Information on EC 7.2.2.10 - P-type Ca2+ transporter

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IUBMB Comments
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolysed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolysed. In muscle cells Ca2+ is transported from the cytosol (side 1) into the sarcoplasmic reticulum (side 2).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
serca, ca2+-atpase, serca2a, ca2+ pump, serca2, ca-atpase, calcium pump, ca2+ atpase, serca1, serca2b, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2]
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