3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

3.1.1.1

lipase

insecticide

leukocyte

lymphocyte

alpha-naphthyl

leukemia

cytochemical

urine

isozymes

p-nitrophenyl

organophosphate

prodrugs

ache

phagocytic

marrow

urinary

organophosphorus

hydrolases

pesticide

lysosomal

fluoride

myeloid

granulocyte

lipolytic

pyrethroids

nitrite

neurotoxic

paraoxon

phagocytosis

carbamate

mosquito

chlorpyrifos

paraoxonase

histiocytic

urinalysis

cytochemistry

kallikreins

culex

irinotecan

dfp

fluorophosphate

diptera

diisopropyl

myelomonocytic

pmsf

soman

parathion

allozymes

diisopropylfluorophosphate

oseltamivir

industry

environmental protection

agriculture

analysis

diagnostics

synthesis

degradation

biotechnology

medicine

drug development

pharmacology

Reaction

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.1.1 carboxylesterase

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Results	in table
65	Activating Compound
7823	AA Sequence
71	Application
1	CAS Registry Number
134	Cloned(Commentary)
36	Crystallization (Commentary)
5824	Disease/ Diagnostics
25	Expression
74	General Information
19	General Stability
229	IC50 Value
1150	Inhibitors
187	kcat/KM [mM/s]
202	Ki Value [mM]
771	KM Value [mM]
102	Localization
64	Metals/Ions
219	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
198	Organic Solvent Stability
666	Organism
9	Pathway
267	PDB ID
188	pH Optimum
72	pH Range
46	pH Stability
41	pI Value
41	Posttranslational Modification
190	Protein Variants
156	Purification (Commentary)
20	Reaction
5	Reaction Type
444	Reference
3	Renatured (Commentary)
317	Source Tissue
279	Specific Activity [micromol/min/mg]
20	Storage Stability
1976	Substrates and Products (Substrate)
233	Subunits
538	Synonyms
1	Systematic Name
150	Temperature Optimum [°C]
60	Temperature Range [°C]
181	Temperature Stability [°C]
506	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.1.1.1 - carboxylesterase

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(+)-1,2-O-isopropylidenglycerol caprylate + H2O

(+)-1,2-O-isopropylidenglycerol + caprylate

3 entries

(+)-menthylacetate + H2O

(+)-menthol + acetate

unidentified soil organism

enzyme is highly enantioselective for (+)-menthylacetate

677663

(+)-trans 4-nitrophenyl crysanthemate + H2O

(+)-trans-crysanthemic acid + 4-nitrophenol

Arthrobacter globiformis

714544

(+)-trans-ethyl crysanthemate + H2O

(+)-trans-crysanthemic acid + ethanol

Arthrobacter globiformis

714544

(+/-)-1,2-O-isopropylidenglycerol butanoate + H2O

(+/-)-1,2-O-isopropylidenglycerol + butanoate

6 entries

(+/-)-3-endo-acetyloxy-1,8-cineole + H2O

(1S,3S,4R)-(+)-3-acetyloxy-1,8-cineole + (1R,3R,4S)-(-)-3-hydroxy-1,8-cineole

Oryctolagus cuniculus

730450

(-)-1,2-O-isopropylidenglycerol caprylate + H2O

(-)-1,2-O-isopropylidenglycerol + caprylate

4 entries

(-)-cocaine + H2O

O-benzoylecgonine + methanol

Homo sapiens

P23141

CE-1 catalyzed hydrolysis of (-)-cocaine, reaction mechanism of cocaine hydrolysis catalyzed by CE-1, overview. Two reaction steps: a single-step acylation process and a single-step deacylation process. In the transition states of both single-step processes, the cocaine NH group joins the oxyanion hole to form an additional hydrogen bond with the negatively charged carbonyl oxygen atom of the cocaine. The transition states are stabilized by both intermolecular and intramolecular hydrogen bonds with the methyl ester of cocaine, specifically the carbonyl oxygen atom. The rate-limiting transition state is associated with the acylation process

751606

(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

(1R)-bioresmethrin + H2O

2 entries

(1RS)-cis-permethrin + H2O

cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol

3 entries

(1RS)-trans-permethrin + H2O

trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol

3 entries

(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

(2R)-fenvalerate + H2O

Mus musculus

Q8BK48

669240

(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

(2S)-fenvalerate + H2O

Mus musculus

Q8BK48

669240

(alphaR)(2R)-fenvalerate + H2O

Mus musculus

Q8BK48

669240

(alphaR)(2S)-fenvalerate + H2O

Mus musculus

Q8BK48

669240

(alphaS)(2R)-fenvalerate + H2O

Mus musculus

Q8BK48

669240

(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O

(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate

2 entries

(E)-2-hexenyl acetate + H2O

(E)-2-hexenol + acetate

Spodoptera exigua

729831, 751800

(E)-2-hexenyl butyrate + H2O

(E)-2-hexenol + butyrate

Spodoptera exigua

751800

(R)-2-(3-benzoylphenyl)propanoic methyl ester + H2O

methanol + (R)-2-(3-benzoylphenyl)propanoate

Saccharolobus solfataricus

Q97VW1

when tested with the racemic substrate, the enzyme leads to the production of the R-configured acid with an enantiomeric excess of 80% at the conversion rate of 20% in 32 h

724578

(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,2S,3S)-2-(2,2-dichloroethenyl)-3-methylcyclopropanecarboxylate + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O

(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O

(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid

Homo sapiens

P23141

667322

(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O

(2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2R)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(R)-ketoprofen ethyl ester + H2O

(R)-ketoprofen + ethanol

Archaeoglobus fulgidus

(R)-ketoprofen or (S)-ketoprofen is produced by esterase hydrolysis of the ester bond of (R,S)-ketoprofen ethyl ester

729051

(R)-naproxen methyl ester + H2O

(R)-naproxen + methanol

Bacillus subtilis

669899

(R)-propranolyl 2-methyl-n-valerate + H2O

(R)-propranolol + 2-methylpentanoate

2 entries

(R)-propranolyl 2-methylbutanoate + H2O

(R)-propranolol + 2-methylbutanoate

2 entries

(R)-propranolyl 3-methylbutanoate + H2O

(R)-propranolol + 3-methylbutanoate

2 entries

(R)-propranolyl 3-methylpentanoate + H2O

(R)-propranolol + 3-methylpentanoate

2 entries

(R)-propranolyl hexanoate + H2O

(R)-propranolol + hexanoate

2 entries

(R)-propranolyl n-valerate + H2O

(R)-propranolol + pentanoate

2 entries

(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O

(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid

4 entries

(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoate + H2O

(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O

(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid

Homo sapiens

P23141

667322

(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate + H2O

(2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + (2S)-hydroxy(6-methoxynaphthalen-2-yl)ethanenitrile

Lucilia cuprina

Q25252

729826

(S)-ibuprofen methyl ester + H2O

(S)-ibuprofen + methanol

2 entries

(S)-ketoprofen ethyl ester + H2O

(S)-ketoprofen + ethanol

3 entries

(S)-naproxen methyl ester + H2O

(S)-naproxen + methanol

4 entries

(S)-propranolol 3-methylpentanoate + H2O

(S)-propranolol + 3-methylpentanoate

2 entries

(S)-propranolyl 2-methylbutanoate + H2O

(S)-propranolol + 2-methylbutanoate

2 entries

(S)-propranolyl 2-methylpentanoate + H2O

(S)-propranolol + 2-methylpentanoate

2 entries

(S)-propranolyl 3-methylbutanoate + H2O

(S)-propranolol + 3-methylbutanoate

2 entries

(S)-propranolyl hexanoate + H2O

(S)-propranolol + hexanoate

2 entries

(S)-propranolyl n-valerate + H2O

(S)-propranolol + pentanoate

2 entries

(Z)-3-hexenyl acetate + H2O

(Z)-3-hexenol + acetate

2 entries

(Z)-3-hexenyl butyrate + H2O

(Z)-3-hexenol + butyrate

Spodoptera exigua

729831, 751800

(Z)-3-hexenyl caproate + H2O

(Z)-3-hexenol + caproate

Spodoptera exigua

751800

(Z9,E11)-tetradec-9,11-enyl acetate + H2O

(Z9,E11)-tetradec-9,11-en-1-ol + acetate

Spodoptera littoralis

about 40% hydrolysis (native enzyme), 7.63% hydrolysis (recombinant enzyme)

716684

(Z9,E12)-tetradec-9,12-enyl acetate + H2O

(Z9,E11)-tetradec-9,12-en-1-ol + acetate

Spodoptera littoralis

about 40% hydrolysis (native enzyme), 8.98% hydrolysis (recombinant enzyme)

716684

1,2-dioctanoyl-glycerol + H2O

octanoate + glycerol

Culex quinquefasciatus

171032

1,2-O-dilauryl-rac-glycero-3-glutaric acid-resorufin ester + H2O

2 entries

1,3-dioctanoyl-glycerol + H2O

octanoate + glycerol

Culex quinquefasciatus

171032

1,4-diacetoxybenzene + H2O

Cereibacter sphaeroides

729255

1-chloro-3-(1-naphthyloxy)-2-propanol acylester + H2O

(R)-1-chloro-3-(1-naphthyloxy)-2-propanol + carboxylic acid

Trichosporon sp.

