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Literature summary for 7.2.2.10 extracted from
- Kinetics of Ca2+ binding to the SR Ca-ATPase in the E1 state (2005), Biophys. J., 89, 2427-2433.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| thapsigargin | complete inhibition at 0.001 mM | Oryctolagus cuniculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Oryctolagus cuniculus | 16020 | - |
| sarcoplasmic reticulum | - |
Oryctolagus cuniculus | 16529 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Oryctolagus cuniculus | |
| Mg2+ | required | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | Oryctolagus cuniculus | Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities | ADP + phosphate + Ca2+/trans | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from psoas muscle | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | psoas muscle | Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
determination of enzyme activity in a coupled assay method using linked pyruvate kinase/lactate dehydrogenase | Oryctolagus cuniculus |
| 5.2 | - |
purified calcium pump activity | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities | Oryctolagus cuniculus | ADP + phosphate + Ca2+/trans | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SR Ca-ATPase | - |
Oryctolagus cuniculus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
temperature dependence of the Ca2+ transport at different pH values, overview | Oryctolagus cuniculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 9.5 | - |
Ca2+ | calcium pump activity, pH 7.2, 37°C | Oryctolagus cuniculus | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | 8.2 | - |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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