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Disease on EC 7.2.2.10 - P-type Ca2+ transporter

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DISEASE
TITLE OF PUBLICATION
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6-phosphofructokinase deficiency
The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency.
The contribution of Ca2+-calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency.
Acantholysis
Mechanisms of synergy of autoantibodies to M3 muscarinic acetylcholine receptor and secretory pathway Ca2+/Mn2+-ATPase isoform 1 in patients with non-desmoglein pemphigus vulgaris.
Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.
Synergy among non-desmoglein antibodies contributes to the immunopathology of desmoglein antibody-negative pemphigus vulgaris.
Weak immunohistochemical expression of galectin-3 near blisters in Hailey-Hailey disease.
[Dyskeratosis follicularis].
Acidosis
Acidosis alters the phosphorylation of Ser16 and Thr17 of phospholamban in rat cardiac muscle.
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.
Coronary artery acidosis: pH and calcium pump stability.
Effect of pH on stability of sarcoplasmic reticulum calcium pump in rabbit heart.
Glucose 6-phosphate and fructose 1,6-bisphosphate can be used as ATP-regenerating systems by cerebellum Ca2+-transport ATPase.
Glycoside inotropy in the absence of an increase in potassium efflux in the rabbit heart.
Magnesium role in cardiovascular diseases.
Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum.
Monitoring Exercise-Induced Muscle Fatigue and Adaptations: Making Sense of Popular or Emerging Indices and Biomarkers.
Phospholamban and cardiac function: a comparative perspective in vertebrates.
Sarco/endoplasmic reticulum Ca2+-ATPase isoforms: diverse responses to acidosis.
Sodium Accumulation in SERCA Knockout-Induced Heart Failure.
[The mechanism of contractile dysfunction in heart failure, focussing on SERCA2a function]
Acidosis, Respiratory
Effect of respiratory acidosis and respiratory alkalosis on renal transport enzymes.
Acute Coronary Syndrome
[The immune-enzyme technique of detection of Ca2+ ATPase of sarcoplasmic reticulum--a new biologic marker of acute cardiac infarction].
Adenocarcinoma
Advanced oxidation protein products decrease the expression of calcium transport channels in small intestinal epithelium via the p44/42 MAPK signaling pathway.
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation.
Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer.
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Adenocarcinoma of Lung
Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma.
Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation.
[Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines]
[Inhibitory effects of the survivin siRNA transfection on human lung adenocarcinoma cells SPCA1 and SH77].
[Prolonged hypoxia induces GST-pi expression and drug resistance in lung adenocarcinoma cell line SPCA1]
[Serophysiological study on the effects of high-fat diet on proliferation of human lung adenocarcinoma cell line SPCA1]
[Toxicity of arsenic trioxide to human lung adenocarcinoma cell line SPCA1 and its mechanism.]
Adenoma
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Adenoviridae Infections
Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients.
Regulation of expression of cardiac sarcoplasmic reticulum proteins under pathophysiological conditions.
Adrenal Insufficiency
Cardiac impairment in adrenal insufficiency in the cat. Reduced adenosinetriphosphatase activity of myocardial contractile proteins.
Albuminuria
Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice.
Alkalosis
Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: a comparison of trout with mammals.
Alkalosis, Respiratory
Effect of respiratory acidosis and respiratory alkalosis on renal transport enzymes.
Altitude Sickness
Transport ATPases in the erythrocytes of rats acclimatized to intermittent altitude hypoxia.
Alzheimer Disease
A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice.
Altered Ca2+ dependence of synaptosomal plasma membrane Ca2+-ATPase in human brain affected by Alzheimer's disease.
Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase (SERCA) 2a pump activity on cytosolic calcium in living cells.
Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase.
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
The endoplasmic reticulum Ca2+ -ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis.
Anemia
Biochemical changes associated with the osmotic fragility of young and mature erythrocytes caused by parathyroid hormone in relation to the uremic syndrome.
Effect of parathyroid hormone on the fragility and enzyme activities of red blood cells from young and mature rabbits.
Iron deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
The enzymes of the red blood cell plasma membrane.
Anemia, Iron-Deficiency
Iron deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
Anemia, Sickle Cell
[Erythrocyte membrane proteins]
Anthrax
Novel aspects of calmodulin target recognition and activation.
Aortic Aneurysm
Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm.
Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPAR?.
Aortic Coarctation
Na,K-ATPase and Ca-ATPase activities of the myocardial sarcolemma in aging rats after aorta coarctation: role of invertors.
Aortic Stenosis, Supravalvular
Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats.
Aortic Valve Stenosis
Transgenic expression of sarcoplasmic reticulum Ca(2+) atpase modifies the transition from hypertrophy to early heart failure.
Arrhythmias, Cardiac
Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts.
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats.
Dyssynchronous calcium removal in heart failure-induced atrial remodeling.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effect of age and sex on the incidence of ventricular arrhythmia in a rat model of acute ischemia.
Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon.
Exposure to low-level metalaxyl impacts the cardiac development and function of zebrafish embryos.
Improved systolic function of rat cardiocytes during heart failure by overexpression of SERCA2a.
Ion channelopathy and hyperphosphorylation contributing to cardiac arrhythmias.
PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia.
SERCA in genesis of arrhythmias: what we already know and what is new?
Two patterns of ion channelopathy in the myocardium: perspectives for development of anti-arrhythmic agents.
Arthritis
Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.
Arthritis, Experimental
Modulation of SERCA in the chronic phase of adjuvant arthritis as a possible adaptation mechanism of redox imbalance.
Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants.
Asthenozoospermia
Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase.
Sperm Na(+), K(+)-ATPase ?4 and plasma membrane Ca(2+)-ATPase (PMCA) 4 regulation in asthenozoospermia.
Asthma
Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases.
Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids.
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.
Increased intracellular calcium and decreased activities of leucocyte Na+,K+-ATPase and Ca2+-ATPase in asthma.
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.
ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma.
Reduced sarcoplasmic reticulum Ca2+ ATPase activity underlies skeletal muscle wasting in asthma.
The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro.
[Activity of sodium-potassium adenosinetriphosphatase and cotransport of sodium, potassium and chloride ions in patients with bronchial asthma and chronic obstructive pulmonary diseases]
Astrocytoma
Histamine-induced calcium mobilization in single cultured cells expressing histamine H1 receptors: a relationship between its sensitivity and the density of H1 receptors.
Ataxia
A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene.
A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: Biochemical characterization of the pump defect.
A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia.
Calcium pumps of plasma membrane and cell interior.
Enhanced Synaptic Inhibition in the Cerebellar Cortex of the Ataxic PMCA2(-/-) Knockout Mouse.
Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia.
Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice.
Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance.
The Effect of Passive Movement on Denervated Soleus Highlights a Differential Nerve Control on SERCA and MyHC Isoforms.
The plasma membrane calcium pump in health and disease.
Atherosclerosis
Activation of AMP-activated Protein Kinase Inhibits oxidized Low Density Lipoprotein-triggered Endoplasmic Reticulum (ER) Stress in vivo.
Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide.
Targeting the redox regulation of SERCA in vascular physiology and disease.
Atrial Fibrillation
Angiotensin II does not influence expression of sarcoplasmic reticulum Ca2 + ATPase in atrial myocytes.
Effect of SERCA2a overexpression in the pericardium mediated by the AAV1 gene transfer on rapid atrial pacing in rabbits.
Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study.
Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation.
Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy.
Prevention of Atrial Fibrillation by Using Sarcoplasmic Reticulum Calcium ATPase Pump Overexpression in a Rabbit Model of Rapid Atrial Pacing.
Regulation of calcium pump through Notch/Jagged/Hes signaling pathway in canine model of chronic atrial fibrillation.
Atrioventricular Block
Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.
Blindness
The effect of glucose and calcium on Ca2+-adenosine triphosphatase in pancreatic islets isolated from a normal and a non-insulin-dependent diabetes mellitus rat model.
Blister
A calcium conducting channel akin to a calcium pump.
Diseases involving the Golgi calcium pump.
Identification of the cardiac ryanodine receptor channel in membrane blebs of sarcoplasmic reticulum.
Weak immunohistochemical expression of galectin-3 near blisters in Hailey-Hailey disease.
Bradycardia
Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance.
SERCA2a was serotonylated and may regulate sino-atrial node pacemaker activity.
Brain Diseases
Chronic but not acute pharmacological activation of SERCA induces behavioral and neurochemical effects in male and female mice.
Brain Edema
THE RELATIONSHIP BETWEEN ADENOSINETRIPHOSPHATASE ACTIVITY AND TRIETHYLTIN TOXICITY IN THE PRODUCTION OF CEREBRAL EDEMA OF THE RAT.
Ultracytochemical study of capillary Ca2+-ATPase activity in brain edema.
Brain Ischemia
Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling.
Changes in IP3R1 and SERCA2b mRNA levels in the gerbil brain after chronic ethanol administration and transient cerebral ischemia-reperfusion.
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity.
Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death.
Ultracytochemical study of Ca2+-ATPase activity in isolated, superoxide-treated rat brains.
Breast Neoplasms
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.
An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1.
ATP2A3 gene as an important player for resveratrol anticancer activity in breast cancer cells.
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.
Distinct Regulation of Cytoplasmic Calcium Signals and Cell Death Pathways by Different Plasma Membrane Calcium ATPase Isoforms in MDA-MB-231 Breast Cancer Cells.
Down-Regulation of Store-Operated Ca2+ Entry and Na+ Ca2+ Exchange in MCF-7 Breast Cancer Cells by Pharmacological JAK3 Inhibition.
Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells.
Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells.
Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK.
Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells.
Histone deacetylase inhibitors promote ATP2A3 gene expression in hepatocellular carcinoma cells: p300 as a transcriptional regulator.
Inhibition of ezrin causes PKC?-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.
NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland.
Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation.
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.
PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263.
SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation.
Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Subtype specific targeting of calcium signaling in breast cancer.
Thapsigargin, Inhibitor of Sarco-Endoplasmic Ca2+-ATPase, Effectively Suppresses the Expression of S100A4 Protein in Human Breast Cancer Cell Line.
The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.
The Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells.
The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival.
The Plasma Membrane Ca2+ Pump PMCA4b Regulates Melanoma Cell Migration through Remodeling of the Actin Cytoskeleton.
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
Burkitt Lymphoma
Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.
Calcinosis
Secretory pathway Ca(2+) -ATPases promote in vitro microcalcifications in breast cancer cells.
calpain-3 deficiency
Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Carcinogenesis
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Adenosinetriphosphatase study during rat liver damage. II. ATP-ase activity of rat liver during 4-dimethylaminoazobenzene carcinogenesis.
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Endoplasmic reticulum calcium pumps and cancer.
Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.
Intracellular calcium pool emptying induces DNA synthesis in HaCaT keratinocytes.
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Pathogenic roles of altered calcium channels and transporters in colon tumorogenesis.
Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer.
Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation.
Plasma membrane Ca2+-permeable channels and sodium/calcium exchangers in tumorigenesis and tumor development of the upper gastrointestinal tract.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
[Expression of SERCA pumps during cell differentiation and tumorigenesis: application to colonic carcinogenesis]
Carcinoma
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on ICRAC-like calcium channels.
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
Calcium, calcium-ATPase and cyclic AMP changes in Ehrlich ascites cells submitted to hyperthermia.
Changes of adenosinetriphosphatase (ATPase) activities in lymphocytes from patients with carcinomas of the gastrointestinal tract.
Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.
Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation.
Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.
Loss of RhoA expression prevents proliferation and metastasis of SPCA1 lung cancer cells in vitro.
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer.
Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Purification and characterization of the Ca2+-ATPase of plasma membranes from Ehrlich ascites mammary carcinoma cells.
RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells.
Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.
The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms.
Tumor-derived vascular endothelial growth factor (VEGF)-A facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway.
Ultraviolet Radiation-Induced Downregulation of SERCA2 Mediates Activation of NLRP3 Inflammasome in Basal Cell Carcinoma.
[Adenosinetriphosphatase, 5-nucleotidase and alkaline phosphatase in the connective tissue of carcinoma including a contribution to the differentiation of carcinoma.]
[Comparison of the adenosinetriphosphatase activity of the mitochondria of Guerin's T-8 epithelioma and of the rat liver.]
Carcinoma, Basal Cell
Ultraviolet Radiation-Induced Downregulation of SERCA2 Mediates Activation of NLRP3 Inflammasome in Basal Cell Carcinoma.
Carcinoma, Ductal
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Carcinoma, Ehrlich Tumor
Calcium metabolism in Ehrlich Ascites tumour cells.
[Adenosinetriphosphatase activity of nuclear envelopes and from the cells of rat liver, Zaigdel hepatoma of rats and Ehrlich ascites tumour of mice]
Carcinoma, Hepatocellular
A high-affinity (Ca2+ + Mg2+)-ATPase in plasma membranes of rat ascites hepatoma AH109A cells.
A stress-inducible rat liver endoplasmic reticulum protein, ERp29.
Fine structure and surface adenosinetriphosphatase activity of a human hepatoma.
Intracellular distribution of enzymes. VII. The distribution of nucleic acids and adenosinetriphosphatase in normal mouse liver and mouse hepatoma.
Intracellular distribution of enzymes; the distribution of succinic dehydrogenase, cytochrome oxidase, adenosinetriphosphatase, and phosphorus compounds in normal rat liver and in rat hepatomas.
Isolation and characterization of the plasma membranes from rat ascites hepatomas and from normal rat livers, including newborn, regenerating, and adult livers.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
[Adenosinetriphosphatase activity of nuclear envelopes and from the cells of rat liver, Zaigdel hepatoma of rats and Ehrlich ascites tumour of mice]
[Change in prostaglandin levels and ATPase activity of cardiac membrane fractions during the formation of cerebral hematomas in animals with a hereditary predisposition to stroke]
Carcinoma, Lobular
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Carcinoma, Non-Small-Cell Lung
Chemotherapy resistance research of lung cancer based on micro-fluidic chip system with flow medium.
Carcinoma, Squamous Cell
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Cardiac Output, Low
Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.
Cardiomegaly
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.
Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.
Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy.
Altered force-frequency response in non-failing hearts with decreased SERCA pump-level.
An updated role of astragaloside IV in heart failure.
Calcium regulatory proteins and their alteration by transgenic approaches.
Cardiac hypertrophy and thyroid hormone signaling.
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.
Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a.
Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes.
Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy.
Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of combination of irbesartan and perindopril on calcineurin expression and sarcoplasmic reticulum Ca(2+)-ATPase activity in rat cardiac pressure-overload hypertrophy.
Effects of mild cardiac hypertrophy, induced by volume overload in turkeys, on myocardial sarcoplasmic reticulum calcium-pump and calcium-channel activities and on the creatine kinase system.
Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats.
Expression of sarcoplasmic reticulum Ca2+ -ATPase mRNA in the hypertrophied heart of young spontaneously hypertensive rats.
Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.
Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.
Hemodynamics and mitochondrial energy metabolism in right heart hypertrophy after acute hypoxic stress.
Increased active elastic stiffness in tetanized papillary muscles from hypertrophied rabbit hearts.
Interleukin-6-induced reciprocal expression of SERCA and natriuretic peptides mRNA in cultured rat ventricular myocytes.
Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes.
Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function.
Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats.
Long-term treatment with kefir probiotics ameliorates cardiac function in spontaneously hypertensive rats.
