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Literature summary for 7.2.2.10 extracted from

  • Hong, C.; Lee, H.; Choi, N.; Jung, S.; Vo, M.; Hoang, M.; Kim, H.; Lee, J.
    Sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells (2016), Exp. Mol. Med., 48, e253 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Inhibitors

Inhibitors Comment Organism Structure
cyclopiazonic acid specific inhibitor Homo sapiens
phospholamban
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum
-
 Homo sapiens 16529
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Homo sapiens
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
 Homo sapiens ADP + phosphate + Ca2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
sarcoplasmic reticulum Ca2+ ATPase 2
-
 Homo sapiens
SERCA2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens CCL21 inhibits enzyme expression through phospholipase C and protein kinase C down
Homo sapiens CCL21 does not affect the mRNA levels of the enzyme additional information
Homo sapiens enzyme protein expression is up-regulated after 30 min in CCL21-treated dendritic cells up

General Information

General Information Comment Organism
physiological function the enzyme contributes to the migration of lymphoid chemokine CCL21-activated dendritic cells as an important feature of the adaptive immune response Homo sapiens