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(+)-2-bromo-3-(4-nitrophenyl)propanoic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid + HBr
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
(2,3-dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid + glutathione
?
-
i.e. ethacrynic acid
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
1,1-dichloro-2,2-bis-(4-chlorophenyl)ethylene + ?
i.e. DDT, modeling of DDT into the putative DDT-binding pocket, catalytic mechanism of isozyme agGSTe2 that shows high activity through the inclination of the upper part of H4 helix, H4'' helix, which brings residues Arg112, Glu116, and Phe120 closer to the GSH-binding site resulting in a more efficient GS- stabilizing hydrogen-bond-network and higher DDT-binding affinity, overview
product formation through an elimination reaction triggered by the nucleophilic attack of the thiolate group of GS- on the beta-hydrogen of DDT
-
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
?
detoxification of the insecticide DDT, especially by isozyme agGSTe2
-
-
?
1,2-dichloro-4-nitrobenzene + glutathione
?
-
low activity
-
-
?
1,2-dichloro-4-nitrobenzene + glutathione
S-(2-chloro-4-nitro-phenyl)glutathione + HCl
binding structure with wild-type and mutant Y119E and F123A enzymes, overview
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione
?
1,2-epoxy-3-(p-nitrophenoxy)propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(p-nitrophenoxy)propane + GSH
?
-
-
-
-
?
1,3,5-triacryloyl-1,3,5-triazinane + glutathione
L-gamma-glutamyl-S-[3-(3,5-diacryloyl-1,3,5-triazinan-1-yl)-3-oxopropyl]-L-cysteinylglycine
-
-
-
-
?
1,3,5-trinitrobenzene + glutathione
S-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione
an anionic sigma-complex is formed between GSH and 1,3,5-trinitrobenzene and is stabilized by Arg15. The trinitrocyclohexadienate moiety of the sigma-complex binds the H-site where the catalytic residue, Tyr9, was identified to hydrogen bond to an o-nitro group of the sigma-complex
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
1-bromo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HBr
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
1-chloro-2,3-dinitrobenzene + GSH
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrophenyl-glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
?
1-chloro-2,4-dinitrobenzene + glutathione
chloride + L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)-glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
1-chloro-2,4-dinitrobenzene + GSH
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
1-iodo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
1-methyl-4-nitro-5-[(4-nitrophenyl)thio]-1H-imidazole + glutathione
?
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
10-S-glutathionyl-12-oxo-phytodienoic acid + H2O
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
?
-
-
-
?
2,3-hexadienal + GSH
?
-
at 7.5% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
2-chloro-5-nitropyridine + glutathione
chloride + L-gamma-glutamyl-S-(5-nitropyridin-2-yl)-L-cysteinylglycine
-
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
2-hydroxychromene-2-carboxylic acid + reduced glutathione
trans-o-hydroxybenzylidene pyruvic acid + ?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
3,4-dichloronitrobenzene + glutathione
?
-
-
-
?
4-chloro-7-nitrobenzofurazan + glutathione
?
-
-
-
-
?
4-hydroxy-(E)-2-nonenal + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
4-hydroxynonenal + glutathione
?
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
4-nitrophenethyl bromide + glutathione
?
4-nitrophenethyl bromide + glutathione
S-(4-nitrophenyl)glutathione + HBr
-
-
-
?
4-nitrophenyl acetate + glutathione
?
-
-
-
?
4-nitrophenyl acetate + GSH
?
4-nitrophenyl butyrate + glutathione
S-(4-nitrophenyl)glutathione + butyrate
-
-
-
?
4-nitrophenylacetate + glutathione
?
-
-
-
-
?
4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
-
-
-
?
5-androstene-3,17-dione + glutathione
?
5-pregnene-3,20-dione + glutathione
?
5-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
7-chloro-4-glutathionylbenzo-2-oxa-1,3-diazole
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
7-oxabicyclo[4.1.0]heptan-2-one + glutathione
chloride + L-gamma-glutamyl-S-(6-oxocyclohex-1-en-1-yl)-L-cysteinylglycine
-
-
-
-
?
acetyl-gamma-Glu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
substrate for mutant enzyme I104V/A113V
-
-
?
alachlor + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
allyl-isothiocyanate + glutathione
?
-
-
-
?
aminochrome + glutathione
?
-
-
-
-
?
androstenedione + glutathione
?
-
-
-
-
?
atrazine + glutathione
?
-
-
-
-
?
atrazine + glutathione
atrazine-S-glutathione + HCl
-
-
-
-
?
azathioprine + glutathione
?
-
aromatic substitution. Wild-type hGST M2-2 has modest activity with azathioprine, but mutant C87A/C115A/C174A/M212C displays no detectable activity. The azathioprine activity of wild-type hGST M2-2 can be enhanced 30fold by two point mutations of other residues in the active site
-
-
?
benzyl isothiocyanate + glutathione
?
benzyl-isothiocyanate + glutathione
?
-
-
-
?
bromosulfophthalein + glutathione
?
-
-
-
-
?
bromosulfophthalein + GSH
?
brostallicin + glutathione
glutathionyl-brostallicin
butyl nitrite + glutathione
?
-
-
-
-
?
chlorofluoroacetic acid + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
cumene hydroperoxide + GSH
?
dehydroascorbate + glutathione
?
dehydroascorbic acid + glutathione
?
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
dichloroacetate + glutathione
2-(glutathion-S-yl)-chloroacetate + HCl
-
-
-
?
dichloroacetate + glutathione
glyoxylate + HCl + ?
-
-
-
-
?
dichloroacetic acid + glutathione
?
ethacrynic acid + glutathione
?
fluazifop-p-butyl + glutathione
?
-
-
-
-
?
fluorodifen + glutathione
?
gamma-Glu-Cys-Aib + 1-chloro-2,4-dinitrobenzene
?
substrate for mutant enzyme I104V/A113V
-
-
?
gamma-Glu-Cys-Nle + 1-chloro-2,4-dinitrobenzene
?
26.4% activity compared to glutathione
-
-
?
gamma-Glu-Cys-Nva + 1-chloro-2,4-dinitrobenzene
?
16% activity compared to glutathione
-
-
?
gamma-Glu-Cys-Sar + 1-chloro-2,4-dinitrobenzene
?
17% activity compared to glutathione
-
-
?
glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
-
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
glutathione + (2Z,4E)-3-chloro-6-(3,5-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
?
-
-
-
-
?
glutathione + (E)-2-hexenal
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + (R)-styrene-7,8-oxide
?
-
-
-
-
?
glutathione + (R,R)-1-phenylpropylene oxide
?
-
-
-
-
?
glutathione + (R,R)-trans-stilbene oxide
?
-
-
-
-
?
glutathione + (S)-styrene-7,8-oxide
?
-
-
-
-
?
glutathione + (S,S)-1-phenylpropylene oxide
?
-
-
-
-
?
glutathione + (S,S)-trans-stilbene oxide
?
-
-
-
-
?
glutathione + 1,2-dichloro-4,5-dinitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
glutathione + 1,2-diiodoethane
?
glutathione + 1,2-dinitrobenzene
?
glutathione + 1,2-epoxy-3-(4-nitro-phenoxy)propane
?
-
best substrate for the wild-type GST T1-1 and mutant W234K
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)-propane
?
-
substrate of the theta class isozyme
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
glutathione + 1,4-diiodobutane
?
glutathione + 1,6-diiodohexane
?
glutathione + 1,8-diiodooctane
?
glutathione + 1-bromo-4-nitrobenzene
bromide + 4-nitrophenyl-glutathione
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
glutathione + 1-chloro-2,3-dinitrobenzoate
?
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + S-(2,4-dinitrophenyl)-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
glutathione + 1-fluoro-2,4-dinitrobenzene
?
-
-
-
-
?
glutathione + 1-iodo-3-phenylpropane
iodide + 3-phenylpropyl-glutathione
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
glutathione + 1-iodoethane
iodide + ethylglutathione
-
-
-
-
?
glutathione + 1-iodoheptane
iodide + heptyl-glutathione
-
-
-
-
?
glutathione + 1-iodohexane
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
glutathione + 1-iodomethane
iodide + methylglutathione
glutathione + 1-iodooctane
iodide + octyl-glutathione
-
-
-
-
?
glutathione + 1-iodopentane
iodide + pentyl-glutathione
-
-
-
-
?
glutathione + 1-iodopropane
iodide + propyl-glutathione
-
-
-
-
?
glutathione + 1-menaphthyl sulfate
?
