Cloned (Comment) | Organism |
---|---|
expression in Sf9 cell | Homo sapiens |
expression in Sf9 cell | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus | |
benzil | comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme | Homo sapiens | |
benzil | comparison with inhibition of human isoforms hCE1 and hCE2 | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00748 | isoform hCE2 | - |
Homo sapiens | P23141 | isoform hCE1 | - |
Oryctolagus cuniculus | P12337 | isoform rCE1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-nitrophenyl acetate + H2O | - |
Homo sapiens | 2-nitrophenol + acetate | - |
? | |
2-nitrophenyl acetate + H2O | - |
Oryctolagus cuniculus | 2-nitrophenol + acetate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000033 | - |
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
0.00000334 | - |
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
0.00000498 | - |
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000083 | - |
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone | - |
Oryctolagus cuniculus | |
0.0000136 | - |
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000151 | - |
benzil | - |
Homo sapiens | |
0.0000184 | - |
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | - |
Oryctolagus cuniculus | |
0.0000228 | - |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
0.0000257 | - |
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone | - |
Homo sapiens | |
0.0000259 | - |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.000026 | - |
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone | - |
Homo sapiens | |
0.0000289 | - |
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
0.0000306 | - |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000317 | - |
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone | - |
Oryctolagus cuniculus | |
0.0000319 | - |
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000347 | - |
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000362 | - |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
0.0000451 | - |
benzil | - |
Homo sapiens | |
0.0000483 | - |
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | - |
Oryctolagus cuniculus | |
0.0000552 | - |
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.0000618 | - |
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | - |
Oryctolagus cuniculus | |
0.000071 | - |
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.0000913 | - |
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000972 | - |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.0000995 | - |
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone | - |
Homo sapiens | |
0.0001 | - |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.000103 | - |
benzil | - |
Oryctolagus cuniculus | |
0.00012 | - |
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.00014 | - |
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
0.00017 | - |
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.00019 | - |
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.00023 | - |
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | - |
Homo sapiens | |
0.000665 | - |
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone | - |
Homo sapiens |