Literature summary for 7.2.2.10 extracted from

Kawase, Y.; Hajjar, R.J.
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases (2008), Nat. Clin. Pract. Cardiovasc. Med., 5, 554-565.

Search for more literature for 7.2.2.10

Application

Application	Comment	Organism
medicine	isoform SERCA2-mediated Ca2+-regulation decreases in the failing heart, isoform SERCA2a overexpression can potentially reduce arrhythmias and is a therapy for heart failure and cardiac hypertrophy	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
phospholamban	phospholamban inhibits SERCA2a activity in its dephosphorylated state	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	SERCA2a transfers Ca2+ from the cytosol of the cardiomyocyte to the lumen of the sarcoplasmic reticulum during muscle relaxation	Homo sapiens	5829	-
sarcoplasmic reticulum	SERCA2a transfers Ca2+ from the cytosol of the cardiomyocyte to the lumen of the sarcoplasmic reticulum during muscle relaxation	Homo sapiens	16529	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	SERCA2a transfers Ca2+ from the cytosol of the cardiomyocyte to the lumen of the sarcoplasmic reticulum during muscle relaxation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+/cis	-	Homo sapiens	ADP + phosphate + Ca2+/trans	-	?

Synonyms

Synonyms	Comment	Organism
sarcoplasmic/endoplasmic reticulum calcium ATPase	-	Homo sapiens
SERCA2a	isoform	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)