Literature summary for 7.2.2.10 extracted from

Zhu, S.; Xu, T.; Luo, Y.; Zhang, Y.; Xuan, H.; Ma, Y.; Pan, D.; Li, D.; Zhu, H.
Luteolin enhances sarcoplasmic reticulum Ca2+-ATPase activity through p38 MAPK signaling thus improving rat cardiac function after ischemia/reperfusion (2017), Cell. Physiol. Biochem., 41, 999-1010 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
luteolin	-	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
phospholamban	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
sarcoplasmic reticulum	-	Rattus norvegicus	16529	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	Rattus norvegicus	-	ADP + phosphate + Ca2+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte cell line	-	Rattus norvegicus	-
heart	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	-	Rattus norvegicus	ADP + phosphate + Ca2+[side 2]	-	?

Subunits

Subunits	Comment	Organism
?	x * 114000, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
sarcoplasmic reticulum Ca2+-ATPase	-	Rattus norvegicus
SERCA2a	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	luteolin enhances sarcoplasmic reticulum Ca2+-ATPase activity to improve systolic/diastolic function during ischemia/reperfusion in rat hearts and cardiomyocytes by attenuating the inhibitive effects of the p38 pathway on phospholamban	Rattus norvegicus

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Release 2023.1 (January 2023)