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3.1.1.1: carboxylesterase

This is an abbreviated version!
For detailed information about carboxylesterase, go to the full flat file.

Word Map on EC 3.1.1.1

Reaction

a carboxylic ester
+
H2O
=
an alcohol
 +
a carboxylate

Synonyms

4-nitrophenyl esterase, ACAT, Acetyl esterase, acetyl xylan esterase, acid retinyl ester hydrolase, AcXE, Acyl coenzyme A:cholesterol acyltransferase, acylcarnitine hydrolase, AF1716, AF1763, AFEST, ali-esterase, aliesterase, alpha-carboxylesterase, alpha-esterase 7, alphaE7, alphaEsterase7, AOPP herbicide carboxylesterase, APE1547, AREH, aspirin hydrolase, Axe1NaM1, Axe1NaM2, Axe1NaM3, B-esterase, Bacillus esterase, BdB1, BioHe, BioHs, Brain carboxylesterase hBr1, BSE, BsE-NP01, BSE01701, butyrate esterase, butyryl esterase, CaE, CaesCCR11, carboxyesterase, Carboxyesterase ES-10, carboxyl ester hydrolase, carboxyl esterase, carboxyl/cholinesterase, carboxylate esterase, carboxylesterase, carboxylesterase 1, carboxylesterase 1A2, carboxylesterase 1C, carboxylesterase 2, carboxylesterase B, carboxylesterase B1, carboxylesterase-1, carboxylesterase-2, Carboxylesterase-5C, carboxylic acid esterase, carboxylic ester hydrolase, carboxylic esterase, Carboxylic-ester hydrolase, CarE, CbE, CCE, CE, CE-1, CE-2, CE1, CE2, CE21p, CE7 AcXE, CEH, CES, CES 1C, CES-2, CES1, CES1-b, CES1-c, CES1A, CES1A1, CES1A2, Ces1c, Ces1d, Ces1e, Ces1g, CES2, CES2A1, Ces3-1, Ces3a, cholesteryl ester hydrolase, cocaine esterase, cocaine:benzoylecgonine esterase, COE, CPT-CE, CXE, CXE1, CXE10, D1CarE5, de-arenethiolase, DEHP, E3 carboxylesterase, E34Tt, EC 3.1.1.21, Egasyn, ES-10, Es-22, ES-HTEL, ES-HVEL, ES-Male, ES-THET, ES10, ES11, ES3, ES4, ES5, ES6, ES7, ES9, EST, EST-3, EST-4, EST-5A, EST-5B, EST-5C, Est-AF, Est0071, Est1, Est1C, EST2, ESt3, Est3 esterase, Est30, Est55, EstA, EstA esterase, EstB, estBB1, EstC, EstC1, esterase, esterase 1F, esterase 2, esterase 2B, esterase 6A, esterase 9A, esterase A, esterase B, esterase B1, esterase D, esterase Sso2518, esterase, carboxyl, Esterase-22, Esterase-31, esterase-6, EStFa, EstGtA2, EstP, EstPS1, EstSt7, EstU1, Fluazifop-P-butyl carboxylesterase, Fluazifop-P-butyl hydrolase, FpbH, fungus-inducible pepper carboxylesterase, general odorant degradation enzyme, GODE, hCE-2, HCE1, HCE2, hCES1, hiCE, HMSE, hormone-sensitive lipase, HSL, human carboxylesterase 1, human carboxylesterase 2, human liver carboxylesterase, ICE, ICXE14, JHE-related, JHER, kidney bean esterase, Kidney microsomal carboxylesterase, LcalphaE7, LIP4, LipA, LipC, Liver microsomal carboxylesterase, malathion carboxylesterase, MAP esterase, MCE, ME, MeIAA esterase, MeSA esterase, methylbutyrase, methylbutyrate esterase, mfCES2v3, Microsomal palmitoyl-CoA hydrolase, monobutyrase, Monocyte/macrophage serine esterase, More, mouse carboxylesterase, MT2282, NaM1, NaM2, NaM3, Non-specific carboxylesterase, nonspecific carboxylesterase, ODE, odorant degradation enzyme, P186_1588, PA3859, PepEST, PF2001, Pf2001 esterase, PI 5.5 esterase, PI 6.1 esterase, pig liver esterase, PLE, PMPMEase, pnbA, PnbA1, PnbA2, polyisoprenylated methylated protein methyl esterase, porcine liver carboxylesterase, PPE, PPMTase, PrbA, prenylated methylated protein methyl esterase, procaine esterase, Proline-beta-naphthylamidase, propionyl esterase, pyrethroid-hydrolysing esterase, Rsp3690, SABP2's methyl salicylate esterase, salicylic acid-binding protein 2, SeE, serine protease-like, serine-type carboxylesterase, SexiCXE10, SiRe0290, SshEstI, SshEstI esterase, Sso P1 carboxylesterase, Sso-EST1, SSO2493, SSO2517, SSoP1 CE, SsoPEst, ST0071, ST2026, STK_00710, Sto-Est, TGH, triacetin esterase, triacylglycerol hydrolase, vitamin A esterase, VmoLac

