Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bupivacaine | inhibition by bupivacaine is not competitive with respect to the specific transport and catalytic sites of the enzyme | Oryctolagus cuniculus | |
lidocaine | inhibition by lidocaine is not competitive with respect to the specific transport and catalytic sites of the enzyme | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
sarcoplasmic reticulum membrane | - |
Oryctolagus cuniculus | 33017 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+/cis | Oryctolagus cuniculus | sarcoplasmic reticulum Ca-ATPase transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis | ADP + phosphate + Ca2+/trans | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
adult New Zealand rabbits | - |
Purification (Comment) | Organism |
---|---|
partially by preparation of sarcoplasmic reticulum vesicles | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
masticatory muscle | masseter and medial pterygoid | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+/cis | sarcoplasmic reticulum Ca-ATPase transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis | Oryctolagus cuniculus | ADP + phosphate + Ca2+/trans | - |
? | |
ATP + H2O + Ca2+/cis | the enzyme has one high affinity ATP binding site (catalytic site) and two calcium-binding sites | Oryctolagus cuniculus | ADP + phosphate + Ca2+/trans | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca-ATPase | - |
Oryctolagus cuniculus |
sarcoplasmic reticulum Ca-ATPase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibitory potencies of narcotic substances on Ca2+-ATPase activity in masticatory muscles, masseter and medial pterygoid, overview | Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
physiological function | sarcoplasmic reticulum Ca-ATPase is a membrane-bound protein which transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis, leading to muscle relaxation | Oryctolagus cuniculus |