Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.5.2.6: beta-lactamase

This is an abbreviated version!
For detailed information about beta-lactamase, go to the full flat file.

Word Map on EC 3.5.2.6

Reaction

A beta-lactam
+
H2O
=
a substituted beta-amino acid

Synonyms

ACT-3, ALI-1, Ambler class A beta-lactamase, AmpC, AmpC beta-lactamase, AmpC beta-lactamases M19, AmpC beta-lactamases M29, AmpC beta-lactamases M37, AmpC M19, AmpC M29, AmpC M37, AmpC-A, AmpC-B2, AmpC-type beta-lactamase, apo Bacillus cereus 569/H/9 enzyme, apo-BcII, B1 metallo-beta-lactamase, B3 MBL, BcII, BCL-1, BEL-1, Beta lactamase OXA-10, beta-lactamase, beta-lactamase A-C, beta-lactamase ACT-1, beta-lactamase AME I, beta-lactamase Bla-A, beta-lactamase Bla-B, beta-lactamase CMY-1, beta-lactamase CMY-2, beta-lactamase I-III, beta-lactamase II, beta-lactamase MIR-1, beta-lactamase OXA-1, beta-lactamase OXA-10, beta-lactamase P99, beta-lactamase PSE-1, beta-lactamase YRC-1, beta-lactamase, class C, beta-lactamases CTX-M-25, beta-lactamases CTX-M-26, beta-lactamse A-D, BLA, Bla-A, Bla-B, Bla1, Bla2, BlaA, blaACT-12, blaACT-14, blaACT-15, blaACT-17, blaACT-18, blaACT-19, blaACT-22, BlaB, BlaC, blaCMY-126, blaCMY-2, blaCMY-65, blaCMY-66, blaCMY-67, blaCMY-68, blaCMY-70, blaCMY-71, blaCMY-74, blaCMY-83, blaCMY-93, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, blaCTX-M-55, BLAIMP, blaIMP-4, blaKPC-2, blaLUT-1, BlaMab, blaNDM-1, blaNDM-7, blaoxa-1, blaSHV-1, blaSHV-14, blaTEM-1, blaToho-11, blaVIM-2, BS3, CAR-1 enzyme, CARB-3, carbapenem-hydrolysing MBL, carbapenem-hydrolyzing ambler class D beta-lactamase, carbapenem-hydrolyzing class A beta-lactamase, carbapenemase, carbapenemase CphA, Carbenicillinase, CcrA, cefotaximase, ceftazidimase, cefurooximase, Cefuroximase, Cephalosporinase, cephamycinase, CIA-1, CKO, class A beta-lactamase, class A beta-lactamase CKO-1, class A beta-lactamase CKO-2, class A beta-lactamase CKO-3, class A beta-lactamase CKO-4, class A TEM-2 beta-lactamase, class A TEM-2 enzyme, class B beta-lactamase SFB-1, class B beta-lactamase SLB-1, class B carbapenemase, class B metallo-beta-lactamase, class B metallo-beta-lactamase L-1, class C beta-lactamase, class C cephalosporinase, class C P99 beta-lactamase, class D beta lactamase, class D beta-lactamase, class D OXA-1 beta-lactamase, class D oxacillinase, CMY-1, CMY-10, CMY-2-type beta-lactamase, CMY-37, CphA, CTX-M beta-lactamase, CTX-M-1, CTX-M-14, CTX-M-64, CTX-M-64 beta-lactamase, EC 3.5.2.8, ESBL, Est-Y29, EstSRT1, exo-small beta-lactamase, extended spectrum beta-lactamase, extended-spectrum beta-lactamase, extended-spectrum beta-lactamase TEM-60, extended-spectrum-beta-lactamase, FEZ-1 