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Literature summary for 7.2.2.10 extracted from

  • Wang, Y.; Wilson, C.; Cartwright, E.J.; Lei, M.
    Plasma membrane Ca2+ -ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse (2017), J. Physiol., 595, 7383-7398 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Mus musculus
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrium atrial monocyte Mus musculus
-
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
 Mus musculus ADP + phosphate + Ca2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
plasma membrane Ca2+-ATPase 1
-
 Mus musculus
PMCA1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction plasma membrane Ca2+-ATPase 1 deficiency increases susceptibility to atrial tachyarrhythmia in Langendorff-perfused hearts under stress conditions. Enzyme deficiency produces instabilities in membrane potentials and Ca2+ handling in atrial myocytes Mus musculus
physiological function plasma membrane Ca2+-ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in mouse atria under stress conditions Mus musculus