668446

high stereoselectivity

1-monocaprylylglycerol + H2O

caprylic acid + glycerol

2 entries

1-monodecanoyl-glycerol + H2O

decanoate + glycerol

Culex quinquefasciatus

171032

1-monolauroyl-glycerol + H2O

lauric acid + glycerol

2 entries

1-monomyristoyl-glycerol + H2O

myristic acid + glycerol

2 entries

1-monooctanoyl-glycerol + H2O

octanoate + glycerol

Culex quinquefasciatus

171032

1-monooleyl glycerol + H2O

oleic acid + glycerol

Rattus norvegicus

170994

1-monopalmitin + H2O

palmitic acid + glycerol

Rattus norvegicus

3.8% of the activity with tributyrin

170993

1-monostearin + H2O

stearic acid + glycerol

Rattus norvegicus

1.6% of the activity with tributyrin

170993

1-naphthyl acetate + H2O

1-naphthol + acetate

15 entries

1-naphthyl butanoate + H2O

1-naphthol + butanoate

2 entries

1-naphthyl butyrate + H2O

1-naphthol + butyrate

5 entries

1-naphthyl caprylate + H2O

1-naphthol + caprylate

Pseudomonas aeruginosa

14% of the activity with 1-naphthyl acetate

661545

1-naphthyl laurate + H2O

1-naphthol + laurate

Pseudomonas aeruginosa

9% of the activity with 1-naphthyl acetate

661545

1-naphthyl oleate + H2O

1-naphthol + oleate

Pseudomonas aeruginosa

2% of the activity with 1-naphthyl acetate

661545

1-naphthyl propionate + H2O

1-naphthol + propionate

4 entries

2'-ethylcarbonate-linked paclitaxel + H2O

paclitaxel + propanoate

3 entries

2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

2,4-dinitrophenyl butyrate + H2O

2,4-dinitrophenol + butyrate

3 entries

2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine + H2O

2-[2-oxo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone + ?

Homo sapiens

also called prasugrel, the hydrolysis is at least 25times greater with CE2 than CE1

692036

also called R-95913

2-carboxyethyl-3-cyano-5-methylhexanoic acid ethyl ester + H2O

(3S)-2-carboxyethyl-3-cyano-5-methylhexanoic acid + ethanol

Thermomyces lanuginosus

W8DVW0

743730

2-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine + H2O

decitabine + ?

