Literature summary for 3.1.1.1 extracted from

Schiel, M.A.; Green, S.L.; Davis, W.I.; Sanghani, P.C.; Bosron, W.F.; Sanghani, S.P.
Expression and characterization of a human carboxylesterase 2 splice variant (2007), J. Pharmacol. Exp. Ther., 323, 94-101.

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Protein Variants

Protein Variants	Comment	Organism
DELTA458-473	inactive splice variant of isoform CES2, lacks activity against 4-methylumbelliferyl acetate and 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin and accounts for about 6% of total isoform transcripts in colon tissue	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform CES2, several splice variants	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl acetate + H2O	-	Homo sapiens	4-methylumbelliferone + acetate	-	?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O	i.e. irinotecan, CPT-11, prodrug	Homo sapiens	7-ethyl-10-hydroxycampothecin + ?	i.e. SN-38, topoisomerase inhibitor used in cancer therapy	?

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Release 2023.1 (January 2023)