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Literature summary for 2.5.1.18 extracted from

  • Dirr, H.; Reinemer, P.; Huber, R.
    X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function (1994), Eur. J. Biochem., 220, 645-661.
    View publication on PubMed
Search for more literature for 2.5.1.18

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with glutathione or its analogues Mammalia
hanging drop vapor diffusion method Schistosoma mansoni

Protein Variants

Protein Variants Comment Organism
T13A reduced hydrogen bonding strength to the glutathione's sulfur and decreased stability of the thiolate anion Mammalia
T13V reduced hydrogen bonding strength to the glutathione's sulfur and decreased stability of the thiolate anion Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mammalia 5829
-
microsome
-
 Mammalia
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RX + glutathione Schistosoma mansoni
-
 HX + R-S-glutathione
-
 ?
RX + glutathione Mammalia phase II detoxification mechanism, isomerization of 3-ketosteroids and biosynthesis of peptide leukotrienes HX + R-S-glutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
 cytosolic enzymes, referred to as alpha, mu, pi and theta, and microsomal enzyme
-
Schistosoma mansoni
-
-
-

Reaction

Reaction Comment Organism Reaction ID
RX + glutathione = HX + R-S-glutathione kinetic mechanism Mammalia
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Schistosoma mansoni ?
-
 ?
additional information catalyzes S-conjugation between the thiol group of glutathione and an electrophilic moiety in the hydrophobic and toxic sustrate Mammalia ?
-
 ?
RX + glutathione
-
 Schistosoma mansoni HX + R-S-glutathione
-
 ?
RX + glutathione phase II detoxification mechanism, isomerization of 3-ketosteroids and biosynthesis of peptide leukotrienes Mammalia HX + R-S-glutathione
-
 ?

Subunits

Subunits Comment Organism
dimer pi and theta class enzymes are homodimers, alpha and mu class enzymes can be homo- or heterodimeric Mammalia