Homo sapiens

691594

2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

2-monopalmitin + H2O

palmitic acid + glycerol

Rattus norvegicus

2.6% of the activity with tributyrin

170993

2-naphthyl acetate + H2O

2-naphthol + acetate

20 entries

2-naphthyl butyrate + H2O

2-naphthol + butyrate

Escherichia coli

170987

2-naphthyl propionate + H2O

2-naphthol + propionate

4 entries

2-nitrophenyl acetate + H2O

2-nitrophenol + acetate

8 entries

2-nitrophenyl butyrate + H2O

2-nitrophenol + butyrate

6 entries

2-nitrophenyl laurate + H2O

2-nitrophenol + laurate

Aspergillus nidulans

690570

2-nitrophenylpropionate + H2O

2-nitrophenol + propionate

Equus caballus

170975

2-octanyl acetate + H2O

2-octanol + acetate

2 entries

2-phenethyl acetate + H2O

2-phenylethanol + acetate

Cereibacter sphaeroides

729255

2-phenyl-3-butyn-2-yl acetate

2-phenyl-3-butyn-2-ol + acetate

Bacillus subtilis

P37967

678865

2-phenyl-3-butyn-2-yl acetate + H2O

2-phenyl-3-butyn-2-ol + acetate

2 entries

2-phenyloxazolin-5-one + H2O

3 entries

2-thionaphthyl acetate + H2O

2-thionaphthol + acetate

Cereibacter sphaeroides

729255

2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O

anordiol + 2 propanoate

Homo sapiens

O00748, P23141

i.e anordrin

752336

3'-D-phenylalanyl-gemcitabine + H2O

D-phenylalanine + gemcitabine

Sus scrofa

669998

3'-D-valyl-gemcitabine + H2O

D-valine + gemcitabine

Sus scrofa

669998

3'-L-isoleucyl-gemcitabine + H2O

L-isoleucine + gemcitabine

Sus scrofa

669998

3'-L-phenylalanyl-gemcitabine + H2O

L-phenylalanine + gemcitabine

Sus scrofa

669998

3'-L-valyl-gemcitabine + H2O

L-valine + gemcitabine

Sus scrofa

669998

3-acetoxypyridine + H2O

Cereibacter sphaeroides

729255

3-methyl-1-pentyn-3-yl acetate + H2O

3-methyl-1-pentyn-3-ol + acetate

3 entries

3-nitrophenyl acetate + H2O

3-nitrophenol + acetate

Equus caballus

170975

3-nitrophenyl butyrate + H2O

3-nitrophenol + butyrate

2 entries

3-O-(4-ethylbenzoyl)-3-hydroxyflavone + H2O

3-hydroxylflavone + 4-ethylbenzoate

Homo sapiens

O00748

750021

3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol

2 entries

3-phenoxybenzyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol

2 entries

3-phenoxybenzyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol

2 entries

3-phenoxybenzyl (1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

(1S,3S)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol

2 entries

4'-chloroacetanilide + H2O

Cereibacter sphaeroides

729255

4-aminobenzoic acid butyl ester + H2O

4-aminobenzoic acid + butanol

Homo sapiens

679473

4-aminobenzoic acid ethyl ester + H2O

4-aminobenzoic acid + ethanol

Homo sapiens

679473

4-aminobenzoic acid propyl ester + H2O

4-aminobenzoic acid + propanol

Homo sapiens

679473

4-hydroxyphenyl acetate + H2O

4-hydroxyphenol + acetate

Cereibacter sphaeroides

729255

4-methylbenzyl acetate + H2O

4-methylbenzyl alcohol + acetate

Cereibacter sphaeroides

729255

4-methylumbelliferyl (2E)-but-2-enoate + H2O

4-methylumbelliferone + (2E)-but-2-enoic acid

Arabidopsis thaliana

682300

4-methylumbelliferyl 3-phenoxybutanoate + H2O

4-methylumbelliferone + 3-phenoxybutanoate

Arabidopsis thaliana

682300

4-methylumbelliferyl acetate + H2O

4-methylumbelliferol + acetate

7 entries

4-methylumbelliferyl acetate + H2O

4-methylumbelliferone + acetate

19 entries

4-methylumbelliferyl butanoate + H2O

4-methylumbelliferol + butanoate

Mycobacterium tuberculosis

enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate

680782

4-methylumbelliferyl butanoate + H2O

4-methylumbelliferone + butanoate

Arabidopsis thaliana

682300

4-methylumbelliferyl butyrate + H2O

4-methylumbelliferol + butyrate

4 entries

4-methylumbelliferyl butyrate + H2O

4-methylumbelliferone + butyrate

6 entries

4-methylumbelliferyl cyclopentane carboxylate + H2O

4-methylumbelliferone + cyclopentane carboxylate

Arabidopsis thaliana

682300

4-methylumbelliferyl heptanoate + H2O

4-methylumbelliferol + heptanoate

4 entries

4-methylumbelliferyl heptanoate + H2O

4-methylumbelliferone + heptanoate

3 entries

4-methylumbelliferyl hexanoate + H2O

4-methylumbelliferone + hexanoate

Arabidopsis thaliana

682300

4-methylumbelliferyl laurate + H2O

4-methylumbelliferol + laurate

Actinidia eriantha

Q0ZPV7

678253

4-methylumbelliferyl laurate + H2O

4-methylumbelliferone + laurate

Malus domestica

best substrate

716466

4-methylumbelliferyl octanoate + H2O

4-methylumbelliferol + octanoate

Actinidia eriantha

Q0ZPV7

678253

4-methylumbelliferyl octanoate + H2O

4-methylumbelliferone + octanoate

2 entries

4-methylumbelliferyl oleate + H2O

4-methylumbelliferol + oleate

3 entries

4-methylumbelliferyl p-trimethylammoniocinnamate chloride + H2O

4-methylumbelliferol + p-trimethylammoniocinnamate chloride

2 entries

4-methylumbelliferyl palmitate + H2O

4-methylumbelliferol + palmitate

2 entries

4-methylumbelliferyl palmitate + H2O

4-methylumbelliferone + palmitate

2 entries

4-methylumbelliferyl pentanoate + H2O

4-methylumbelliferone + pentanoate

Arabidopsis thaliana

682300

4-methylumbelliferyl propionate + H2O

4-methylumbelliferone + propionate

Arabidopsis thaliana

682300

4-nitroacetanilide + H2O

Cereibacter sphaeroides

729255

4-nitrobenzoic acid methyl ester + H2O

4-nitrobenzoic acid + methanol

Homo sapiens

ratio of the rates of hydrolysis in liver to intestine 5.5

679473

4-nitrophenol acetate + H2O

4-nitrophenol + acetate

Homo sapiens

Q6LAP9

749814

4-nitrophenyl 2-chloropropionate + H2O

4-nitrophenol + (S)-2-chloropropionic acid

Archaeoglobus fulgidus

O28558

722216

4-nitrophenyl acetate + H2O

4-nitrophenol + acetate

122 entries

4-nitrophenyl butanoate + H2O

4-nitrophenol + butanoate

30 entries

4-nitrophenyl butyrate + H2O

4-nitrophenol + butyrate

83 entries

4-nitrophenyl caprate + H2O

4-nitrophenol + caprate

3 entries

4-nitrophenyl caprate + H2O

4-nitrophenol + capric acid

4 entries

4-nitrophenyl caproate + H2O

4-nitrophenol + caproate

22 entries

4-nitrophenyl caprylate + H2O

4-nitrophenol + caprylate

14 entries

4-nitrophenyl chrysanthemate + H2O

4-nitrophenol + chrysanthemate

Arthrobacter globiformis

171029

4-nitrophenyl decanoate + H2O

4-nitrophenol + decanoate

25 entries

4-nitrophenyl dodecanoate + H2O

4-nitrophenol + dodecanoate

23 entries

4-nitrophenyl heptanoate + H2O

4-nitrophenol + heptanoate

Pseudomonas aeruginosa

Q9HXE7

714366

4-nitrophenyl hexadecanoate + H2O

4-nitrophenol + hexadecanoate

6 entries

4-nitrophenyl hexadecanoate + H2O

4-nitrophenol + palmitate

Saccharolobus solfataricus

M5DDN2

725745

4-nitrophenyl hexanoate + H2O

4-nitrophenol + hexanoate

46 entries

4-nitrophenyl laurate + H2O

4-nitrophenol + laurate

18 entries

4-nitrophenyl laurate + H2O

4-nitrophenol + lauric acid

6 entries

4-nitrophenyl methylphosphonate + H2O

4-nitrophenol + methylphosphonate

Cereibacter sphaeroides

729255

4-nitrophenyl myristate + H2O

4-nitrophenol + myristate

3 entries

4-nitrophenyl myristate + H2O

4-nitrophenol + myristic acid

2 entries

4-nitrophenyl nonanoate + H2O

4-nitrophenol + nonanoate

Pseudomonas aeruginosa

Q9HXE7

714366

4-nitrophenyl octanoate + H2O

4-nitrophenol + octanoate

47 entries

4-nitrophenyl palmitate + H2O

4-nitrophenol + palmitate

15 entries

4-nitrophenyl palmitate + H2O

4-nitrophenol + palmitic acid

Niallia circulans

649395

4-nitrophenyl pentanoate + H2O

4-nitrophenol + pentanoate

21 entries

4-nitrophenyl propanoate + H2O

4-nitrophenol + propanoate

8 entries

4-nitrophenyl propionate + H2O

4-nitrophenol + propionate

31 entries

4-nitrophenyl stearate + H2O

4-nitrophenol + stearate

Pseudomonas aeruginosa

Q9HXE7

714366

4-nitrophenyl tetradecanoate + H2O

4-nitrophenol + tetradecanoate

6 entries

4-nitrophenyl valerate + H2O

4-nitrophenol + valerate

9 entries

4-nitrophenylacetate + H2O

4-nitrophenol + acetate

Canis lupus familiaris

F1P6W8, Q95N05

750478

5'-D-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O

D-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole

Sus scrofa

669998

5'-D-phenylalanyl-gemcitabine + H2O

D-phenylalanine + gemcitabine

Sus scrofa

669998

5'-D-valyl-gemcitabine + H2O

D-valine + gemcitabine

Sus scrofa

669998

5'-L-isoleucyl-gemcitabine + H2O

L-isoleucine + gemcitabine

Sus scrofa

669998

5'-L-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O

L-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole

Sus scrofa

669998

5'-L-phenylalanyl-gemcitabine + H2O

L-phenylalanine + gemcitabine

Sus scrofa

669998

5'-L-valyl-gemcitabine + H2O

L-valine + gemcitabine

Sus scrofa

669998

5'-O-cinnamoyl-2'-deoxy-5-fluorouridine + H2O

cinnamic acid + 2'-deoxy-5-fluorouridine

Sus scrofa

669998

5'-O-L-phenylalanyl-2'-deoxy-5-fluorouridine + H2O

L-phenylalanine + 2'-deoxy-5-fluorouridine

Sus scrofa

669998

5-methyl-2-(propan-2-yl)cyclohexyl acetate + H2O

2 entries

6-methoxy-alpha-methyl-2-naphthaleneacetic acid methyl ester

(S)-naproxen + methanol

Trichosporon sp.

i.e. naproxen methyl ester

668446

high stereoselectivity

6-monoacetylmorphine + H2O

morphine + acetate

Homo sapiens

P23141

hCE1 can metabolize the conversion of heroin to both 6-monoacetylmorphine and morphine. hCE1 is able to catalyze both reactions, but it is more efficient at the hydrolysis of heroin to 6-monoacetylmorphine, the first step of heroin metabolism

700370

7-acetoxy-3-(2-benzothiazolyl)-4-cyanocoumarin + H2O

Burkholderia gladioli

Q9LAB8

low activity

649399

7-amino cephalosporanic acid + H2O

Agrobacterium tumefaciens

681338

7-aminocephalosporanic acid + H2O

(6R,7R)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid + acetate

uncultured bacterium

749674

7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin + H2O

7-ethyl-10-hydroxycampothecin + 4-aminopiperidine-1-carboxylic acid

Homo sapiens

i.e. NPC

668390

7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin + H2O

7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid

Homo sapiens

i.e. irinotecan, CPT-11

668390

7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin + H2O

7-ethyl-10-hydroxycampothecin + 4-((4-carboxybutyl)amino)piperidine-1-carboxylic acid

Homo sapiens

i.e. APC

668390

7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O

7-ethyl-10-hydroxycampothecin + ?

2 entries

7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O

7-ethyl-10-hydroxy-camptothecin + ?

