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3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

Reaction

a carboxylic ester
+
H2O
=
an alcohol
 +
a carboxylate

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase

Turnover Number

Turnover Number on EC 3.1.1.1 - carboxylesterase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.004 - 0.056
(1RS)-cis-permethrin
0.0008 - 0.036
(1RS)-trans-permethrin
26.1
(E)-2-hexenyl acetate
-
pH 7.4, 28°C
22.5
(E)-2-hexenyl butyrate
-
pH 7.4, 28°C
65.4 - 385.5
(S)-ketoprofen ethyl ester
21.9
(Z)-3-hexenyl acetate
-
pH 7.4, 28°C
13.2
(Z)-3-hexenyl butyrate
-
pH 7.4, 28°C
1.9
(Z)-3-hexenyl caproate
-
pH 7.4, 28°C
108
1,4-diacetoxybenzene
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
4.8 - 3000
1-naphthyl acetate
18.7 - 1600
1-naphthyl butanoate
9 - 48
1-naphthyl butyrate
64 - 233
2,4-dinitrophenyl butyrate
40 - 133.3
2-naphthyl acetate
83
2-naphthyl propionate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
233 - 245
2-Nitrophenyl butyrate
1.7
2-nitrophenylacetate
-
-
1.4
2-nitrophenylbutyrate
-
-
1.3
2-nitrophenylpropionate
-
-
111
2-phenyloxazolin-5-one
-
-
8.7
3'-D-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
1.1
3'-D-valyl-gemcitabine
-
pH 7.4, 37°C
0.08
3'-L-isoleucyl-gemcitabine
-
pH 7.4, 37°C
6.1
3'-L-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
0.11
3'-L-valyl-gemcitabine
-
pH 7.4, 37°C
4.3
3-acetoxypyridine
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
345
3-nitrophenyl butyrate
-
-
1.3
3-nitrophenylbutyrate
-
-
0.1
4'-chloroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
47
4-methylbenzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.65 - 166.7
4-methylumbelliferyl acetate
10.1
4-methylumbelliferyl butanoate
pH 8.0, 25°C
0.067 - 69.5
4-Methylumbelliferyl butyrate
0.063 - 6.94
4-methylumbelliferyl heptanoate
0.01 - 6.38
4-methylumbelliferyl laurate
0.162 - 4.66
4-methylumbelliferyl octanoate
0.0018 - 0.254
4-methylumbelliferyl palmitate
0.36
4-nitroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.0245 - 6400
4-nitrophenyl acetate
0.000022 - 5240
4-nitrophenyl butanoate
4 - 1670
4-nitrophenyl butyrate
0.089 - 800
4-nitrophenyl caprate
0.119 - 507
4-nitrophenyl caproate
0.125 - 360
4-nitrophenyl caprylate
1.5 - 2337
4-nitrophenyl decanoate
0.2 - 1312
4-nitrophenyl dodecanoate
0.03 - 1138
4-nitrophenyl hexadecanoate
2 - 4440
4-nitrophenyl hexanoate
0.024 - 555
4-nitrophenyl laurate
0.0313 - 3080
4-nitrophenyl octanoate
0.00318 - 1080
4-nitrophenyl palmitate
46.3 - 15300
4-nitrophenyl pentanoate
238 - 1480
4-nitrophenyl propanoate
2 - 1230
4-nitrophenyl propionate
0.11 - 235
4-nitrophenyl tetradecanoate
69 - 580
4-nitrophenyl valerate
1.6
4-nitrophenylbutyrate
-
-
1.61 - 8500
4-yethylumbelliferyl acetate
1.38
5'-cinnamic acid-floxuridine
-
pH 7.4, 37°C
0.55
5'-D-phenylalanyl-BDCRB
-
pH 7.4, 37°C
1.1
5'-D-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
0.008
5'-D-valyl-gemcitabine
-
pH 7.4, 37°C
0.33
5'-L-isoleucyl-gemcitabine
-
pH 7.4, 37°C
0.62
5'-L-phenylalanine-floxuridine
-
pH 7.4, 37°C
8
5'-L-phenylalanyl-BDCRB
-
pH 7.4, 37°C
1.1
5'-L-phenylalanyl-gemcitabine
-
pH 7.4, 37°C
0.008
5'-L-valyl-gemcitabine
-
pH 7.4, 37°C
11.8
7-amino cephalosporanic acid
-
pH 7.0, 25°C
46.7 - 133.3
7-aminocephalosporanic acid
0.000003 - 0.004
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
0.000015 - 0.017