Low density lipoprotein receptor-related protein 1 regulates cardiac hypertrophy induced by pressure overload.
MicroRNA-328 as a regulator of cardiac hypertrophy.
Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin.
Molecular and functional signature of heart hypertrophy during pregnancy.
Molecular changes in the early phase of renin-dependent cardiac hypertrophy in hypertensive cyp1a1ren-2 transgenic rats.
Molecular cloning and analysis of the human cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2) gene promoter.
Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM.
On the mechanism of the reduction by thyroid hormone of beta-adrenergic relaxation rate stimulation in rat heart.
Overexpression of junctate induces cardiac hypertrophy and arrhythmia via altered calcium handling.
Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake.
Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA.
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.
Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein.
Prolonged administration of a dithiol antioxidant protects against ventricular remodeling due to ischemia-reperfusion in mice.
Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy.
Prostaglandin F2alpha inhibits SERCA2 gene transcription through an induction of Egr-1 in cultured neonatal rat cardiac myocytes.
Reduced myocardial sarcoplasmic reticulum Ca(2+)-ATPase protein expression in compensated primary and secondary human cardiac hypertrophy.
Regulation of phospholamban and sarcoplasmic reticulum Ca2+-ATPase by atorvastatin: implication for cardiac hypertrophy.
Regulation of sarco(endo)plasmic reticulum Ca(2+)-ATPase and calsequestrin gene expression in the heart.
Regulation of sarco(endo)plasmic reticulum Ca2+ adenosine triphosphatase by phospholamban and sarcolipin: implication for cardiac hypertrophy and failure.
Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart.
Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy.
Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.
Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca 2+ cycling proteins.
Sarcoplasmic reticulum Ca2+ pumps in heart and diaphragm of cardiomyopathic hamster: effects of perindopril.
Sarcoplasmic reticulum gene expression in pressure overload-induced cardiac hypertrophy in rabbit.
Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats.
Sub-antihypertensive doses of ramipril normalize sarcoplasmic reticulum calcium ATPase expression and function following cardiac hypertrophy in rats.
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.
TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells.
The Ca2+ ATPase of cardiac sarcoplasmic reticulum: Physiological role and relevance to diseases.
The effect of treatment with coenzyme Q10 on the mitochondrial function and superoxide radical formation in cardiac muscle hypertrophied by mild aortic stenosis.
The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice.
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy.
The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy.
The sarco(endo)plasmic reticulum Ca(2+)-ATPase gene is regulated at the transcriptional level during compensated left ventricular hypertrophy in the rat.
Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level.
Total glycosides of Ranunculus japonius prevent hypertrophy in cardiomyocytes via alleviating chronic Ca(2+) overload.
Transcription of the SERCA2 gene is decreased in pressure-overloaded hearts: A study using in vivo direct gene transfer into living myocardium.
Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy.
Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin gene.
[Biochemistry of myocardium taken at autopsy. Preliminary report]
[Depression of contractile function and decrease of the effectiveness of oxygen utilization during compensatory heart hypertrophy]
[Effect of astragalus on calcium accumulation and SERCA2a gene expression in myocardial tissues in rats with pressure overload-induced left ventricular hypertrophy]
Cardiomyopathies
A study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.
Adenosinetriphosphatase activity of cellular organelles in experimental potassium depletion cardiomyopathy.
Altered calcium regulation in the cardiac plasma membrane in experimental renal hypertension.
Cardiac sarcoplasmic reticulum calcium ATPase, an autoimmune antigen in experimental cardiomyopathy.
Circulating cytokine levels in mice with heart failure are etiology dependent.
Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy.
Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy.
Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes.
Exacerbation of dystrophic cardiomyopathy by phospholamban deficiency-mediated chronically increased cardiac Ca2+ cycling in vivo.
Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a.
Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study.
Impaired Ca2+-ATPase oligomerization and increased phospholamban expression in dilated cardiomyopathy.
In vitro selection and characterization of DNA aptamers specific for phospholamban.
Intramyocardial injection of SERCA2a-expressing lentivirus improves myocardial function in doxorubicin-induced heart failure.
Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription.
Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.
More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice.
Phospholamban cardiomyopathy: a Canadian perspective on a unique population.
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.
Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides.
Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
SERCA2a activity correlates with the force-frequency relationship in human myocardium.
Study on the effect of doxorubicin on expressions of genes encoding myocardial sarcoplasmic reticulum Ca2+ transport proteins and the effect of taurine on myocardial protection in rabbits.
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function.
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
[Functional genomics of pressure-loaded cardiomyocytes: etomoxir in heart failure?]
Cardiomyopathy, Dilated
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure.
Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol.
Compensatory asymmetry in down-regulation and inhibition of the myocardial Ca2+ cycle in congestive heart failure produced in dogs by idiopathic dilated cardiomyopathy and rapid ventricular pacing.
Impaired Ca2+-ATPase oligomerization and increased phospholamban expression in dilated cardiomyopathy.
Impaired Ca2+-sequestration in dilated cardiomyopathy (review).
Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.
Myocardial Ca-sequestration failure and compensatory increase in Ca-ATPase with congestive cardiomyopathy: kinetic characterization by a homogenate microassay using real-time ratiometric indo-1 spectrofluorometry.
Reconstitution of the cytoplasmic interaction between phospholamban and Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy.
Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity.
Unchanged protein expression of sarcoplasmic reticulum Ca2+-ATPase, phospholamban, and calsequestrin in terminally failing human myocardium.
Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts.
Cardiomyopathy, Hypertrophic
Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice.
Reduced myocardial sarcoplasmic reticulum Ca(2+)-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophic cardiomyopathy.
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
Cardiomyopathy, Hypertrophic, Familial
Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Cardiotoxicity
Anthracycline cardiotoxicity in transgenic mice overexpressing SR Ca2+-ATPase.
Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Erratum: Sarcoendoplasmic Reticulum Ca2+ ATPase. A Critical Target In Chlorine Inhalation-induced Cardiotoxicity.
In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes.
Melatonin protects against ischemic heart failure in rats.
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a.
Cardiovascular Diseases
A Therapeutic Role for the F1FO-ATP Synthase.
Benefit of SERCA2a gene transfer to vascular endothelial and smooth muscle cells: a new aspect in therapy of cardiovascular diseases.
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation.
Targeting the redox regulation of SERCA in vascular physiology and disease.
Targeting the sarcolemmal calcium pump: a potential novel strategy for the treatment of cardiovascular disease.
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases.
Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overload.
Carotid Artery Injuries
Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.
Cataract
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Comparison of the mechanisms of cataract development involving differences in Ca2+ regulation in lenses among three hereditary cataract model rats.
Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats.
Effect of oxidation on Ca2+ -ATPase activity and membrane lipids in lens epithelial microsomes.
Plasma membrane Ca-ATPase isoform expression in human cataractous lenses compared to age-matched clear lenses.
The relationship between properties of antipsychotic drugs and cataract formation.
[Ca(2+)-ATPase activity in the hypocalcemic cataract]
Cerebellar Ataxia
A Novel Mutation in Isoform 3 of the Plasma Membrane Ca2+ Pump Impairs Cellular Ca2+ Homeostasis in a Patient with Cerebellar Ataxia and Laminin Subunit 1? Mutations.
A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: Biochemical characterization of the pump defect.
A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia.
Enhanced Synaptic Inhibition in the Cerebellar Cortex of the Ataxic PMCA2(-/-) Knockout Mouse.
Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis.
Survival strategies for mouse cerebellar Purkinje neurons lacking PMCA2.
The ataxia related G1107D mutation of the plasma membrane Ca(2+) ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process.
Cerebral Hemorrhage
Modulation of crucial adenosinetriphosphatase activities due to U-74389G administration in a porcine model of intracerebral hemorrhage.
Cerebral Infarction
Secretory pathway Ca2+-ATPase isoform 1 knockdown promotes Golgi apparatus stress injury in a mouse model of focal cerebral ischemia-reperfusion: In vivo and in vitro study.
Chagas Disease
Upregulation of cardiac cell plasma membrane calcium pump in a canine model of Chagas disease.
Cholera
Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A.
Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.
Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
The effect of cholera toxin on human red cell Ca-ATPase.
Cholestasis
Induction of cholestasis in the perfused rat liver by 2-aminoethyl diphenylborate, an inhibitor of the hepatocyte plasma membrane Ca2+ channels.
Choriocarcinoma
81 MEMBRANE AND CYTOSOLIC CALCIUM PROTEINS, TRPV6, PMCA1, NCKX3, NCX1 AND CaBP-28k, APPEAR TO BE DISTINCTLY REGULATED IN HUMAN CHORIOCARCINOMA AND PLACENTAL CELLS.
Choroid Plexus Neoplasms
Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
Colitis
CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.
Colonic Neoplasms
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation.
Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation.
Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.
The Ca2+/Mn2+-transporting SPCA2 pump is regulated by oxygen and cell density in colon cancer cells.
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Colorectal Neoplasms
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Dihydroartemisinin-Induced Apoptosis is Associated with Inhibition of Sarco/Endoplasmic Reticulum Calcium ATPase Activity in Colorectal Cancer.
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.
Sarco/endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer.
Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer.
[The activity of adenosinetriphosphatase of erythrocytes in peripheral blood of patients with colorectal cancer]
Coma
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila.
Contracture
Ca2+ handling by rat myocardium exposed to ATP solutions of different [Ca2+] and Ca2+ buffering capacity.
Dependence of cyclopiazonic-acid-induced muscle contractures on extracellular Ca2+.
Effect of halothane on the Ca2+-transport system of surface membranes isolated from normal and malignant hyperthermia pig skeletal muscle.
Evidence for Mg2, ATP-dependent accumulation of Ca2+ by the intracellular non-mitochondrial calcium store in uterine smooth muscle cells.
Inhibition of sarcoplasmic Ca2+-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals.
Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres.
Mitochondrial Bioenergetics During Ischemia and Reperfusion.
Na(+)-Ca2+ exchange induces low Na+ contracture in frog skeletal muscle fibers after partial inhibition of sarcoplasmic reticulum Ca(2+)-ATPase.
Role of calcium in acute hyperthermic myocardial injury.
SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes.
The effects of quinine on the calcium and magnesium content of the sarcoplasmic reticulum and the temperature-dependence of quinine contractures.
[Myocardial mechanical injury in acute ischemia: a pathophysiologic and histopathologic review]
[The calcium pump in the sarcolemma controls smooth muscle relaxation]
[Uterotonic action of sigetin and its effect on the Mg2+, ATP-dependent transport and stationary metabolism of Ca2+ through the myometrial sarcolemma]
Coronary Disease
[Study of the calmodulin-dependent regulation of calcium adenosine triphosphatase of erythrocyte membranes in patients with ischemic heart disease]
Coronary Occlusion
Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum.
Craniocerebral Trauma
[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma]
Cryptorchidism
Sarco(endo)plasmic reticulum and plasmalemmal Ca(2+)-ATPase activities in cremaster muscles and sacs differ according to the associated inguinal pathology.
Cystic Fibrosis
A study of erythrocyte fatty acids, adenosinetriphosphatase and acetylcholinesterase in cystic fibrosis.
Activator-associated Ca2+-ATPase in erythrocyte membranes from cystic fibrosis patients.
Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death.
Calcium and sodium transport processes in patients with cystic fibrosis 2. Mg2+- dependent, Ca2+ ATPase activity in fibroblast membrane preparations from cystic fibrosis patients and controls.
Calcium and sodium transport processes in patients with cystic fibrosis. I. A specific decrease in Mg2+-dependent, Ca2+-adenosine triphosphatase activity in erythrocyte membranes from cystic fibrosis patients.
Calcium-ATPase activity in cystic fibrosis erythrocyte membranes: decreased activity in patients with pancreatic insufficiency.
Characterization of the adenosinetriphosphatase and transport activities of purified cystic fibrosis transmembrane conductance regulator.
Curcumin modulation of Na,K-ATPase: phosphoenzyme accumulation, decreased K+ occlusion, and inhibition of hydrolytic activity.
Erythrocyte cytosolic free Ca2+ and plasma membrane Ca2+-ATPase activity in cystic fibrosis.
Identification of the cofilin-binding sites in the large cytoplasmic domain of Na,K-ATPase.
Isolation and characterization of erythrocyte membrane Ca2+-ATPase in cystic fibrosis.
Phosphoinositide content of erythrocyte membranes in cystic fibrosis.
Red cell membrane Ca-ATPase in cystic fibrosis: increased activation by Na.
SERCA Pump Inhibitors Do Not Correct Biosynthetic Arrest of {Delta}F508 CFTR in Cystic Fibrosis.
Cystinosis
Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA.
Cysts
Entamoeba invadens: Identification of a SERCA protein and effect of SERCA inhibitors on encystation.
Proposed function of the accumulation of plasma membrane-type Ca2+-ATPase mRNA in resting cysts of the ciliate Sterkiella histriomuscorum.
Darier Disease
A case of segmental Darier disease treated with doxycycline monotherapy.
Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease.
Autosomal-dominant calcium ATPase disorders.
Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier's disease, causes behavioral abnormalities and a hyper-dopaminergic state.
Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.
Congenital acantholytic dyskeratotic epidermal naevus following Blaschko's lines versus segmental Darier's disease.
Consequences of depleted SERCA2-gated calcium stores in the skin.
Darier disease is associated with heart failure: a cross-sectional case-control and population based study.
Darier's disease associated with bipolar affective disorder: a case report.
Darier's disease following radiotherapy for carcinoma of cervix.
Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.
Deletions of any single residues in Glu40-Ser48 loop connecting a domain and the first transmembrane helix of sarcoplasmic reticulum Ca(2+)-ATPase result in almost complete inhibition of conformational transition and hydrolysis of phosphoenzyme intermediate.
Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.
Endoplasmic reticulum calcium, stress, and cell-to-cell adhesion.
Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease.
Exacerbation of darier disease by lithium carbonate.
Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder.
Expression of sarco/endo-plasmic reticulum Ca2+-ATPase type 2 isoforms (SERCA2) in normal human skin and mucosa, and Darier's disease skin.
Expression of the sarco/endoplasmic reticulum calcium ATPase type 2 and 3 isoforms in normal skin and Darier's disease.
Genotype-phenotype correlations in Darier disease: A focus on the neuropsychiatric phenotype.
Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility.
Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.
How do keratinizing disorders and blistering disorders overlap?
Is Darier Disease a Multi-organ Condition?
Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation.
Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat.
Metabolic phenotype in Darier disease: a cross-sectional clinical study.
Multiple effects of SERCA2b mutations associated with Darier's disease.
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease.
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.
Mutations in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase isoform cause Darier's disease.
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Novel ATP2A2 mutations in a large sample of individuals with Darier disease.
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Plasticity and adaptation of Ca2+ signaling and Ca2+-dependent exocytosis in SERCA2(+/-) mice.
Platelet and cardiac function in Darier's disease.
Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.
Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes.
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.
SERCA pumps and human diseases.
SERCA2 Dysfunction in Darier Disease Causes Endoplasmic Reticulum Stress and Impaired Cell-to-Cell Adhesion Strength: Rescue by Miglustat.
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.
The Focal Nature of Darier's Disease Lesions: Calcium Pumps, Stress, and Mutation?
Treatment of Darier's disease with oral magnesium: a case report.
Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options.