3 entries

7-[4-octylcarboxy-(3-hydroxy-3-methyl)-butyloxy]-coumarin + H2O

unidentified

677663

acetanilide + H2O

acetate + aniline

Sus scrofa

171000

acetylsalicylic acid + H2O

acetate + salicylate

Homo sapiens

Q6LAP9

CES2A1-specific substrate

749814

acetylsalicylic acid + H2O

salicylic acid + acetate

2 entries

alpha-cypermethrin + H2O

Mus musculus

Q8BK48

669240

alpha-naphthyl acetate + H2O

1-naphthol + acetate

2 entries

alpha-naphthyl acetate + H2O

alpha-naphthol + acetate

18 entries

alpha-naphthyl butanoate + H2O

alpha-naphthol + butanoate

Mycobacterium tuberculosis

enzyme activity increases from acetate to propionate to butanoate substrate

680782

alpha-naphthyl butyrate + H2O

alpha-naphthol + butyrate

5 entries

alpha-naphthyl caprate + H2O

alpha-naphthol + caprate

Reticulitermes flavipes

651506

alpha-naphthyl caproate + H2O

alpha-naphthol + caproate

Reticulitermes flavipes

651506

alpha-naphthyl caprylate + H2O

alpha-naphthol + caprylate

2 entries

alpha-naphthyl nonanoate + H2O

alpha-naphthol + nonanoate

Burkholderia gladioli

Q9LAB8

low activity

649399

alpha-naphthyl propionate + H2O

1-naphthol + propionate

Burkholderia gladioli

Q9LAB8

best substrate

649399

alpha-naphthyl propionate + H2O

alpha-naphthol + propionate

2 entries

alpha-naphthyl valerate + H2O

alpha-naphthol + valerate

Burkholderia gladioli

ampicillin + H2O

Amplex red + H2O

resorufin + acetate

2 entries

anisamidobutyric acid + H2O

anisilic acid + H2O

aspirin + H2O

acetate + salicylate

3 entries

benazepril + H2O

Rattus norvegicus

171025

benzoyl-Gly-farnesyl-L-cysteine methyl ester + H2O

Sus scrofa

692927

benzyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O

benzol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate

Microbacterium sp.

i.e. benzyl cetraxate

651369

benzyl acetate + H2O

benzyl alcohol + acetate

2 entries

benzyl propionate + H2O

benzyl alcohol + propionate

Pseudomonas fluorescens

171026

benzyloxycarbonyl-D-Tyr-p-nitrophenyl ester + H2O

benzyloxycarbonyl-D-Tyr + 4-nitrophenol

3 entries

benzyloxycarbonyl-Gly-p-nitrophenyl ester + H2O

benzyloxycarbonyl-Gly + 4-nitrophenol

Geobacillus stearothermophilus

171021

benzyloxycarbonyl-L-Ala-p-nitrophenyl ester + H2O

benzyloxycarbonyl-L-Ala + 4-nitrophenol

Geobacillus stearothermophilus

171021

benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester + H2O

benzyloxycarbonyl-L-Tyr + 4-nitrophenol

4 entries

beta-naphthyl acetate + H2O

beta-naphthol + acetate

7 entries

beta-naphthyl butyrate + H2O

beta-naphthol + butyrate

Burkholderia gladioli

Q9LAB8

649399

beta-naphthyl caproate + H2O

beta-naphthol + caproate

Burkholderia gladioli

Q9LAB8

low activity

649399

beta-naphthyl propionate + H2O

2-naphthol + propionate

Burkholderia gladioli

Q9LAB8

best substrate

649399

beta-naphthyl valerate + H2O

beta-naphthol + valerate

Burkholderia gladioli

Q9LAB8

649399

beta-phenethyl acetate + H2O

Pseudomonas fluorescens

171026

beta-thionaphthyl acetate + H2O

beta-thionaphthol + acetate

Caenorhabditis elegans

171017

betamethasone valerate + H2O

betamethasone + valerate

Homo sapiens

ratio of the rates of hydrolysis in liver to intestine 0.21

679473

bifenthrin + H2O

Pseudomonas synxantha

A0A0K0Q1Y2

752220

bioresmethrin + H2O

3 entries

bis(2-ethylhexyl)phthalate + H2O

Triticum aestivum

170988

bisphenyl carbonate + H2O

Sus scrofa

170997

butanilicain + H2O

2 entries

butyl 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoate + H2O

2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid + butanol

Alopecurus myosuroides

Q6H8W7

i.e. fluazifop butyl

670552

butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O

fluazifop-P + butanol

2 entries

butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate + H2O

cyhalofop + butanol

2 entries

butyl 4-aminobenzoate + H2O

4-aminobenzoate + butanol

2 entries

butyl acetate + H2O

butanol + acetate

4 entries

butyl benzoate + H2O

benzoate + butanol

2 entries

butyl octanoate + H2O

butanol + octanoate

Pseudomonas sp.

Q8GR22

653767

butyl paraben + H2O

butanol + 4-hydroxybenzoate

Enterobacter cloacae

652371

butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O

Homo sapiens

P23141

750061

butyrylthiocholine + H2O

butyric acid + thiocholine

2 entries

camostat mesilate + H2O

Rattus norvegicus

171025

camptothecin-11 + H2O

4 entries

capecitabin + H2O

6 entries

capric acid + glycerol

1-monocaprin + H2O

Sus scrofa

PLE-catalyzed esterification of capric acid with glycerol in reverse micelles. The most suitable structure of reverse micelles is comprised of isooctane (reaction medium) and bis(2-ethylhexyl) sodium sulfosuccinate ( anionic surfactant) with 0.1 of R-value ([water]/[surfactant]) and 3.0 of G/F-value ([glycerol]/[fatty acid]) for the PLE-catalyzed esterification. PLE mainly produces 1-monocaprin without any other products (di- and/or tricaprins of subsequent reactions). The degree of esterification at equilibrium state (after 4 h from the initiation) is 62.7% under optimum conditions. Method optimization, overview

750445

capric acid + sn-glycerol

1-monocaprin

Calotropis procera

the carboxylesterase performs also the esterification reaction using capric acid and glycerol as substrates resulting in formation of 1-monocaprin, product analysis by HPLC and method optimization, overview

710129

capsaicin + H2O

Rattus norvegicus

171025

carbaryl + H2O

Pseudomonas synxantha

A0A0K0Q1Y2

752220

carboxyfluorescein diacetate + H2O

Pseudomonas aeruginosa PAO1

661545

carboxyfluorescein diacetate + H2O

carboxyfluorescein + acetate

Pseudomonas aeruginosa

661545

cefazolin + H2O

(6R,7R)-7-amino-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid + (1H-tetrazol-1-yl)acetic acid

cefazolin + H2O

67% conversion

cefoperazone + H2O

(2R)-2-[(4-ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid + 1-methyl-1H-tetrazole-5-thiol + ?

83% conversion

cefotaxime + H2O

16% conversion

ceftriaxone + H2O

18% conversion

cephaloridine + H2O

(6R,7R)-7-amino-8-oxo-3-[(pyridin-1-ium-1-yl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + (thiophen-2-yl)acetic acid

uncultured bacterium

713856

cephalothin + H2O

acetate + deacetylcephalothin

uncultured bacterium

713856

chlorpyrifos + H2O

Culex quinquefasciatus

poor substrate

171028

cholesterol ester + H2O

3 entries

cholesterol oleate + H2O

cholesterol + oleate

2 entries

cholesteryl oleate + H2O

cholesterol + oleate

Homo sapiens

691075

cilazapril + H2O

6 entries

cis-cypermethrin + H2O

3 entries

cis-permethrin + H2O

2 entries

clodinafop-propargyl + H2O

? + prop-2-yn-1-ol

Arabidopsis thaliana

680793

clofibrate + H2O

clofibric acid + ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

clopidogrel + H2O

(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol

4 entries

clopidogrel + H2O

clopidogrel carboxylic acid + methanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

cocaine + H2O

benzoylecgonine + methanol

10 entries

cocaine + H2O

ecgonine methyl ester + benzoate

12 entries

cocaine + H2O

O-benzoylecgonine + methanol

5 entries

CPT-11 + H2O

SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2

6 entries

CPT-11 + H2O

SN-38 + ?

