Literature summary for 7.2.2.10 extracted from

Plenge-Tellechea, F.; Dominguez-Solis, C.A.; Diaz-Sanchez, A.G.; Melendez-Martinez, D.; Vargas-Medrano, J.; Sierra-Fonseca, J.A.
Chlorpromazine and dimethyl sulfoxide modulate the catalytic activity of the plasma membrane Ca2+-ATPase from human erythrocyte (2018), J. Bioenerg. Biomembr., 50, 59-69 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	177% activity in the presence of 0.002 mg/ml calmodulin	Homo sapiens
Trypsin	-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
chlorpromazine	non-competitive inhibition, complete inhibition at 1 mM	Homo sapiens
dimethyl sulfoxide	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	Homo sapiens	-	ADP + phosphate + Ca2+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	-	Homo sapiens	ADP + phosphate + Ca2+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
plasma membrane Ca2+-ATPase	-	Homo sapiens
PMCA	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.085	-	trypsin-activated enzyme, at pH 7.2 and 25°C	Homo sapiens	chlorpromazine
0.15	-	native enzyme in the presence of 0.002 mg/ml calmodulin, at pH 7.2 and 25°C	Homo sapiens	chlorpromazine
0.42	-	native enzyme, at pH 7.2 and 25°C	Homo sapiens	chlorpromazine

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Release 2023.1 (January 2023)