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase

pH Range

pH Range on EC 3.1.1.1 - carboxylesterase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1 - 3
pH 1.0: about 70% of maximal activity, pH 3.0: about 65% of maximal activity
10
completely inactive above
2.5
-
30 min, 60% residual activity
3 - 8
pH 3.0: about 60% of maximal activity, pH 8.0: about 60% of maximal activity, hydrolysis of 4-nitrophenol butyrate, wild-type enzyme
4
-
no activity below
4 - 10
4 - 7
-
pH 4.0: about 70% of maximal activity, pH 7.0: about 50% of maximal activity
4 - 8
-
70-80% of maximal activity at pH 4.0 and pH 8.0
4 - 9
4 - 9.5
activity range, profile overview
4.8 - 10
-
pH 4.8: about 55% of maximal activity, pH 10.0: about 75% of maximal activity, wild-type enzyme
4.8 - 11
-
pH 4.8: about 75% of maximal activity, pH 11.0: about 75% of maximal activity, mutant enzyme V138G
4.8 - 9
-
pH 4.8: about 85% of maximal activity, pH 9.0: about 40% of maximal activity, mutant enzyme V138G/L200R
4.8 - 9.2
-
pH 4.8: about 40% of maximal activity, pH 9.2: about 40% of maximal activity
5
-
no activity below
5 - 10
5 - 7.4
-
80-90% of maximum activity
5 - 8
10fold reduced activity at pH 5.0 and 4fold reduced activity at pH 8.0 compared to maximal activity at pH 7.0
5 - 8.5
5 - 9
5.5 - 7.3
more than 50% activity between pH 5.5 and 7.3
5.5 - 7.5
-
over 60% of maximal activity within this range
5.5 - 9
5.5 - 9.5
-
pH 5.5: about 45% of maximal activity, pH 9.5: about 80% of maximal activity, hydrolysis of methyl hexanoate, isoenzyme I
5.8 - 8.8
pH 5.8: about% of maximal activity, pH 8.8: about% of maximal activity
6
-
inactive below
6 - 10
6 - 10.5
-
pH 6.0: about 50% of maximal activity, pH 10.5: about 50% of maximal activity, wild-type enzyme
6 - 11
6 - 12
-
less than 50% of maximal activity at pH less than 6 or more than 12
6 - 8
pH 6.0: 71% of maximal activity, pH 8.0: 82% of maximal activity
6 - 8.5
6 - 9
-
80% of maximal activity at pH 6 and 9
6.5 - 10
pH 6.5: about 40% of maximal activity, pH 10.0: about 50% of maximal activity
6.5 - 7.8
-
50% of maximum activity within this range, both E1 and E2
6.5 - 8
7 - 10
7 - 11
7 - 12
pH 7.0: about 40% of maximal activity, pH 12: about 30% of maximal activity, at room temperature
7 - 8.2
7 - 9
-
more than 80% of maximum activity within this range
7 - 9.5
-
50% of maximal activity at pH 7.0 and pH 9.5
7.3 - 8.4
-
pH 7.3: about 95% of maximal activity, pH 8.4: about 80% of maximal activity
7.5 - 9
7.7 - 8.8
-
pH 7.7: about 75% of maximal activity, pH 8.8: about 90% of maximal activity
8 - 10
8 - 10.5
-
pH 8.0: about 35% of maximal activity, pH 10.5: about 80% of maximal activity, hydrolysis of phenolphthalein dibutyrate
8 - 12
pH 8: about 60% of maximal activity, pH 12: about 30% of maximal activity, at room temperature
9 - 12