6 entries

cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

hydroxy(3-phenoxyphenyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + H2O

hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2,3,3-tetramethylcyclopropanecarboxylic acid

Homo sapiens

P23141

667322

cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O

hydroxy(6-methoxy-2-naphthyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Mus musculus

Q8BK48

669240

cyano(6-methoxy-2-naphthyl)methyl butanoate + H2O

hydroxy(6-methoxy-2-naphthyl)acetonitrile + butanoate

Mus musculus

Q8BK48

669240

cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O

(2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + hydroxy(6-methoxy-2-naphthyl)acetonitrile

Mus musculus

Q8BK48

669240

cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid + H2O

hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid

Homo sapiens

P23141

667322

cyclic poly(ethylene terephthalate) trimer + H2O

2 entries

cyclohexyl 4-nitrophenyl methylphosphonate + H2O

Cereibacter sphaeroides

729255

cypermethrin + H2O

2 entries

D-glucose pentaacetate + H2O

? + acetate

Agrobacterium tumefaciens

681338

D-methyl phenidate + H2O

Homo sapiens

P23141

690327

D-methylphenidate + H2O

methanol + phenyl(piperidin-2-yl)acetate

Homo sapiens

710629

D-Tyr ethyl ester + H2O

D-Tyr + ethanol

Sus scrofa

171010

D-xylose tetraacetate + H2O

? + acetate

Agrobacterium tumefaciens

681338

delapril + H2O

N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol

Rattus norvegicus

171025

deltamethrin + H2O

3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide

3 entries

derapril + H2O

N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol

2 entries

dibutyl phthalate + H2O

dicaprin + H2O

diethyl (6-methoxynaphthalen-2-yl)(methyl)propanedioate + H2O

ethanol + (2S)-3-ethoxy-2-(6-methoxynaphthalen-2-yl)-2-methyl-3-oxopropanoic acid

2 entries

diethyl methyl(phenyl)propanedioate + H2O

ethanol + (2S)-3-ethoxy-2-methyl-3-oxo-2-phenylpropanoic acid

2 entries

diethyl succinate + H2O

Culex quinquefasciatus

171032

diethyl-4-methylumbelliferyl phosphate + H2O

diltiazem + H2O

dimethyl cis-cyclohex-4-ene-1,2-dicarboxylate + H2O

methyl hydrogen (1S,2R)-cyclohex-4-ene-1,2-dicarboxylate + methanol

Sus scrofa

enantioselectivity, 98% at 25°C, 96% at 50°C

652612

94-97% of the R-enantiomer

652612

diolein + H2O

2 entries

DL-methyl 2-chloropropionate + H2O

4 entries

DL-methylphenidate + H2O

methanol + phenyl(piperidin-2-yl)acetate

enalapril + H2O

epsilon-caprolactone + H2O

6-hydroxyhexanoate

Archaeoglobus fulgidus

O28558

the enzyme catalyzes a ring-opening polymerization of epsilon-caprolactone

722994

epsilon-cypermethrin + H2O

Mus musculus

Q8BK48

669240

estrone acetate + H2O

estrone + acetate

Sus scrofa

171000

ethanol + acetate

ethyl acetate + H2O

2 entries

ethanol + acetyl-CoA

ethyl acetate + CoA

Lactococcus lactis

Q8KWI9

ester formation

651608

ethanol + butyrate

ethyl butanoate + H2O

Lactococcus lactis

Q8KWI9

ester formation

651608

ethyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate + H2O

ethanol + (2S)-2-(6-methoxynaphthalen-2-yl)propanoate

2 entries

ethyl (2S)-2-phenylpropanoate + H2O

ethanol + (2S)-2-phenylpropanoate

2 entries

ethyl (4-nitrophenyl)acetate + H2O

ethanol + (4-nitrophenyl)acetate

Cereibacter sphaeroides

729255

ethyl (naphthalen-2-yl)acetate + H2O

(naphthalen-2-yl)acetate + ethanol

Cereibacter sphaeroides

729255

ethyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O

ethanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate

2 entries

ethyl 2-(4-((6-chloro-1,3-benzothiazol-2-yl)oxy)phenoxy)propanoate + H2O

2-(4-((6-chloro-1,3-benzothiazol-2-yl)oxy)phenoxy)propanoic acid + ethanol

Alopecurus myosuroides

Q6H8W7

i.e. fenthiaprop ethyl

670552

ethyl 2-(4-((6-chloro-1,3-benzoxazol-2-yl)oxy)phenoxy)propanoate + H2O

2-(4-((6-chloro-1,3-benzoxazol-2-yl)oxy)phenoxy)propanoic acid + ethanol

Alopecurus myosuroides

Q6H8W7

i.e. fenoxaprop ethyl

670552

ethyl 2-hydroxy-4-phenylbutanoate + H2O

2-hydroxy-4-phenylbutanoate + ethanol

Bacillus subtilis

Q4PNS3

680960

enantiopreference for (S)-isomer with enantiomeric excess of 80%

ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate

fenoxaprop-P + ethanol

2 entries

ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate + H2O

quizalofop-P + ethanol

2 entries

ethyl 3,4-dihydroxybenzoate + H2O

ethanol + 3,4-dihydroxybenzoate

Enterobacter cloacae

low activity

652371

ethyl 3-hydroxybenzoate + H2O

ethanol + 3-hydroxybenzoate

Aspergillus nomiae

651381

ethyl 3-methoxybenzoate + H2O

ethanol + 3-methoxybenzoate

Aspergillus nomiae

651381

ethyl 4-aminobenzoate + H2O

4-aminobenzoate + ethanol

2 entries

ethyl 4-hydroxybenzoate + H2O

ethanol + 4-hydroxybenzoate

Aspergillus nomiae

651381

ethyl 4-methoxybenzoate + H2O

ethanol + 4-methoxybenzoate

Aspergillus nomiae

651381

ethyl 4-nitrophenyl methylphosphonate + H2O

Cereibacter sphaeroides

729255

ethyl acetate + H2O

ethanol + acetate

11 entries

ethyl benzoate + H2O

ethanol + benzoate

Aspergillus nomiae

651381

ethyl bromoacetate + H2O

ethanol + bromoacetate

Rattus norvegicus

171016

ethyl butanoate + H2O

butanoate + ethanol

Sus scrofa

679535

ethyl butanoate + H2O

ethanol + butanoate

2 entries

ethyl butyrate + H2O

ethanol + butanoate

2 entries

ethyl butyrate + H2O

ethanol + butyrate

5 entries

ethyl butyrylacetate + H2O

Cereibacter sphaeroides

729255

ethyl caproate + H2O

ethanol + caproate

Microbacterium sp.

651369

ethyl caprylate + H2O

ethanol + caprylate

Sus scrofa

677732

ethyl cetraxate + H2O

ethanol + cetraxate

Microbacterium sp.

651369

ethyl chloroacetate + H2O

ethanol + chloroacetate

Rattus norvegicus

171016

ethyl D-pantothenate + H2O

ethanol + D-pantothenate

Microbacterium sp.

651369

ethyl DL-beta-acetylthioisobutyrate + H2O

2 entries

ethyl fexofenadine + H2O

fexofenadine + ethanol

2 entries

ethyl fluoroacetate + H2O

ethanol + fluoroacetate

Rattus norvegicus

171016

ethyl hexanoate + H2O

ethanol + hexanoate

3 entries

ethyl iodoacetate + H2O

ethanol + iodoacetate

Rattus norvegicus

171016

ethyl L-pantothenate + H2O

ethanol + L-pantothenate

Microbacterium sp.

651369

ethyl laurate + H2O

ethanol + laurate

Pseudomonas sp.

Q8GR22

653767

ethyl myristate + H2O

ethanol + myristate

Pseudomonas sp.

Q8GR22

653767

ethyl octanoate + H2O

ethanol + octanoate

Pseudomonas sp.

Q8GR22

653767

ethyl paraben + H2O

ethanol + 4-hydroxybenzoate

2 entries

ethyl pelargonate + H2O

ethanol + pelargonate

Pseudomonas sp.

