5, 37°C