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3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

Reaction

a carboxylic ester
+
H2O
=
an alcohol
+
a carboxylate

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase

IC50 Value

IC50 Value on EC 3.1.1.1 - carboxylesterase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.007
(10Z)-hexadecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.002
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.019
(6Z,9Z,12Z)-octadecatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.007
(9Z)-octadecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.012
(9Z)-tetradecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.009
(9Z,12Z)-octadecadienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.000102
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000259
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000144
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000251
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.027
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00402
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.1
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.038
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.013
15-deoxy-DELTA12,14-prostaglandin J2
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00695 - 0.01053
18beta-11-deoxo-olean-12-en-30-oic acid
0.00399 - 0.02509
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.0057 - 0.02626
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
0.00561 - 0.02236
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
0.00395 - 0.00913
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.1
18beta-3, 11-dioxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.00002 - 0.02041
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.00066 - 0.1
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
0.04051 - 0.04986
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
0.00342 - 0.01231
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.02075 - 0.02361
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
0.02097 - 0.06926
18beta-glycyrrhetinic acid
0.0033
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000054
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.002425
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.000495
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.00487
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0474
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.000302
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.001054
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000122
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.000042
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000487
2-fluorophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000425
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.001223
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0025
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0000662
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-3,5,7-triyl hexaethyl tris(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00000893
2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0000194
2-[3-[(diethoxyphosphoryl)oxy]-4-methoxyphenyl]-4-oxo-3,4-dihydro-2H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0000158
2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0081
24(S),25-epoxycholesterol
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.000033
27-Hydroxycholesterol
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.03706
3',4'-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.0011
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000135
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.00506
3,6-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.00025
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0023
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.1
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
Homo sapiens
pH 7.4, 37°C
0.00000372
3-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.000326
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000213
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000132
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.00000454
4-[7-[(diethoxyphosphoryl)oxy]-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.000024
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]benzene-1,2-diyl tetraethyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00000249
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl diethyl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00000158
4-[7-[(diethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-3-yl]phenyl diethyl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00036
4-[7-[(dimethoxyphosphoryl)oxy]-5-hydroxy-4-oxo-4H-chromen-2-yl]phenyl dimethyl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00388
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
Homo sapiens
pH and temperature not specified in the publication
0.00395
4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
Homo sapiens
pH and temperature not specified in the publication
0.000131
5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0035
5,6-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.058
5,7,8-trihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.022
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.07549
5,7-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.0000255
5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl dimethyl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.03344
5-hydroxy-6-methoxyflavone
Homo sapiens
pH 7.4, 37°C
0.001871
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000319
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.01457
6,7-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.03067
6-hydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.004204
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.01569
7-methoxybaicalein
Homo sapiens
pH 7.4, 37°C
0.0382
8-ethyl 3-methyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
Sus scrofa
pH 8.0, 25°C
0.01
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.00699 - 0.01421
8beta-11-oxo-olean-12-en-30-amide
0.00736 - 0.01097
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
0.00473
apigenin 7-O-methyl ether
Homo sapiens
pH 7.4, 37°C
0.00524 - 0.0617
aripiprazole
0.00407
atomoxetine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.02112
baicalein
Homo sapiens
pH 7.4, 37°C
0.00347 - 0.00431
bavachinin
0.00016
benzil
Homo sapiens
-
-
0.0000104 - 0.000788
bis(4-nitrophenyl)phosphate
0.00014 - 0.00611
bis-4-nitrophenyl phosphate
0.00499
bisdehydrophorbol
Homo sapiens
