3.1.1.1: carboxylesterase This is an abbreviated version!go to the full flat file .
Reaction
a carboxylic ester H2O an alcohol a carboxylate
Synonyms 4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac
ECTree
Natural Substrates Products
Natural Substrates Products on EC 3.1.1.1 - carboxylesterase
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(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
i.e anordrin
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
acetylsalicylic acid + H2O
acetate + salicylate
CES2A1-specific substrate
-
-
?
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
fluazifop-P + butanol
-
-
-
?
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate + H2O
cyhalofop + butanol
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
cocaine + H2O
O-benzoylecgonine + methanol
ethanol + acetate
ethyl acetate + H2O
ester formation
-
?
ethanol + acetyl-CoA
ethyl acetate + CoA
ester formation
-
?
ethanol + butyrate
ethyl butanoate + H2O
ester formation
-
?
ethyl 2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate
fenoxaprop-P + ethanol
-
-
-
?
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate + H2O
quizalofop-P + ethanol
-
-
-
?
methyl 1H-indole-3-carboxylate + H2O
methanol + 1H-indole-3-carboxylate
-
-
-
?
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate + H2O
haloxyfop-P + methanol
-
-
-
?
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate + H2O
diclofop + methanol
-
-
-
?
methyl salicylate + H2O
methanol + salicylate
-
-
-
-
?
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
CES1A-specific substrate
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
-
prodrug, activation
-
-
?
polyisoprenylated methylated protein + H2O
?
-
-
-
-
?
tributyrin + H2O
?
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-
-
?
additional information
?
-
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
-
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
-
-
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
-
-
-
?
(S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
(2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
-
-
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
-
i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors
i.e. SN-38
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
-
isozyme CE-2 is responsible for activation of the prodrug
i.e. SN-38
?
camptothecin-11 + H2O
?
-
i.e. CPT-11, an anti-tumor agent
-
-
?
camptothecin-11 + H2O
?
-
i.e. CPT-11, an anti-tumor agent
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
an anti-thrombogenic agent
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
-
an anti-thrombogenic agent
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
-
-
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
CE-1 is responsible for the methyl ester hydrolysis of cocaine
-
-
?
malathion + H2O
?
i.e. S-(1,2-dicarbethoxyethyl)-O,O-dimethyldithiophosphate
-
-
?
malathion + H2O
?
i.e. S-(1,2-dicarbethoxyethyl)-O,O-dimethyldithiophosphate
-
-
?
malathion + H2O
?
-
-
-
?
oseltamivir + H2O
?
-
an anti-viral drug
-
-
?
oseltamivir + H2O
?
-
an anti-viral drug
-
-
?
additional information
?
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the Aquamicrobium strain FPB-1 is capable of efficiently degrading AOPP herbicides
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?
additional information
?
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the enzyme is involved in organophosphate insecticide resistance
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-
?
additional information
?
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imaging and detection of carboxylesterase in zebrafish by a near-infrared fluorescence off-on probe, overview
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-
?
additional information
?
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the enzyme plays an important role in the reproductive biology
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-
?
additional information
?
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the enzyme BioH is involved in biotin biosynthesis
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?
additional information
?
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the enzyme BioH is involved in biotin biosynthesis
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?
additional information
?
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BioHe shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHe BioH also shows low enzymatic activities for thioesterase, lipase, and aminopeptidase, but shows no detectable enzymatic activity for phosphatase, trypsin-like endopeptidase, or perhydrolase
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-
?
additional information
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the enzyme may function as a blood-brain barrier to protect the central nervous system from ester or amide compounds
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?
additional information
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the enzyme may function as a blood-brain barrier to protect the central nervous system from ester or amide compounds
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?
additional information
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the enzyme plays an important role in the detoxification of xenobiotic chemicals that contain organophosphate compounds
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?
additional information
?
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the enzyme plays an important role in the detoxification of xenobiotic chemicals that contain organophosphate compounds
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?
additional information
?
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the enzyme also catalyzes the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene
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-
?
additional information
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carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid
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?
additional information
?
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xenobiotic substrates are pyrethroid insecticides
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-
?
additional information
?
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imaging and detection of carboxylesterase in living cells by a near-infrared fluorescence off-on probe, overview
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-
?
additional information
?
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in comparison with the (-)-cocaine hydrolysis (benzoyl ester) in vivo, the faster (-)-cocaine hydrolysis (methyl ester) in vivo is solely due to the high abundance of CE-1 in the body
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-
?
additional information
?
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in comparison with the (-)-cocaine hydrolysis (benzoyl ester) in vivo, the faster (-)-cocaine hydrolysis (methyl ester) in vivo is solely due to the high abundance of CE-1 in the body
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?
additional information
?
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carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid
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?
additional information
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O35535
phylogenetic tree for rat liver carboxylesterases
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?
additional information
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phylogenetic tree for rat liver carboxylesterases
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?
additional information
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phylogenetic tree for rat liver carboxylesterases
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?
additional information
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phylogenetic tree for rat liver carboxylesterases
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?
additional information
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phylogenetic tree for rat liver carboxylesterases
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additional information
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phylogenetic tree for rat liver carboxylesterases
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additional information
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BioHs shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHs also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis
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-
?
additional information
?
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BioHs shows carboxylesterase activity with a preference for short chain fatty acid esters with acyl chain length of up to C6. BioHs also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis
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-
?
3.1.1.1 carboxylesterase
results (
results (
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