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
0.00041
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
1.8 - 3000
Alpha-naphthyl acetate
1600
alpha-naphthyl butyrate
-
-
2.5
Benzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.57 - 0.9
benzyloxycarbonyl-D-Tyr p-nitrophenyl ester
0.92 - 24
benzyloxycarbonyl-L-Tyr p-nitrophenyl ester
0.034 - 0.11
bioresmethrin
1200
bisphenyl carbonate
-
-
4.46
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
4.17
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
11.1
butyl butyrate
-
-
2800
carboxyfluorescein diacetate
0.000238
cefazolin
-
at 35°C in 100 mM sodium phosphate (pH 7.0)
1.05
cis-permethrin
pH 7.0, 30°C
0.11
cyano(6-methoxy-2-naphthyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
pH 8.0, 30°C
0.099
cyano(6-methoxy-2-naphthyl)methyl butanoate
pH 8.0, 30°C
0.067
cyano(6-methoxynaphthalen-2-yl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid
pH 8.0, 30°C
0.12 - 0.288
cypermethrin
4.22
D-glucose pentaacetate
-
pH 7.0, 25°C
71
D-Tyr ethyl ester
-
-
12.2
D-xylose tetraacetate
-
pH 7.0, 25°C
0.016
deltamethrin
pH 7.0, 30°C
1.7
ethyl 2-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
5.01 - 5.28
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate
1.8
ethyl 4-nitrophenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
84
ethyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
4 - 559
ethyl butyrate
0.79
ethyl butyrylacetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
4.4
ethylbutyrate
-
-
0.103
fenvalerate
pH 7.0, 30°C
170
fluorescein diacetate
0.5
geranyl acetate
-
pH 7.4, 28°C
13.1
hexyl acetate
-
pH 7.4, 28°C
2.3
indoxyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.01
irinotecan
-
pH 7.4, 37°C
8
isobutyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
3.1
isopropyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.08
L-phenylalanine butyl ester
-
pH 7.4, 37°C
63.6
L-phenylalanine ethyl ester
-
pH 7.4, 37°C
71
L-Tyr ethyl ester
-
-
0.07 - 13
malathion
6.31
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
5.92
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
10 - 454
methyl butyrate
2.1
methyl paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.45
N-acetyl L-phenylalanine ethyl ester
-
pH 7.4, 37°C
651
N-acetyl-L-Ala-1-naphthyl ester
-
-
323 - 366
o-nitrophenyl butyrate
17 - 6400
p-nitrophenyl acetate
14
p-nitrophenyl butanoate
-
60°C, pH 7.5
6.1 - 1700
p-nitrophenyl butyrate
4 - 39760
p-nitrophenyl caproate
13
p-nitrophenyl caprylate
-
60°C, pH 7.5
10.8
p-nitrophenyl decanoate
-
60°C, pH 7.5
2.47 - 4320
p-nitrophenyl hexanoate
1.5
p-nitrophenyl laurate
+/- 0.2
4.9
p-nitrophenyl myristate
-
60°C, pH 7.5
13.1
p-nitrophenyl propionate
+/- 1.2
0.1
palmitoyl-CoA
-
1.3
paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
59
pentyl acetate
-
pH 7.4, 28°C
30 - 550
phenyl acetate
204 - 661
phenyl butyrate
660 - 3100
phenyl formate
263 - 860
phenyl pentanoate
9.7
phenyl pivalate
-
-
6.5
phenyl trimethyl acetate
-
-
3.5
phenylbutyrate
-
-
5
phenylthioacetate
-
-
4.4
phenylthiobutyrate
-
-
3.7
phenylthioisobutyrate
-
-
4.6
phenylthiopentanoate
-
-
8.9
phenylthiopropionate
-
-
0.00083 - 0.0075
retinyl palmitate
0.5 - 2.9
trans-permethrin
40 - 945
Triacetin
18 - 1290
tributyrin
7 - 835
tripropionin
50 - 140
vinyl acetate
210 - 1930
vinyl butanoate
31
vinyl laurate
-
pH 7.5, 25°C
105 - 980
vinyl propionate
additional information
additional information
-