metallo-beta-lactamase, FOX-4, FUS-1, GC1 beta-lactamase, GES-1, GES-2, GES-5, GES-type beta-lactamase, GIM-1, Imipenem-cefoxitin hydrolyzing enzyme, imipenemase, ImiS, IMP-1, IMP-10, IMP-12, IMP-13, IMP-15, IMP-16, IMP-18, IMP-2, IMP-2 MBL, IMP-9-type metallo-beta-lactamase, IMP-like metallo-beta-lactamase, IMP-type beta-lactamase, IMP-type metallo-beta-lactamase, IND-5, KHM-1, KLUA-9, KPC beta-lactamase, KPC-2, KPC-2 beta-lactamase, KPC-3, L1, L1 beta-lactamase, L1 metallo-beta-lactamase, L2 beta-lactamase, LHK-5, LUT-1 beta-lactamase, M19, M29, M37, MacQ, MbetaL, mbetal L1, MBL, metagenome-derived family VIII carboxylesterase, metallo-beta -lactamase, metallo-beta-L-lactamase, metallo-beta-lactamase, metallo-beta-lactamase BceII, metallo-beta-lactamase BcII, metallo-beta-lactamase ImiS, metallo-beta-lactamase IMP-1, metallo-beta-lactamase L1, metallo-beta-lactamase type 2, metallo-beta-lactamase VIM-1, metallo-beta-lactamase VIM-2, metallo-beta-lactamase VIM-6, MFO, MIR-4 beta-lactamase, More, Mox-1, Mox-1 beta-lactamase, MSMEG_4455, NDM, NDM-1, NDM-10, NDM-12, NDM-2, NDM-3, NDM-4, NDM-5, NDM-6, NDM-7, NDM-8, NDM-9, neutrapen, New Delhi MbetaL-1, New Delhi MBL, New Delhi metallo-beta-lactamase, New Delhi metallo-beta-lactamase-1, OXA group I, OXA group II, OXA-1, oxa-1 beta-lactamase, OXA-10, OXA-10 beta-lactamase, OXA-10 enzyme, OXA-17, OXA-18, OXA-2, OXA-229, OXA-24, OXA-24 beta-lactamase, OXA-40, OXA-48 carbapenemase, Oxa-50, OXA-55, OXA-57, OXA-63, OXA-69, OXA-85, OXA-type metallo-beta-lactamase, OXA114, Oxacillinase, oxycillinase, P99, P99 beta-lactamase, PenA, PenB1 beta-lactamase, PenB2, PenB3, PenB4, penicillinase, penicillinase I, II, PenP, PER-1, PER-2, plasmidic class C beta-lactamase, POM-1, poxB, PSE-1, PSE-4, serine beta-lactamase, SFC-1, Sfh-I, SHV, SHV beta-lactamase, SHV-1, SHV-1 beta-lactamase, SHV-1 penicillinase, SHV-14 beta-lactamase, SHV-2A, SHV-4, SHV-5, SHV-55, SHV-type beta-lactamase, SHV-type extended spectrum beta-lactamase, SIM-1, SMB-1, SME-1, SPM-1, ST1585, subclass B1 metallo-?-lactamase, subclass B3 metallo-beta-lactamase, TEM, TEM extended-spectrum beta-lactamase, TEM-1, TEM-1 beta-lactamase, TEM-107, TEM-116, TEM-149, TEM-21, TEM-8, TEM-type beta-lactamase, TEM1, THIN-B metallo-beta-lactamase, TMB-1, Toho-1, TRU-1, Verona integron-encoded MBL, Verona integron-encoded MBL-2, VIM, VIM-1, VIM-1 metallo-beta-lactamase, VIM-11, VIM-12, VIM-13, VIM-2, VIM-2 metallo-beta-lactamase, VIM-3, VIM-4, VIM-5, VIM-6, VIM-6 enzyme, VIM-7, VIM-metallo beta-lactamase, VIM-type MBL, VIM-type metallo-beta-lactamase, zinc beta-lactamase, Zn-beta-lactamase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.6 beta-lactamase

KI Value

KI Value on EC 3.5.2.6 - beta-lactamase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00374
(2Z)-2-(((E)-2-carboxy-2-[(2-thienylacetyl)amino]vinyl)imino)-3-mercaptobut-3-enoic acid
-
-
0.3 - 2.1
(R)-3-(N-benzyloxycarbonylamino)-2-oxo-butylphosphate
0.088 - 0.97
(RS)-4-(N-benzyloxycarbonyl)amino-3-oxo-2-butylphosphate
0.00007
([(benzylsulfonyl)amino]methyl)boronic acid
pH 6.5, 22°C
0.000033
([[(2-ethoxynaphthalen-1-yl)carbonyl]amino]methyl)boronic acid
pH 6.5, 22°C
0.0073
1,10-ophenanthroline
-
0.029
2-(7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylidene)-malononitrile
-
pH 7.0, temperature not specified in the publication
0.0057 - 0.013
2-picolinic acid
0.00034 - 0.052
2-[[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-phenylacetamide
0.00051 - 0.00064
2-[[5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-phenylacetamide
0.000073 - 0.0022
2-[[5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl]-N-phenylacetamide
0.15 - 5
3-(N-benzyloxycarbonyl)amino-2-oxopropylphenylphosphonate
0.1 - 2
3-(N-benzyloxycarbonyl)amino-2-oxopropylphosphate
0.15 - 0.73
3-(N-benzyloxycarbonyl)amino-2-oxopropylphosphonate
0.086
3-aminophenyl boronic acid
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.000001
3-[(2R)-2-(dihydroxyboranyl)-2-[[(thiophen-2-ylmethyl)sulfonyl]amino]ethyl]benzoic acid
pH 6.5, 22°C
0.00043
3-[(2R)-2-[(benzylsulfonyl)amino]-2-(dihydroxyboranyl)ethyl]benzoic acid
pH 6.5, 22°C
0.47 - 1.23
4-(N-benzyloxycarbonyl)amino-3-oxobutylphosphonate
0.000025
4-([[(dihydroxyboranyl)methyl]sulfamoyl]methyl)benzoic acid
pH 6.5, 22°C
0.012
4-chloro-7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine
-
pH 7.0, temperature not specified in the publication
0.019
4-chloro-7-(4-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine
-
pH 7.0, temperature not specified in the publication
0.033
4-chloro-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
-
pH 7.0, temperature not specified in the publication
0.015
7-(4-methylphenyl)-8,9-diphenyl-7H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-3-thione
-
pH 7.0, temperature not specified in the publication
0.072 - 0.468
AAGHYY
0.0195
ampicillin
37°C, pH 7.0
0.00004 - 3.6
aztreonam
0.009
BAL29880
-
pH 74, temperature not specified in the publication
0.0007
BAL30072
-
pH 74, temperature not specified in the publication
0.0000005 - 0.0011
beta-lactamase inhibitor protein
-
0.0025 - 0.23
bulgecin A
0.042
captopril
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
0.505
cefepime
37°C, pH 7.0
0.000027 - 0.103
cefotaxime
0.000013
cefuroxime
-
versus cephalothin, pH 7.5, 25°C
0.0379
cephalothin
37°C, pH 7.0
0.0024
clavulanate
-
-
0.00011 - 4.6
clavulanic acid
0.009 - 0.016
Cys-Val-His-Ser-Pro-Asn-Arg-Glu-Cys
0.0011
dansyl-C2SH
at 30°C
0.0013
dansyl-C3SH
at 30°C
0.00014
dansyl-C4SH
at 30°C
0.00028
dansyl-C5SH
at 30°C
0.00016
dansyl-C6SH
at 30°C
0.003
dipicolinic acid
-
0.0023
doripenem
-
pH 74, temperature not specified in the publication
0.00028
ertapenem
-
pH 74, temperature not specified in the publication
0.93 - 0.95
ethyl 3-(benzyloxycarbonyl)amino-2-oxo-1,1-difluoropropylphosphonate
0.07 - 0.298
HSAYSDTRRGDYG
0.0011 - 0.0806
Imipenem
0.0014 - 0.017
JDB/ASR-II-292
0.0007 - 0.008
JDB/LN-1-255
0.00027 - 0.0042
meropenem
0.24 - 1.13
methyl 3-(N-benzyloxycarbonyl)amino-2-oxo-1-propylphosphate
0.014
moxalactam
-
-
0.056
N(2-mercaptoethyl)phenylacetamide
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
0.0061
N,3-dihydroxy-5-[(4-hydroxyphenyl)carbonyl]benzamide
-
-
0.00065 - 0.015
N-(1,3-benzothiazol-2-yl)-2-[[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
0.00081 - 0.0018
N-(1,3-benzothiazol-2-yl)-2-[[5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
0.00025 - 0.0063
N-(1,3-benzothiazol-2-yl)-2-[[5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl]acetamide
0.001
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
pH and temperature not specified in the publication
0.0014
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
pH and temperature not specified in the publication
0.00086 - 0.0053
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]acetamide
0.00082 - 0.045
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
0.00033 - 0.0068
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
0.00034 - 0.0085
N-(1,3-benzothiazol-2-yl)-2-[[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]acetamide
11
N-(phenylacetyl)thioglycylglycolic acid
-
pH 7.5, 25°C
0.018
N-benzylidene-N'-(7-(4-methylphenyl)-5,6-diphenyl-7Hpyrrolo[2,3-d]pyramidin-4-yl)-hydrazine
-
pH 7.0, temperature not specified in the publication
0.02