Up-Regulation of Transient Receptor Potential Canonical 1 (TRPC1) following Sarco(endo)plasmic Reticulum Ca2+ ATPase 2 Gene Silencing Promotes Cell Survival: A Potential Role for TRPC1 in Darier's Disease.
Variable response to low-dose naltrexone in patients with Darier disease: a case series.
[Detection and analysis of an ATP2A2 mutation in a family with Darier-White disease].
[Improvement of Darier's disease on treatment with topical 5-fluorouracil]
Deafness
Ca2+ homeostasis defects and hereditary hearing loss.
Calcium pumps of plasma membrane and cell interior.
Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice.
Hair cells, plasma membrane Ca(2+) ATPase and deafness.
Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance.
Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.
Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice.
Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.
Neuroplastin expression is essential for hearing and hair cell PMCA expression.
Phenotypes of SERCA and PMCA knockout mice.
PMCA2 pump mutations and hereditary deafness.
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The plasma membrane calcium pump in health and disease.
The plasma membrane calcium pump in the hearing process: physiology and pathology.
Death, Sudden, Cardiac
Acute heart failure--basic pathomechanism and new drug targets.
SERCA2a gene therapy for the prevention of sudden cardiac death: a future theranostic for heart failure?
Decompression Sickness
Mutation of Gly-94 in transmembrane segment M1 of Na+,K+-ATPase interferes with Na+ and K+ binding in E2P conformation.
Dehydration
Concentration-dependent suppressive effect of shrimp head protein hydrolysate on dehydration-induced denaturation of lizardfish myofibrils.
Effect of proteolytic squid protein hydrolysate on the state of water and dehydration-induced denaturation of lizard fish myofibrillar protein.
Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits.
Demyelinating Diseases
Changes in the distribution of a calcium-dependent ATPase during demyelination and remyelination in the central nervous system.
Dengue
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
Diabetes Insipidus, Nephrogenic
Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism.
Diabetes Mellitus
Alterations in cardiac sarcolemmal Ca2+ pump activity during diabetes mellitus.
Cardiac contracile protein ATPase activity in a diet induced model of noninsulin dependent diabetes mellitus.
Cellular Ca2+ ATPase activity in diabetes mellitus.
Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.
Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.
Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer.
Phospholamban Antisense RNA Improves SR Ca2+-ATPase Activity and Left Ventricular Function in STZ-induced Diabetic Rats.
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
Regulation of SERCA pumps expression in diabetes.
Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model.
Diabetes Mellitus, Type 1
Altered platelet membrane dynamic properties in type 1 diabetes.
ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes.
Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes.
Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes.
Cellular Ca2+ ATPase activity in diabetes mellitus.
Effects of type 1 diabetes, sprint training and sex on skeletal muscle sarcoplasmic reticulum Ca2+ uptake and Ca2+-ATPase activity.
Influence of low density lipoprotein from insulin-dependent diabetic patients on platelet functions.
Regulation of SERCA pumps expression in diabetes.
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum.
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
Diabetes Mellitus, Type 2
Ca++, Mg++-ATPase activity in insulin-dependent and non-insulin dependent diabetic Nigerians.
Ca2+-Mg2+-ATPase activity in kidney basolateral membrane in non-insulin-dependent diabetic rats. Effect of insulin.
Cardiac contracile protein ATPase activity in a diet induced model of noninsulin dependent diabetes mellitus.
Cellular Ca2+ ATPase activity in diabetes mellitus.
Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus.
Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a.
Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.
Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.
Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans.
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
PPAR-? activation restores pancreatic islet SERCA2 levels and prevents ?-cell dysfunction under conditions of hyperglycemic and cytokine stress.
Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus.
Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension.
Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.
Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders.
The effect of glucose and calcium on Ca2+-adenosine triphosphatase in pancreatic islets isolated from a normal and a non-insulin-dependent diabetes mellitus rat model.
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
The pathobiochemical role of the dystrophin-dystroglycan complex and the Ca2+-handling apparatus in diabetes-related muscle weakness (Review).
Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model.
Diabetic Cardiomyopathies
A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats.
Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes.
Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy.
Enhanced L-type calcium currents in cardiomyocytes from transgenic rats overexpressing SERCA2a.
Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a.
Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.
Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats.
Leukocytic toll-like receptor 2 knockout protects against diabetes-induced cardiac dysfunction.
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.
Regulation of SERCA pumps expression in diabetes.
SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.
Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats.
Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.
Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.
Diabetic Retinopathy
Inactivation of cysteine 674 in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 causes retinopathy in the mouse.
dna topoisomerase (atp-hydrolysing) deficiency
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Down Syndrome
Cardiac expression of sarcoplasmic reticulum calcium ATPase in fetuses with trisomy 21 and trisomy 18 presenting with nuchal translucency.
Duodenal Ulcer
Effect of daily oral omeprazole on 24 hour intragastric acidity.
Dyskinesias
A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats.
Dyslipidemias
Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine.
Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca2+ -ATPase and Na+/K+ -ATPase activity in the heart of streptozotocin-diabetic rats.
Increased calcium buffering in coronary smooth muscle cells from diabetic dyslipidemic pigs.
[Metabolic syndrome. Part III: Its prevention and therapeutic management.]
Eclampsia
Association of ATP2B1 gene polymorphism with incidence of eclampsia.
Encephalomyelitis
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Role of plasma membrane calcium ATPase 2 in spinal cord pathology.
Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Role of plasma membrane calcium ATPase 2 in spinal cord pathology.
Endolymphatic Hydrops
Changes in Ca2+-ATPase in a guinea pig endolymphatic hydrops model.
Na+,K+-ATPase and Ca2+-ATPase activities in the cochlear lateral wall following surgical induction of hydrops.
Endotoxemia
Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization.
Thaliporphine ameliorates cardiac depression in endotoxemic rats through attenuating TLR4 signaling in the downstream of TAK-1 phosphorylation and NF-?B signaling.
Essential Hypertension
Ca2+ ATPase activity in essential and renal hypertension.
Calmodulin distribution and Ca2+ transport in the erythrocytes of patients with essential hypertension.
Combined SSCP and heteroduplex analysis of the human plasma membrane Ca(2+)-ATPase isoform 1 in patients with essential hypertension.
Comparison of calcium, magnesium-ATPase activity and membrane fluidity in patients with essential hypertension and in normotensive controls.
Erythrocyte membrane Ca2+-pumping ATPase of hypertensive humans: reduced stimulation by calmodulin.
Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.
Platelet membrane calmodulin-stimulated calcium-adenosine triphosphatase. Altered activity in essential hypertension.
Red blood cells Ca2+ pump is not altered in essential hypertension of humans and Kyoto rats.
[Hemodynamics and cell membrane effects of angiotensin II receptor antagonists in treatment of hypertension]
[Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential hypertension]
Euthyroid Sick Syndromes
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome.
Exocrine Pancreatic Insufficiency
Calcium-ATPase activity in cystic fibrosis erythrocyte membranes: decreased activity in patients with pancreatic insufficiency.
Fatty Liver
MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.
Favism
Impairment of the calcium pump of human erythrocytes by divicine.
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
Fetal Growth Retardation
Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.
IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review.
Gangliosidoses
An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses.
Gaucher Disease
Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.
Genetic Diseases, Inborn
Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism.
[Antidesmoglein antibodies in a patient with Hailey-Hailey disease].
Glioblastoma
Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes.
Glioma
5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells.
ACYP2 contributes to malignant progression of glioma through promoting Ca2+ efflux and subsequently activating c-Myc and STAT3 signals.
Bradykinin and muscarine induce Ca(2+)-dependent oscillations of membrane potential in rat glioma cells indicating a rhythmic Ca2+ release from internal stores: thapsigargin and 2,5-di(tert-butyl)-1, 4-benzohydroquinone deplete InsP3-sensitive Ca2+ stores in glioma and in neuroblastoma-glioma hybrid cells.
Differentiation of answer of glioma C6 cells to SERCA pump inhibitors by actin disorganization.
Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib.
Glomerulonephritis
[The functional properties of the erythrocyte membranes in patients with chronic glomerulonephritis]
Glucose Intolerance
Phospholamban Deficiency Does Not Alter Skeletal Muscle SERCA Pumping Efficiency or Predispose Mice to Diet-Induced Obesity.
Glycogen Storage Disease Type V
A Transcriptomic Approach to Search for Novel Phenotypic Regulators in McArdle Disease.
Glycogen Storage Disease Type VII
Increased erythrocyte content of Ca2+ in patients with Tarui's disease.
Goiter
[Cytochemical definition of oxidation-reduction enzyme activity peripheral blood lymphocytes in patients with thyrotoxic goiter]
Gray Platelet Syndrome
Abnormal cAMP-induced phosphorylation of rap 1 protein in grey platelet syndrome platelets.
Hearing Disorders
Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase 2.
Hearing Loss
A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene.
A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.
A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia.
Ca2+ homeostasis defects and hereditary hearing loss.
Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia.
Modification of human hearing loss by plasma-membrane calcium pump PMCA2.
Plasma membrane Ca(2+)-ATPase: from a housekeeping function to a versatile signaling role.
The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
The plasma membrane calcium ATPase and disease.
The plasma membrane calcium pump in the hearing process: physiology and pathology.
[Age-related expression of plasma membrane Ca(2+) -ATPase isoform 2 in the cochleas of C57BL/6J mice].
Hearing Loss, High-Frequency
Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.
The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.
Hearing Loss, Noise-Induced
Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice.
[Protective effect of indirect activator of calcium pump on noise-induced hearing loss]
Heart Defects, Congenital
Molecular genetic analysis of the 3p- syndrome.
SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects.
Heart Diseases
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart Failure.
Circulating cytokine levels in mice with heart failure are etiology dependent.
Conditional mutations in SERCA, the Sarco-endoplasmic reticulum Ca(2+)-ATPase, alter heart rate and rhythmicity in Drosophila.
Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias.
Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure: The CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b).
Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements.
Left Ventricular Remodelling: A Problem in Search of Solutions.
Lnc'ing Ca2+, SERCA and cardiac disease.
Long Term Effects of AAV1/SERCA2a Gene Transfer in Patients with Severe Heart Failure: Analysis of Recurrent Cardiovascular Events and Mortality.
Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure.
Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity.
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.
SERCA2a gene therapy can improve symptomatic heart failure in delta-sarcoglycan deficient animals.
SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.
Targeting sarcoplasmic reticulum calcium ATPase by gene therapy.
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease.
The sarco-endoplasmic reticulum Ca2+ ATPase is required for development and muscle function in Caenorhabditis elegans.
[Biochemistry of myocardium taken at autopsy. Preliminary report]
Heart Failure
?-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco[endo]plasmic Reticulum Ca(2+)-ATPase-Dependent Positive Inotropy in Cardiomyocytes.
A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.
A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban.
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.
Acetylation of SERCA2a, Another Target for Heart Failure Treatment?
Acute cellular actions of thyroid hormone and myocardial function.
Acute heart failure--basic pathomechanism and new drug targets.
Acute Inotropic and Lusitropic Effects of Cardiomyopathic R9C Mutation of Phospholamban.
Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy.
Adenoviral gene transfer of phospholamban in isolated rat cardiomyocytes. Rescue effects by concomitant gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.
Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ?
Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients.
Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure.
Advances in gene therapy for heart failure.
Age-dependent suppression of SERCA2a mRNA in pediatric atrial myocardium.
Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
Altered force-frequency response in non-failing hearts with decreased SERCA pump-level.
Altered sarcoplasmic reticulum Ca2+ ATPase gene expression in congestive heart failure: effect of chronic norepinephrine infusion.
Ameliorated stress related proteins are associated with improved cardiac function by sarcoplasmic reticulum calcium ATPase gene transfer in heart failure.
AQP4 knockout mice manifest abnormal expressions of calcium handling proteins possibly due to exacerbating pro-inflammatory factors in the heart.
Astragalosides Rescue Both Cardiac Function and Sarcoplasmic Reticulum Ca(2+) Transport in Rats with Chronic Heart Failure.
Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure.
Benefit of SERCA2a gene transfer to vascular endothelial and smooth muscle cells: a new aspect in therapy of cardiovascular diseases.
Biventricular pacing cardiac contractility modulation improves cardiac contractile function via upregulating SERCA2 and miR-133 in a rabbit model of congestive heart failure.
C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling.
Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only.
Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c).
Calcium cycling proteins and heart failure: mechanisms and therapeutics.
Calcium pump overexpression and myocardial function. Implications for gene therapy of myocardial failure.
Calcium pumps of plasma membrane and cell interior.
Calcium signaling phenomena in heart diseases: a perspective.
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart Failure.
Calcium-induced delayed afterdepolarizations are triggered by dyadic subspace calcium affirming that increasing SERCA reduces aftercontractions.
CaMKII?B mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart.
cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure.
cAMP-mediated signal transduction and sarcoplasmic reticulum function in heart failure.
Cardiac contractility modulation improves left ventricular systolic function partially via miR-25 mediated SERCA2A expression in rabbit trans aortic constriction heart failure model.
Cardiac expression of sarcoplasmic reticulum calcium ATPase in fetuses with trisomy 21 and trisomy 18 presenting with nuchal translucency.
Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata.
Cardiac gene therapy with SERCA2a: From bench to bedside.
Cardiac SERCA2A/B: therapeutic targets for heart failure.
Cardiac surgical delivery of the sarcoplasmic reticulum calcium ATPase rescues myocytes in ischemic heart failure.
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis.
Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats.
Cardioprotective Effects of Serca2a Overexpression Against Ischemiareperfusion- induced Injuries in Rats.
Changes in intracellular Na+ in heart failure following SERCA knockout--more of a solution or more of a problem?
Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Circulating Sphingosine-1-Phosphate as A Non-Invasive Biomarker of Heart Transplant Rejection.
Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.
Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction.
Comparison of heart sarcolemmal enzyme activities in normal and cardiomyopathic (UM-X7.1) hamsters.
Compartmentalized expression of three novel sarco/endoplasmic reticulum Ca2+ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart.
Compensatory asymmetry in down-regulation and inhibition of the myocardial Ca2+ cycle in congestive heart failure produced in dogs by idiopathic dilated cardiomyopathy and rapid ventricular pacing.
Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a.
Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias.
Contractile Behavior of Mouse Aorta Depends on SERCA2 Isoform Distribution: Effects of Replacing SERCA2a by SERCA2b.
Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure.
Control of protein expression through mRNA stability in calcium signalling.
Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy.
Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Cytosolic H2O2 mediates hypertrophy, apoptosis and decreased SERCA activity in mice with chronic hemodynamic overload.
Darier disease is associated with heart failure: a cross-sectional case-control and population based study.
Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology.
Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.
Diminished posttetanic potentiation in failing human myocardium.
Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway.
Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy.
Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA).
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Early expression of natriuretic peptides and SERCA in mild heart failure: association with severity of the disease.
Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure.
Effect of Valsartan on Sarcoplasmic Reticulum Ca2+-ATPase Pump of the Left Ventricular Myocardium in Rats with Heart Failure with Preserved Ejection Fraction.
Effects of inhibition of sarcoplasmic reticulum calcium uptake on contraction in myocytes isolated from failing human ventricle.
Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility.
Elevated afterload, neuroendocrine stimulation, and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation.
Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure.
Endomyocardial gene expression during development of pacing tachycardia-induced heart failure in the dog.
Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon.
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure.
Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice.
Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium.
Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
Exercise training prior to cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice.
Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene.
Expression of skeletal muscle sarcoplasmic reticulum calcium-ATPase is reduced in rats with postinfarction heart failure.