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
glutathione + 2,4-hexadienal
?
-
-
-
?
glutathione + 2,5-dinitrophenol
?
-
-
-
-
?
glutathione + 2-hydroxyethyl disulfide
?
isozyme GSTO2, low activity
-
-
?
glutathione + 2-methyl-4-nitrobenzyl alcohol
?
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
glutathione + 3,4-dinitrobenzanilide
?
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
glutathione + 3-iodopropylbenzene
?
glutathione + 4-chloro-3-nitroacetophenone
?
-
-
-
?
glutathione + 4-chloro-3-nitrobenzophenone
?
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
glutathione + 4-chloro-7-nitrobenzofurazan
?
-
8.2% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 4-fluoro-3-nitrobenzanilide
?
-
-
-
?
glutathione + 4-hydroxy-(E)-2-nonenal
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + 4-hydroxydecenal
?
-
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
glutathione + 4-hydroxynonenal
?
glutathione + 4-methylumbelliferyl acetate
?
-
-
-
?
glutathione + 4-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
glutathione + 4-nitrobenzyl chloride
chloride + S-(4-nitrobenzyl)-glutathione
glutathione + 4-nitrobenzyl chloride
S-(4-nitrobenzyl)glutathione + HCl
glutathione + 4-nitrobenzylchloride
?
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
?
weak substrate
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenethyl-glutathione
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenylethyl-glutathione
-
-
-
?
glutathione + 4-nitrophenyl acetate
?
-
-
-
-
?
glutathione + 4-nitrophenyl acetate
S-(4-nitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 4-nitrophenyl bromide
?
-
-
-
-
?
glutathione + 4-nitropyridine
?
-
-
-
-
?
glutathione + 4-nitroquinoline-1-oxide
?
-
-
-
-
?
glutathione + 5-chloromethylfluorescein diacetate
?
-
-
-
?
glutathione + 5-nitrofurfural
?
glutathione + 5-nitrofurfural diacetal
?
glutathione + 7-amino-4-chloromethyl coumarin
?
glutathione + 7-chloro-4-nitrobenz-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
glutathione + acetochlor
?
glutathione + adenine propenal
?
-
-
-
-
?
glutathione + allyl isothiocyanate
?
-
58.9% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + allyl-isothiocyanate
?
glutathione + alpha-O-(beta-methylumbelliferyl)acetovanillone
?
-
-
-
?
glutathione + androst-5-ene-3,17-dione
?
-
-
-
-
?
glutathione + anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide
?
-
-
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
glutathione + benzo[a]pyrene 4,5-oxide
?
glutathione + benzyl isothiocyanate
?
-
substrate of GSTF9
-
-
?
glutathione + beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
beta-(S)-hydroxypropiovanillonyl-glutathione + guaiacol
glutathione + bromosulfophthalein
?
glutathione + bromosulphthalein
?
glutathione + butachlor
?
glutathione + chlorambucil
?
-
-
-
?
glutathione + cis-6-(2-acetylvinylthio)purine
?
O15217, O43708, P08263, P09210, P09211, P09488, P28161, P30711, P46439, P78417, Q03013, Q16772 -
-
-
?
glutathione + crotonaldehyde
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + cryptophycin 52
?
glutathione + cryptophycin 53
?
glutathione + cumene hydroperoxide
?
glutathione + cyclohexyl-isothiocyanate
?
glutathione + dehydroascorbate
?
-
43.6% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + ethacrynic acid
?
glutathione + ethylene diiodide
?
-
-
-
?
glutathione + fenchlorim
?
-
-
-
-
?
glutathione + fenoxaprop
4-hydroxyphenoxypropanoic acid + glutathione conjugate
-
herbicide
-
?
glutathione + fluorodifen
4-nitrophenol + (2-nitro-4-trifluoromethylphenyl)glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
glutathione + fluorodifen
?
glutathione + H2O2
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + hexa 2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
glutathione + hydrogen peroxide
?
-
-
-
?
glutathione + hydroxyethyldisulfide
?
-
-
-
-
?
glutathione + indomethane
?
glutathione + iodomethane
?
glutathione + linoleic acid hydroperoxide
?
glutathione + methacrolein
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + metolachlor
?
glutathione + microcystin-LR
?
glutathione + naphthalene oxide
?
-
-
-
-
?
glutathione + nitrobutyl chloride
chloride + nitrobutyl-glutathione
-
-
-
?
glutathione + nodularin
?
glutathione + petrilachlor
?
-
-
-
-
?
glutathione + phenethyl isothiocyanate
?
-
129.7% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + phenethyl isothiocyanate
glutathionyl-phenethylthiocarbamate
-
-
-
r
glutathione + phenethyl-isothiocyanate
?
glutathione + pretilachlor
?
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
glutathione + styrene 7,8-oxide
?
glutathione + styrene oxide
?
glutathione + sulfanilamide
?
-
81.8% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + sulforaphane
?
glutathione + terbuthylazine
?
glutathione + tert-butyl hydroperoxide
?
glutathione + trans,trans-2,4-decadienal
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
glutathione + trans-4-phenyl-3-buten-2-one
?
glutathione + trans-4-phenyl-3-butene-2-one
?
glutathione + trans-6-(2-acetylvinylthio)guanine
?
O15217, O43708, P08263, P09210, P09211, P09488, P28161, P30711, P46439, P78417, Q03013, Q16772 -
-
-
?
glutathione + trans-trans-2,4-decadienal
?
glutathione + trans-trans-2,4-hexadienal
?
-
-
-
-
?
glutathione + trans-trans-2,4-nonadienal
?
-
-
-
-
?
harderoporphyrinogen + glutathione
harderoporphyrinogen-S-glutathione + H2O
-
-
-
-
?
hydrogen peroxide + glutathione
?
Hyp-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
39.5% activity compared to glutathione
-
-
?
iodobutane + glutathione
?
-
-
-
-
?
iodohexane + glutathione
?
-
-
-
-
?
iodomethane + glutathione
?
-
-
-
-
?
maleylacetone + glutathione
?
-
-
-
-
?
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate + glutathione
chloride + L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine
-
-
-
-
?
metolachlor + glutathione
?
-
-
-
-
?
monochlorobimane + glutathione
?
-
-
-
-
?
monochlorobimane + glutathione
bimane-glutathione + HCl
-
-
-
-
?
nitrophenyl acetate + GSH
?
-
6.5% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
NMe-Glu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
3.9% activity compared to glutathione
-
-
?
nonenal + glutathione
?
-
-
-
-
?
pGlu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
11.5% activity compared to glutathione
-
-
?
phenethyl isothiocyanate + glutathione
?
Pro-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
21.6% activity compared to glutathione
-
-
?
propyl isothiocyanate + glutathione
?
propyl-isothiocyanate + glutathione
?
-
-
-
?
protoporphyrinogen + glutathione
protoporphyrinogen-S-glutathione + H2O
-
-
-
-
?
rac-4-hydroxynonenal + glutathione
S-(4-hydroxy-1-oxononan-3-yl)glutathione
-
elimination of the lipid peroxidation product 4-hydroxynonenal, a toxic compound that contributes to numerous diseases
-
-
?
rac-4-hydroxynonenal + glutathione
S-[(2S)-3-hydoxy-2-(2-oxoethyl)octyl]glutathione
-
GSTA1-1 isoform has poor catalytic efficiency with 4-hydroxynonenal, GSTA4-4 has negligible stereoselectivity towards the two 4-hydroxynonenal enantiomers, despite its high catalytic chemospecificity for alkenals
product binding, overview
-
?
reduced glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
reduced glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
reduced glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
reduced glutathione + 4-nitrophenethyl bromide
?
-
-
-
-
?
reduced glutathione + ethacrynic acid
?