pH and temperature not specified in the publication
0.00000021
chlorpyrifos
Homo sapiens
-
-
0.0000244 - 0.00321
chlorpyrifos-oxon
0.00409
clozapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.0124
curcumin
Homo sapiens
-
pH 7.4, 37°C
0.0075
diazinon
Archaeoglobus fulgidus
pH 7.1, 50°C
0.0000224 - 0.012
dichlorvos
0.01346
didehydrolangduin A-20-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.0344
diethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydroimidazo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
Sus scrofa
pH 8.0, 25°C
0.0093
diethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,8-dicarboxylate
Sus scrofa
pH 8.0, 25°C
0.00025
diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00392
diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0415
diethyl 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00000179
diethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00033
diethyl 7-hydroxy-4-oxo-2-phenyl-4H-chromen-5-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0573
diethyl coumarylphosphate
Malus domestica
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.00745
dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00056
dimethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0092
dimethylchlorophosphate
Actinidia eriantha
pH 8.0, 25°C
0.01786
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.05327
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.0039
ethyl 3-amino-5-(trifluoromethyl)-1,2,4-triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0036
ethyl 4-hydroxy-4-(trifluoromethyl)-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0136
ethyl 7-hydroxy-7-(trifluoromethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00144
ethyl-4-hydroxy-7-methyl-4-nonaluorobuthyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0483
ethyl-4-hydroxy-7-methyl-4-trifluoromethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00046
ethyl-4-hydroxy-7-phenyl-4-nonafluorobutyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00391
ethyl-4-hydroxy-7-phenyl-4-pentafluoroethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0164
ethyl-4-hydroxy-7-phenyl-4-trifluoromethyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00083
ethyl-7-hydroxy-7-nonafluorobutyl-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00098
ethyl-7-hydroxy-7-nonafluorobutyl-4,7-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00685
eupatilin
Homo sapiens
pH 7.4, 37°C
0.02168
fischeroside A
Homo sapiens
pH and temperature not specified in the publication
0.0293
fischeroside A-16-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.01372
fisetin
Homo sapiens
pH 7.4, 37°C
0.00521 - 0.0589
fluoxetine
0.01279
galangin
Homo sapiens
pH 7.4, 37°C
0.00359
haloperidol
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.025
hexadecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00764
hispidulin
Homo sapiens
pH 7.4, 37°C
0.00372
imipramine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.03249
ingenol-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.00363
isorhamnetin
Homo sapiens
pH 7.4, 37°C
0.02016
kaempferol
Homo sapiens
pH 7.4, 37°C
0.00521
langduin F
Homo sapiens
pH and temperature not specified in the publication
0.000287 - 0.1
loperamide
0.03473
luteolin
Homo sapiens
pH 7.4, 37°C
0.0107
methyl 4-hydroxy-4-(nonafluorobutyl)-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00329
methyl 7-(heptafluoropropyl)-7-hydroxy-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0123
methyl 7-hydroxy-7-(1,1,2,2-tetrafluoroethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00131
methyl 7-hydroxy-7-(nonafluorobutyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.000018 - 0.00027
methyl paraoxon
0.00096
methyl-4-hydroxy-7-phenyl-4-nonafluorobutyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0586
methyl-7-hydroxy-7-trifluoromethyl-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00253
miltirone
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000079
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide)
Homo sapiens
-
-
0.00057
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide)
Homo sapiens
-
-
0.0001
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide)
Homo sapiens
-
-
0.0000252
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide)
Homo sapiens
-
-
0.0000984
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide
Homo sapiens
-
-
0.00399
n-desmethylclozapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.000055
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000177
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000059
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.008
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0024
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000354
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.00054
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000868
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.08049
nobiletin
Homo sapiens
pH 7.4, 37°C
0.1
octadecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00338
olanzapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.02082
oroxylin A
Homo sapiens
pH 7.4, 37°C
0.00000029 - 0.0011
paraoxon
0.00486 - 0.065
perphenazine
0.000942
phenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0534
phenyl 4-(heptafluoropropyl)-4-hydroxy-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazine-3-carboxylate
Sus scrofa
pH 8.0, 25°C
0.0172
phenyl 7-hydroxy-7-(trifluoromethyl)-4,7-dihydrotetrazolo[5,1-c][1,2,4]triazine-6-carboxylate
Sus scrofa
pH 8.0, 25°C
0.00883
phorbol-13-acetate
Homo sapiens
pH and temperature not specified in the publication
0.0765
prasugrel
Homo sapiens
-
isozyme CE2
0.1
prostaglandin E2
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.1
prostaglandin F2alpha
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.01885
quercetin
Homo sapiens
pH 7.4, 37°C
0.00415
quetiapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.02405
scutellarein
Homo sapiens
pH 7.4, 37°C
0.00694 - 0.0109
simvastatin
0.027
tetrachlorvinphos
Equus caballus
-
at 37°C
0.009
tetradecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.0000217
tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.0000323
tetraethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromene-6,7-diyl bis(phosphate)
Sus scrofa
-
in 0.1 M sodium phosphate buffer, pH 7.0, at 30°C
0.00515 - 0.0583
thioridazine
0.01216
wogonin
Homo sapiens
pH 7.4, 37°C
0.00479
yuexiandajisu D
Homo sapiens
pH and temperature not specified in the publication
0.00447
yuexiandajisu E
Homo sapiens
pH and temperature not specified in the publication
0.00413
ziprasidone
Homo sapiens
-
versus substrate 4-nitrophenyl acetate