Fine-tuning SERCA activity to treat distinct heart failure syndromes.
Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase.
Function and regulation of sarcoplasmic reticulum Ca2+-ATPase: advances during the past decade and prospects for the coming decade.
Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium.
Gene therapy for heart failure.
Gene therapy for heart failure: where do we stand?
Gene therapy in heart failure. SERCA2a as a therapeutic target.
Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure.
GL Brown Prize Lecture Matters of the Heart: The Physiology of Cardiac Function and Failure.
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
Hemodynamics and mitochondrial energy metabolism in right heart hypertrophy after acute hypoxic stress.
Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.
HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility.
High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays.
Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase (SERCA) 2a pump activity on cytosolic calcium in living cells.
HuR regulates phospholamban expression in isoproterenol-induced cardiac remodeling.
Hydralazine-induced promoter demethylation enhances sarcoplasmic reticulum Ca(2+)-ATPase and calcium homeostasis in cardiac myocytes.
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes.
Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.
Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium.
Immunosuppression Decreases Inflammation and Increases AAV6-hSERCA2a-Mediated SERCA2a Expression.
Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study.
Impaired Ca2+-ATPase oligomerization and increased phospholamban expression in dilated cardiomyopathy.
Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats.
Improved cardiac function after sarcoplasmic reticulum Ca(2+)-ATPase gene transfer in a heart failure model induced by chronic myocardial ischaemia.
Improved exercise capacity and reduced systemic inflammation after adenoviral-mediated SERCA-2a gene transfer.
Improved systolic function of rat cardiocytes during heart failure by overexpression of SERCA2a.
Improvement in cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a beagle heart failure model.
Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure.
Improving cardiac Ca?² transport into the sarcoplasmic reticulum in heart failure: lessons from the ubiquitous SERCA2b Ca?² pump.
In vitro selection and characterization of DNA aptamers specific for phospholamban.
In vivo effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction.
Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic beta3-adrenoceptor deficiency.
Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.
Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure.
Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats.
Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.
Influences of increased expression of the Ca2+ ATPase of the sarcoplasmic reticulum by a transgenic approach on cardiac contractility.
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-?B-dependent suppression of SERCA2a and Cav1.2 expression.
Interleukin-6-induced reciprocal expression of SERCA and natriuretic peptides mRNA in cultured rat ventricular myocytes.
Intramyocardial injection of SERCA2a-expressing lentivirus improves myocardial function in doxorubicin-induced heart failure.
Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL.
Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes.
Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.
LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport.
Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats.
Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats.
Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats.
Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.
Long Term Effects of AAV1/SERCA2a Gene Transfer in Patients with Severe Heart Failure: Analysis of Recurrent Cardiovascular Events and Mortality.
Matters of the heart: the physiology of cardiac function and failure.
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.
Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.
miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a.
miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives.
Modulation of SERCA: implications for the failing human heart.
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
Molecular cloning and analysis of the human cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2) gene promoter.
Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca2+-ATPase Expression in Cardiomyocytes.
New insights into SERCA2a gene therapy in heart failure: pay attention to the negative effects of B-type natriuretic peptides.
Novel therapies in acute and chronic heart failure.
Observations on atrial natriuretic peptide, sympathetic activity and renal Ca2+ pump in diabetic and hypertensive rats.
Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation.
Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca(2+) Regulation.
Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure.
Pak1 is required to maintain ventricular Ca²? homeostasis and electrophysiological stability through SERCA2a regulation in mice.
Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²? homeostasis but not Ca²?-dependent hypertrophic signaling.
Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model.
Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase.
Phospholamban mutants compete with wild type for SERCA binding in living cells.
Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy.
Phospholamban, a predicted candidate for early cardiac problem detection using signal processing techniques.
Phospholamban: a crucial regulator of cardiac contractility.
Phospholamban: a promising therapeutic target in heart failure?
Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase.
Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA.
Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes.
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.
Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure.
Post-translational Modifications in Heart Failure: Small Changes, Big Impact.
Potential of gene therapy as a treatment for heart failure.
Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure.
Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction.
Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency.
Protective effect of oxymatrine on chronic rat heart failure.
Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats.
PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes.
Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Reduced cardiac myosin adenosinetriphosphatase activity in dogs with spontaneously occurring heart failure.
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity.
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression.
Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease.
Regulation of expression of cardiac sarcoplasmic reticulum proteins under pathophysiological conditions.
Regulation of myocardial SERCA2a expression in ventricular hypertrophy and heart failure.
Regulation of SERCA pumps expression in diabetes.
Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart.
Research on the Effects of the Chronic Treatment With Different Doses of Urocortin 2 in Heart Failure Rats.
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a.
Restoration of sarcoplasmic reticulum protein level by thyroid hormone contributes to partial improvement of myocardial function, but not to glucose metabolism in an early failing heart.
Retraction. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin.
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure.
Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure.
Right Ventricular Beneficial Effects of Intracoronary SERCA2a Gene Transfer in an Experimental Model of Heart Failure.
Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart.
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Role of SR Ca2+-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure.
Role of the PRC2-Six1-miR-25 signaling axis in heart failure.
Sarco(endo)plasmic Reticulum Calcium ATPase (SERCA) Inhibition by Sarcolipin Is Encoded in Its Luminal Tail.
Sarcoendoplasmic reticulum calcium transport ATPase 2a: a potential gene therapy target in heart failure.
Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.
Sarcoplasmic reticulum adenosine triphosphatase overexpression in the L-type Ca2+ channel mouse results in cardiomyopathy and Ca2+ -induced arrhythmogenesis.
Sarcoplasmic reticulum ATPase activity in type I and II skeletal muscle fibres of chronic heart failure patients.
Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure.
Sarcoplasmic reticulum Ca(2+)-ATPase overexpression by adenovirus mediated gene transfer and in transgenic mice.
Sarcoplasmic Reticulum Ca-ATPase and Heart Failure 20 Years Later.
Sarcoplasmic reticulum Ca2+ ATPase gene expression to the rescue of myocardial contractility in hypothyroid associated heart failure.
Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?
Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure.
SERCA in genesis of arrhythmias: what we already know and what is new?
SERCA in heterogeneity of diastolic dysfunction in post-infarction heart failure with reduced ejection fraction.
SERCA pump isoforms: their role in calcium transport and disease.
SERCA pump level is a critical determinant of Ca(2+)homeostasis and cardiac contractility.
SERCA pumps and human diseases.
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.
SERCA2a gene therapy can improve symptomatic heart failure in delta-sarcoglycan deficient animals.
SERCA2a gene therapy for heart failure: ready for primetime?
SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.
SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.
SERCA2a Gene Transfer Decreases SR Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure.
SERCA2a in heart failure: role and therapeutic prospects.
SERCA2a, a Potential Gene Therapy Target in Heart Failure.
SERCA2a-phospholamban interaction monitored by an interposed circularly permutated green fluorescent protein.
SERCA2a: a key protein in the Ca2+ cycle of the heart failure.
SERCA2a: a prime target for modulation of cardiac contractility during heart failure.
Serendipitous discovery of a novel protein signaling mechanism in heart failure.
Short-term effects of ?2-AR blocker ICI 118,551 on sarcoplasmic reticulum SERCA2a and cardiac function of rats with heart failure.
Simvastatin prevents decreased SERCA2a activity in non-ischemic heart failure in rabbits via inhibition of ?-adrenergic signaling.
Skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase gene expression in congestive heart failure.
Sleeve gastrectomy in obese Wistar rats improves diastolic function and promotes cardiac recovery independent of weight loss.
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
Sodium Accumulation in SERCA Knockout-Induced Heart Failure.
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.
SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.
Structures of the heart specific SERCA2a Ca2+-ATPase.
SUMO1-dependent modulation of SERCA2a in heart failure.
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.
Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.
Targeting phospholamban by gene transfer in human heart failure.
Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells.
Targeting sarcoplasmic reticulum calcium ATPase by gene therapy.
Targeting SERCA2a as an innovative approach to the therapy of congestive heart failure.
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases.
The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin.
The Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective.
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
The effects of a thyroid hormone analog on left ventricular performance and contractile and calcium cycling proteins in the baboon.
The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.
The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA).
The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility.
The role of CaMKII regulation of phospholamban activity in heart disease.
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function.
The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy.
The sarcoplasmic reticulum Ca2+-ATPase (SERCA2) gene promoter activity is decreased in response to severe left ventricular pressure-overload hypertrophy in rat hearts.
The transmembrane peptide DWORF activates SERCA2a via dual mechanisms.
The war against heart failure: the Lancet lecture.
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome.
Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level.
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.
Transcriptional changes following restoration of SERCA2a levels in failing rat hearts.
Transgenic expression of sarcoplasmic reticulum Ca(2+) atpase modifies the transition from hypertrophy to early heart failure.
Transgenic mouse models for cardiac dysfunction by a specific gene manipulation.
Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overload.
Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes*
Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes.
Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017.
Velvet Antler Ameliorates Cardiac Function by Restoring Sarcoplasmic Reticulum Ca2+-ATPase Activity in Rats With Heart Failure After Myocardial Infarction.
Weighing in on heart failure: the role of SERCA2a SUMOylation.
[Abnormal abundances of calcium cycling regulatory proteins in rabbit myocytes with heart failure]
[Abnormal calcium re-uptake in myocardium sarcoplasmic reticulum in rabbits with heart failure and the influencing factors].
[Adeno-associated viral gene transfer of SERCA2a improves heart function in chronic congestive heart failure rats]
[Bone marrow stem cells-based SERCA2a gene therapy for heart failure after acute myocardium infarction]
[Calcium kinetics in the progression of heart failure]
[Changes of sarcolemma Na+/K+ ATPase and sarcoplasmic reticulum membrane Ca2+ ATPase activity after stem cell transplantation in chronic heart failure]
[Effect of losartan on sarcoplasmic reticulum Ca2+ handing proteins in heart failure rabbit]
[Effect of Yixinshu Capsules on calcium regulatory protein in cardiac myocytes of rats with heart failure].
[Effects of Astragalus membranaccus on cardiac function and SERCA2a gene expression in myocardial tissues of rats with chronic heart failure]
[Effects of curcumin on sarcoplasmic reticulum Ca2+-ATPase in rabbits with heart failure]
[Effects of valsartan on sarcoplasmic reticulum calcium adenodine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]
[Expressions of SERCA2a and miR-25-3p/5p in myocardium of rats with heart failure and therapeutic effects of Xiefei Lishui recipe].
[Gene therapy in heart failure: the unexpected results from the CUPID 2 trial].
[Genetic complementation studies using genetically engineered mice have revealed the impact of phospholamban on progression of cardiomyopathy]
[Molecular mechanism of the changes in ventricular electrical remodeling caused by mechano-electrical feedback in rabbits with congestive heart failure]
[Myocardial metabolism of calcium in heart failure: from physiology to new therapeutic perspectives]
[Overexpression of sarcoplasmic reticulum calcium ATPase induced hemodynamic and proteomic changes in a dog model of heart failure]
[Preliminary study on mechanism of electroacupuncture with the involvement of SERCA2a/PLB on the synergistic and attenuated effect of aconitine in treatment of heart failure].
[Research progress of sarcolipin-a new regulatory protein of sarcoplasmic reticulum Ca2+ ATPase].
[The effect of the relative amount of sarcoplasmic reticulum Ca2+ -ATPase on the cardiac contractile and relaxation function]
[The mechanism of contractile dysfunction in heart failure, focussing on SERCA2a function]
[Treatment of chronic heart failure by overexpressing sarcoplasmic reticulum calcium ATPase through gene therapy: an experiment with rats]
Heart Failure, Diastolic
Plasma levels of tumor necrosis factor-? and interleukin-6 are associated with diastolic heart failure through downregulation of sarcoplasmic reticulum Ca2+ ATPase.
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.
Heart Rupture
N-acetyl-seryl-aspartyl-lysyl-proline treatment protects heart against excessive myocardial injury and heart failure in mice.
Heart Valve Diseases
Analysis of azide-insensitive Ca2+-dependent ATPase activity in atrial specimens from patients with coronary or valvular heart disease.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Hepatic Encephalopathy
Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain.
Hepatitis
ADENOSINETRIPHOSPHATASE OF LIVER MITOCHONDRIA IN VIRUS HEPATITIS OF MICE.
[Lactate dehydrogenase, glucosephosphate dehydrogenase, glutathione reductase and adenosine triphosphatase activities in the erythrocytes of patients with acute viral hepatitis]
Hepatitis B
Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis.
Hepatolenticular Degeneration
ATP-dependent copper transporter, in the Golgi apparatus of rat hepatocytes, transports Cu(II) not Cu(I).
Hernias, Diaphragmatic, Congenital
Myocardium expression of connexin 43, SERCA2a, and myosin heavy chain isoforms are preserved in nitrofen-induced congenital diaphragmatic hernia rat model.
Herpes Zoster
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.
[Action of adenosinetriphosphatase on zona.]
Huntington Disease
Evaluating the SERCA2 and VEGF mRNAs as Potential Molecular Biomarkers of the Onset and Progression in Huntington's Disease.
Hypercalcemia
Ca2+-dependent phosphatase and Ca2+-dependent ATPase activities in plasma membranes of eel gill epithelium--III. Stimulation of branchial high-affinity Ca2+-ATPase activity during prolactin-induced hypercalcemia in American eels.
Calcitropic actions of prolactin in freshwater North American eel (Anguilla rostrata LeSueur).
Hypercholesterolemia
Targeting the redox regulation of SERCA in vascular physiology and disease.
[Change in the molecular properties of sarcoplasmic reticulum Ca-ATPase during modification of the membranes with cholesterol]
[Effect of cholesterol on the cooperativeness of the Ca-ATPase of the sarcoplasmic reticulum in rabbit skeletal muscle]
[Lipid peroxidation as a major factor in the modification of the catalytic function of Ca-ATPase of the sarcoplasmic reticulum in hypercholesterolemia]
[Modification of the functional properties of sarcoplasmic reticulum Ca-ATPase in hypercholesterolemia]
[Protective effect of alpha-tocopherol on the Ca2+-transport system of the sarcoplasmic reticulum membranes in hypercholesterolemia]
[Role of lipid peroxidation in changes in the structure of Ca-ATPase in skeletal muscle sarcoplasmic reticulum during hypercholesterolemia]
[Several properties of the Ca-pump of rabbit skeletal muscle sarcoplasmic reticulum in hypercholesteremia]
[Spin labels in the analysis of Ca-ATPase in the sarcoplasmic reticulum of rabbit skeletal muscles in hypercholesteremia]
Hyperglycemia
Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress.
Corneal hydration control in normal and alloxan-induced diabetic rabbits.
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.
Effects of Hyperglycemia on Vascular Smooth Muscle Ca(2+) Signaling.
Influence of hyperglycemia on Ca2+-Mg2+ -ATPase of red blood cells from diabetic patients.
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis.
Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.
Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats.
Sarcoplasmic reticulum Ca(2+) ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.
The effect of in vivo glucose administration on human erythrocyte Ca2+-ATPase activity and on enzyme responsiveness in vitro to thyroid hormone and calmodulin.
Hyperhomocysteinemia
Response of secretory pathways Ca(2+) ATPase gene expression to hyperhomocysteinemia and/or ischemic preconditioning in rat cerebral cortex and hippocampus.
Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats.
Hyperkalemia
Works on heart, how about brain? Effect of hyperkalemia on focal cerebral ischemia/reperfusion injury in rats.
Hyperlipidemias
Blocking the urotensin II receptor pathway ameliorates the metabolic syndrome and improves cardiac function in obese mice.
Regulation of rabbit erythrocyte Ca(2+)-pump sensitivity to calmodulin in experimental hyperlipidemia.
Hyperparathyroidism, Secondary
Depression of calcium pump activity in renal cortex of vitamin D-deficient rats with secondary hyperparathyroidism.
Hypersensitivity
A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.
Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus.
Hypersensitivity to calcium associated with an increased sarcolemmal Ca2+-ATPase activity in diabetic rat heart.
In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes.
Hypertension
(Na+,K+)-activated adenosinetriphosphatase and hypertension in DAHL salt- sensitive and -resistant rats.
Alteration of cellular calcium metabolism as primary cause of hypertension.
Ca2+ buffering function of the sarcoplasmic reticulum is increased in the carotid artery from spontaneously hypertensive rats.
Calcium and abnormal reactivity of vascular smooth muscle in hypertension.
Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension.
Cellular Ca2+ ATPase activity in diabetes mellitus.
Combined SSCP and heteroduplex analysis of the human plasma membrane Ca(2+)-ATPase isoform 1 in patients with essential hypertension.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of sarcoplasmic reticulum calcium pump inhibitors on vascular smooth muscle.
Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice.
Expression of sarcoplasmic reticulum Ca2+ -ATPase mRNA in the hypertrophied heart of young spontaneously hypertensive rats.
Functional characterization of alternatively spliced human SERCA3 transcripts.
Genotypes of sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase II gene in substrains of spontaneously hypertensive rats.
Impaired calcium metabolism associated with hypertension in Zucker obese rats.
Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.
Increased expression of plasma membrane Ca(2+)ATPase 4b in platelets from hypertensives: A new sign of abnormal thrombopoiesis?
Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins.
Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
Kinetic study of the Ca2+ pump in erythrocytes from essential hypertensive patients.
Localisation of calcium-activated adenosine-triphosphatase (Ca2+-ATPase) in intracerebral arterioles in acute hypertension.
Membrane transport and disease.
Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control.
NO donors-relaxation is impaired in aorta from hypertensive rats due to a reduced involvement of K(+) channels and sarcoplasmic reticulum Ca(2+)-ATPase.
Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension.
Platelet Ca(2+)ATPases : a plural, species-specific, and multiple hypertension-regulated expression system.
Preeclampsia and calcium-ATPase activity of plasma membranes from human myometrium and placental trophoblast.
Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.
Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension.
Sarcoplasmic reticulum Ca2+ uptake is not decreased in aorta from deoxycorticosterone acetate hypertensive rats: functional assessment with cyclopiazonic acid.
Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR?27b?3p/ATPase plasma membrane Ca2+ transporting 1 axis.
Thapsigargin-insensitive calcium pools in vascular smooth muscle cells.
[Calcium pump changes in patients with essential arterial hypertension]
[INCREASE OF SERUM ADENOSINETRIPHOSPHATASE IN ARTERIAL HYPERTENSION.]
Hypertension, Pulmonary
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.
Hypertension, Renal
Ca2+ ATPase activity in essential and renal hypertension.
Hypertension, Renovascular
Effects of systolic overload and swim training on cardiac mechanics and biochemistry in rats.
Senescent heart compared with pressure overload-induced hypertrophy.
Hyperthyroidism
Cardiac microRNA-133 is down-regulated in thyroid hormone-mediated cardiac hypertrophy partially via Type 1 Angiotensin II receptor.
Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone.
Cellular mechanisms of reduced sarcoplasmic reticulum Ca2+ content in L-thyroxininduced rat ventricular hypertrophy.
Compensatory adaptation of the heart to chronic rate overload: increase in calcium transport ATPase activity of myocardial sarcoplasmic reticulum.
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Coordinated fast-to-slow transitions of myosin and SERCA isoforms in chronically stimulated muscles of euthyroid and hyperthyroid rabbits.
Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism.
Differential effects of thyroid hormone on the expression of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat skeletal muscle fibers.
Differential influences of carnitine palmitoyltransferase-1 inhibition and hyperthyroidism on cardiac growth and sarcoplasmic reticulum phosphorylation.
Effects of hyperthyroidism and hypothyroidism on human red blood cell Ca2+-ATPase activity.
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Hyperthyroid dog left ventricle has the same oxygen consumption versus pressure-volume area (PVA) relation as euthyroid dog.
Hyperthyroidism and cation pumps in human skeletal muscle.
Hyperthyroidism causes mechanical insufficiency of myocardium with possibly increased SR Ca2+-ATPase activity.
Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase.
Increased acylphosphatase levels in erythrocytes from hyperthyroid patients.
Myosin and SERCA isoform expression in denervated slow-twitch muscle of euthyroid and hyperthyroid rabbits.
Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NF?B/AKT/mTOR/KEAP1 signalling in rat heart.
Reconstitution of heavy chain and light chain 1 in cardiac subfragment-1 from hyperthyroid and euthyroid rabbit hearts.
Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis.
Special sensitization pattern in adenosine-induced myocardial responses after thyroxine-treatment.
The thermogenic function of the sarcoplasmic reticulum Ca2+-ATPase of normal and hyperthyroid rabbit.
Thyroid control of sarcolemmal Na+/Ca2+ exchanger and SR Ca2+-ATPase in developing rat heart.
Thyroid hormone differentially affects mRNA levels of Ca-ATPase isozymes of sarcoplasmic reticulum in fast and slow skeletal muscle.
Thyroid hormone downregulates the expression and function of sarcoplasmic reticulum-associated CaM kinase II in the rabbit heart.
Thyroid hormone enhances Ca2+ pumping activity of the cardiac sarcoplasmic reticulum by increasing Ca2+ ATPase and decreasing phospholamban expression.
Thyroid hormone markedly increases the mRNA coding for sarcoplasmic reticulum Ca2+-ATPase in the rat heart.
Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts.
Thyroid hormones differentially regulate the distribution of rabbit skeletal muscle Ca(2+)-ATPase (SERCA) isoforms in light and heavy sarcoplasmic reticulum.
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
[Increased activity of sarcoplasmic reticulum Ca(2+)-ATPase in soleus of hyperthyroid rat accelerates fatigue during intermittent tetanic contraction.]
Hypertrophy, Left Ventricular
Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats.
Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload.
Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy.
PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes.
The sarco(endo)plasmic reticulum Ca(2+)-ATPase gene is regulated at the transcriptional level during compensated left ventricular hypertrophy in the rat.
[Effect of astragalus on calcium accumulation and SERCA2a gene expression in myocardial tissues in rats with pressure overload-induced left ventricular hypertrophy]
[Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential hypertension]
Hypertrophy, Right Ventricular
Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.
Hypocalcemia
Alkaline phosphatases in endochondral ossification of rats low in calcium and vitamin D deficient.
Chronic hypocalcemia of vitamin D deficiency leads to lower intracellular calcium concentrations in rat hepatocytes.
The sarcolemmal Ca2+-ATPase of the ischemic-reperfused myocardium: protective effect of hypocalcemia on calmodulin-stimulated activity.
Hypokinesia
[Energy-dependent transport of Ca2+ and lipid peroxidation in the sarcoplasmic reticular membranes of rats during hypokinesia]
Hypophosphatemia
[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma]
Hypotension
[Treatment of heart failure patients with inotropic drugs: beyond traditional agents].
Hypothyroidism
Cardiac sarcoplasmic reticulum calcium transport activity of thyroidectomized rats: the role of endogenous myocardial acylcarnitines and calcium pump protein.
Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats.
Effects of experimentally-induced maternal hypothyroidism on crucial offspring rat brain enzyme activities.
Effects of hyperthyroidism and hypothyroidism on human red blood cell Ca2+-ATPase activity.
Influence of hypothyroidism on testicular mitochondrial oxidative stress by activating the p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase signaling pathways in rats.
Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction.
Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism.
Overexpression of sarcoplasmic reticulum Ca(2+)-ATPase improves cardiac contractile function in hypothyroid mice.
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.
The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement.
Thyroid control of sarcolemmal Na+/Ca2+ exchanger and SR Ca2+-ATPase in developing rat heart.
Thyroid hormone differentially affects mRNA levels of Ca-ATPase isozymes of sarcoplasmic reticulum in fast and slow skeletal muscle.
Thyroid hormone influences muscle mechanics in carp (Cyprinus carpio) independently from SERCA activity.
Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio).
Thyroid hormone regulates Na(+)-Ca2+ exchanger expression during postnatal maturation and in adult rabbit ventricular myocardium.
Thyroid hormone response of slow and fast sarcoplasmic reticulum Ca2+ ATPase mRNA in striated muscle.
Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts.
Thyroid hormones differentially regulate the distribution of rabbit skeletal muscle Ca(2+)-ATPase (SERCA) isoforms in light and heavy sarcoplasmic reticulum.
Ventricular myosin from young and adult animals with respect to the thyroid state.
Hypoxia, Brain
Nuclear mechanisms of hypoxic cerebral injury in the newborn.
Infections
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Adenoviral SERCA1 overexpression triggers an apoptotic response in cultured neonatal but not in adult rat cardiomyocytes.
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.
Cardiac protective effect of astragalus on viral myocarditis mice: comparison with perindopril.
Cell-specific expression of SERCA, the exogenous Ca2+ transport ATPase, in cardiac myocytes.
Chronic treatment with insulin-like growth factor I enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway.
Differential expression of the plasma membrane Mg2+ ATPase and Ca2+ ATPase activity during adhesion and interiorization of Leishmania amazonensis in fibroblasts in vitro.
Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility.
Effects of peroxynitrite on sarco/endoplasmic reticulum Ca2+ pump isoforms SERCA2b and SERCA3a.
Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola.
Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells.
Influences of increased expression of the Ca2+ ATPase of the sarcoplasmic reticulum by a transgenic approach on cardiac contractility.
Inhibitor of Sarco/Endoplasmic Reticulum Calcium-ATPase Impairs Multiple Steps of Paramyxovirus Replication.
Intracellular disassembly of infectious rotavirus particles by depletion of Ca2+ sequestered in the endoplasmic reticulum at the end of virus cycle.
Localization of intracellular Ca2+ stores in HeLa cells during infection with Chlamydia trachomatis.
Membrane transport and disease.
Mitochondrial ATP-ASE as a measure of uncoupling of rat muscle mitochondria in experimental infection with Trichinella spiralis and Trichinella pseudospiralis.
Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.
Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes.
Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes.
Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes.
PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes.
Regulation and rate limiting mechanisms of Ca2+ ATPase (SERCA2) expression in cardiac myocytes.
Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.
SERCA2a gene transfer prevents intimal proliferation in an organ culture of human internal mammary artery.
Tacaribe virus infection may induce inhibition of the activity of the host cell Ca2+ and Na+/K+ pumps.
The effect of Mycoplasma pneumoniae infection on human erythrocytes: changes in osmotic fragility, lipid composition, sialic acid content, Ca2+-ATPase activities, and ATP concentration.
The Golgi calcium ATPase pump plays an essential role in AAV trafficking and transduction.
The influence of porcine epidemic diarrhea virus on pig small intestine mucosal epithelial cell function.
The Na+/Ca2+ exchanger/SR Ca2+ ATPase transport capacity regulates the contractility of normal and hypertrophied feline ventricular myocytes.
The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria.
The t-SNARE protein FgPep12, associated with FgVam7, is essential for ascospore discharge and plant infection by trafficking Ca2+ ATPase FgNeo1 between Golgi and endosome/vacuole in Fusarium graminearum.
Total Flavonoids of Astragalus Plays a Cardioprotective Role in Viral Myocarditis.
Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection.
[Effects of lentivirus-mediated heat shock protein 70 gene on endoplasmic reticulum calcium homeostasis and calcium channels of PC12 cells induced by ischemia and hypoxia].
[Expression of sarco/endoplasmic reticulum Ca(2+)-ATPase from Bombyx mori by baculovirus expression system].
Infertility
A New Baltic Population-Specific Human Genetic Marker in the PMCA4 Gene.
Abnormal deficiency of both Mg2+ and Ca2+-dependent adenosine triphosphatase and secretory granules and vesicles in human seminal plasma.
Evaluation of plasma membrane calcium/calmodulin-dependent ATPase isoform 4 as a potential target for fertility control.
Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump - a novel therapeutic target for contraception and malaria.
Plasma membrane Ca(2+)-ATPase: from a housekeeping function to a versatile signaling role.
Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation.
Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase.
Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity.
Infertility, Male
Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm.
Oviductal extracellular vesicles (oviductosomes, OVS) are conserved in humans: murine OVS play a pivotal role in sperm capacitation and fertility.
Phenotypes of SERCA and PMCA knockout mice.
Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase.
Influenza, Human
Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells.
Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication.
Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.
Insulin Resistance
A natural compound jaceosidin ameliorates endoplasmic reticulum stress and insulin resistance via upregulation of SERCA2b.
DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression.
Hugan Qingzhi medication ameliorates free fatty acid-induced L02 hepatocyte endoplasmic reticulum stress by regulating the activation of PKC-?.
Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.
MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
Prolonged preoperative fasting induces postoperative insulin resistance by ER-stress mediated Glut4 down-regulation in skeletal muscles.
Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders.
Insulinoma
Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic ?-cells in vitro by activation of Smoothened.
Iron Overload
Oxidative damage to sarcoplasmic reticulum Ca2+-ATPase AT submicromolar iron concentrations: evidence for metal-catalyzed oxidation.
Isaacs Syndrome
A defective SERCA1 protein is responsible for congenital pseudomyotonia in Chianina cattle.
Fast-twitch skeletal muscle fiber adaptation to SERCA1 deficiency in a Dutch Improved Red and White calf pseudomyotonia case.
Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: an animal model of human Brody disease.
Inhibition of ubiquitin proteasome system rescues the defective sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1) protein causing Chianina cattle pseudomyotonia.
Ischemic Contracture
[Role of disorders of calcium homeostasis in the development of ischemic contracture of the heart]
Ischemic Stroke
Olfactory Mucosa Mesenchymal Stem Cells Alleviate Cerebral Ischemia/Reperfusion Injury Via Golgi Apparatus Secretory Pathway Ca2+ -ATPase Isoform1.
Kidney Diseases
Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease: Pathogenesis and Therapeutic Targets.
[Behavior of adenosinetriphosphatase activity of the kidneys in some experimental and human kidney diseases.]
Kidney Failure, Chronic
A circulating inhibitor of the RBC membrane calcium pump in chronic renal failure.
Biochemical changes associated with the osmotic fragility of young and mature erythrocytes caused by parathyroid hormone in relation to the uremic syndrome.
Characterization of dimethylguanosine, phenylethylamine, and phenylacetic acid as inhibitors of Ca2+ ATPase in end-stage renal failure.
Characterization of p-hydroxy-hippuric acid as an inhibitor of Ca2+-ATPase in end-stage renal failure.
Effect of chronic renal failure on Ca2+ ATPase of brain synaptosomes.
Effect of end-stage renal disease on responsiveness to calmodulin and thyroid hormone of calcium-ATPase in human red blood cells.
Effect of parathyroid hormone on the fragility and enzyme activities of red blood cells from young and mature rabbits.
