Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Bombyx mori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
thapsigargin | - |
Bombyx mori |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
sarcoplasmic reticulum | - |
Bombyx mori | 16529 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+[side 1] | Bombyx mori | - |
ADP + phosphate + Ca2+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bombyx mori | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
silk gland | - |
Bombyx mori | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+[side 1] | - |
Bombyx mori | ADP + phosphate + Ca2+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sarcoplasmic reticulum Ca2+-ATPase | - |
Bombyx mori |
SERCA | - |
Bombyx mori |
General Information | Comment | Organism |
---|---|---|
malfunction | after injection of thapsigargin to block enzyme activity, silkworms show a silk-spinning deficiency (30% of silkworms cannot spin normally and another 25% constructes abnormal cocoons) and their cocoons have higher calcium content compared to that of controls | Bombyx mori |
physiological function | the enzyme has a key function in calcium transportation in anterior silk gland that is related to maintaining a suitable ionic environment. This ionic environment with a proper Ca2+ concentration is crucial for the formation of silk fibers with favorable mechanical performances | Bombyx mori |