Literature summary for 7.2.2.10 extracted from

Boczek, T.; Lisek, M.; Ferenc, B.; Kowalski, A.; Stepinski, D.; Wiktorska, M.; Zylinska, L.
Plasma membrane Ca2+-ATPase isoforms composition regulates cellular pH homeostasis in differentiating PC12 cells in a manner dependent on cytosolic Ca2+ elevations (2014), PLoS ONE, 9, e102352.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in PC-12 cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	Homo sapiens	-	ADP + phosphate + Ca2+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	-	Homo sapiens	ADP + phosphate + Ca2+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
plasma membrane Ca2+-ATPase	-	Homo sapiens
PMCA	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	isoform PMCA2 or PMCA3 knock-down delays Ca2+ clearance and partially attenuates cellular acidification during KCl-stimulated Ca2+ influx	Homo sapiens
physiological function	isoforms PMCA2 and PMCA3 are mainly responsible for transport of protons to the intracellular milieu and the regulation of cellular pH	Homo sapiens

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Release 2023.1 (January 2023)