-
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
RX + glutathione
HX + R-S-glutathione
S-(4-nitrophenacyl)-glutathione
4-nitroacetophenone + glutathione
S-glutathionyl-phenylacetophenone + glutathione
?
-
-
-
?
S-glutathionyltetralone + glutathione
?
-
-
-
?
S-phenylacetylglutathione + glutathione
?
-
-
-
?
Sar-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
15.8% activity compared to glutathione
-
-
?
styrene oxide + glutathione
?
sulforaphane + glutathione
?
-
-
-
?
tert-butyl peroxide + glutathione
?
tertiary butyl hydroperoxide + glutathione
?
Tic-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
41.3% activity compared to glutathione
-
-
?
trans-2-nonenal + glutathione
?
trans-2-nonenal + GSH
?
-
at 1% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
trans-4-phenyl-3-buten-2-one + glutathione
?
-
-
-
-
?
trans-phenyl-butenone + GSH
?
[(methylamino)[methyl(nitroso)amino]methyl]cyanamide + glutathione
[bis(methylamino)methyl]cyanamide + S-nitrosoglutathione
-
transnitrosylation
-
-
?
[3-(4-nitrophenyl)oxiran-2-yl]methanol + glutathione
?
-
-
-
-
?
additional information
?
-
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
-
12% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
-
-
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
-
-
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
-
2.3% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
-
-
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
-
-
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
-
4.6% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
-
-
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
-
-
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
-
8% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
-
at 8% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione
?
A0A023JBX1, A0A023JBX8, A0A023JCA5, A0A023JCC0, A0A023JCF9, A0A023JCM9, A0A023JCN4, A0A023JCQ9, A0A023JCR5, G7P4V9, G7P5X8, Q2PFL7 -
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione
?
A0A023JBX5, A0A023JCA8, A0A023JCQ7, A0A023JCR6, F6TP78, F6WWX7, F6Z1G0, F7H5D7, G7N132, G8F1C9, H9Z845, I0FRI5 -
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
?
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrophenyl-glutathione + HCl
residue Ser13 is directly involved in the reaction chemistry and the correct positioning of GSH and CDNB in the ternary catalytic complex. Asn48 and Pro49 have a direct role on the structural integrity of the GSH-binding site (G-site)
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrophenyl-glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrophenyl-glutathione + HCl
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
A0A023JBX1, A0A023JBX8, A0A023JCA5, A0A023JCC0, A0A023JCF9, A0A023JCM9, A0A023JCN4, A0A023JCQ9, A0A023JCR5, G7P4V9, G7P5X8, Q2PFL7 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
A0A023JBX5, A0A023JCA8, A0A023JCQ7, A0A023JCR6, F6TP78, F6WWX7, F6Z1G0, F7H5D7, G7N132, G8F1C9, H9Z845, I0FRI5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)-glutathione + HCl
Tyr119 not only plays a role in hydrophobic substrate binding but also in packing of the active site pocket, which influences chemical interactions involved in enzyme catalysis
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
synthetic substrate of GST
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
isoform GST-1 is 18.3times more active than GST-2 and 26.8times more active than GST-3
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
aromatic substitution
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
best substrate
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
isoform GSTU45 shows highest activity with 1-chloro-2,4-dinitrobenzene
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
1-chloro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
best substrate
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,4-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
-
-
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
-
1-fluoro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
-
HCCA isomerase catalyzes the glutathione-dependent interconversion of 2-hydroxychromene-2-carboxylic acid and trans-o-hydroxybenzylidene pyruvic acid in the naphthalene catabolic pathway of Pseudomonas putida, mechanisms in the naphthalene catabolic pathwayoverview
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
-
the dimeric protein binds one molecule of GSH very tightly and a second molecule of GSH with much lower affinity, GSH acts as a tightly bound cofactor in the reaction, binding structure, overview
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
-
-
-
-
?
4-hydroxynonenal + GSH
?
-
90% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
4-hydroxynonenal + GSH
?
-
10% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
4-nitrobenzyl chloride + glutathione
?
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
4-nitrobenzyl chloride is conjugated through a single-step bimolecular nucleophilic substitution (SN2) with a pentacoordinate intermediate
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
-
-
-
-
?
4-nitrophenyl acetate + GSH
?
-
198% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
4-nitrophenyl acetate + GSH
?
0.2% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
4-nitrophenyl acetate + GSH
?
-
at 0.2% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
5-androstene-3,17-dione + glutathione
?
-
-
-
?
5-androstene-3,17-dione + glutathione
?
-
-
-
?
5-pregnene-3,20-dione + glutathione
?
-
-
-
?
5-pregnene-3,20-dione + glutathione
?
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
-
15% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
-
80% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
23.4% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
-
at 23% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
acrolein + glutathione
?
-
-
-
?
acrolein + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
-
-
-
?
allyl isothiocyanate + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
-
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
-
?
bromosulfophthalein + GSH
?
-
10.3% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II
-
-
?
bromosulfophthalein + GSH
?
-
8.6% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
brostallicin + glutathione
glutathionyl-brostallicin
-
involved in activation of the prodrug, mechanism, overview. The reaction proceeds via the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug, brostallicin cytotoxicity of brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene
-
-
?
brostallicin + glutathione
glutathionyl-brostallicin
-
isoenzymes GSTP1-1 and GSTM2-2
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
cumene hydroperoxide + GSH
?
-
106% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
cumene hydroperoxide + GSH
?
-
11.9% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II
-
-
?
cumene hydroperoxide + GSH
?
-
-
-
-
?
cumene hydroperoxide + GSH
?
-
18% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
cumene hydroperoxide + GSH
?
-
-
-
-
?
dehydroascorbate + glutathione
?
-
substrate for isoform Gsto2
-
-
?
dehydroascorbate + glutathione
?
-
-
-
?
dehydroascorbate + glutathione
?
-
-
-
?
dehydroascorbate + glutathione
?
-
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
-
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
-
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
-
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
-
-
-
-
?
dichloroacetic acid + glutathione
?
-
-
-
-
?
dichloroacetic acid + glutathione
?
-
substrate for isoform Gstz1
-
-
?
dichloroacetic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
substrate for isoforms Gstp1 and Gstp2
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + glutathione
?
-
ethacrynic acid is conjugated via a Michael addition reaction through the formation of an enole intermediate
-
-
?
ethacrynic acid + glutathione
?
-
-
-
-
?
ethacrynic acid + GSH
?
-
15% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
ethacrynic acid + GSH
?
-
9% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
-
24% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
-
-
-
-
?
ethacrynic acid + GSH
?
8% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
-
at 8% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
fluorodifen + glutathione
?
-
-
-
-
?
fluorodifen + glutathione
?
-
-
-
?
fluorodifen + glutathione
?
-
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
-
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
-
preferred polychlorinated biphenyl metabolite substrate
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
weak substrate
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
substrate of the liver enzyme, no activity by the gill enzyme
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
enzyme MIII
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
substrate of the mu class isozyme
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
low activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
637893, 637894, 637903, 637905, 637908, 637914, 637915, 637918, 637921, 637928, 637934, 637936, 637938 -
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
at a low rate
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
substrate of the liver enzyme, no activity by the gill enzyme
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-diiodoethane
?
best substrate
-
-
?
glutathione + 1,2-diiodoethane
?
best substrate
-
-
?
glutathione + 1,2-diiodoethane
?
best substrate
-
-
?
glutathione + 1,2-dinitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dinitrobenzene
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
anionic isozyme
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
isoenzyme E
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
-
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + 1,4-diiodobutane
?
-
-
-
?
glutathione + 1,4-diiodobutane
?
-
-
-
?
glutathione + 1,4-diiodobutane
?
-
-
-
?
glutathione + 1,6-diiodohexane
?
-
-
-
?
glutathione + 1,6-diiodohexane
?
-
-
-
?
glutathione + 1,6-diiodohexane
?
-
-
-
?
glutathione + 1,8-diiodooctane
?
-
-
-
?
glutathione + 1,8-diiodooctane
?
-
-
-
?
glutathione + 1,8-diiodooctane
?
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
substrate specificity of enzyme from bees of different subspecies differ, overview
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
100% activity
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
Coturnix sp.