Effects of chronic renal failure with and without excess parathyroid hormone on calmodulin content of pancreatic islets and on the response of their Ca2+ ATPase to calmodulin.
[Calpain-calpastatin system in erythrocytes of children with chronc renal failure]
[The immune-enzyme technique of detection of Ca2+ ATPase of sarcoplasmic reticulum--a new biologic marker of acute cardiac infarction].
Kwashiorkor
Erythrocyte membrane (Ca2+ + Mg2+)-ATPase in human protein-energy malnutrition.
Leishmaniasis
Immunomodulator mediated changes in plasma membrane calcium ATPase in controlling visceral leishmaniasis.
Regulation of PKC mediated signaling by calcium during visceral leishmaniasis.
Leishmaniasis, Visceral
Immunomodulator mediated changes in plasma membrane calcium ATPase in controlling visceral leishmaniasis.
Leukemia
Association of enzymes: adenosinetriphosphatase and alkaline phosphatase with the virions of murine leukemias.
Ca2+-ATPase inhibitors and PKC activation synergistically stimulate TNF-alpha production in RBL-2H3 cells.
Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer.
Distribution of inositol 1,4,5-trisphosphate receptor isoforms, SERCA isoforms and Ca2+ binding proteins in RBL-2H3 rat basophilic leukemia cells.
Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.
Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.
Leukemia Inhibitory Factor and Interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes.
Lineage-specific modulation of calcium pump expression during myeloid differentiation.
[Changes in Ca2+-ATPase activity in blast cells of acute leukemia patients]
[Expression of SERCA pumps during cell differentiation and tumorigenesis: application to colonic carcinogenesis]
Leukemia, Erythroblastic, Acute
Early transient suppression of c-myb mRNA levels and induction of differentiation in Friend erythroleukemia cells by the [Ca2+]i-increasing agents cyclopiazonic acid and thapsigargin.
Role of the glycoprotein IIb-IIIa complex in plasma membrane Ca2+ transport: a comparison of results obtained with platelets and human erythroleukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.
Leukemia, Myeloid, Acute
A Novel SERCA Inhibitor Demonstrates Synergy with Classic SERCA Inhibitors and Targets Multidrug-Resistant AML.
Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells is dependent on Ca2+ influx through plasma membrane Ca2+ channels.
Leukemia, Promyelocytic, Acute
Lineage-specific modulation of calcium pump expression during myeloid differentiation.
Liposarcoma
High expression of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2b blocks cell differentiation in human liposarcoma cells.
Targeting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase 2 by Curcumin Induces ER Stress-Associated Apoptosis for Treating Human Liposarcoma.
Liver Diseases
Correction to: Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.
Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.
MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.
Liver Neoplasms, Experimental
Deoxyribonucleic acid dependent adenosinetriphosphatases from the Novikoff hepatoma. Characterization of a homogeneous adenosinetriphosphatase that stimulates DNA polymerase beta.
Lung Diseases
Activator-associated Ca2+-ATPase in erythrocyte membranes from cystic fibrosis patients.
Lung Neoplasms
Analysis of chemoresistance in lung cancer with a simple microfluidic device.
Chemotherapy resistance research of lung cancer based on micro-fluidic chip system with flow medium.
Effect of long non-coding RNA long stress-induced noncoding transcript 5 on erlotinib resistance to lung cancer cells and the underlying mechanisms.
GRP78 upregulation-induced increase in cisplatin sensitivity of SPCA1 lung cancer cells.
Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines.
Loss of RhoA expression prevents proliferation and metastasis of SPCA1 lung cancer cells in vitro.
Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation.
RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells.
Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-?B signaling pathway.
Zebrafish xenograft model of human lung cancer for studying the function of LINC00152 in cell proliferation and invasion.
[Ca2+, Mg2+-ATPase activity of the erythrocyte membrane in patients with lung cancer]
[Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines]
Lupus Erythematosus, Discoid
Incidental Focal Acantholytic Dyskeratosis in a Patient with Discoid Lupus Erythematosus: A Possible Role for SPCA1 in the Pathogenesis of the Disease.
Lymphatic Metastasis
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Sarco/endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer.
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2.
Lymphoma
Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2.
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats.
Lymphoma, B-Cell
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats.
Lymphopenia
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
Magnesium Deficiency
Thalasselis' syndrome and other theories on keratoconus.
Malaria
Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction.
Assessment and Characterization of Ca2+ - ATPase expression in selected isolates and clones of Plasmodium Falciparum.
Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection.
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.
Detecting adenosine triphosphatase 6 (pfATP6) point mutations that may be associated with Plasmodium falciparum resistance to artemisinin: prevalence at baseline, before policy change in Uganda.
Effect of chloroquine phosphate and toxic concentrations of lead acetate on Ca2+-ATPase activity in isolates and clones of Plasmodium Falciparum.
Fragment Molecular Orbital Study of the Interaction between Sarco/Endoplasmic Reticulum Ca2+-ATPase and its Inhibitor Thapsigargin toward Anti-Malarial Development.
Genome-wide association study indicates two novel resistance loci for severe malaria.
Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach.
Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants.
Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene.
Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria.
Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump - a novel therapeutic target for contraception and malaria.
Plasmodium falciparum: Genetic diversity and complexity of infections in an isolated village in western Thailand.
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates.
Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets.
The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria.
Malaria, Cerebral
The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria.
Malnutrition
Effect of exercise during rehabilitation on swimming performance, metabolism and function of muscle in rats.
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
The Ca2+-transporting activity of rat liver microsomes in response to protein undernutrition: implications for liver tumor promotion.
Mania
RBC membrane adenosine triphosphatase activities in patients with major affective disorders.
Mastocytoma
Synthesis and activation of mitotic Ca2+-adenosinetriphosphatase during the cell cycle of mouse mastocytoma cells.
Measles
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
Melanoma
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK.
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.
Properties of adenosinetriphosphatase in sub-cellular particles of mouse melanoma.
Synthetic peptides corresponding to the calmodulin-binding domains of skeletal muscle myosin light chain kinase and human erythrocyte Ca2+ pump interact with and permeabilize liposomes and cell membranes.
The plasma membrane Ca(2+) pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.
The Plasma Membrane Ca2+ Pump PMCA4b Regulates Melanoma Cell Migration through Remodeling of the Actin Cytoskeleton.
Metabolic Diseases
Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Metabolic Syndrome
Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome.
Metabolic Syndrome Abolishes Glucagon-Like Peptide 1 Receptor Agonist Stimulation of SERCA in Coronary Smooth Muscle.
New Insights on the Role of SERCA During Vessel Remodeling in Metabolic Syndrome.
Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells.
OXIDATIVE STRESS IN CARDIOMYOCYTES CONTRIBUTES TO DECREASED SERCA2a ACTIVITY IN METABOLIC SYNDROME RATS.
Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca2+ waves.
Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Mitochondrial Diseases
Acute rhabdomyolysis and inflammation.
Multifunctional Single-Layered Graphene Quantum Dots Used for Diagnosis of Mitochondrial Malfunction-Related Diseases.
Mitochondrial Myopathies
Calcium regulation and muscle disease.
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
Mitral Valve Insufficiency
Alteration of myocardial sarcoplasmic reticulum Ca2+-ATPase and Na+-Ca2+ exchanger expression in human left ventricular volume overload.
Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation.
Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure.
SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells.
Mouth Neoplasms
Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines.
Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer.
Multiple Myeloma
Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells is dependent on Ca2+ influx through plasma membrane Ca2+ channels.
Multiple Sclerosis
Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers.
Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis.
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Role of plasma membrane calcium ATPase 2 in spinal cord pathology.
Muscle Hypotonia
A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: Biochemical characterization of the pump defect.
Muscle Spasticity
Tail muscle parvalbumin content is decreased in chronic sacral spinal cord injured rats with spasticity.
Muscle Weakness
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure.
From excitation to intracellular Ca2+ movements in skeletal muscle: Basic aspects and related clinical disorders.
Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.
Reduced sarcoplasmic reticulum Ca2+ ATPase activity underlies skeletal muscle wasting in asthma.
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.
Muscular Atrophy
Reduced sarcoplasmic reticulum Ca2+ ATPase activity underlies skeletal muscle wasting in asthma.
Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice.
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
The Effect of Passive Movement on Denervated Soleus Highlights a Differential Nerve Control on SERCA and MyHC Isoforms.
Muscular Atrophy, Spinal
Elevated calmodulin levels and reduced calmodulin-stimulated calcium-ATPase in Duchenne progressive muscular dystrophy.
Muscular Diseases
Acute rhabdomyolysis and inflammation.
Characterization of sarcoplasmic reticulum Ca(2+) ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy.
Effect of Stem Cells, Ascorbic Acid and SERCA1a Gene Transfected Stem Cells in Experimentally Induced Type I Diabetic Myopathy.
Elevated calmodulin levels and reduced calmodulin-stimulated calcium-ATPase in Duchenne progressive muscular dystrophy.
Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility.
Fast-twitch skeletal muscle fiber adaptation to SERCA1 deficiency in a Dutch Improved Red and White calf pseudomyotonia case.
Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: an animal model of human Brody disease.
Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives.
Pinpointing oxidative stress behind the white striping myopathy: depletion of antioxidant defenses, accretion of oxidized proteins and impaired proteostasis.
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
Sarcoplasmic reticulum Ca2+ pumps in heart and diaphragm of cardiomyopathic hamster: effects of perindopril.
SERCA pumps and human diseases.
SERCA1 and calsequestrin storage myopathy: a new surplus protein myopathy.
SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.
Muscular Disorders, Atrophic
Remarkable plasticity of Na(+), K(+)-ATPase, Ca(2+)-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels.
Muscular Dystrophies
Abnormal response to calmodulin in vitro of dystrophic chicken muscle membrane Ca2+-ATPase activity.
Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Elevated whole muscle phosphatidylcholine: phosphatidylethanolamine ratio coincides with reduced SERCA activity in murine overloaded plantaris muscles.
Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.
Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy.
Membrane crystals of Ca2+-ATPase in sarcoplasmic reticulum of normal and dystrophic muscle.
Membrane-bound enzymes of erythrocytes in human muscular dystrophy: (Na+ + K+-ATPase, Ca2+-ATPase, K+- and Ca2+-p-nitrophenylphosphatase.
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.
Oxidative stress and muscular dystrophy.
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.
Postnatal development of Ca2+-sequestration by the sarcoplasmic reticulum of fast and slow muscles in normal and dystrophic mice.
Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy.
Saturation of SERCA's lipid annulus may protect against its thermal inactivation.
The enzymes of the red blood cell plasma membrane.
The neonatal sarcoplasmic reticulum Ca(2+)-ATPase gives a clue to development and pathology in human muscles.
[Changes in the ATP-ase activity of skeletal muscle nuclei of rabbits with dystrophy and following their delipidation]
[Electron-cytochemical study of the localization and properties of ATPases in the isolated nuclei of rabbit skeletal muscle under normal conditions and in experimental muscular dystrophy]
[Erythrocyte membrane proteins]
Muscular Dystrophy, Duchenne
DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient.
Elevated calmodulin levels and reduced calmodulin-stimulated calcium-ATPase in Duchenne progressive muscular dystrophy.
Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction induced damage.
Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
Sarcoplasmic reticulum Ca2+-ATPase and acylphosphatase activities in muscle biopsies from patients with Duchenne muscular dystrophy.
Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy.
Myalgia
Ca2+-ATPase deficiency in a patient with an exertional muscle pain syndrome.
Investigation of the relationships between different enzymes and postmortem duck muscle tenderization.
Myocardial Infarction
Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis.
Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats.
Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.
Circulating cytokine levels in mice with heart failure are etiology dependent.
Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias.
Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction.
Differences in expression of sarcoplasmic reticulum Ca2+-ATPase and Na+-Ca2+ exchanger genes between adjacent and remote noninfarcted myocardium after myocardial infarction.
Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of chronic dobutamine on cardiac mechanics and biochemistry after myocardial infarction in rats.
Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes.
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.
In vivo effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction.
Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.
Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats.
lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca2+ overload in myocardial infarction mice model.
Low-Dose Empagliflozin Improves Systolic Heart Function after Myocardial Infarction in Rats: Regulation of MMP9, NHE1, and SERCA2a.
Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice.
Luteolin modulates SERCA2a via Sp1 upregulation to attenuate myocardial ischemia/reperfusion injury in mice.
MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis.
Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.
PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia.
Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction.
rAAV-asPLB transfer attenuates abnormal sarcoplasmic reticulum Ca2+ -ATPase activity and cardiac dysfunction in rats with myocardial infarction.
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.
Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats.
Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.
SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.
SNX17 produces anti-arrhythmic effects by preserving functional SERCA2a protein in myocardial infarction.
Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.
Time course of changes in the expression of DHPR, RyR(2), and SERCA2 after myocardial infarction in the rat left ventricle.
Total Saponins of Aralia Elata (Miq) Seem Alleviate Calcium Homeostasis Imbalance and Endoplasmic Reticulum Stress-Related Apoptosis Induced by Myocardial Ischemia/Reperfusion Injury.
Velvet Antler Ameliorates Cardiac Function by Restoring Sarcoplasmic Reticulum Ca2+-ATPase Activity in Rats With Heart Failure After Myocardial Infarction.
Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction.
[Effect of riboxine on the ATPase activity and adenine nucleotide content in the myocardium in experimental myocardial infarct]
[Lentiviral vector-mediated in vivo SERCA2a gene transfer improved cardiac function and remodeling of failing heart induced by myocardial infarction in the rat]
[The changes of cardioelectrical activity of rat with myocardial infarction receiving sarcoplasmic reticulum Ca(2+)-ATPase gene modified bone marrow stem cell transplantation by microelectrode array technology].
Myocardial Ischemia
An updated role of astragaloside IV in heart failure.
Attenuation of Endoplasmic Reticulum Stress-Related Myocardial Apoptosis by SERCA2a Gene Delivery in Ischemic Heart Disease.
Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology.
Gene Expression of the Na-Ca(2+) Exchanger, SERCA2a and Calsequestrin after Myocardial Ischemia in the Neonatal Rabbit Heart.
Palmitylcarnitine inhibition of the calcium pump in cardiac sarcoplasmic reticulum: a possible role in myocardial ischemia.
Possible mechanism responsible for mechanical dysfunction of ischemic myocardium: a role of oxygen free radicals.
Protective effects of cyclopiazonic acid on ischemia-reperfusion injury in rabbit hearts.
Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.
[Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca2+-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury]
Myocardial Reperfusion Injury
Injury to the Ca2+ ATPase of the sarcoplasmic reticulum in anesthetized dogs contributes to myocardial reperfusion injury.
Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1.
Myocardial Stunning
Effect of increased free [Mg2+]i with myocardial stunning on sarcoplasmic reticulum Ca(2+)-ATPase activity.
Increased activity of the sarcoplasmic reticular calcium pump in porcine stunned myocardium.
Involvement of the sarcoplasmic reticulum calcium pump in myocardial contractile dysfunction: comparison between chronic pressure-overload and stunning.
Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice.
Mechanisms underlying myocardial stunning.
The sarcoplasmic reticulum Ca(2+)-ATPase is depressed in stunned myocardium after ischemia-reperfusion, but remains functionally coupled to sarcoplasmic reticulum-bound glycolytic enzymes.
