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Literature summary for 7.2.2.10 extracted from
- Calcium transport mechanisms of PC12 cells (2008), J. Gen. Physiol., 131, 307-323.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | PMCA is inhibited by acutely lowering extracellular proton concentration (pH raised to 9.0) | Rattus norvegicus | |
| thapsigargin | SERCA is inhibited by 0.001 mM thapsigargin | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00071 | - |
Ca2+/cis | PMCA from undifferentiated PC-12 cells | Rattus norvegicus | |
| 0.00097 | - |
Ca2+/cis | PMCA from differentiated PC-12 cells | Rattus norvegicus | |
| 0.0013 | - |
Ca2+/cis | SERCA from undifferentiated or differentiated PC-12 cells | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| PC-12 cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | - |
Rattus norvegicus | ADP + phosphate + Ca2+/trans | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| plasma membrane Ca2+ ATPase | - |
Rattus norvegicus |
| PMCA | - |
Rattus norvegicus |
| sarco-endoplasmic reticulum Ca2+ ATPase | - |
Rattus norvegicus |
| SERCA | - |
Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
PMCA is inhibited at pH 9.0 | Rattus norvegicus |
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