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Literature summary for 7.2.2.10 extracted from

  • Prasad, A.M.; Inesi, G.
    Regulation and rate limiting mechanisms of Ca2+ ATPase (SERCA2) expression in cardiac myocytes (2012), Mol. Cell. Biochem., 361, 85-96.
    View publication on PubMed
Search for more literature for 7.2.2.10

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum
-
 Rattus norvegicus 16529
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis
-
 Rattus norvegicus ADP + phosphate + Ca2+/trans
-
 ?
ATP + H2O + Ca2+/out
-
 Rattus norvegicus ADP + phosphate + Ca2+/in
-
 ?

Synonyms

Synonyms Comment Organism
sarcoplasmic reticulum Ca2+ ATPase
-
 Rattus norvegicus
SERCA2
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus isoform SERCA2 downregulation (30-60%) occurs following infection of myocytes with adenovirus vectors carrying luciferase or isoform SERCA1 cDNA under control of nuclear factor of activated T cells (NFAT)-dependent promoters. Competitive engagement of the CN/NFAT pathway by endogenous genes involved in hypertrophy produces downregulation of SERCA2 down
Rattus norvegicus in the presence of protein kinase C, inhibition with 100 nM 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (Goe 6983) maintains adequate isoform SERCA2 levels additional information