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
100% activity
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
high activity with isozyme GSTO2, not with isozyme GSTO1-1
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
preferred substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
substrate of mu, pi, theta, alpha, and tau class isozymes
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
substrate binding structure, overview
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
preferred substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
i.e. CDNB
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
Thermosynechococcus vestitus
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
SNAr reaction between GSH and 1-chloro-2,4-dinitrobenzene. Role of Arg15 in the binding and activation of GSH and in sigma-complex formation, overview
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
the catalytic activity of purified GST from Nanyang city population with GSH is much higher than the activity of the enzyme from other populations, while the Wuzhou population reaches the highest in Vmax for substrate 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
Q8MU52
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
preferred substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
O04437, P30110, P30111, Q6U6G6, Q8GRI3, Q8GTB7, Q8GTB8, Q8GTB9, Q8GTC0, Q8GTC1, Q8LGN5, Q8LGN6, Q8LL15, Q8RW00, Q8RW01, Q8RW02, Q8RW03, Q8RW04, Q9SP56 -
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
enzyme has only weak activity towards the substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
best substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
low activity towards the substrate
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
-
-
-
-
?
glutathione + 1-iodohexane
?
-
-
-
?
glutathione + 1-iodohexane
?
-
-
-
?
glutathione + 1-iodohexane
?
-
-
-
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
-
highest affinity substrate for isoforms GSTT1 and GSTM5
-
-
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
-
-
-
-
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
-
-
-
-
?
glutathione + 1-iodomethane
iodide + methylglutathione
-
best substrate of GST T1-1 mutant W234R
-
-
?
glutathione + 1-iodomethane
iodide + methylglutathione
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
-
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
-
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
-
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
-
-
-
-
?
glutathione + 3-iodopropylbenzene
?
-
-
-
?
glutathione + 3-iodopropylbenzene
?
-
-
-
?
glutathione + 3-iodopropylbenzene
?
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
-
-
-
?
glutathione + 4-hydroxynonenal
?
a lipid peroxidation product
-
-
?
glutathione + 4-hydroxynonenal
?
-
-
-
?
glutathione + 4-hydroxynonenal
?
-
-
-
-
?
glutathione + 4-hydroxynonenal
?
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
best substrate
-
-
?
glutathione + 4-nitrobenzyl chloride
?
weak substrate
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
-
30.5% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
-
substrate of the alpha class isozyme
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + S-(4-nitrobenzyl)-glutathione
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + S-(4-nitrobenzyl)-glutathione
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrobenzyl)glutathione + HCl
-
-
-
-
?
glutathione + 5-nitrofurfural
?
-
-
-
-
?
glutathione + 5-nitrofurfural
?
-
-
-
-
?
glutathione + 5-nitrofurfural diacetal
?
-
-
-
-
?
glutathione + 5-nitrofurfural diacetal
?
-
-
-
-
?
glutathione + 7-amino-4-chloromethyl coumarin
?
-
-
-
?
glutathione + 7-amino-4-chloromethyl coumarin
?
-
isozyme GSt T2-2 shows high activity
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
-
poor substrate
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + acetochlor
?
-
-
-
-
?
glutathione + acetochlor
?
-
-
-
-
?
glutathione + acrolein
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + acrolein
?
-
-
-
-
?
glutathione + alachlor
?
-
-
-
-
?
glutathione + alachlor
?
-
-
-
-
?
glutathione + alachlor
?
-
herbicide
-
-
?
glutathione + alachlor
?
-
i.e. 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide
-
-
?
glutathione + alachlor
?
-
isozyme GSTI
-
-
?
glutathione + alachlor
?
-
i.e. 2-chloro-N-[2,6-diethylphenyl]-N-[methoxymethyl]acetamide, isozyme GSTI
-
-
?
glutathione + allyl-isothiocyanate
?
-
-
-
?
glutathione + allyl-isothiocyanate
?
-
-
-
-
?
glutathione + allyl-isothiocyanate
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + atrazine
?
-
high specific activity
-
-
?
glutathione + atrazine
?
-
herbicide
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
-
-
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
-
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
-
-
-
?
glutathione + benzo[a]pyrene 4,5-oxide
?
-
-
-
-
?
glutathione + benzo[a]pyrene 4,5-oxide
?
-
-
-
-
?
glutathione + beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
beta-(S)-hydroxypropiovanillonyl-glutathione + guaiacol
Q2G4B4; Q2G4B5
the enzyme stereospecifically cleaves the beta(R)-aryl ether bond of the di-aromatic compound beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
-
-
?
glutathione + beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
beta-(S)-hydroxypropiovanillonyl-glutathione + guaiacol
Q2G4B4; Q2G4B5
the enzyme stereospecifically cleaves the beta(R)-aryl ether bond of the di-aromatic compound beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
-
-
?
glutathione + bromosulfophthalein
?
-
-
-
-
?
glutathione + bromosulfophthalein
?
-
-
-
-
?
glutathione + bromosulphthalein
?
-
-
-
?
glutathione + bromosulphthalein
?
-
-
-
?
glutathione + butachlor
?
-
-
-
-
?
glutathione + butachlor
?
-
-
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
56.3% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
isozyme MI
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + cumene hydroperoxide
?
-
114% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
the enzyme has selenium-independent peroxidase activity
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
?
glutathione + cyclohexyl-isothiocyanate
?
-
-
-
-
?
glutathione + cyclohexyl-isothiocyanate
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
weak substrate
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
low activity
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
substrate of the pi class isozyme
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
Q8MU52
-
-
-
?
glutathione + ethacrynic acid
?
low activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + ethacrynic acid
?
-
best substrate
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
low activity towards substrate
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
highest activity
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
-
?
glutathione + ethacrynic acid
?
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
-
-
-
-
?
glutathione + fluorodifen
?
-
i.e. 2,4-nitrophenyl 2'-nitro-alpha,alpha,alpha-trifluoro-4-tolyl ester
-
-
?
glutathione + fluorodifen
?
-
1.2% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + fluorodifen
?
-
substrate of the tau class isozyme
-
-
?
glutathione + fluorodifen
?
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
-
-
?
glutathione + hematin
?
GST-1 is involved in parasite heme detoxification during hemoglobin digestion or heme uptake
-
-
?
glutathione + hematin
?
high affinity binding by GST-1
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
-
-
-
?
glutathione + indomethane
?
-
-
-
-
?
glutathione + indomethane
?
-
-
-
-
?
glutathione + iodomethane
?
-
-
-
-
?
glutathione + iodomethane
?
-
-
-
-
?
glutathione + iodomethane
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
cationic isozyme
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + metolachlor
?
-
herbicide
-
-
?
glutathione + metolachlor
?
-
-
-
-
?
glutathione + metolachlor
?
-
herbicide
-
-
?
glutathione + microcystin-LR
?
-
-
-
-
?
glutathione + microcystin-LR
?
-
cyanobacterial toxins are hypothesized to contribute to the mortality of prawns, many aquatic organisms have the possibility of detoxifying cyanobacterial toxins, e.g. nodularin or microcystin-LR, via conjugation to glutathione
-
-
?
glutathione + microcystin-LR
?
-
a cyanobacterial toxin
-
-
?
glutathione + microcystin-LR
?
-
-
-
-
?
glutathione + nodularin
?
-
cyanobacterial toxins are hypothesized to contribute to the mortality of prawns, many aquatic organisms have the possibility of detoxifying cyanobacterial toxins, e.g. nodularin or microcystin-LR, via conjugation to glutathione
-
-
?
glutathione + nodularin
?
-
a cyanobacterial toxin
-
-
?
glutathione + phenethyl-isothiocyanate
?
-
-
-
?
glutathione + phenethyl-isothiocyanate
?
-
-
-
-
?
glutathione + phenethyl-isothiocyanate
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + propyl-isothiocyanate
?
-
-
-
?
glutathione + propyl-isothiocyanate
?
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + styrene 7,8-oxide
?
-
highest affinity substrate for isoforms GSTM2 and GSTM5
-
-
?
glutathione + styrene 7,8-oxide
?
-
-
-
-
?
glutathione + styrene oxide
?
-
-
-
-
?
glutathione + styrene oxide
?
-
-
-
-
?
glutathione + sulforaphane
?
