KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0003 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0007 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0007 | - |
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0008 | - |
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0009 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0009 | - |
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0014 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0015 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0015 | - |
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0017 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0017 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0018 | - |
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0019 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0019 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.002 | - |
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.002 | - |
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0021 | - |
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0024 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
0.0025 | - |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0025 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0028 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0031 | - |
p-nitrophenyl acetate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0038 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.004 | - |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0054 | - |
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.0091 | - |
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens | |
0.027 | - |
p-nitrophenyl acetate | isoform hCE-1,pH 8.0, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23141 | isoforms hCE-1 and hCE-2, recombinant enzymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzymic activities against further pyrethroid substrates | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O | - |
Homo sapiens | (2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | - |
? | |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | (2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O | - |
Homo sapiens | (2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid | - |
? | |
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | hydroxy(3-phenoxyphenyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + H2O | - |
Homo sapiens | hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2,3,3-tetramethylcyclopropanecarboxylic acid | - |
? | |
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid + H2O | - |
Homo sapiens | hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid | - |
? | |
additional information | both enzyme isoforms hydrolyze type I and type II pyrethroids with strong stereoselectivity | Homo sapiens | ? | - |
? | |
p-nitrophenyl acetate + H2O | - |
Homo sapiens | p-nitrophenol + acetate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
17 | - |
p-nitrophenyl acetate | isoform hCE-1, pH 8.0, 37°C | Homo sapiens | |
70 | - |
p-nitrophenyl acetate | isoform hCE-2, pH 8.0, 37°C | Homo sapiens |