Myocarditis
An evidence for surface expression of an immunogenic epitope of sarcoplasmic/endoplasmic reticulum calcium-ATPase2a on antigen-presenting cells from naive mice in the mediation of autoimmune myocarditis.
Cardiac protective effect of astragalus on viral myocarditis mice: comparison with perindopril.
Cardiac sarcoplasmic reticulum calcium ATPase, an autoimmune antigen in experimental cardiomyopathy.
Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice.
SR-Ca2+ ATPase as an autoimmunogen in experimental myocarditis.
[Effects of Astragaloside in treating myocardial injury and myocardial Sarco/Endoplasmic Ca(2+)-ATPase of viral myocarditis mice]
Myopathies, Structural, Congenital
Detection of a new polymorphism in the plasma-membrane Ca2+ ATPase isoform-3 gene and its exclusion as a candidate for X-linked myotubular myopathy (MTM1).
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Myopathy, Central Core
Changes in motor innervation and histochemical pattern of muscle fibers in some congenital myopathies.
Myositis
Acute rhabdomyolysis and inflammation.
Myotonia
From excitation to intracellular Ca2+ movements in skeletal muscle: Basic aspects and related clinical disorders.
Sarcoplasmic reticulum ATPase in tibialis anterior muscle from rats with experimental myotonia.
Myotonia Congenita
Immunochemical quantification of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin in muscle biopsies from patients with myotonia congenita and paramyotonia congenita Eulenburg.
Myotonic Disorders
Immunochemical quantification of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin in muscle biopsies from patients with myotonia congenita and paramyotonia congenita Eulenburg.
Myotonic Dystrophy
Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.
Characterization of sarcoplasmic reticulum Ca(2+) ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy.
Deficiency of Na+/K(+)-ATPase and sarcoplasmic reticulum Ca(2+)-ATPase in skeletal muscle and cultured muscle cells of myotonic dystrophy patients.
Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle.
Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.
Ion transport in human skeletal muscle cells: disturbances in myotonic dystrophy and Brody's disease.
Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.
The neonatal sarcoplasmic reticulum Ca(2+)-ATPase gives a clue to development and pathology in human muscles.
Three-dimensional imaging in myotonic dystrophy type 1: Linking molecular alterations with disease phenotype.
Myotoxicity
Differential Effect of Articaine on Sarcoendoplasmic Reticulum Calcium Adenosine Triphosphatase of Medial Pterygoid Muscle.
Neoplasm Metastasis
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells.
Loss of RhoA expression prevents proliferation and metastasis of SPCA1 lung cancer cells in vitro.
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Sarco/endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer.
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2.
shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis.
The calcium pump PMCA4 prevents epithelial-mesenchymal transition by inhibiting NFATc1-ZEB1 pathway in gastric cancer.
The plasma membrane Ca(2+) pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.
Neoplasms
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Activation of calcium oscillations by thapsigargin in parotid acinar cells.
Adenosinetriphosphatase as the factor inhibiting the enzymic synthesis of diphosphopyridine nucleotides in the tissues of rats and mice with transplanted tumours.
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis.
Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways.
Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).
Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: An overview of pharmacological studies.
Artemisinin-Resistant Mutants of Toxoplasma gondii Have Altered Calcium Homeostasis.
Assignment of 20 microsatellite markers to the porcine linkage map.
ATP2A3 gene as an important player for resveratrol anticancer activity in breast cancer cells.
Attenuation of the upregulation of NF??B and AP?1 DNA?binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression.
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.
Ca2+ translocation in Ehrlich ascites tumor cells.
Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling.
Calcium metabolism in Ehrlich Ascites tumour cells.
Calcium permeability of Ehrlich ascites tumour cell plasma membrane in vivo.
Calcium pump expression in human bone and soft tissue tumours.
Calcium transport by HeLa cell mitochondria.
Cardiac remodeling and dysfunction in nephrotic syndrome.
Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.
Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes.
Clinical significance of P-class pumps in cancer.
Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer.
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.
Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs.
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Discovery of novel SERCA inhibitors by virtual screening of a large compound library.
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.
Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA).
Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.
Effect of drug resistance modulator, NO donor, on membrane structure and function of membrane-bound Ca2+-activated Mg2+-dependent ATPase.
Effect of Pro-Inflammatory Cytokines on Regulation of Sarcoplasmic Reticulum Ca2+ Reuptake in Human Airway Smooth Muscle.
Endoplasmic reticulum calcium pumps and cancer cell differentiation.
Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.
Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.
Endothelial cell intracellular Ca2+ concentration is increased upon breast tumor cell contact and mediates tumor cell transendothelial migration.
Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells.
Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.
Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy.
Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells.
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation.
FCY-302, a Novel Small Molecule, Induces Apoptosis in Leukemia and Myeloma Cells by Attenuating Key Antioxidant and Mitochondrial Enzymes.
Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.
Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5'-triphosphate.
Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility.
Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis.
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.
Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase (SERCA) 2a pump activity on cytosolic calcium in living cells.
Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells.
Hsp60 and IL-8 axis promotes apoptosis resistance in cancer.
Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Inhibition of ezrin causes PKC?-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.
Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats.
Isoform-specific up-regulation of plasma membrane Ca(2+)ATPase expression during colon and gastric cancer cell differentiation.
LINC01619 promotes non-small cell lung cancer development via regulating PAX6 by suppressing microRNA-129-5p.
Lipopolysaccharide acutely suppresses right-ventricular strain in rats with pulmonary artery hypertension.
Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
Molecular dynamics in mouse atrial tumor sarcoplasmic reticulum.
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. IV. Ultrastructural characters of the thymus in myeloblastosis and the adenosinetriphosphatase activity of thymic cells and associated virus.
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. VI. Ultrastructural aspects of adenosinetriphosphatase activity of nephroblastoma cells and virus.
N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca(2+) Mobilization.
Nifetepimine, a dihydropyrimidone, ensures CD4+ T cell survival in tumor micro-environment by maneuvering Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA).
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).
Novel phenolic inhibitors of the sarco/endoplasmic reticulum calcium ATPase: identification and characterization by quantitative structure-activity relationship modeling and virtual screening.
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.
Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells.
One-megabase yeast artificial chromosome and 400-kilobase cosmid-phage contigs containing the von Hippel-Lindau tumor suppressor and Ca(2+)-transporting adenosine triphosphatase isoform 2 genes.
Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership.
Ovarian Metabolic activity in Dehydroepiandrosterone-Induced Polycystic Ovary in Wistar rats Treated with Aspirin.
p53 and Ca(2+) signaling from the endoplasmic reticulum: partners in anti-cancer therapies.
Phenotypes of SERCA and PMCA knockout mice.
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Plasma levels of tumor necrosis factor-? and interleukin-6 are associated with diastolic heart failure through downregulation of sarcoplasmic reticulum Ca2+ ATPase.
Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer.
Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer.
Plasma membrane Ca2+-permeable channels and sodium/calcium exchangers in tumorigenesis and tumor development of the upper gastrointestinal tract.
Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells.
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Plasma membrane calcium pumps and their emerging roles in cancer.
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.
Platelet-derived growth factor isoforms AA, AB, and BB differentially activate poly r(I):r(C)-induced genes in human fibroblast FS4 cells.
PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263.
PMCA4b as tumor suppressor: The Ca
Prognostic significance of left ventricular diastolic function in burn patients.
Quantification of ATP-producing and consuming processes of Ehrlich ascites tumour cells.
Reduced SERCA Function Preferentially Affects Wnt Signaling by Retaining E-Cadherin in the Endoplasmic Reticulum.
Regulation of sarco(endo)plasmic reticulum Ca(2+)-ATPase and calsequestrin gene expression in the heart.
Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.
Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation.
Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective.
Sarco/endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer.
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.
Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.
SERCA control of cell death and survival.
Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump.
Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Structural Changes of Sarco/Endoplasmic Reticulum Ca2+-ATPase Induced by Rutin Arachidonate: A Molecular Dynamics Study.
Structure, function and subcellular localization of a human platelet Ca2+-ATPase.
Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation.
Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2?-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression.
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death.
Switching to instant black coffee modulates sodium selenite-induced cataract in rats.
Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy.
Thapsigargin--from Thapsia L. to mipsagargin.
The Ca2+-transporting activity of rat liver microsomes in response to protein undernutrition: implications for liver tumor promotion.
The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
The expression of the sarco/endoplasmic reticulum Ca2+-ATPases in thyroid and its down-regulation following neoplastic transformation.
The Focal Nature of Darier's Disease Lesions: Calcium Pumps, Stress, and Mutation?
The Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer.
Trilobolide-porphyrin conjugates: on synthesis and biological effects evaluation.
Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes*
Tumour promoter tert-butyl-hydroperoxide induces peroxynitrite formation in human erythrocytes.
[Activity of water-soluble adenosinetriphosphatase in transplanted tumors and in the spleen.]
[Actomyosin from a low-differentiation skeletal muscle tumor]
[Adenosinetriphosphatase activity of nuclear envelopes and from the cells of rat liver, Zaigdel hepatoma of rats and Ehrlich ascites tumour of mice]
[Behavior of adenosinetriphosphatase activity in cerebral tumor.]
[Cytochemical determination of adenosinetriphosphatase (ATP-ase) in the cells of an ascites tumor in the mouse.]
[Dependence of adhesive properties on Ca2+-ATPase activity in tumor cells]
[Expression of SERCA pumps during cell differentiation and tumorigenesis: application to colonic carcinogenesis]
[Fibrolamellar liver carcinoma]
[HCO3-sensitive adenosinetriphosphatase from ascites tumour cells]
[Na+,K+-ATPase and Ca2+-ATPase isozymes in malignant neoplasms]
Neoplasms, Squamous Cell
Phenotypes of SERCA and PMCA knockout mice.
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Nephrolithiasis
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
Neural Tube Defects
Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.
Neuralgia
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase.
Neuritis
[Expression of plasma membrane Ca(2+)-ATPase isoform 2 in spiral ganglion cells of newborn rats.]
Neurobehavioral Manifestations
Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
Neuroblastoma
Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.
Influence of inositol 1,4,5-trisphosphate and guanine nucleotides on intracellular calcium release within the N1E-115 neuronal cell line.
Interaction between acylphosphatase and SERCA in SH-SY5Y cells.
PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion.
Regulation of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) 2 gene transcript in neuronal cells.
RNA--induced silencing of the plasma membrane Ca2+-ATPase 2 in neuronal cells: effects on Ca2+ homeostasis and cell viability.
Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.
Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity.
Neurodegenerative Diseases
A Role for SERCA Pumps in the Neurobiology of Neuropsychiatric and Neurodegenerative Disorders.
Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase.
Nevus
Congenital acantholytic dyskeratotic epidermal naevus following Blaschko's lines versus segmental Darier's disease.
The plasma membrane Ca(2+) pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.
Niemann-Pick Disease, Type A
Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease.
Niemann-Pick Diseases
Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease.
Non-alcoholic Fatty Liver Disease
Correction to: Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.
Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.
Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.
Obesity
ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle.
ATP consumption by sarcoplasmic reticulum Ca²? pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle.
Calcium and magnesium ATPase activities in women with varying BMIs.
Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch.
Elevated whole muscle phosphatidylcholine: phosphatidylethanolamine ratio coincides with reduced SERCA activity in murine overloaded plantaris muscles.
Impaired calcium metabolism associated with hypertension in Zucker obese rats.
Involvement of L-type calcium channel and SERCA2A in myocardial dysfunction induced by obesity.
Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells.
Obesity induces upregulation of genes involved in myocardial Ca2+ handling.
Phospholamban Deficiency Does Not Alter Skeletal Muscle SERCA Pumping Efficiency or Predispose Mice to Diet-Induced Obesity.
Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency.
Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.
SERCA2 Deficiency Impairs Pancreatic ? Cell Function in Response to Diet-Induced Obesity.
Sleeve gastrectomy in obese Wistar rats improves diastolic function and promotes cardiac recovery independent of weight loss.
THADA Regulates the Organismal Balance between Energy Storage and Heat Production.
Oligospermia
Reduced activity of Mg2+- and Ca2+-dependent adenosine triphosphatase in seminal fluid of patients with oligozoospermia.
Osteoarthritis
Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress.
Osteoporosis
Intracellular Ca2+ signaling mediates IGF-1-induced osteogenic differentiation in bone marrow mesenchymal stem cells.
Osteosarcoma
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.
RAC1-Dependent ORAI1 Translocation to the Leading Edge Supports Lamellipodia Formation and Directional Persistence.
Ototoxicity
Correlation of increased activities of Na+, K+-ATPase and Ca2+-ATPase with the reversal of cisplatin ototoxicity induced by D-methionine in guinea pigs.
Ovarian Neoplasms
Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca(2+) ATPase activity in ovarian cancer cells.
Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.
p-type ca2+ transporter deficiency
Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy.
Ca2+-ATPase deficiency in a patient with an exertional muscle pain syndrome.
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.
Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice.
Fast-twitch skeletal muscle fiber adaptation to SERCA1 deficiency in a Dutch Improved Red and White calf pseudomyotonia case.
Hailey-Hailey disease: investigation of a possible compensatory SERCA2 up-regulation and analysis of SPCA1, p63, and IRF6 expression.
Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency.
Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.
Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
SERCA2 Deficiency Impairs Pancreatic ? Cell Function in Response to Diet-Induced Obesity.
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.
SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.
SPCA1 governs the stability of TMEM165 in Hailey-Hailey disease.
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death.
Pancreatic Neoplasms
Glycolytic ATP fuels the plasma membrane calcium pump critical for pancreatic cancer cell survival.
Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer.
The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.
Pancreatitis
Effect of Chaiqinchengqi decoction on sarco/endoplasmic reticulum Ca2+-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats.
Effect of Qingyitang on activity of intracellular Ca2+-Mg2+-ATPase in rats with acute pancreatitis.
Parenchymal pressure injury Ca2+ entry mechanism in pancreatitis.
THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Paralysis
Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability.
From excitation to intracellular Ca2+ movements in skeletal muscle: Basic aspects and related clinical disorders.
Sarco(endo)plasmic reticulum calcium pump isoforms in paralyzed rat slow muscle.
Stop the crop: Insights into the insecticidal mode of action of cinnamodial against mosquitoes.
Thyrotoxic periodic paralysis. Periodic variation in the muscle calcium pump activity.
[Modifications of myocardial adenosinetriphosphatase activity induced by sodium, potassium, calcium and magnesium in sudden death caused by so-called cardiac paralysis.]
Paraplegia
Increased susceptibility to ventricular arrhythmias is associated with changes in Ca2+ regulatory proteins in paraplegic rats.
PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion.
PMCA4 (ATP2B4) mutation in familial spastic paraplegia.
Parasitemia
Direct exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases infectivity of human erythrocytes to a malarial parasite.
Examining Plasmodium falciparum and P. vivax clearance subsequent to antimalarial drug treatment in the Myanmar-China border area based on quantitative real-time polymerase chain reaction.
Parkinson Disease
A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats.
Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson's disease.
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies.
Parkinsonian Disorders
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain.
Pemphigus
Mechanisms of synergy of autoantibodies to M3 muscarinic acetylcholine receptor and secretory pathway Ca2+/Mn2+-ATPase isoform 1 in patients with non-desmoglein pemphigus vulgaris.
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.
Pemphigus, Benign Familial
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain.
Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes.
ATP2C1 gene mutations in Hailey-Hailey disease and possible roles of SPCA1 isoforms in membrane trafficking.
