Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Young, B.M.; Hyatt, J.L.; Bouck, D.C.; Chen, T.; Hanumesh, P.; Price, J.; Boyd, V.A.; Potter, P.M.; Webb, T.R.
    Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors (2010), J. Med. Chem., 53, 8709-8715.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
Homo sapiens
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
Homo sapiens
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
Homo sapiens
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
Homo sapiens
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
Homo sapiens
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
-
Homo sapiens
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CPT-11 + H2O
-
Homo sapiens SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
-
?

Synonyms

Synonyms Comment Organism
carboxylesterase 1
-
Homo sapiens
carboxylesterase 2
-
Homo sapiens
CE1
-
Homo sapiens
CES
-
Homo sapiens
CES1
-
Homo sapiens
CES2
-
Homo sapiens
ICE
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000117
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000148
-
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000155
-
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000273
-
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000286
-
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000323
-
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.0000036
-
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000368
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000465
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.00000467
-
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens
0.000279
-
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.000381
-
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.000437
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.000756
-
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.001034
-
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.001244
-
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.1
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide Ki above 0.1 mM, carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.1
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide Ki above 0.1 mM, carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.1
-
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide Ki above 0.1 mM, carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens
0.1
-
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide Ki above 0.1 mM, carboxylesterase 1, pH and temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000054
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000055
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
0.000059
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
0.000132
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000135
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000177
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
0.000213
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.00025
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000302
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
0.000326
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000354
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
0.00054
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
0.000868
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
0.0011
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
0.0023
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
0.0024
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
0.0025
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
0.0033
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens 2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
0.008
-
intestinal carboxylesterase, pH and temperature not specified in the publication Homo sapiens N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide