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2.5.1.18: glutathione transferase

This is an abbreviated version!
For detailed information about glutathione transferase, go to the full flat file.

Word Map on EC 2.5.1.18

Reaction

RX
+
glutathione
=
HX
 +
R-S-glutathione

Synonyms

2-hydroxychromene-2-carboxylic acid isomerase, 26GST, adGSTD4-4, agGSTe2, allergen Der p 2, allergen Der p 8, alpha class glutathione transferase, Alpha class GST, alpha GST, alpha-class glutathione transferase, asGST5.5, AtGSTF2, AtuGSTH1-1, BaeAB, beta-etherase, bmGSTD, BphK, CgGSTM1, CgGSTM2, cGST, Chi class GST, Chi GST, class mu glutathione S-transferase, delta class glutathione transferase, delta-class glutathione S-transferase, Delta-class glutathione transferase, EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14, EC 4.4.1.7, EGST, epsilon class GST, Epsilon glutathione S-transferase, Epsilon glutathione transferase, Epsilon GST, epsilon-class glutathione S-transferase, epsilon-class glutathione transferase, GHR, glutathione S-alkyl transferase, glutathione S-aralkyltransferase, glutathione S-aryltransferase, glutathione S-transferase, glutathione S-transferase 2, glutathione S-transferase A1-1, glutathione S-transferase A3-3, glutathione S-transferase AdFSTD3-3, glutathione S-transferase I, glutathione S-transferase omega 1, glutathione S-transferase omega 2, glutathione S-transferase P1-1, glutathione S-transferase pi, glutathione S-transferase Pi-1, glutathione S-transferase X, glutathione transferase, glutathione transferase A1-1, glutathione transferase A4-4, glutathione transferase M1-1, glutathione transferase M2-2, glutathione transferase Omega 3S, glutathione transferase omega-1, glutathione transferase P1-1, glutathione transferase Pi, glutathione transferase T1-1, glutathione transferase zeta, glutathione transferase zeta 1, glutathione transferase Zeta 1-1, glutathione transferase zeta1-1, glutathione transferase-like protein, glutathione-S-transferas, glutathione-S-transferase, glutathione-S-transferase pi, glutathione-transferase, GmGSTU4-4, GSH S-transferase, GSH transferase, GSH transferase homologue, GSH-S transferase rho, GSHTase-P, GST, GST A1-1, GST A2-2, GST A3-3, GST A4-4, GST adgstD4-4, GST alpha, GST Delta 2, GST I, GST II, GST III, GST IV, GST M1-1, GST M2-2, GST M4-4, GST M5-5, GST mu, GST O1-1, GST P1-1, GST pi, GST T1-1, GST Tau, GST Tau19, GST Z1-1, GST-1, GST-2, GST-26, GST-3, GST-Acr, GST-OCX-32, GST-T, GST-theta, GST1, GST1b, GST2, GST20, GST3, GST4, GST5, GST5118, GST7, GST83044, Gsta, GSTA1, GSTA1-1, GSTA2-2, GSTA3, GSTA3-3, GSTA4, GSTA4-4, GSTA4L, GSTA5, GSTA5-5, GSTalpha1, GSTD, GSTD1, GSTD10, GSTd14, GSTD2, GSTD4, GSTD4-4, GSTE1, GSTE2, GSTE3, GSTE4, GSTE5, GSTE6, GSTE7, GSTE8, GSTF12-1, GSTF12-2, GSTF3, GSTF5, GSTF9, GSTFuA1, GSTk, GSTK1, GSTL1, GSTL2, GSTL3, Gstm, GSTm09, GSTM1, GSTM1-1, GSTM2, GSTM2-2, GSTM3, GSTM3-3, GSTM4, GSTM4-4, GSTM5, GSTM5-5, GSTmu, GSTO, GSTO1, GSTO1-1, GSTO2, GSTO2-2, GstO2A, GstO2B, GSTO3, GSTO3S, GSTO4, GSTO7, GSTP, GSTP 1-1, GSTP-1, GSTP1, GSTP1-1, Gstr1, GSTrho, GSTS, GSTS1, GSTS1-1, GSTS2, GSTS3, GSTT, GSTT1, GSTT1-1, Gstt1a, GSTT2, GSTT2-2, GSTT2B-2B, GSTT4, GSTT4L, GSTU1, GSTU10, GSTU10-10, GSTU11, GSTU12, GSTU13, GSTU13-1, GSTU14, GSTU16, GSTU17, GSTU18, GSTU19, GSTU2, GSTU2-2, GSTU21, GSTU24, GSTU24-1, GSTU25, GSTU26, GSTU28, GSTU3, GSTU4, GSTU45, GSTU5, GSTU6, GSTU7, GSTU8, GSTU9, GSTZ, Gstz1, GSTZ1-1, GTT1.2, HCCA isomerase, Hematopoietic prostaglandin D synthase, hGSTA-3, hGSTA1-1, hGSTZ1-1, kappa class glutathione transferase, kappa class GSH transferase, Kappa class GST, KKSG9, lambda glutathione transferase, MAAI, MGST1, MGST2, MGST3, Mgst3a, Mgst3b, microsomal glutathione transferase 1, microsomal glutathione transferase-1, More, mtMGST1, mu class glutathione S-transferase, Mu class GST, mu glutathione transferase, Mu GST, mu-class glutathione S-transferase, mu-class glutathione S-transferase1, Mu-class GST, Mu-GST, nu-class glutathione transferase, Omega class GST, omega glutathione S-transferase, omega glutathione transferase, omega-class glutathione S-transferase, omega-class glutathione S-transferase 2, pGSTA1, phi class glutathione transferase, Pi class GST, pm-GSTR1, PmGST, PtGSTU1, PvGSTF1-1, PvGSTU2-2, PvGSTU3-3, rho class glutathione S-transferase, rho-GST, RX: glutathione R-transferase, RX:glutathione R-transferase, S-(hydroxyalkyl)glutathione lyase, Saro_2873/Saro_2872, selenium-containing glutathione transferase zeta1-1, seleno-hGSTZ1-1, SGST26.5, sigma class glutathione transferase, Sigma class GST, sigma glutathione S-transferase, sigma-class glutathione S-transferase, sigma-class GST, SIGST, Sj26GST, sjGST, sll1545, ssGST3, ssGST5, tau class glutathione S-transferase, tau class glutathione transferase, tau class GST, tau class GSTU4-4, TDR1, theta class glutathione S-transferase, theta class glutathione transferase T1-1, theta class GST, theta-class glutathione transferase, thiol-dependent reductase I, Ure2p mutant A122C, Ure2pB1, Xi class glutathione transferase, Ya-GST, YghU, zeta class glutathione S-transferase, Zeta class GST

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.18 glutathione transferase

Cloned

Cloned on EC 2.5.1.18 - glutathione transferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
79 genes encoding GSTs, DNA and amino acid sequence determination and analysis, sequence compariosns and phylogenetic analysis, detailed overview
-
a synthetic GST gene based on the wild type amino acid sequence, changing the second residue to an isoleucine, is overexpressed in Escherichia coli strain BL21 to obtain GST as a soluble protein
co-expression of HA-tagged GST P1 with Flag-tagged DELTAMEKK1 in HEK-293 cells, the overexpression of isozyme GST P1 leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview
-
constitutive gst gene, expression of the enzyme as fusion protein with the full-length intracellular domain of the human insulin receptor, i.e. GST-IRK, comprising the coding region of IRK, residues Val966–Lys1271, C969S, Y972F, and containing a thrombin-cleavage site as a linker between GSTand IRK, in Spodoptera frugiperda Sf9 cells
construction of large libraries of isozyme GST T1-1 constructed by error prone PCR, DNA shuffling, saturation mutagenesis, or a random mutagenesis in conjunction with homologous recombination, screening for improved catalytic activity towards CMAC in a quantitative fashion using flow cytometry, up to a 20000fold increase in kcat/KM compared to wild-type GSTT1-1 is achieved, residue Trp234 is important, overview, recombinant expression of wild-type and mutants as His6-tagged enzymes
correlation of expression of GST family members with alterations in the transcription of other genes, expression patterns, overview
-
Der p 8, DNA and amino acid sequence determination and analysis, expression of Der p 8 in Pichia pastoris srain GS115
-
DNA and amino acid sequence determination and analysis, expression analysis
DNA and amino acid sequence determination and analysis, expression of the His-tagged enzyme in Escherichia coli strain DH5alpha
-
DNA and amino acid sequence determination and analysis, phylogenetic analysis
DNA and amino acid sequence determination and analysis, recombinant expression in Escherichia coli strain BL21 (DE3)
-
EgGST, expression of the cytosolic isozyme in Escherichia coli strain BL21(DE3)
-
enzyme form GSTR1
expressed as His6-tagged protein in Escherichia coli BL21(DE3) cells
Q2G4B4; Q2G4B5
expressed as His6-tagged protein in Haloferax volcanii strain H1325
expressed in Escherichia coli
expressed in Escherichia coli as fusion protein GST-OCX-32
expressed in Escherichia coli BL-21(DE3) cells
-
expressed in Escherichia coli BL21 (DE3) cells
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli BL21 Gold (DE3) cells
expressed in Escherichia coli BL21 Silex cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3)-pLysS cells
expressed in Escherichia coli BL21(DE3)pLysS cells
expressed in Escherichia coli BL21(DE3)pLysSL cells
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
-
expressed in Escherichia coli ER2523 cells
expressed in Escherichia coli K12 (Tb1) cells as soluble fusion protein
expressed in Escherichia coli M15 cells
expressed in Escherichia coli Rosetta (DE3) cells
-
expressed in Escherichia coli Rosetta (DE3) pLysS cells
expressed in Escherichia coli Rosetta2 (DE3) pLysS cells
expressed in Escherichia coli Rosetta2(DE3)pLysS cells
expressed in Escherichia coli Rosettagami B (DE3) cells
expressed in Escherichia coli strain C41
expressed in Escherichia coli strain JM105
expressed in Escherichia coli strain Origami (DE3)
expressed in Escherichia coli strain XL1-Blue
expressed in Escherichia coli XL-1 Blue cells
expression in Escherichia coli
expression in Escherichia coli strain BL21(DE3)
-
expression of GST2 in Escherichia coli
-
expression of GSTU21 in Escherichia coli, functional co-expression of the enzyme with tau class glutathione in transgenic tobacco plants, Nicotiana tabacum, which show enhanced enzyme activity and resistance to the diterpenyl herbicide fomesafen
-
expression of His-tagged enzyme in Escherichia coli
expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain XL1-Blue
-
expression of His-tagged wild-type enzyme in Escherichia coli strain XL1-Blue
-
expression of His6-tagged isozyme MdGST6B in Escherichia coli strain BL21 CodonPlus (DE3)-RIL
expression of isozyme GSTA1-1 in Escherichia coli strain BL21 (DE3)
-
expression of isozymes in Escherichia coli
-
expression of N-terminally Strep-tagged AtGSTF2 and AtGSTF3 in Escherichia coli, expression of untagged GSTF2
-
Expression of recombinant proteins with glutathione S-transferase as fusion expression partner in Escherichia coli strain BL21 (DE3).
-
expression of wild-type and mutant enzymes in Escherichia coli
-
expression of wild-type and mutant enzymes in Escherichia coli strain JM105
-
expression of wild-type and mutant enzymes in Escherichia coli strain XL1-Blue
-
expression of wild-type and mutant GST5118 in Escherichia coli strain BL21(DE3), production of the selenomethionine-substituted GST5118 in a methionine auxotroph strain BL21(DE3)Met-
expression of wild-type and mutant GSTP1-1s in Escherichia coli
expression of wild-type and mutant isozyme GST T1-1
-
expression of wild-type and mutant isozyme GSTA4-4, and of isozyme GSTA1-1GIMFhelix mutant in Escherichia coli
-
expression of wild-type and mutant N-terminally His6-tagged isozymes GST T1-1 in Escherichia coli strain XL-1 blue
-
expression of wild-type GSTA1-1 and mutants in Escherichia coli strain BL21 (DE3) pLysS
functional expression of 41 GST genes in Escherichia coli strain Tuner(DE3), phylogenetic tree, expression of theta class GSTs as GFP-fusion proteins in Nicotiana benthamiana peroxisomes via the Agrobacterium tumefaciens transfection system. Through alternative splicing, two of these GSTTs form fusions with Myb transcription factor-like domains. Examination of one of these variants showed discrete localization within the nucleus, possibly serving a role in reducing nucleic acid hydroperoxides or in signalling
gene Atu3701, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression of His-tagged wild-type and mutant AtuGSTH1-1s in Escherichia coli strain BL21 (DE3)
-
gene bphK, expression in Escherichia coli strain GJ1158
-
gene CgGSTM1, DNA and amino acid sequence determination and analysis, phylogenetic analysis
gene CgGSTM2, DNA and amino acid sequence determination and analysis, phylogenetic analysis
gene gst, DNA and amino acid sequence determination and analysis, expression of wild-type enzyme in Escherichia coli strain DH5alpha, expression of His-tagged enzyme in Escherichia coli strain M15
gene gst, DNA and amino acid sequence determination and analysis, phylogenetic tree, sequence comparisons, overexpression of soluble enzyme in Escherichia coli
gene gst-1, DNA and amino acid sequence determination and analysis, expression of His-tagged GST-1 in Pichia pastoris strain X-33
gene GSTA1, from ovary and testis, DNA and amino acid sequence determination and analysis, expression of isozyme GST A1-1 in Escherichia coli strain Rosetta(DE3)
gene GSTA1, localized at 6p12.2, phylogenetic classification of the cytosolic GSTs, overview. Expression in HepG2, GLC4 and Caco-2 cell lines
gene GSTA2, localized at 6p12.2, phylogenetic classification of the cytosolic GSTs, overview
gene GSTA3, localized at 6p12.2, phylogenetic classification of the cytosolic GSTs, overview
gene GSTA4, localized at 6p12.2, phylogenetic classification of the cytosolic GSTs, overview
gene GSTA5, localized at 6p12.2, phylogenetic classification of the cytosolic GSTs, overview
gene gstB, quantitative PCR enzyme expression analysis in wild-type and glrA-deletion DGR1 mutant strain
-
gene GSTF9, encoding a tau class isozyme, DNA and amino acid determination and analysis, genomic and phylogenetic analysis, overview, expression in Escherichia coli, expression analysis
-
gene GSTM1, localized at 1p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTM2, localized at 1p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTM3, localized at 1p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTM4, localized at 1p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTM5, localized at 1p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTO1, localized at 10q25.1, phylogenetic classification of the cytosolic GSTs, overview
gene GSTO2, localized at 10q25.1, phylogenetic classification of the cytosolic GSTs, overview
gene GSTP1, localized at 11p13.3, phylogenetic classification of the cytosolic GSTs, overview
