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Literature summary for 7.2.2.10 extracted from
- Suppressive effect of ATP on the denaturation of sarcoplasmic reticulum (Ca2+)-ATPase from southern bluefin tuna Thunnus maccoyii and its biochemical properties (2016), Fish. Sci., 82, 147-153 .
No PubMed abstract available
General Stability
| General Stability | Organism |
|---|---|
| denaturation by acid treatment is strongly suppressed by the addition of 2 mM ATP. ATP also shows a strong suppressive effect against denaturation of the enzyme by freezing and heating | Thunnus maccoyii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EGTA | - |
Thunnus maccoyii |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| sarcoplasmic reticulum | - |
Thunnus maccoyii | 16529 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Thunnus maccoyii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+[side 1] | Thunnus maccoyii | - |
ADP + phosphate + Ca2+[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thunnus maccoyii | - |
southern bluefin tuna | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Thunnus maccoyii | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+[side 1] | - |
Thunnus maccoyii | ADP + phosphate + Ca2+[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 100000, SDS-PAGE | Thunnus maccoyii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sarcoplasmic reticulum (Ca2+)-ATPase | - |
Thunnus maccoyii |
| SR Ca2+-ATPase | - |
Thunnus maccoyii |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
the enzyme is half inactivated when heated at 45°C for 4 min and completely inactivated when heated at 45°C for 15 min | Thunnus maccoyii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Thunnus maccoyii |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
the enzyme is almost inactivated (about 25% residual activity) by pH 5.5 acid treatment for 2 h at 0°C. The activity is reduced to about 80% at pH 6.0-6.5 for 2 h at 0°C | Thunnus maccoyii |
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