Autosomal-dominant calcium ATPase disorders.
Calcium in the Golgi apparatus.
Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism.
Diseases involving the Golgi calcium pump.
Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1).
Exacerbation of darier disease by lithium carbonate.
Functional expression of heterologous proteins in yeast: insights into Ca2+ signaling and Ca2+-transporting ATPases.
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Hailey-Hailey disease: investigation of a possible compensatory SERCA2 up-regulation and analysis of SPCA1, p63, and IRF6 expression.
How do keratinizing disorders and blistering disorders overlap?
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
Hypotonic, Acidic Oxidizing Solution Containing Hypochlorous Acid (HClO) as a Potential Treatment of Hailey-Hailey Disease.
Involucrin expression is decreased in Hailey-Hailey keratinocytes owing to increased involucrin mRNA degradation.
Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation.
Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat.
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.
SPCA1 governs the stability of TMEM165 in Hailey-Hailey disease.
SPCA1 pumps and Hailey-Hailey disease.
The Ca2+/Mn2+ pumps in the Golgi apparatus.
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
[Antidesmoglein antibodies in a patient with Hailey-Hailey disease].
Peripheral Nerve Injuries
Painful nerve injury decreases sarco-endoplasmic reticulum Ca²?-ATPase activity in axotomized sensory neurons.
Peripheral Nervous System Diseases
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor.
The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
Pheochromocytoma
Anesthetic-induced alteration of Ca2+ homeostasis in neural cells: a temperature-sensitive process that is enhanced by blockade of plasma membrane Ca2+-ATPase isoforms.
Plasma membrane calcium ATPase plays a role in reducing Ca(2+)-mediated cytotoxicity in PC12 cells.
Pneumonia, Mycoplasma
The effect of Mycoplasma pneumoniae infection on human erythrocytes: changes in osmotic fragility, lipid composition, sialic acid content, Ca2+-ATPase activities, and ATP concentration.
Polycystic Kidney, Autosomal Dominant
Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKK?-AMPK-mTOR pathway in ADPKD cells.
Polymyositis
Dysfunction of the sarcoplasmic reticulum in polymyositis.
Pre-Eclampsia
Ca-ATPase Activity of Human Red Cell Ghosts: Preeclampsia, Lipid Peroxidation and MgSO(4).
Ca-ATPase activity of human red cell ghosts: preeclampsia, lipid peroxidation and MgSO4.
Calcium metabolism in pre-eclampsia.
Calcium-ATPase activity of red blood cell ghosts from preeclamptic women, antepartum and postpartum.
Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.
Effect of magnesium sulfate on the calcium-stimulated adenosine triphosphatase activity and lipid peroxidation of red blood cell membranes from preeclamptic women.
Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia.
Lipid peroxidation and active calcium transport in inside-out vesicles of red blood cells from preeclamptic women.
Preeclampsia and calcium adenosine triphosphatase activity of red blood cell ghosts.
Preeclampsia, Placenta, Oxidative Stress, and PMCA.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.
Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.
Premature Birth
Drug action of ritodrine on the sarcoplasmic reticulum Ca(2+)-ATPase from skeletal muscle.
Primary Graft Dysfunction
Plasma Levels of SERCA2a as a Noninvasive Biomarker of Primary Graft Dysfunction After Heart Transplantation.
Prostatic Neoplasms
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells.
Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells.
Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.
Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells.
Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression.
Identification and characterization of a kunzeaol synthase from Thapsia garganica: Implications for the biosynthesis of the pharmaceutical thapsigargin.
Istaroxime, a potential anticancer drug in prostate cancer, exerts beneficial functional effects in healthy and diseased human myocardium.
Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells.
Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis.
Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+ Transport ATPase (SPCA1a).
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer.
Psoriasis
[Calcium-transporting system of erythrocytes in psoriasis]
[Permeability for 45Ca and Ca-ATPase activity in erythrocyte membranes of patients with psoriasis]
Pulmonary Arterial Hypertension
Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Abnormal sarcoplasmic reticulum Ca2+-sequestering properties in skeletal muscle in chronic obstructive pulmonary disease.
Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.
[Activity of sodium-potassium adenosinetriphosphatase and cotransport of sodium, potassium and chloride ions in patients with bronchial asthma and chronic obstructive pulmonary diseases]
[Reduced expression of the sarcoplasmic calcium pump SERCA2 in skeletal muscle from patients with chronic obstructive pulmonary disease and low body weight]
Pulmonary Fibrosis
AAV1.SERCA2a Gene Therapy Reverses Pulmonary Fibrosis by Blocking the STAT3/FOXM1 Pathway and Promoting the SNON/SKI Axis.
Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis.
Pyelonephritis
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
[The importance of studies of calcium reabsorption and of the capacity of the blood plasma to inhibit Ca-ATPase activity for the diagnosis of the activity of the inflammatory process and for the prognosis of tubular function in patients with chronic pyelonephritis]
[The suppression of the Ca ATpase activity of rat kidney microsomes under the action of blood plasma as an index of the severity of the status of pyelonephritis patients]
Renal Insufficiency
A circulating inhibitor of the RBC membrane calcium pump in chronic renal failure.
Characterization of dimethylguanosine, phenylethylamine, and phenylacetic acid as inhibitors of Ca2+ ATPase in end-stage renal failure.
Renal Insufficiency, Chronic
Ca2+-Mg2+-dependent ATP-ase activity and calcium homeostasis in children with chronic kidney disease.
The effect of vitamin D(3) supplementation on intracellular calcium and plasma membrane calcium ATPase activity in early stages of chronic kidney disease.
Reperfusion Injury
Antioxidant Network Expression Abrogates Oxidative Post-Translational Modifications in Mice.
Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection.
Distribution of plasma membrane Ca2+ pump (PMCA) isoforms in the gerbil brain: effect of ischemia-reperfusion injury.
Effects of Compound Shenhua Tablet () on renal tubular Na(+)-K (+)-ATPase in rats with acute ischemic reperfusion injury.
Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.
Generation of free radicals and the damage done to the sarcoplasmic reticulum during reperfusion injury following brief ischemia in the canine heart.
Injury to the Ca2+ ATPase of the sarcoplasmic reticulum in anesthetized dogs contributes to myocardial reperfusion injury.
Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice.
Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1.
Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury.
Role of sodium pump activity in warm induction of cardioplegia combined with reperfusion of oxygenated cardioplegic solution.
Secretory pathway Ca2+-ATPase isoform 1 knockdown promotes Golgi apparatus stress injury in a mouse model of focal cerebral ischemia-reperfusion: In vivo and in vitro study.
SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury.
The role of the rat sarcoplasmic reticulum Ca(2+)-ATPase promoter in myocardial ischemia-preconditioning.
[Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca2+-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury]
[Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion in vitro model].
Respiratory Insufficiency
SERCA pumps and human diseases.
SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.
Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.
Respiratory Paralysis
Crotalus oreganus concolor: Envenomation Case with Venom Analysis and a Diagnostic Conundrum of Myoneurologic Symptoms.
Rhabdomyolysis
Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis.
Exclusion of linkage of the RYR1, CACNA1S, and ATP2A1 genes to recurrent exertional rhabdomyolysis in Thoroughbreds.
Rhabdomyosarcoma
Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells.
Sandhoff Disease
Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.
Sarcoma
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
[Mitochondrial adenosinetriphosphatase activity of Galliera sarcoma and of hepatic, muscular and renal tissues of bearing rats.]
Sarcoma 37
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
Sarcoma, Yoshida
Inactivation of (Na-++K-+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells.
Sarcopenia
Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.
Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice.
Seizures
A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses.
Calcium ATPase activities in synaptic plasma membranes of seizure-prone mice.
Deficiency of a Ca2+-ATPase in brains of seizure prone mice.
Genetic association between Ca2+-ATPase activity and audiogenic seizures in mice.
Oxidative stress and Na,K-ATPase activity differential regulation in brainstem and forebrain of Wistar Audiogenic rats may lead to increased seizure susceptibility.
Plasma membrane calcium ATPase plays a role in reducing Ca(2+)-mediated cytotoxicity in PC12 cells.
Selenium and topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in pentylentetrazol-induced seizures in rats.
Sepsis
Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction.
Altered phospholamban-calcium ATPase interaction in cardiac sarcoplasmic reticulum during the progression of sepsis.
Calcium uptake by sarcoplasmic reticulum is impaired during the hypodynamic phase of sepsis in the rat heart.
Complement and sepsis-induced heart dysfunction.
Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.
Erythrocyte Ca2+ pump is defective during sepsis.
Sepsis and burn complicated by sepsis alter cardiac transporter expression.
SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.
Slowed relaxation of diaphragm in septic rats is associated with reduced expression of sarco-endoplasmic reticulum Ca(2+) -ATPase genes SERCA1 and SERCA 2.
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Transcriptional regulation of cardiac sarcoplasmic reticulum calcium-ATPase gene during the progression of sepsis.
Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes*
[Impaired calcium uptake by cardiac sarcoplasmic reticulum and its underlying mechanism during rat septic shock]
Sexually Transmitted Diseases
Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate.
Shock, Septic
Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway.
Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis.
O-GlcNAc stimulation: A new metabolic approach to treat septic shock.
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Sick Sinus Syndrome
The impact of paced QRS duration on the expression of genes related to contractile function of the left ventricle in chronically paced patients from the right ventricular apex.
Skin Diseases
Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes.
An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1.
Consequences of depleted SERCA2-gated calcium stores in the skin.
Darier disease is associated with heart failure: a cross-sectional case-control and population based study.
Expression of SERCA2 (Darier's disease gene product) in acantholytic dermatoses.
Expression of SPCA1 (Hailey-Hailey disease gene product) in acantholytic dermatoses.
Expression of the sarco/endoplasmic reticulum calcium ATPase type 2 and 3 isoforms in normal skin and Darier's disease.
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
Involucrin expression is decreased in Hailey-Hailey keratinocytes owing to increased involucrin mRNA degradation.
Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation.
Metabolic phenotype in Darier disease: a cross-sectional clinical study.
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.
SERCA pumps and human diseases.
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
Skin Diseases, Genetic
Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.
Skin Neoplasms
Intracellular calcium pool emptying induces DNA synthesis in HaCaT keratinocytes.
SERCA pumps and human diseases.
Small Cell Lung Carcinoma
[Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines]
Spherocytosis, Hereditary
[Erythrocyte membrane proteins]
Sphingolipidoses
Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease.
Spinal Cord Injuries
Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2.
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury.
Plasma membrane calcium ATPase expression in the rat spinal cord.
Role of plasma membrane calcium ATPase 2 in spinal cord pathology.
Sarco(endo)plasmic reticulum calcium pump isoforms in paralyzed rat slow muscle.
Squamous Cell Carcinoma of Head and Neck
Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer.
ST Elevation Myocardial Infarction
Diabetes mellitus exacerbates post-myocardial infarction heart failure by reducing sarcolipin promoter methylation.
Starvation
Chloride channel function in the yeast TRK-potassium transporters.
Effects of starvation on haemolymphatic glucose levels, glycogen contents and nucleotidase activities in different tissues of Helix aspersa (Müller, 1774) (Mollusca, Gastropoda).
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Stomach Neoplasms
Clinical significance of P-class pumps in cancer.
Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation.
The calcium pump PMCA4 prevents epithelial-mesenchymal transition by inhibiting NFATc1-ZEB1 pathway in gastric cancer.
Stroke
Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome.
G?q protein carboxyl terminus imitation polypeptide GCIP-27 improves cardiac function in chronic heart failure rats.
Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation.
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the SERCA2 gene.
Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation.
Multiscale Modeling of Cardiovascular Function Predicts That the End-Systolic Pressure Volume Relationship Can Be Targeted via Multiple Therapeutic Strategies.
Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.
Selenoprotein T as a new positive inotrope in the goldfish, Carassius auratus.
[Change in prostaglandin levels and ATPase activity of cardiac membrane fractions during the formation of cerebral hematomas in animals with a hereditary predisposition to stroke]
Tachycardia
SERCA2a was serotonylated and may regulate sino-atrial node pacemaker activity.
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
[Treatment of heart failure patients with inotropic drugs: beyond traditional agents].
Tachycardia, Ventricular
Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion.
Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction.
Teratoma
Complete primary structure of a human plasma membrane Ca2+ pump.
Tetanus
Changes in the functioning of the electromechanical connection during tetanic contraction.
Electron probe X-ray microanalysis of post-tetanic Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situ.
Energetics, mechanics and molecular engineering of calcium cycling in skeletal muscle.
The effects of caffeine on intracellular calcium, force and the rate of relaxation of mouse skeletal muscle.
The steady-state force-Ca2+ relationship in intact lobster (Homarus americanus) cardiac muscle.
Tetralogy of Fallot
SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects.
Thrombosis
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
Thyroid Diseases
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Thyrotoxicosis
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
[Effect of thyroxine on the function of rabbit skeletal muscle sarcoplasmic reticulum]
Triple Negative Breast Neoplasms
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Trisomy 18 Syndrome
Cardiac expression of sarcoplasmic reticulum calcium ATPase in fetuses with trisomy 21 and trisomy 18 presenting with nuchal translucency.
Tuberculosis
Mycobacterium tuberculosis Calcium Pump CtpF Modulates the Autophagosome in an mTOR-Dependent Manner.
Urinary Bladder Neck Obstruction
Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction.
Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions.
Urinary Bladder Neoplasms
LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca2+ concentration via transcription factor GATA6.
Uterine Cervical Neoplasms
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2.
Vascular Diseases
Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
Targeting the redox regulation of SERCA in vascular physiology and disease.
Vascular System Injuries
Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.
Ventricular Dysfunction
Molecular and physiological alterations in murine ventricular dysfunction.
Plasma Levels of SERCA2a as a Noninvasive Biomarker of Primary Graft Dysfunction After Heart Transplantation.
Ventricular Dysfunction, Left
Suppressed phospholamban levels differentiate irreversibly dysfunctional from hibernating myocardium in humans.
Ventricular Fibrillation
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion.
Ventricular Premature Complexes
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.
Vesicular Stomatitis
The SPCA1 Ca(2+) pump and intracellular membrane trafficking.
Virus Diseases
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
Pak1 is required to maintain ventricular Ca²? homeostasis and electrophysiological stability through SERCA2a regulation in mice.
Vitamin D Deficiency
Depression of calcium pump activity in renal cortex of vitamin D-deficient rats with secondary hyperparathyroidism.
Effect of vitamin D deficiency on lipid composition and calcium transport in basolateral membrane vesicles from chick intestine.
The adenosine triphosphate-dependent calcium pump in rat small intestine: effects of vitamin D deficiency and cell isolation methods.
Vitamin E Deficiency
Ascorbic acid-Fe2+ treatment mimics effect of vitamin E deficiency on sarcoplasmic Ca-ATPase of rabbit muscle.
Change of adenosinetriphosphatase activity in the case of muscular distrophy due to vitamin E deficiency.
[PROTEIN CONTENT AND ADENOSINETRIPHOSPHATASE ACTIVITY OF MUSCLE CELLULAR ELEMENTS UNDER NORMAL CONDITIONS AND IN VITAMIN E DEFICIENCY.]
Whooping Cough
Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.
Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
Wilms Tumor
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. VI. Ultrastructural aspects of adenosinetriphosphatase activity of nephroblastoma cells and virus.
Wolfram Syndrome
Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.