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Literature summary for 3.1.1.1 extracted from
- Human liver carboxylesterase. Properties and comparison with human serum carboxylesterase (1983), J. Biochem., 94, 793-797.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| neostigmine | serum enzyme is inhibited, liver enzyme is not affected | Homo sapiens |  |
| p-trimethylammoniumanilinium dichloride | serum enzyme is inhibited, liver enzyme is not affected | Homo sapiens | |
| PMSF | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
methyl butyrate | serum enzyme | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 61000 | - |
1 * 61000, liver enzyme, SDS-PAGE | Homo sapiens |
| 61000 | - |
3 * 61000, liver enzyme, SDS-PAGE | Homo sapiens |
| 62000 | - |
liver enzyme, monomeric enzyme form, gel filtration in 0.1 M acetate buffer | Homo sapiens |
| 180000 | - |
liver enzyme, trimeric form, gel filtration in 50 mM Tris-HCl, pH 7.5, 200 mM KCl | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
monomeric and trimeric enzyme form | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylthiocholine + H2O | activity of serum enzyme, no activity of liver enzyme | Homo sapiens | butyric acid + thiocholine | - |
? | |
| methyl butyrate + H2O | - |
Homo sapiens | methanol + butyrate | - |
? | |
| tributyrylglycerol + H2O | - |
Homo sapiens | butyrate + glycerol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 61000, liver enzyme, SDS-PAGE | Homo sapiens |
| trimer | 3 * 61000, liver enzyme, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
hydrolysis of methyl butyrate, liver and serum enzyme | Homo sapiens |
| 8.3 | - |
hydrolysis of butyrylcholine, serum enzyme | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 10 | pH 5.0: about 40% of maximal activity, pH 10: about 35% of maximal activity | Homo sapiens |
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Release 2023.1 (January 2023)
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