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3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

Reaction

a carboxylic ester
+
H2O
=
an alcohol
 +
a carboxylate

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase

Temperature Range

Temperature Range on EC 3.1.1.1 - carboxylesterase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 60
activity range, profile overview
15 - 50
15 - 60
20 - 48
-
about 50% of maximal activity at 20°C and 48°C
20 - 50
20 - 55
21 - 74
-
50% of maximal activity at 30-37°C, maximal activity at 55°C, 60% activity at 74°C
25 - 45
-
the activity of CXE1 declines by approximately 3fold by 50°C compared to the optimum at 35°C
25 - 50
-
-
25 - 70
-
25°C: esterase shows 55.9% relative activity, 70°C: 23.3% of maximal activity
25 - 75
-
recombinant mutant NaM1H2, activity range, profile overview
25 - 90
-
the enzymatic activity decreases significantly at temperatures below 25°C and above 90°C
27 - 55
-
50% of maximum activity within this range, both E1 and E2
29 - 35
-
90% of maximal activity at 29°C and 35°C
30 - 45
over 80% of maximal activity within this range
30 - 70
more than 50% activity between 30 and 70°C
30 - 80
30 - 90
activity at 30°C is 16% of the maximum activity (at 90°C)
35 - 55
-
35°C: about 45% of maximal activity, 55°C: about 60% of maximal activity
36 - 51
-
at least 50% of maximum activity within this range
37
-
activity is 10% lower than at 39°C
38 - 56
-
at least 50% of maximum activity within this range
40 - 55
40 - 80
40 - 90
40 - 95
40°C: about 40% of maximal activity, 95°C: about 40% of maximal activity
45 - 65
-
45°C: about 60% of maximal activity, 65°C: about 50% of maximal activity
50
active up to
50 - 100
50°C: about 50% of maximal activity, 100°C: about 90% of maximal activity
50 - 75
50°C: about 50% of maximal activity, 75°C: about 90% of maximal activity
50 - 80
50°C: about 50% of maximal activity, 80°C: temperature optimum
50 - 90
50°C: about 50% of maximal activity, 90°C: about 70% of maximal activity, wild-type enzyme
50 - 95
55 - 70
-
more than 90% of maximum activity
55 - 75
the enzyme retains over 90% of its maximal activity at 55 and 60°C. However, a decrease in activity is observed at 65°C (83% left), while only 15% of relative activity is observed at 75°C
60 - 75
60°C: 55% of maximal activity, 75°C: about 35% of maximal activity, substrate: 4-nitrophenyl hexanoate, mutant enzyme expressed from the gene that has a deletion of about 60 residues at the N terminus
60 - 90
65
80% of maximum activtiy
70 - 100
-
70°C: about 65% of maximal activity, 100°C: about 85% of maximal activity
70 - 90
70°C: about 55% of maximal activity, 90°C: about 80% of maximal activity
80 - 110
-
80°C: about 55% of maximal activity, 110°C: about 80% of maximal activity