-
-
-
-
?
glutathione + sulforaphane
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + terbuthylazine
?
-
-
-
-
?
glutathione + terbuthylazine
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
anionic isozyme
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
5.9% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-2-nonenal
?
Thermosynechococcus vestitus
-
-
-
?
glutathione + trans-2-nonenal
?
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
1.2% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
low activity
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
-
-
-
?
glutathione + trans-4-phenyl-3-butene-2-one
?
-
-
-
-
?
glutathione + trans-4-phenyl-3-butene-2-one
?
-
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
-
-
-
-
?
GSH reductase + GSH
?
-
271% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II
-
-
?
GSH reductase + GSH
?
-
87% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
hydrogen peroxide + glutathione
?
-
-
-
?
hydrogen peroxide + glutathione
?
-
-
-
-
?
hydrogen peroxide + glutathione
?
-
-
-
-
?
monochlorobimane + GSH
?
-
-
-
-
?
monochlorobimane + GSH
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
phenethyl isothiocyanate + glutathione
?
isoform GSTU16 shows highest activity with phenethyl isothiocyanate
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
?
propyl isothiocyanate + glutathione
?
-
-
-
?
propyl isothiocyanate + glutathione
?
-
-
-
-
?
propyl isothiocyanate + glutathione
?
-
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
-
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
-
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
involved both with bilirubin transport and detoxification of electrophils
-
-
?
RX + glutathione
HX + R-S-glutathione
-
first step in mercapturic acid synthesis
-
-
?
RX + glutathione
HX + R-S-glutathione
-
phase II detoxification mechanism, isomerization of 3-ketosteroids and biosynthesis of peptide leukotrienes
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
biotransformation and detoxification of electrophilic xenobiotics
-
-
?
RX + glutathione
HX + R-S-glutathione
-
detoxification of electrophilic products of cytochrome P-450-dependent reactions, toxic catabolite of heme, bilirubin is bound and thereby neutralized
-
-
?
RX + glutathione
HX + R-S-glutathione
-
detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides
-
-
?
RX + glutathione
HX + R-S-glutathione
-
may be involved in preventing lipid peroxidation
-
-
?
RX + glutathione
HX + R-S-glutathione
-
microsomal enzyme is likely to be involved in drug metabolism
-
-
?
RX + glutathione
HX + R-S-glutathione
-
first step in mercapturic acid synthesis
-
-
?
RX + glutathione
HX + R-S-glutathione
-
-
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
S-(4-nitrophenacyl)-glutathione
4-nitroacetophenone + glutathione
-
-
-
-
?
S-(4-nitrophenacyl)-glutathione
4-nitroacetophenone + glutathione
-
-
-
?
styrene oxide + glutathione
?
-
-
-
?
styrene oxide + glutathione
?
-
-
-
-
?
styrene oxide + glutathione
?
-
-
-
-
?
tert-butyl peroxide + glutathione
?
-
-
-
-
?
tert-butyl peroxide + glutathione
?
-
-
-
?
tertiary butyl hydroperoxide + glutathione
?
-
-
-
?
tertiary butyl hydroperoxide + glutathione
?
-
-
-
-
?
tertiary butyl hydroperoxide + glutathione
?
-
-
-
-
?
trans-2-nonenal + glutathione
?
-
-
-
?
trans-2-nonenal + glutathione
?
-
-
-
-
?
trans-2-nonenal + glutathione
?
-
-
-
?
trans-phenyl-butenone + GSH
?
-
312% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II
-
-
?
trans-phenyl-butenone + GSH
?
-
71% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
additional information
?
-
the enzyme also displays dehalogenation function against dichloroacetate, permethrin, and dieldrin
-
-
-
additional information
?
-
-
only isozymes GSTE2-2 and GSTE5-5 are able to metabolize DDT to DDE
-
-
?
additional information
?
-
-
AtuGSTH1-1 exhibits significant transferase activity against the common substrates aryl halides, as well as very high peroxidase activity towards organic hydroperoxides
-
-
?
additional information
?
-
-
AtuGSTH1-1 exhibits significant transferase activity against the common substrates aryl halides, as well as very high peroxidase activity towards organic hydroperoxides
-
-
?
additional information
?
-
-
isoforms GTT1.2, GSTO1, and Ure2pB1 show no activity with allyl-isothiocyanate,, benzyl-isothiocyanate, or phenylethyl-isothiocyanate
-
-
?
additional information
?
-
-
isoforms GTT1.2, GSTO1, and Ure2pB1 show no activity with allyl-isothiocyanate,, benzyl-isothiocyanate, or phenylethyl-isothiocyanate
-
-
?
additional information
?
-
-
the enzyme is involved in phase II detoxication processes by conjugation of a thiol group from reduced glutathione to an electrophilic centre of diverse xenobiotic compounds, producing less reactive and more polar substances in order to facilitate elimination from cells
-
-
?
additional information
?
-
positive cooperativity upon GSH binding indicating that the residue replacement affects the communication between subunits of the dimeric enzyme
-
-
?
additional information
?
-
agGSTe2 has a long narrow cleft at the interface of the N- and C-domains, in which a GSH molecule tightly fits, binding of glutathione does not induce significant conformational changes in the isozyme agGSTe2 protein, structure, overview
-
-
?
additional information
?
-
-
agGSTe2 has a long narrow cleft at the interface of the N- and C-domains, in which a GSH molecule tightly fits, binding of glutathione does not induce significant conformational changes in the isozyme agGSTe2 protein, structure, overview
-
-
?
additional information
?
-
-
benoxacor, fenclorim, and fluxofenim do not protect the plant from herbicide injury but induce RNA expression of the glutathione-conjugate transporters encoded by genes AtMRP1, AtMRP2, AtMRP3, and AtMRP4
-
-
?
additional information
?
-
-
no activity with 4-nitrobenzylchloride
-
-
?
additional information
?
-
-
no activity with 4-nitrobenzylchloride, GSTF9 also shows glutathione peroxidase activity, EC 1.11.1.9, overview
-
-
?
additional information
?
-
three recombinant theta class GSTs, GSTTs, show conserved activities as hydroperoxide-reducing glutathione peroxidases
-
-
?
additional information
?
-
-
glutathione conjugation reactions are often freely reversible, formation of unstable glutathionylated natural products in plants, the detection is difficult, overview
-
-
?
additional information
?
-
-
GSTs selectively bind GSH
-
-
?
additional information
?
-
-
overexpressed in bacteria, family members GSTF2 and GSTF3 bind a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. GSTF2 also selectively binds the indole-derived phytoalexin camalexin, as well as the flavonol quercetin-3-O-rhamnoside, recombinant GSTF2 ligand binding studies and kinetics, overview
-
-
?
additional information
?
-
-
enzyme has also activity towards reactive carbonyls
-
-
?
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
?
additional information
?
-
-
1,2-dichloro-4-nitrobenzene and ethacrynic acid are no substrates
-
-
?
additional information
?
-
the enzyme shows high affinity for organophosphorus insecticide
-
-
?
additional information
?
-
the enzyme shows high affinity for organophosphorus insecticide
-
-
?
additional information
?
-
the enzyme shows high affinity for organophosphorus insecticide
-
-
?
additional information
?
-
-
the enzyme shows high affinity for organophosphorus insecticide
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
enzyme has also selenium-independent peroxidase activity
-
-
?
additional information
?
-
-
no activity with bromosulfophthalein, 2,3-dichloro-(4-[2-methylene-butyryl]phenoxy)acetic acid (ethacrynic acid), 2-hydroxyethyl disulfide (2,2-dithiodiethanol), tert-butyl hydroperoxide, and benzoyl peroxide
-
-
-
additional information
?
-
1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates
-
-
?
additional information
?
-
-
the recombinant cytosolic GST displays glutathione peroxidase activity towards cumene hydroperoxide, and conjugates reactive carbonyls, trans-2-nonenal and trans,trans-2,4-decadienal, indicating that it may intercept damaging products of lipid peroxidation
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
YghU from Escherichia coli binds two molecules of GSH in each active site. YghU exhibits little or no GSH transferase activity with most typical electrophilic substrates but does possess a modest catalytic activity toward several organic hydroperoxides. The enzyme also exhibits disulfide-bond reductase activity towards 2-hydroxyethyl disulfide
-
-
?
additional information
?
