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Literature summary for 7.2.2.10 extracted from
- High sensibility to reactivation by acidic lipids of the recombinant human plasma membrane Ca2+-ATPase isoform 4xb purified from Saccharomyces cerevisiae (2008), Biochim. Biophys. Acta, 1778, 2757-2764.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | native and recombinant enzymes achieve maximal activity when supplemented with acidic phospholipids | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae strain DBY 2062 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the function of recombinant PMCA is highly sensitive to delipidation | Homo sapiens | |
| phosphatidylcholine | native PMCA from erythrocytes in mixed micelles of phosphatidylcholine-detergent has 30% of its maximal activity, while the recombinant PMCA enzyme is nearly inactive, increasing the phosphatidylcholine content of the micelles does not increase the activity of recombinant PMCA but the activity in the presence of phosphatidylcholine improves by partially removing the detergent | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | hydrolyzes ATP in a Ca2+ dependent manner | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| calmodulin-affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | - |
Homo sapiens | ADP + phosphate + Ca2+/trans | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| plasma membrane Ca2+ pump 4xb | isoform | Homo sapiens |
| plasma membrane Ca2+-ATPase 4xb | isoform | Homo sapiens |
| PMCA | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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