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Literature summary for 3.5.2.6 extracted from

  • Heritier, C.; Poirel, L.; Nordmann, P.
    Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae (2004), Antimicrob. Agents Chemother., 48, 1670-1675.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Shewanella algae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
Imipenem 30°C, pH 7.0 Shewanella algae
0.02
-
ticarcillin 30°C, pH 7.0 Shewanella algae
0.025
-
benzylpenicillin 30°C, pH 7.0 Shewanella algae
0.07
-
cephalothin 30°C, pH 7.0 Shewanella algae
0.11
-
piperacillin 30°C, pH 7.0 Shewanella algae
0.19
-
Cloxacillin 30°C, pH 7.0 Shewanella algae
0.39
-
Oxacillin 30°C, pH 7.0 Shewanella algae
0.5
-
ampicillin 30°C, pH 7.0 Shewanella algae
0.5
-
meropenem 30°C, pH 7.0 Shewanella algae
0.67
-
cefpirome 30°C, pH 7.0 Shewanella algae
0.75
-
cephaloridine 30°C, pH 7.0 Shewanella algae
4.7
-
ceftazidime 30°C, pH 7.0 Shewanella algae

Organism

Organism UniProt Comment Textmining
Shewanella algae Q6VCW0 clinical isolate KB-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Shewanella algae (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Shewanella algae (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefpirome + H2O
-
Shewanella algae (2S)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-[(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
ceftazidime + H2O
-
Shewanella algae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
Shewanella algae (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalothin + H2O
-
Shewanella algae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cloxacillin + H2O
-
Shewanella algae (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
imipenem + H2O
-
Shewanella algae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O
-
Shewanella algae (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
oxacillin + H2O
-
Shewanella algae (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
piperacillin + H2O
-
Shewanella algae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ticarcillin + H2O
-
Shewanella algae (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
carbapenem-hydrolyzing ambler class D beta-lactamase
-
Shewanella algae
OXA-55
-
Shewanella algae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.05
-
meropenem 30°C, pH 7.0 Shewanella algae
0.1
-
Imipenem 30°C, pH 7.0 Shewanella algae
0.1
-
cefpirome 30°C, pH 7.0 Shewanella algae
0.5
-
Cloxacillin 30°C, pH 7.0 Shewanella algae
0.6
-
cephalothin 30°C, pH 7.0 Shewanella algae
1
-
ticarcillin 30°C, pH 7.0 Shewanella algae
2
-
ceftazidime 30°C, pH 7.0 Shewanella algae
3
-
piperacillin 30°C, pH 7.0 Shewanella algae
4
-
benzylpenicillin 30°C, pH 7.0 Shewanella algae
5
-
Oxacillin 30°C, pH 7.0 Shewanella algae
8
-
ampicillin 30°C, pH 7.0 Shewanella algae
10
-
cephaloridine 30°C, pH 7.0 Shewanella algae