Application | Comment | Organism |
---|---|---|
medicine | since the enzyme may be useful as a treatment for cocaine overdose, and may afford protection against chemical weapons like Sarin, Soman and VX gas, hCE1 could serve as both a drug and a drug target | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure of hCE1 in complex with the cocaine analogue homatropine to 2.8 A resolution, and with the heroin analogue naloxone to 2.9 A resolution | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cocaine + H2O | Homo sapiens | - |
O-benzoylecgonine + methanol | - |
? | |
additional information | Homo sapiens | the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cocaine + H2O | - |
Homo sapiens | O-benzoylecgonine + methanol | - |
? | |
additional information | the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 1 | - |
Homo sapiens |
HCE1 | - |
Homo sapiens |