-
-
no activity against 1,2-dichloro-4-nitrobenzene and ethacrynic acid
-
-
-
additional information
?
-
1,2-epoxy-3-(4-nitrophenoxy) propane is no substrate
-
-
?
additional information
?
-
-
obligate requirement for reduced glutathione as thiol donor
-
-
?
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, and 4-nitrophenethyl bromide
-
-
?
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, and 4-nitrophenethyl bromide
-
-
?
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, and 4-nitrophenethyl bromide
-
-
?
additional information
?
-
-
enzyme ligand binding site structure, overview
-
-
?
additional information
?
-
-
no substrate: bromosulfophthalein
-
-
?
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
-
-
?
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
?
additional information
?
-
-
no substrate: methyl iodide
-
-
?
additional information
?
-
isoform GSTmu shows no activity with 1,2-dichloro-4-nitrobenzene
-
-
-
additional information
?
-
isoform GSTmu shows no activity with 1,2-dichloro-4-nitrobenzene
-
-
-
additional information
?
-
-
isoform GSTmu shows no activity with 1,2-dichloro-4-nitrobenzene
-
-
-
additional information
?
-
isoform GSTrho shows no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, 4-nitrophenethyl bromide and ethacrynic acid
-
-
-
additional information
?
-
isoform GSTrho shows no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, 4-nitrophenethyl bromide and ethacrynic acid
-
-
-
additional information
?
-
-
isoform GSTrho shows no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, 4-nitrophenethyl bromide and ethacrynic acid
-
-
-
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
conjugation of glutathione with base propenals and related alkenes, A1-1 and M1-1 are more active with 4-hydroxyalkenals than with base propenals
-
-
?
additional information
?
-
-
any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible
-
-
?
additional information
?
-
-
no substrates: sulfobromophthalein and hydrogen peroxide
-
-
?
additional information
?
-
-
catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether
-
-
?
additional information
?
-
-
isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids
-
-
?
additional information
?
-
-
enzyme has also selenium-independent peroxidase activity
-
-
?
additional information
?
-
-
assays for differentiation of glutathione S-transferase isoenzymes from rat and human by different specific acitivities with selected substrates
-
-
?
additional information
?
-
-
microsomal Ya-GST might be involved in the protection of membranes from peroxidative damage and its function is greatly affected by its localization in the membranes
-
-
?
additional information
?
-
-
the enzyme may play an important role in the protection of cellular membranes from peroxidative damage
-
-
?
additional information
?
-
-
the enzyme plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity
-
-
?
additional information
?
-
-
isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview
-
-
?
additional information
?
-
isozyme GSTO2 may play an important role in cellular signaling inducing apoptosis
-
-
?
additional information
?
-
-
isozyme GSTO2 may play an important role in cellular signaling inducing apoptosis
-
-
?
additional information
?
-
-
glutathione binds in the G site of the isozyme GST-A1-1, glutathione binding alone is sufficient to stabilize the C-terminal helix of the protein
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant isozymes GST T1-1, overview
-
-
?
additional information
?
-
-
the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
?
additional information
?
-
-
does not use acifluorofen, fluorodifen, metochlor, and pretilachlor as a substrate
-
-
?
additional information
?
-
pentafluorobenzanilide and 4-chloro-3-nitrobenzanilide are no substrates
-
-
?
additional information
?
-
-
the human isozyme GST T1-1 is 80fold less active than the murine isozyme GST T1-1
-
-
?
additional information
?
-
Arg15, conserved in class alpha GSTs, is located at the interface between the G- and H-sites of the active site where its cationic guanidinium group might play a role in catalysis and ligand binding. Binding of the anionic non-substrate ligand 8-anilino-1-naphthalene sulfonate to the H-site involving residue Arg15. The sigma-complex 5-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione is an analogue of the anionic transition state of the SNAr reaction between S-(2,4-dinitrophenyl)glutathione and GSH, docking structure, overview
-
-
?
additional information
?
-
-
Arg15, conserved in class alpha GSTs, is located at the interface between the G- and H-sites of the active site where its cationic guanidinium group might play a role in catalysis and ligand binding. Binding of the anionic non-substrate ligand 8-anilino-1-naphthalene sulfonate to the H-site involving residue Arg15. The sigma-complex 5-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione is an analogue of the anionic transition state of the SNAr reaction between S-(2,4-dinitrophenyl)glutathione and GSH, docking structure, overview
-
-
?
additional information
?
-
GST T1-1 displays both glutathione transferase and glutathione peroxidase enzyme activities, the latter with CuOOH
-
-
?
additional information
?
-
-
GST T1-1 displays both glutathione transferase and glutathione peroxidase enzyme activities, the latter with CuOOH
-
-
?
additional information
?
-
-
isozyme GSTA4-4 shows high catalytic chemospecificity for alkenals, but negligible stereoselectivity, GSTA4-4 undergoes no enantiospecific induced fit, mechanism of the combination of high substrate chemoselectivity and low substrate stereoselectivity, overview
-
-
?
additional information
?
-
-
quantitative structure-activity relationship analyses, overview
-
-
?
additional information
?
-
-
structure-activity relationships, overview
-
-
?
additional information
?
-
substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
-
-
?
additional information
?
-
-
substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTO2-2 has strikingly high dehydroascobate reductase activity
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
interaction between GSTM monomers and ASK1
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
thioltransferase and reductase reactions that are a feature of the Omega class GSTs
-
-
?
additional information
?
-
-
development of analytical quantification assays for pesticides dieldrin and spiromesifen in water with isozyme GSTA1-1, overview
-
-
?
additional information
?
-
-
monochlorobimane and 1-chloro-2,4-dinitrobenzene are used to determine GST activity
-
-
?
additional information
?
-
-
the enzyme catalyzes the biosynthesis of the pro-inflammatory mediator leukotriene C4
-
-
?
additional information
?
-
-
the enzyme also displays glutathione-dependent peroxidase activity toward several lipid hydroperoxides
-
-
?
additional information
?
-
the wild type enzyme shows no activity with acetyl-gamma-Glu-Cys-Gly, gamma-Glu-NMeCys-Gly, gamma-Glu-Cys-Aib, gamma-Glu-Cys-a-t-butyl-Gly, Tic-Cys-Ala, Hyp-Cys-Ala, Gly-Cys-Hyp, Tic-Cys-Aib, Tic-Cys(Acm)-Gly, and Tic-Cys-Sar
-
-
-
additional information
?
-
-
the wild type enzyme shows no activity with acetyl-gamma-Glu-Cys-Gly, gamma-Glu-NMeCys-Gly, gamma-Glu-Cys-Aib, gamma-Glu-Cys-a-t-butyl-Gly, Tic-Cys-Ala, Hyp-Cys-Ala, Gly-Cys-Hyp, Tic-Cys-Aib, Tic-Cys(Acm)-Gly, and Tic-Cys-Sar
-
-
-
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
the enzyme also exhibits glutathione peroxidase activity towards cumene hydroperoxide
-
-
?
additional information
?
-
-
TDR1 displays weak GSTactivity with 1-chloro-2,4-dinitrobenzene, and a glutaredoxin-like thioltransferase activity, with hydroxyethyl disulfide, together with a previously noted dihydroascorbate reductase activity. The peptide substrate SQLWCLSN, with a bulky tryptophan adjacent to the cysteine, may not be optimal for binding to the sterically restricted G-I site on TDR1 leading to low deglutathionylation activity
-
-
?
additional information
?
-
-
no activity with 1,2-dichloro-nitrobenzene
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
catalyzes S-conjugation between the thiol group of glutathione and an electrophilic moiety in the hydrophobic and toxic sustrate
-
-
?
additional information
?
-
-
detoxification protein protects against oxidative damage in certain aquatic organisms
-
-
?
additional information
?
-
-
the enzyme shows nearly no glutathione peroxidase activity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
GST isozymes play independent roles that characterize multiple processes within vomeronasal organ chemosensitivity
-
-
?
additional information
?