N-carbobenzoxy-D-cysteine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.003
N-carbobenzoxy-D-cysteinyl-D-phenylalanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.011
N-carbobenzoxy-D-cysteinyl-L-phenylalanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.046
N-carbobenzoxy-DL-cysteinyl-glycine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.097
N-carbobenzoxy-L-cysteine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
0.009
N-carbobenzoxy-L-cysteinyl-D-phenylalanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.062
N-carbobenzoxy-L-cysteinyl-DL-alanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.017
N-carbobenzoxy-L-cysteinyl-DL-phenylalanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.095
N-carbobenzoxy-L-cysteinyl-DL-proline
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.073
N-carbobenzoxy-L-cysteinyl-DL-serine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.048
N-carbobenzoxy-L-cysteinyl-DL-valine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.042
N-carbobenzoxy-L-cysteinyl-glycine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.136
N-carbobenzoxy-L-cysteinyl-L-leucine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.027
N-carbobenzoxy-L-cysteinyl-L-phenylalanine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.084
N-carbobenzoxy-L-cysteinyl-L-serine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
-
0.00023 - 0.00051
N-phenyl-2-[[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
0.00038 - 0.0012
N-phenyl-2-[[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
0.00025 - 0.0043
N-phenyl-2-[[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]acetamide
0.515
N-phenylacetyl-DL-penicillamine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
0.108
N-phenylacetyl-L-cysteine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
1
N-phenylacetylglycine
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+
0.43 - 0.93
N-[N'-(benzyloxycarbonyl)aminoacetyl]amino-methylphosphonate
0.0148 - 0.146
nitrocefin
0.00003 - 0.00005
penem 1
0.00015 - 0.00038
penem 3
0.11 - 0.7
phenyl 3-(N-benzyloxycarbonyl)amino-2-oxopropylphosphate
0.077 - 1.59
phenyl 3-(N-benzyloxycarbonyl)amino-2-oxopropylphosphonate
0.00032 - 0.144
phosphate
0.0045 - 0.028
pyridine-2,4-dicarboxylic acid
0.00022
rac-2-omega-phenylpropyl-3-mercaptopropionic acid
-
-
0.042 - 0.14
RRGHYY
0.44 - 1.08
sodium benzyl (2-hydroxy-2-phenylethyl)phosphonate
0.15 - 1
sodium benzyl (2-oxo-2-phenylethyl)phosphonate
0.024 - 3600
sodium benzyl 2-(1',3'-benzothiazol-2'-yl)-2-oxo-ethylphosphonate
0.26 - 1
sodium benzyl [2-(biphenyl-4-yl)-2-hydroxyethyl]phosphonate
0.19 - 1
sodium benzyl [2-(biphenyl-4-yl)-2-oxoethyl]phosphonate
0.07 - 1.5
sodium benzyl [2-oxo-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)ethyl]phosphonate
0.43 - 1
sodium benzyl {2-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-2-oxoethyl}phosphonate
0.2 - 1
sodium biphenyl-4-ylmethyl (2-oxo-2-phenylethyl)phosphonate
0.006 - 0.2
sodium biphenyl-4-ylmethyl [2-(biphenyl-4-yl)-2-oxoethyl]phosphonate
0.2 - 1.05
sodium phenyl (2-oxo-2-phenylethyl)phosphonate
0.1 - 0.92
sodium phenyl [2-(biphenyl-4-yl)-2-oxoethyl]phosphonate
0.35 - 1
sodium phenyl [2-oxo-2-(pentafluorophenyl)ethyl]phosphonate
0.00015 - 0.74
Sulbactam
0.000018 - 3.5
tazobactam
5.5
thiono derivative of N-(phenylacetyl)thioglycylglycolic acid
-
pH 7.5, 25°C
-
0.0109 - 0.045
vanadate/(3,4-dihydroxyphenyl)methanaminium complex
0.01
vanadate/2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione complex
pH 7.0, 25°C
0.00065
vanadate/2,3-dihydroxynaphthalene-1,4-dione complex
pH 7.0, 25°C
0.0042 - 0.14
vanadate/2-(3,4-dihydroxyphenyl)acetate complex
0.05
vanadate/2-methoxyphenol complex
pH 7.0, 25°C
0.0019
vanadate/3,4,5,6-tetrafluorobenzene-1,2-diol complex
pH 7.0, 25°C
0.0057 - 0.2
vanadate/3,4-dihydroxybenzoate complex
0.00043 - 0.023
vanadate/3-phenylcatechol complex
0.0016
vanadate/4-methoxybenzohydroxamic acid complex
pH 7.5, 25°C
-
0.00051 - 0.16
vanadate/4-nitrobenzene-1,2-diol complex
0.00048
vanadate/4-nitrobenzohydroxamic acid complex
pH 7.5, 25°C
-
0.006
vanadate/benzylhydroxamic acid complex
pH 7.5, 25°C
0.0009 - 0.03
vanadate/biphenyl-3,4-diol complex
0.0012
vanadate/methylhydroxamic acid complex
pH 7.5, 25°C
-
0.00115
vanadate/N-methylbenzohydroxamic acid complex
pH 7.5, 25°C
-
0.00086
vanadate/naphthalene-1,2-diol complex
pH 7.0, 25°C
0.00058 - 0.077
vanadate/naphthalene-2,3-diol complex
0.22
vanadate/phenol complex
pH 7.0, 25°C
0.0015 - 0.062
vanadate/pyrocatechol complex
0.0438
ZINC01807204
pH 7.0, 30°C
additional information
additional information
-