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Literature summary for 7.2.2.10 extracted from

  • Park, S.W.; Zhou, Y.; Lee, J.; Lee, J.; Ozcan, U.
    Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity (2010), Proc. Natl. Acad. Sci. USA, 107, 19320-19325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum
-
 Mus musculus 16529
-

Organism

Organism UniProt Comment Textmining
Mus musculus O55143
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/out
-
 Mus musculus ADP + phosphate + Ca2+/in
-
 ?

Synonyms

Synonyms Comment Organism
sarco(endo)plasmic reticulum Ca2+-ATPase 2b
-
 Mus musculus
SERCA2b
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus isoform SERCA2b protein and mRNA levels are dramatically reduced in the liver of obese mice down

General Information

General Information Comment Organism
physiological function isoform SERCA2b plays an important role in dysregulated glucose and lipid homeostasis in the liver of obese mice. Overexpression of isoform SERCA2b in the liver of obese mice significantly reduces the lipogenic gene expression and the triglyceride content in the liver and reduces steatohepatitis. Increasing the levels of isoform SERCA2b greatly reduces endoplasmic reticulum stress in the liver, increases glucose tolerance, and establishes euglycemia in severely obese and diabetic mice. Isoform SERCA2b can increase endoplasmic reticulum folding capacity Mus musculus