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Literature summary for 7.2.2.10 extracted from

  • Vargas-Medrano, J.; Sierra-Fonseca, J.; Plenge-Tellechea, L.
    1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum (2016), BMC Biochem., 17, 5-5 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Activating Compound

Activating Compound Comment Organism Structure
1,2-dichlorobenzene concentrations of 0.05-0.2 mM of 1,2-dichlorobenzene stimulate the hydrolytic activity of the enzyme in a medium-containing Ca2+-ionophore Oryctolagus cuniculus
potassium oxalate Ca2+ uptake is supported by potassium oxalate Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1,2-dichlorobenzene at concentrations of 0.25-0.75 mM, 1,2-dichlorobenzene inhibits the ATP hydrolysis to about 80%. Starting at 0.05 mM, 1,2-dichlorobenzene is able to uncouple the ratio of hydrolysis/Ca2+transporte Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum
-
 Oryctolagus cuniculus 16529
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Oryctolagus cuniculus
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
 Oryctolagus cuniculus ADP + phosphate + Ca2+[side 2]
-
 ?

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
Ca2+-ATPase
-
 Oryctolagus cuniculus
SERCA
-
 Oryctolagus cuniculus