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Literature summary for 3.1.1.1 extracted from

  • Baker, A.A.; Guo, G.L.; Aleksunes, L.M.; Richardson, J.R.
    Isoform-specific regulation of mouse carboxylesterase expression and activity by prototypical transcriptional activators (2015), J. Biochem. Mol. Toxicol., 29, 545-551 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus P23953
-
-
Mus musculus Q63880
-
-
Mus musculus Q64176
-
-
Mus musculus Q8VCC2
-
-
Mus musculus Q8VCT4
-
-
Mus musculus C57Bl6/J P23953
-
-
Mus musculus C57Bl6/J Q63880
-
-
Mus musculus C57Bl6/J Q64176
-
-
Mus musculus C57Bl6/J Q8VCC2
-
-
Mus musculus C57Bl6/J Q8VCT4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
intestine
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl acetate + H2O
-
 Mus musculus 4-methylumbelliferol + acetate
-
 ?
4-methylumbelliferyl acetate + H2O
-
 Mus musculus C57Bl6/J 4-methylumbelliferol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
CES
-
 Mus musculus
Ces1c
-
 Mus musculus
Ces1d
-
 Mus musculus
Ces1e
-
 Mus musculus
Ces1g
-
 Mus musculus
Ces3a
-
 Mus musculus
mouse carboxylesterase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) and Nrf2 activator BHA reduces expression of Ces1e down
Mus musculus the CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) and the Nrf2 activator butylated hydroxyanisole (BHA) reduce Ces3a mRNA expression down
Mus musculus the CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) slightly reduces Ces1c expression down
Mus musculus Nrf2 activator BHA, PXR ligand pregnenolone-16a-carbonitrile (PCN), and CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) induce Ces1d mRNA expression up
Mus musculus PXR ligand pregnenolone-16a-carbonitrile (PCN) and Nrf2 activator butylated hydroxyanisole (BHA) increase Ces1c expression up
Mus musculus PXR ligand pregnenolone-16a-carbonitrile (PCN) and Nrf2 activator butylated hydroxyanisole (BHA) increase Ces1g expressio, while the CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) only slightly induces Ces1g expression up
Mus musculus PXR ligand pregnenolone-16a-carbonitrile (PCN) increases Ces3a mRNA expression up
Mus musculus PXR ligand pregnenolone-16a-carbonitrile (PCN) induces Ces1e expression up

General Information

General Information Comment Organism
physiological function isoform-specific regulation of hepatic Ces mRNA expression and activity following administration of pharmacological activators of the constitutive androstane receptor (CAR), pregnane X receptor (PXR) and nuclear factor-E2-related protein (Nrf2) to mice, overview Mus musculus