Q8GR22

653767

ethyl pentanoate + H2O

ethanol + pentanoate

2 entries

ethyl propionate + H2O

ethanol + propionate

5 entries

ethyl thiolacetate + H2O

ethanol + ethanethioic S-acid

Sus scrofa

170997

ethyl valerate + H2O

ethanol + valerate

Microbacterium sp.

651369

ethyl valerate + H2O

ethanol + valeric acid

Sulfolobus acidocaldarius

Q7M529

678016

ethylene glycol dibenzoate + H2O

2 entries

fenitrothion + H2O

Culex quinquefasciatus

poor substrate

fenofibrate + H2O

fenofibrate + H2O

fenofibric acid + propan-2-ol

Canis lupus familiaris

F1P6W8, Q95N05

750478

fenpropathrin + H2O

Pseudomonas synxantha

A0A0K0Q1Y2

752220

fenvalerate + H2O

3 entries

fluorescein diacetate + H2O

3 entries

fluorescein diacetate + H2O

fluorescein + acetate

2 entries

geranyl acetate + H2O

geraniol + acetate

Spodoptera exigua

729831, 751800

glucose pentaacetate + H2O

2 entries

glyceryl tributyrate + H2O

4 entries

glyceryl tridecanoate + H2O

2 entries

glyceryl trihexanoate + H2O

Saccharolobus solfataricus

Q97VU2

activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus

669844

glyceryl trioctanoate + H2O

Saccharolobus solfataricus

Q97VU2

activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus

669844

glyceryl trioleate + H2O

4 entries

heptyl acetate + H2O

heptanol + acetate

2 entries

heroin + H2O

6-monoacetylmorphine + acetate

7 entries

hexyl acetate + H2O

hexanol + acetate

2 entries

hexyl valerate + H2O

hexanol + valeric acid

Sulfolobus acidocaldarius

hostacaine + H2O

hydrocinnamoyl farnesyl-L-cysteine methyl ester + H2O

N-(3-phenylpropanoyl)-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine + methanol

Sus scrofa

692927

hydroxyethylflurbiprofen + H2O

ethanol + flurbiprofen

4 entries

hydroxypropylflurbiprofen + H2O

propanol + flurbiprofen

4 entries

imidapril + H2O

7 entries

imidapril + H2O

imidaprilat + ?

2 entries

imidapril + H2O

imidaprilat + ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

indoxyl acetate + H2O

indol-3-ol + acetate

2 entries

irinotecan + H2O

7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid

2 entries

irinotecan + H2O

4 entries

irinotecan + H2O

SN-38 + 1,4'-bipiperidine-1'-carboxylic acid

Canis lupus familiaris

F1P6W8, Q95N05

750478

isobutyl 4-nitrophenyl methylphosphonate + H2O

4-nitrophenol + isobutyl methylphosphonate

Cereibacter sphaeroides

729255

isobutyl 4-nitrophenyl methylphosphonate + H2O

Cereibacter sphaeroides

729255

isobutyl acetate + H2O

isobutanol + acetate

Pyrobaculum calidifontis

isocarbophos + H2O

isopentyl octanoate + H2O

isopentanol + octanoate

Pseudomonas sp.

Q8GR22

653767

isopropyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O

isopropanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate

2 entries

isopropyl 4-nitrophenyl methylphosphonate + H2O

Cereibacter sphaeroides

729255

isopropyl acetate + H2O

isopropanol + acetate

2 entries

isopropyl cetraxate + H2O

isopropanol + cetraxate

Microbacterium sp.

651369

isopropyl octanoate + H2O

isopropanol + octanoate

Pseudomonas sp.

Q8GR22

653767

ispopropenyl acetate + H2O

isopropenol + acetate

Rhizobium viscosum

170985

ketoprofen ethyl ester + H2O

ketoprofen + ethanol

Archaeoglobus fulgidus

693586

ketoprofen ethyl ester + H2O

R-ketoprofen + ethanol

Homo sapiens

678552

R-isomer is main product of keratinocyte enzyme

L-methyl phenidate + H2O

Homo sapiens

P23141

690327

L-phenylalanine butyl ester + H2O

L-phenylalanine + butanol

Sus scrofa

669998

L-phenylalanine ethyl ester + H2O

L-phenylalanine + ethanol

Sus scrofa

669998

L-Tyr ethyl ester + H2O

L-Tyr + ethanol

2 entries

lambda-cyhalothrin + H2O

3-phenoxybenzyl alcohol + lambda-cyhalothric acid

Helicoverpa armigera

751967

lidocaine + H2O

2,6-xylidine + N,N-diethylglycine

2 entries

linalyl acetate + H2O

linalool + acetate

3 entries

malathion + H2O

7 entries

malathion + H2O

malathion alpha-monocarboxylic acid + malathion beta-monocarboxylic acid

Triticum aestivum

693444

meperidine + H2O

6 entries

methanethiol + acetyl-CoA

methanethioacetate + coenzyme A

Lactococcus lactis

Q8KWI9

ester formation

651608

methyl (-)-2-(3-benzoylphenyl)propionate + H2O

(-)-2-(3-benzoylphenyl)propionate + methanol

Saccharolobus solfataricus

Q97VW1

724578

methyl (trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate) + H2O

methanol + trans-4-[[4-(aminomethyl)cyclohexyl]carbonyl]oxybenzen-propionate

2 entries

methyl 1H-indole-3-carboxylate + H2O

methanol + 1H-indole-3-carboxylate

Arabidopsis thaliana

Q9SG92

718232

methyl 2-(4-(2,4-dichlorophenoxy)phenoxy)propanoate + H2O

2-(4-(2,4-dichlorophenoxy)phenoxy)propanoic acid + methanol

Alopecurus myosuroides

Q6H8W7

i.e. Diclofop methyl

670552

methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O

haloxyfop-P + methanol

2 entries

methyl 2-aminobenzoate + H2O

methanol + 2-aminobenzoate

Enterobacter cloacae

652371

methyl 2-hydroxybenzoate + H2O

methanol + 2-hydroxybenzoate

Enterobacter cloacae

very low activity

652371

methyl 2-methylbutyrate + H2O

2-methylbutanoic acid + methanol

Microbacterium hydrocarbonoxydans

substrate of mutant L233P

749661

methyl 2-tetrahydrofuroate + H2O

tetrahydrofuran-2-carboxylic acid + methanol

Microbacterium hydrocarbonoxydans

substrate of mutant L233P

749661

methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + H2O

diclofop + methanol

2 entries

methyl 3,5-dihydroxybenzoate + H2O

methanol + 3-hydroxybenzoate

Enterobacter cloacae

low activity

652371

methyl 3-(4-hydroxyphenyl)propionate + H2O

methanol + 3-(4-hydroxyphenyl)propionate

Microbacterium sp.

651369

methyl 3-cyclohexene-1-carboxylic acid + H2O

3-cyclohexene-1-carboxylic acid + methanol

Microbacterium hydrocarbonoxydans

substrate of mutant L233P

749661

methyl 3-hydroxybenzoate + H2O

methanol + 3-hydroxybenzoate

Enterobacter cloacae

652371

methyl 3-phenyloxirane-2-carboxylate + H2O

3-phenyloxirane-2-carboxylic acid + methanol

Microbacterium hydrocarbonoxydans

substrate of mutant L233S

749661

methyl 4-aminobenzoate + H2O

4-aminobenzoate + methanol

2 entries

methyl 4-aminobenzoate + H2O

methanol + 4-aminobenzoate

Enterobacter cloacae

652371

methyl 4-nitrobenzoate + H2O

4-nitrobenzoate + methanol

Homo sapiens

specific substrate for isoform ES1

714820

methyl acetate

methanol + acetate

Sus scrofa

poor substrate

677732

methyl acetate + H2O

methanol + acetate

5 entries

methyl benzoate + H2O

methanol + benzoate

Enterobacter cloacae

low activity

652371

methyl butanoate + H2O

methanol + butanoate

2 entries

methyl butyrate + H2O

methanol + butanoate

Archaeoglobus fulgidus

O28511

preferred substrate. The enzyme preferentially hydrolyzes esters of short-chain fatty acids (C2C4) and especially those of medium chain (C5C6) fatty acids with short chain alcohols

721900

methyl butyrate + H2O

methanol + butyrate

10 entries

methyl caprate + H2O

methanol + decanoate

Pseudomonas fluorescens

171026

methyl cetraxate + H2O

methanol + cetraxate

Microbacterium sp.