-
-
infection of skeletal muscle with Trichinella spiralis affects the Km of the enzyme due to alterations of the enzyme's quarternary structure, overview
-
-
?
additional information
?
-
-
mu- and pi-class GST activities
-
-
?
additional information
?
-
-
the selenomethionine-labeled antibody fragment ScFv2F3 is catalytically inactive
-
-
?
additional information
?
-
-
the murine isozyme GST T1-1 is 80fold more active than the human isozyme GST T1-1
-
-
?
additional information
?
-
-
substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
-
-
?
additional information
?
-
-
infection of skeletal muscle with Trichinella spiralis affects the Km of the enzyme due to alterations of the enzyme's quarternary structure, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in detoxification of many substances including organic pollutants and plant secondary metabolites
-
-
?
additional information
?
-
no thioltransferase activity with dehydroascorbic acid and 2-hydroxyethyldisulfide
-
-
-
additional information
?
-
-
no thioltransferase activity with dehydroascorbic acid and 2-hydroxyethyldisulfide
-
-
-
additional information
?
-
no thioltransferase activity with dehydroascorbic acid and 2-hydroxyethyldisulfide
-
-
-
additional information
?
-
recombinant isozymes GST-1, GST-2, and GST-3, expressed in Pichia pastoris, all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities
-
-
?
additional information
?
-
-
recombinant isozymes GST-1, GST-2, and GST-3, expressed in Pichia pastoris, all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities
-
-
?
additional information
?
-
no activity with 4-hydroxynonenal, ethacrynic acid, 4-nitrobenzyl chloride, 1,2-epoxy-3-(4-nitrophenoxy)-propane, 4-nitrophenethyl bromide, and 4-nitrophenyl acetate
-
-
?
additional information
?
-
-
no activity with 4-hydroxynonenal, ethacrynic acid, 4-nitrobenzyl chloride, 1,2-epoxy-3-(4-nitrophenoxy)-propane, 4-nitrophenethyl bromide, and 4-nitrophenyl acetate
-
-
?
additional information
?
-
-
the purified enzyme shows prostaglandin synthase activity
-
-
-
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, ethacrynic acid, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
?
additional information
?
-
a phase II detoxification enzyme which protect against chemical injury, especially in the context of detoxifying waterborne pollutants
-
-
?
additional information
?
-
a phase II detoxification enzyme which protect against chemical injury, especially in the context of detoxifying waterborne pollutants
-
-
?
additional information
?
-
-
a phase II detoxification enzyme which protect against chemical injury, especially in the context of detoxifying waterborne pollutants
-
-
?
additional information
?
-
substrate specificity, overview, poor activity with cumene hydroperoxide, 4-hydroxynonenal, methyl parathion or atrazine
-
-
?
additional information
?
-
substrate specificity, overview, poor activity with cumene hydroperoxide, 4-hydroxynonenal, methyl parathion or atrazine
-
-
?
additional information
?
-
-
substrate specificity, overview, poor activity with cumene hydroperoxide, 4-hydroxynonenal, methyl parathion or atrazine
-
-
?
additional information
?
-
-
no activity with atrazine and acifluorofen
-
-
?
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrophenyl acetate, and ethacrynic acid
-
-
?
additional information
?
-
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrophenyl acetate, and ethacrynic acid
-
-
?
additional information
?
-
no activity toward 1,2-dichloro-4-nitrobenzene, 4-nitrophenyl acetate and ethacrynic acid
-
-
-
additional information
?
-
-
no activity toward 1,2-dichloro-4-nitrobenzene, 4-nitrophenyl acetate and ethacrynic acid
-
-
-
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
microsomal Ya-GST might be involved in the protection of membranes from peroxidative damage and its function is greatly affected by its localization in the membranes
-
-
?
additional information
?
-
no activity with: cumene hydroperoxide, 1,2-dichloro-4-nitrobenzene, ethacrynic acid, 4-hydroxynonenal and p-nitrobenzyl chloride
-
-
?
additional information
?
-
-
no activity with: cumene hydroperoxide, 1,2-dichloro-4-nitrobenzene, ethacrynic acid, 4-hydroxynonenal and p-nitrobenzyl chloride
-
-
?
additional information
?
-
-
the enzyme catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls and may be responsible for facilitation of PCB degradation by the bph pathway, overview
-
-
?
additional information
?
-
-
no activity towards bromosulphophthalein, 1,2-dichloro-4-nitrobenzene, ethacrynic acid, 1,2-epoxy-2(p-nitrophenoxy) propane, trans-non-2-enal, and hexa-2,4-dienal
-
-
?
additional information
?
-
-
isozyme-dependent tissue-specific substrate specificity, overview
-
-
?
additional information
?
-
GST5118 binds glutathionylated and sulfated compounds but also wood extractive molecules, such as vanillin, chloronitrobenzoic acid, hydroxyacetophenone, catechins, and aldehydes, in the glutathione pocket, overview. Glutathione binding structure and mechanism, detailed overview. The enzyme also shows peroxidase activity
-
-
?
additional information
?
-
-
GST5118 binds glutathionylated and sulfated compounds but also wood extractive molecules, such as vanillin, chloronitrobenzoic acid, hydroxyacetophenone, catechins, and aldehydes, in the glutathione pocket, overview. Glutathione binding structure and mechanism, detailed overview. The enzyme also shows peroxidase activity
-
-
?
additional information
?
-
-
isoform GSTO7 shows no activity with hydroxyethyldisulfide, dehydroascorbate, and S-glutathionyl-phenylacetophenone
-
-
?
additional information
?
-
isoform GSTO7 shows no activity with hydroxyethyldisulfide, dehydroascorbate, and S-glutathionyl-phenylacetophenone
-
-
?
additional information
?
-
isoform GSTO7 shows no activity with hydroxyethyldisulfide, dehydroascorbate, and S-glutathionyl-phenylacetophenone
-
-
?
additional information
?
-
-
fluazifop-inducible glutathione transferase isozymes catalyze a broad range of reactions and exhibit quite varied substrate specificity, molecular modeling and structural analysis reveal key structural characteristics, isozynme substrate specificities and catalytic mechanism, overview. Only PvGSTU2-2 shows appreciable activity towards trans-2-nonenal, but the isozymes are also active with cumene hydroperoxide, tert-butyl hydroperoxide, and lauroyl peroxide, no activity of all isozymes with benzoyl peroxide
-
-
?
additional information
?
-
the recombinant enzyme shows no activity with 1-chloro-2,4-dinitrobenzene, but is highly active with 9(S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoic acid, cumene hydroperoxide, and other hydroperoxide substrates as glutathione peroxidase, EC 1.11.1.9, overview
-
-
?
additional information
?
-
-
the recombinant enzyme shows no activity with 1-chloro-2,4-dinitrobenzene, but is highly active with 9(S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoic acid, cumene hydroperoxide, and other hydroperoxide substrates as glutathione peroxidase, EC 1.11.1.9, overview
-
-
?
additional information
?
-
no activity towards 1,2-dichloro-4-nitrobenzene
-
-
-
additional information
?
-
-
the enzyme plays an importent role in stress tolerance and detoxification in plants
-
-
?
additional information
?
-
-
GSTC: activity towards 1-chloro-2,4-dinitrobenzene, GSTF: activity towards the herbicide fluorodifen, GPOX: peroxidase activity, overview: xenobiotic substrates
-
-
?
additional information
?
-
-
artemisinin is no substrate for glutathione transferase activity but for peroxidase activity, as is cumene hydroperoxide
-
-
?
additional information
?
-
the enzyme is essential for parasite survival by protecting the parasite against oxidative stress and buffering the detoxification of heme-binding compounds
-
-
?
additional information
?
-
-
the enzyme is essential for parasite survival by protecting the parasite against oxidative stress and buffering the detoxification of heme-binding compounds
-
-
?
additional information
?
-
2-nitrophenyl acetate, bromosulfophthalein, and cumene hydroperoxide are poor substrates, overview
-
-
?
additional information
?
-
-
2-nitrophenyl acetate, bromosulfophthalein, and cumene hydroperoxide are poor substrates, overview
-
-
?
additional information
?
