Literature summary for 7.2.2.10 extracted from

Jiang, L.; Allagnat, F.; Nguidjoe, E.; Kamagate, A.; Pachera, N.; Vanderwinden, J.M.; Brini, M.; Carafoli, E.; Eizirik, D.L.; Cardozo, A.K.; Herchuelz, A.
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells (2010), J. Biol. Chem., 285, 30634-30643.

Search for more literature for 7.2.2.10

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
135000	-	x * 135000, SDS-PAGE	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P11506	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BRIN-BD11 cell	-	Rattus norvegicus	-
pancreatic islet	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+/out	-	Rattus norvegicus	ADP + phosphate + Ca2+/in	-	?

Subunits

Subunits	Comment	Organism
?	x * 135000, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
plasma membrane Ca2+-ATPase	-	Rattus norvegicus
PMCA2	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	enzyme overexpression decreases [Ca2+] in the cytosol, the endoplasmic reticulum (ER), and the mitochondria and activates the inositol-requiring transmembrane kinase and endonuclease 1alpha-spliced X-box binding protein 1 but inhibits the PRKR-like ER kinase-eIF2alpha and the activation of transcription factor 6-immunoglobulin heavy chain binding protein pathways of the ER-unfolded protein response. Isoform PMCA2 overexpression depletes cytosolic, ER and mitochondrial Ca2+ stores and induces apoptosis via the mitochondrial pathway. PMCA2-overexpressing cells also display increased levels of caspase-3 cleavage	Rattus norvegicus

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Release 2023.1 (January 2023)