651369

methyl D-pantothenate + H2O

methanol + D-pantothenate

Microbacterium sp.

651369

methyl decanoate + H2O

methanol + decanoic acid

Lucilia cuprina

Q25252

730817

methyl DL-beta-acetylthioisobutyrate + H2O

D-beta-acetylthioisobutyrate + methanol

2 entries

methyl hexanoate + H2O

methanol + hexanoate

4 entries

methyl hexanoate + H2O

methanol + hexanoic acid

Lucilia cuprina

Q25252

730817

methyl L-pantothenate + H2O

methanol + L-pantothenate

Microbacterium sp.

651369

methyl laurate + H2O

methanol + lauric acid

Lucilia cuprina

Q25252

730817

methyl myristate + H2O

methanol + myristic acid

Lucilia cuprina

Q25252

730817

methyl octanoate + H2O

methanol + octanoate

3 entries

methyl octanoate + H2O

methanol + octanoic acid

Lucilia cuprina

Q25252

730817

methyl paraben + H2O

methanol + 4-hydroxybenzoate

2 entries

methyl paraoxon + H2O

Cereibacter sphaeroides

729255

methyl propionate + H2O

methanol + propionate

5 entries

methyl salicylate + H2O

methanol + salicylate

Arabidopsis thaliana

718215

methyl salicylate + H2O

salicylic acid + methanol

Homo sapiens

ratio of the rates of hydrolysis in liver to intestine 15.3

679473

methyl vanillate + H2O

methanol + vanillate

Enterobacter cloacae

652371

methyl-(-)-3-(4-methoxyphenyl) oxirane carboxylate + H2O

Microbacterium hydrocarbonoxydans

substrate of mutant L233S

749661

methyl-2,4-dichlorophenoxyacetate + H2O

2,4-dichlorophenoxyacetic acid + methanol

Arabidopsis thaliana

i.e. 2,4-D-methyl

680793

activation of pro-herbicide to phytotoxic acid. Isoform CXE12 is the major carboxyesterase responsible for activation

methylphenidate + H2O

6 entries

methylprednisolone 21-hemisuccinate + H2O

6 entries

methylumbelliferyl acetate + H2o

methylumbelliferone + acetate

Arabidopsis thaliana

682315

monobutyl phthalate + H2O

phthalate + butanol

2 entries

monocaprin + H2O

glycerol + caproate

Aspergillus nidulans

690570

monoelaidin + H2O

elaidic acid + glycerol

Culex quinquefasciatus

171032

monoethylglycylxylidine + H2O

2,6-xylidene + N-ethylglycine

Homo sapiens

Q6LAP9

CES1A-specific substrate

749814

monoolein + H2O

glycerol + oleic acid

2 entries

monopalmitoin + H2O

glycerol + palmitoleic acid

Aspergillus nidulans

690570

monopentyl phthalate + H2O

phthalate + pentanol

2 entries

monopropyl phthalate + H2O

phthalate + propanol

2 entries

mycophenolate + H2O

mycophenolic acid + 2-(morpholin-4-yl)ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

mycophenolate mofetil + H2O

mycophenolic acid + mofetil

Homo sapiens

prodrug, activation

710688

N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O

2 entries

N-acetyl L-phenylalanine ethyl ester + H2O

N-acetyl L-phenylalanine + ethanol

Sus scrofa

669998

N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O

N-acetyl-DL-phenylalanine + beta-naphthol

2 entries

N-acetyl-L-Ala-1-naphthyl ester + H2O

N-acetyl-L-Ala + 1-naphthol

Homo sapiens

170982

N-acetyl-L-phenylalanine methyl ester + H2O

N-acetyl-L-phenylalanine + methanol

Thermococcus litoralis

724947

N-acetyldapsone + H2O

dapsone + acetate

Canis lupus familiaris

F1P6W8, Q95N05

750478

n-butyl acetate + H2O

n-butanol + acetate

Bacillus subtilis

171008

n-butyl benzoate + H2O

n-butanol + benzoate

Aspergillus nomiae

651381

n-butyl n-butyrate + H2O

n-butanol + n-butyrate

2 entries

n-butyryl salicylate + H2O

n-butanol + salicylate

Cavia porcellus

170989

n-decanoyl salicylate + H2O

? + salicylate

Cavia porcellus

170989

N-ethylglycine xylidide + H2O

Sus scrofa

171000

n-heptyl acetate + H2O

n-heptanol + acetate

Bacillus subtilis

171008

n-hexanoyl salicylate + H2O

n-hexanol + salicylate

Cavia porcellus

170989

n-hexyl acetate + H2O

n-hexanol + acetate

2 entries

n-octanoyl salicylate + H2O

? + salicylate

Cavia porcellus

170989

n-octyl acetate + H2O

n-octanol + acetate

Bacillus subtilis

171008

n-pentyl acetate + H2O

n-pentanol + acetate

Bacillus subtilis

171008

n-propionyl salicylate + H2O

n-propionate + salicylate

Cavia porcellus

170989

N-propyl acetate + H2O

n-propanol + acetate

Bacillus subtilis

171008

n-propyl D-pantothenate + H2O

n-propanol + D-pantothenate

Microbacterium sp.

651369

n-propyl L-pantothenate + H2O

n-propanol + L-pantothenate

Microbacterium sp.

best substrate

651369

n-propyl salicylate + H2O

n-propanol + salicylate

Cavia porcellus

170989

n-valeryl salicylate + H2O

n-pentanol + salicylate

Cavia porcellus

170989

naphthyl acetate + H2O

naphthol + acetate

4 entries

nitrocefin + H2O

uncultured bacterium

i.e. 3-(2,4-dinitrosyl)-(6R,7R)-7-(2-thienylacetamido)-ceph-3-em-4-carboxylic acid

713856

nonyl acetate + H2O

nonanol + acetate

Spodoptera exigua

729831

O-butyryl propranolol + H2O

butanoate + propranolol

4 entries

octyl acetate + H2O

octanol + acetate

2 entries

oleoyl-CoA + H2O

oleic acid + CoA

2 entries

oseltamivir + H2O

10 entries

oseltamivir + H2O

oseltamivir carboxylate + ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

oxybutynin + H2O

2-cyclohexyl-2-phenylglycolic acid + 4-(diethylamino)but-2-yn-1-ol

Canis lupus familiaris

F1P6W8, Q95N05

750478

oxybutynin + H2O

2-cyclohexyl-2-phenylglycolic acid + ?