-
the regulation of GST enzymatic activity through a dimer-tetramer transition via GSH binding is an exclusive feature of Plasmodium, three-dimensional modeling, overview
-
-
?
additional information
?
-
-
the regulation of GST enzymatic activity through a dimer-tetramer transition via GSH binding is an exclusive feature of Plasmodium, three-dimensional modeling, overview
-
-
?
additional information
?
-
-
the soluble enzyme is an essential detoxification enzyme in parasitic species
-
-
?
additional information
?
-
-
no activity with 1,2-epoxy-3-(4-nitrophenoxy) propane, 4-nitrobenzyl chloride, 4-nitrophenethyl bromide, 4-hydroxynonenal, 4-nitrophenyl acetate, and H2O2
-
-
-
additional information
?
-
very low or no activity with iodomethane, 1-iodobutane, 1-iodooctane, H2O2, dehydroascorbate, trans-2-hexenal, trans-2-nonenal, 2,4,6-trinitrotoluene, and 2,4-dinitrotoluene
-
-
?
additional information
?
-
very low or no activity with iodomethane, 1-iodobutane, 1-iodooctane, H2O2, dehydroascorbate, trans-2-hexenal, trans-2-nonenal, 2,4,6-trinitrotoluene, and 2,4-dinitrotoluene
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible
-
-
?
additional information
?
-
-
no substrate: bromosulfophthalein
-
-
?
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
-
-
?
additional information
?
-
-
catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether
-
-
?
additional information
?
-
-
isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids
-
-
?
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
?
additional information
?
-
-
no substrate: trans-4-phenyl-3-buten-2-one
-
-
?
additional information
?
-
-
no substrate: trans-4-phenyl-3-buten-2-one
-
-
?
additional information
?
-
-
no substrate: ethacrynic acid
-
-
?
additional information
?
-
-
assays for differentiation of glutathione S-transferase isoenzymes from rat and human by different specific acitivities with selected substrates
-
-
?
additional information
?
-
-
glutathione transferase X: no reaction of menaphthyl sulfate with glutathione, potent in inactivation of tert-10,11-epoxy-r-8,tert-9-dihydroxy-8,9,10,11-tetrahydrobenz/a/anthracene
-
-
?
additional information
?
-
-
the wild-type dimeric form is not required for catalytic activity
-
-
?
additional information
?
-
-
MGST1 possesses glutathione transferase and peroxidase activity. Native MGST1 binds three GSH molecules per trimer but with different affinities for GSH, it possesses only one high affinity catalytically competent site per trimer, nanoelectrospray mass spectrometric analysis, overview
-
-
?
additional information
?
-
-
quantitative structure-activity relationship analyses, overview
-
-
?
additional information
?
-
-
substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
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additional information
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glutathione transferases from rat liver are able to conjugate GSH to many hydrophobic toxic compounds. Small and hydrophilic disulfides like cystine, cystamine and dithioethanol, and hydrophilic alkylating compounds like iodoacetate, are no substrates of this enzyme. Omega class GST and a peculiar lens GST display a moderate thiol transferase activity with dithioethanol
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additional information
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no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
additional information
?
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no activity with 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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-
additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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-
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
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-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
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additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
-
no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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-
-
additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with dehydroascorbic acid, 4-nitrobenzyl chloride, 1,2-dichloro-4-nitrobenzene and cumene hydroperoxide
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additional information
?
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no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
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additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
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additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
-
no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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-
-
additional information
?
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no activity with fluorodifen, 1,2-dichloro-4-nitrobenzene, dehydroascorbic acid, 4-nitrobenzyl chloride and cumene hydroperoxide
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additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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Q2YFE8
GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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GST may play a role in the pathophysiology associated with crusted scabies
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?
additional information
?
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the enzyme has no detectable activity toward 1,2-dichloro-4-nitrobenzene, ethacrynic acid, bromosulfophthalein, 1,2-epoxy-3-(4-nitrophenoxy) propane, 4-nitrophenethyl bromide and styrene oxide
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additional information
?
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a primary pathway for metabolism of electrophilic compounds in Schistosoma japonicum involves glutathione S-transferase-catalyzed formation of glutathione conjugates, overview, production of nonenzymatic GSH conjugates with electrophilic substrates often overwhelms the activity of the enzyme, overview
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additional information
?
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the enzyme is the major detoxification enzyme of Schistosoma japonicum, a pathogenic helminth causing schistosomiasis
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?
additional information
?
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the enzyme is the major detoxification enzyme of Schistosoma japonicum, a pathogenic helminth causing schistosomiasis
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?
additional information
?
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no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
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?
additional information
?
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GST as fusion expression partner enhances the solubility of recombinant proteins
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?
additional information
?
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?
additional information
?
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enzyme has glutathione-dependent dehydroascorbate reductase and thiol transferase activity
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?
additional information
?
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bromosulphthalein and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates
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?
additional information
?
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-
bacterial enzyme represents a defence against the effects of antibiotics
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?
additional information
?
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bacterial enzyme represents a defence against the effects of antibiotics
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?
additional information
?
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no activity towards hydrogen peroxide, bromosulfophthalein, and 1,2-dichloro-4-nitrobenzene
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?
additional information
?
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no activity with bromosulphathalein, 1,2-dichloro-4-nitrobenzene, t-butyl hydroperoxide, and linoleic hydroperoxide
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?
additional information
?
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-
structure-function study of glutathione transferase-like proteins, overview
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?
additional information
?
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no activity with 4-nitrobenzyl chloride, 4-nitrophenethyl bromide, 4-hydroxynonenal, 4-nitrophenyl acetate, and H2O2
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additional information
?
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?
additional information
?
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specificity
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?
additional information
?
-
the enzyme is active with cumene hydroperoxide. The GST A1-1 catalytic activity in steroid isomerization reactions is at least 10fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene is approximately 8fold higher. Differences in the H-site residues of mammalian Alpha-class GSTs may explain the catalytic divergence
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?
additional information
?
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the enzyme is active with cumene hydroperoxide. The GST A1-1 catalytic activity in steroid isomerization reactions is at least 10fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene is approximately 8fold higher. Differences in the H-site residues of mammalian Alpha-class GSTs may explain the catalytic divergence
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?
additional information
?
-
the enzyme is active with cumene hydroperoxide. The GST A1-1 catalytic activity in steroid isomerization reactions is at least 10fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene is approximately 8fold higher. Differences in the H-site residues of mammalian Alpha-class GSTs may explain the catalytic divergence
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?
additional information
?
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-
no activity with 1,2-dichloro-4-nitrobenzene, iodomethane, 1-iodopenthane, H2O2, trans-2-nonenal, and dichloromethane
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-
?
additional information
?
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-
the enzyme plays an important role in detoxification of many substances including organic pollutants and plant secondary metabolites
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?
additional information
?
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-
bromosulfophthalein, 1,2-epoxy-3-(4-nitrophenoxy) propane and ethacrynic acid do not act as substrates
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-
-
additional information
?
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-
no activity with either bromosulfophthalein, ethacrynic acid, 1,2-epoxy-3-(p-nitrophenoxy)propane, cumene hydroperoxide or hydrogen peroxide
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-
?
additional information
?
-
no activity detected with ethacrynic acid, cumene hydroperoxide, and H2O2
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-
?
additional information
?
-
-
no activity detected with ethacrynic acid, cumene hydroperoxide, and H2O2
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-
?
additional information
?
-
no activity with 1,2-epoxy-3-(p-nitrophenoxy)-propane and bromosulfophthalein
-
-
?
additional information
?
-
-
no activity with 1,2-epoxy-3-(p-nitrophenoxy)-propane and bromosulfophthalein
-
-
?
additional information
?
-
no detectable activity with 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
?
additional information
?
-
Thermosynechococcus vestitus
no activity with 1,2-dichloro-4-nitrobenzene, iodomethane, 1-iodopenthane, and dichloromethane
-
-
?
additional information
?
-
-
specificity
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-
?
additional information
?
-
-
no substrate: bromosulfophthalein
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-
?
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
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-
?
additional information
?
-
-
no substrate: 4-nitropyridine N-oxide
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-
?
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
?
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, hexa-2,4-dienal, and bromosulphthalein
-
-
?