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3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

Reaction

a carboxylic ester
+
H2O
=
an alcohol
 +
a carboxylate

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase

KCat KM Value

KCat KM Value on EC 3.1.1.1 - carboxylesterase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.21
(E)-2-hexenyl acetate
-
pH 7.4, 28°C
4.96
(E)-2-hexenyl butyrate
-
pH 7.4, 28°C
18.5 - 21.3
(S)-ketoprofen ethyl ester
3.59
(Z)-3-hexenyl acetate
-
pH 7.4, 28°C
4.21
(Z)-3-hexenyl butyrate
-
pH 7.4, 28°C
0.78
(Z)-3-hexenyl caproate
-
pH 7.4, 28°C
130
1,4-diacetoxybenzene
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
7.5
1-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
500
1-naphthyl butyrate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
100 - 667
2-naphthyl acetate
150
2-naphthyl propionate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.25
2-phenethyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.47
2-thionaphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
2.4
3-acetoxypyridine
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.063
4'-chloroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
38
4-methylbenzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
2.7 - 2680
4-methylumbelliferyl acetate
3.2 - 3070
4-Methylumbelliferyl butyrate
2.6 - 11200
4-methylumbelliferyl heptanoate
74100
4-methylumbelliferyl laurate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
15100
4-methylumbelliferyl octanoate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
4760
4-methylumbelliferyl palmitate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
0.55
4-nitroacetanilide
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.00548 - 3260
4-nitrophenyl acetate
127 - 49300
4-nitrophenyl butanoate
5.1 - 32400
4-nitrophenyl butyrate
63 - 192
4-nitrophenyl caprylate
1.24 - 97400
4-nitrophenyl decanoate
1.2 - 35900
4-nitrophenyl dodecanoate
0.7 - 8700
4-nitrophenyl hexadecanoate
0.6 - 92200
4-nitrophenyl hexanoate
1.18 - 51800
4-nitrophenyl octanoate
54 - 1800
4-nitrophenyl palmitate
21.1 - 43300
4-nitrophenyl pentanoate
1710 - 4300
4-nitrophenyl propanoate
64.2 - 3300
4-nitrophenyl propionate
11.7 - 40
4-nitrophenyl tetradecanoate
287
4-yethylumbelliferyl acetate
-
in 25 mM Tris-HCl (pH 8.0), at 25°C
122 - 260
7-aminocephalosporanic acid
160
Benzyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
10372.1
butyl 2-(4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
9266.7
butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
0.003035
cefazolin
-
at 35°C in 100 mM sodium phosphate (pH 7.0)
0.21
cyclohexyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
50
diethyl-4-methylumbelliferyl phosphate
in 25 mM Tris-HCl (pH 8.0), at 25°C
2.8
ethyl 2-naphthyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
12571.4 - 12846.2
ethyl 2-[4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy]propanoate
4.3
ethyl 4-nitrophenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
380
ethyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
2.4
ethyl butyrylacetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
0.45
geranyl acetate
-
pH 7.4, 28°C
2.82
hexyl acetate
-
pH 7.4, 28°C
1.2
indoxyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
11
isobutyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
2.6
isopropyl 4-nitrophenyl methylphosphonate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
19718.8
methyl 2-(4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy]phenoxy)propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
15179.5
methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
recombinant His-tagged enzyme, pH 7.0, 37°C
1380
methyl decanoate
in 25 mM Tris-HCl (pH 8.0), at 25°C
280
methyl hexanoate
in 25 mM Tris-HCl (pH 8.0), at 25°C
200
methyl laurate
in 25 mM Tris-HCl (pH 8.0), at 25°C
61
methyl myristate
in 25 mM Tris-HCl (pH 8.0), at 25°C
830
methyl octanoate
in 25 mM Tris-HCl (pH 8.0), at 25°C
5
methyl paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
12
paraoxon
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
7.57
pentyl acetate
-
pH 7.4, 28°C
11
phenyl acetate
-
in 2.5 mM Bicine buffer, pH 8.3, at 30°C
21.3
Triacetin
pH 2.0, 50°C
3.1
tributyrin
pH 2.0, 50°C
12.7
tripropionin
pH 2.0, 50°C