oxybutynin + H2O

p-nitrophenol butanoate + H2O

p-nitrophenol + butanoate

Bacillus subtilis

P37967

678865

p-nitrophenyl acetate + H2O

p-nitrophenol + acetate

10 entries

p-nitrophenyl butanoate + H2O

p-nitrophenol + butanoate

4 entries

p-nitrophenyl butyrate

p-nitrophenol + butyrate

3 entries

p-nitrophenyl butyrate + H2O

p-nitrophenol + butanoate

Escherichia coli

P04335

655643

p-nitrophenyl caprate

p-nitrophenol + caprate

2 entries

p-nitrophenyl caproate

p-nitrophenol + caproate

3 entries

p-nitrophenyl caproate + H2O

p-nitrophenol + caproate

2 entries

p-nitrophenyl caprylate + H2O

p-nitrophenol + caprylate

Thermotoga maritima

677751

p-nitrophenyl decanoate

p-nitrophenol + octanoate

2 entries

p-nitrophenyl hexanoate + H2O

p-nitrophenol + hexanoate

2 entries

p-nitrophenyl laurate

p-nitrophenol + laurate

Escherichia coli

P13001

652416

p-nitrophenyl myristate + H2O

p-nitrophenol + myristate

Thermotoga maritima

677751

p-nitrophenyl octanoate

p-nitrophenol + octanoate

2 entries

p-nitrophenyl palmitate

p-nitrophenol + palmitate

Pseudomonas aeruginosa

O33407

661993

p-nitrophenyl palmitate + H2O

p-nitrophenol + palmitate

3 entries

p-nitrophenyl pentanoate + H2O

p-nitrophenol + pentanoate

Saccharolobus shibatae

and substrates with longer acyl chains, hydrolysis proceeds in biophasic manner

669545

p-nitrophenyl propionate

p-nitrophenol + propionate

Escherichia coli

P13001

652416

p-nitrophenyl stearate

p-nitrophenol + stearate

Escherichia coli

P13001

652416

p-nitrophenyl stearate + H2O

p-nitrophenol + stearate

Thermotoga maritima

50% of the activity with p-nitrophenyl decanoate

677751

p-nitrophenyl valerate + H2O

p-nitrophenol + valeric acid

3 entries

p-tolyl octanoate + H2O

p-toluol + octanoate

palmitin + H2O

palmitoyl-CoA

CoA + palmitate

Escherichia coli

P13001

652416

palmitoyl-CoA + H2O

palmitic acid + CoA

2 entries

paraoxon + H2O

diethylphosphate + 4-nitrophenol

3 entries

penicillin G + H2O

6-aminopenicillanic acid + phenylacetic acid

uncultured bacterium

713856

pentyl acetate + H2O

pentanol + acetate

2 entries

pentyl octanoate + H2O

pentanol + octanoate

Pseudomonas sp.

Q8GR22

653767

pentyl PABC-Doxazolidine + H2O

PABC-Doxazolidine + pentanol

Homo sapiens

681324

pentyl valerate + H2O

pentanol + valeric acid

Sulfolobus acidocaldarius

Q7M529

not hydrolysed in the absence of Triton X-100

permethrin + H2O

phenacetin + H2O

phenolphthalein dibutyrate + H2O

Arthrobacter globiformis

171029, 714544

phenyl acetate + H2O

phenol + acetate

19 entries

phenyl butyrate + H2O

phenol + butyrate

7 entries

phenyl formate + H2O

phenol + formate

3 entries

phenyl pentanoate + H2O

phenol + pentanoate

3 entries

phenyl pivalate + H2O

phenol + pivalate

3 entries

phenyl valerate + H2O

valerate + phenol

Sus scrofa

682913

phenylthioacetate + H2O

2 entries

phenylthioacetate + H2O

thiophenol + acetate

3 entries

phenylthiobutyrate + H2O

thiophenol + butyrate

Equus caballus

170975

phenylthioisobutyrate + H2O

thiophenol + isobutyrate

Equus caballus

170975

phenylthiopentanoate + H2O

thiophenol + pentanoate

Equus caballus

170975

phenylthiopropionate + H2O

thiophenol + propionate

Equus caballus

170975

polyisoprenylated methylated protein + H2O

Homo sapiens

728935, 729359

pranlukast + H2O

Rattus norvegicus

effectively hydrolyzed by carboxylesterase pI 6.2 but not by the pI 6.0 enzyme

171025

prilocaine + H2O

o-toluidine + N-propylalanine

Canis lupus familiaris

F1P6W8, Q95N05

750478

procaine + H2O

4-aminobenzoic acid + 2-(diethylamino)ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

procaine + H2O

2 entries

proline-beta-naphthylamide + H2O

2 entries

prop-2-yn-1-yl 2-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenoxy)propanoate + H2O

2-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenoxy)propanoic acid + prop-2-yn-1-ol

Alopecurus myosuroides

Q6H8W7

i.e. clodinafop propargyl

670552

propanil + H2O

3,4-dichloroaniline + propanoate

Canis lupus familiaris

F1P6W8, Q95N05

750478

propoxur + H2O

Culex quinquefasciatus

poor substrate

171028

propyl 4-aminobenzoate + H2O

4-aminobenzoate + propanol

2 entries

propyl acetate + H2O

propanol + acetate

2 entries

propyl paraben + H2O

propanol + 4-hydroxybenzoate

2 entries

quinapril + H2O

6 entries

rac-2-acetoxy-2-(2'-chlorophenyl) acetate + H2O

2 entries

Rac-ibuprofen methyl ester + H2O

Rac-ibuprofen + methanol

ramipril + H2O

resorufine-butyrate + H2O

Burkholderia gladioli

Q9LAB8

low activity

649399

retinyl palmitate + H2O

retinol + palmitate

3 entries

S-acetylthiocholine iodide + H2O

thiocholine iodide + acetate

Phaseolus vulgaris

low activity

751413

S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate + H2O

Homo sapiens

P23141

750061

S-butyrylthiocholine iodide + H2O

thiocholine iodide + butyrate

Phaseolus vulgaris

low activity

751413

S-methyl thiobutanoate + H2O

methanol + thiobutanoate

Saccharolobus solfataricus

Q97VU2

activity with mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus

669844

S-methyl thiobutyrate + H2O

sarin + H2O

CE1 exhibits a 5fold preference for the PS isomer of a sarin analog

716275

sec-butyl acetate + H2O

sec-butanol + acetate

Pyrobaculum calidifontis

Q8NKS0

726707

stearoyl-CoA + H2O

CoA + stearate

Rattus norvegicus

171023

t-butyl acetate + H2O

t-butanol + acetate

Bacillus subtilis

P37967

678865

t-butyl-gamma-(t-butoxycarbonylamino)-butyrate + H2O

Bacillus subtilis

P37967

678865

effective removal of t-butyl protecting group in organic synthesis

temephos + H2O

Culex quinquefasciatus

poor substrate

171028

temocapril + H2O

(2S)-2-[[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino]-4-phenylbutanoic acid + ethanol

Homo sapiens

ratio of the rates of hydrolysis in liver to intestine 734

679473

temocapril + H2O

8 entries

temocapril + H2O

temocaprilat + ethanol

Canis lupus familiaris

F1P6W8, Q95N05

750478

tert-butyl acetate + H2O

tert-butanol + acetate

Pyrobaculum calidifontis

trandolapril + H2O

trandolapril + H2O

trandolaprilat + ?

Homo sapiens

trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound

690859

trans-cypermethrin + H2O

2 entries

trans-methyl cinnamate + H2O

methanol + cinnamate

Enterobacter cloacae

very low activity

652371

trans-permethrin + H2O

(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid + (3-phenoxyphenyl)methanol

Bacillus subtilis

678538

trans-permethrin + H2O

5 entries

triacetin + H2O

6 entries

triacetin + H2O

acetic acid + glycerol

7 entries

tributyrin + H2O

18 entries

tributyrin + H2O

butanoate + glycerol

6 entries

tributyrylglycerol + H2O

butyrate + glycerol

7 entries

tricaproin + H2O

Bacillus subtilis

poor substrate

670779

tricaproin + H2O

caproic acid + glycerol

2 entries

tricaprylin + H2O

Bacillus subtilis

poor substrate

670779

tricaprylin + H2O

caprylic acid + glycerol

Rattus norvegicus

8.1% of the activity with tributyrin

trinotecan + H2O

triolein + H2O

triolein + H2O

oleic acid + glycerol

Cavia porcellus

170989

tripropionin + H2O

5 entries

tripropionin + H2O

propanoic acid + glycerol

2 entries

tripropionin + H2O

propionic acid + glycerol

Tween 20 + H2O

Tween 80 + H2O

vinyl acetate + H2O

vinyl alcohol + acetate

8 entries

vinyl butanoate + H2O

vinyl alcohol + butanoate

6 entries

vinyl butyrate + H2O

vinyl alcohol + butyrate

3 entries

vinyl caproate + H2O

vinyl alcohol + caproate

unidentified

677663

vinyl caprylate + H2O

vinyl alcohol + caprylate

unidentified

677663

vinyl hexanoate + H2O

vinyl alcohol + hexanoate

2 entries

vinyl laurate + H2O

vinyl alcohol + laurate

3 entries

vinyl octanoate + H2O

vinyl alcohol + octanoate

Pseudomonas sp.

Q8GR22

653767

vinyl propionate + H2O

vinyl alcohol + propionate

9 entries

xylan + H2O

uncultured bacterium

polymeric xylan, low activity by the wild-type enzyme, no activity by enzyme mutant NaM1H2

749674

additional information

188 entries