gene GSTS1, localized at 4q22.3, phylogenetic classification of the cytosolic GSTs, overview
gene gstt1, DNA and amino acid sequence determination and analysis, expression in Escherichia coli
gene GSTT1, localized at 22q11.23, phylogenetic classification of the cytosolic GSTs, overview
gene GSTU26, encoding a phi class isozyme, DNA and amino acid determination and analysis, genomic and phylogenetic analysis, overview, expression in Escherichia coli, expression analysis
-
gene GSTZ1, localized at 14q24.3, phylogenetic classification of the cytosolic GSTs, overview
gene yghU, expression in Escherichia coli strain BL21(DE3), expression of the selenomethionine YghU derivative in Escherichia coli strain B834 DE3
-
genes GSTT2 and GSTT2B, localized at 22q11.23, phylogenetic classification of the cytosolic GSTs, overview
genes Na-gst-1, Na-gst-2, and Na-gst-3, encoding isozymes GST-1, GST-2, and GST-3, phylogenetic analysis, recombinant expression in Pichia pastoris, the recombinant isozymes all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities
GST genes, DNA and amino acid sequence analysis, phylogenetic tree, clustering of GST coding sequences, expression analysis, overview
GST sequence comparisons, overview
GSTD1 and GSTD10, genome organization and sequence comparison, expression in Escherichia coli strain BL21(DE3)pLysS
-
GSTP1-1 expression in Escherichia coli
-
GSTZ, library screening, cloning in Escherichia coli strain DH5alpha, expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
HdGSTO1 and HdGSTO2, DNA and amino acid sequence determination and analysis, expression analysis and phylogenetic analysis
-
isozyme GSTA1-1 expression in Escherichia coli strain BL21(DE3), expression of His-tagged isozymes GSTO1-1 and GSTT2-2 in Escherichia coli strain M15[pREP4]
-
isozyme GSTO, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, functional overexpression in Escherichia coli as soluble protein
isozyme GSTO2, cloning from a human fetal brain cDNA library, DNA and amino acid sequence determination and analysis, expression analysis, expression of isozyme GSTO2-EGFP fusion protein in cytoplasm of COS-7 cells and in cytoplasma and nucleus of L-02, QGY-7703 and SMMC-7721 cells, expression of His-tagged isozyme GSTO2 in Escherichia coli strain M15
isozyme SIGST, DNA and amino acid sequence determination and analysis
isozymes GST A1-1 and GST A4-4, expression in Escherichia coli strain XL-1 Blue, expression of mutant GIMFhelix in Escherichia coli strain Rosetta-gami B(DE3)
-
isozymes GSTP1-1 and GSTM2-2, expression in Escherichia coli
-
isozymes SoGST3 and SoGST6, expression in Escherichia coli strain BL21 (DE3)
-
Mu-GST, quantitative real-time PCR expression analysis, recombinant expression in Escherichia coli strain DH5alpha
mutant enzymes expressed in Escherichia coli
orf Dp7002H05, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Dp7018E11, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Dp7019C10, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Yv4019D08, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Yv4022A06, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Yv5001D03, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Yv5001F03, DNA and amino acid sequence determination and analysis, phylogenetic analysis
orf Yv5004H11, DNA and amino acid sequence determination and analysis, phylogenetic analysis
overexpression in Escherichia coli
-
overexpression of GST adgstD4-4 mutant V107A in Escherichia coli strain BL21(DE3)
-
overexpression of wild-type and mutant enzymes in Escherichia coli
-
overexpression of wild-type and mutant R15L isozyme GSTA1-1 in Escherichia coli strain BL21(DE3)
production of recombinant selenoproteins with internal selenocysteine residues in Escherichia col, introduction of a variant bacterial-type selenocysteine insertion sequence element which afforded substitution with selenocysteine for the catalytic Tyr residue in the active site of the enzyme
-
recombinant expression
-
recombinant expression of the His6-tagged isozyme GST T1-1 in Escherichia coli
-
recombinant expression of the His6-tagged wild-type and mutant isozymes GST T1-1 in Escherichia coli
-
recombinant expression of wild-type and mutannt isozymes GSTU4-4
recombinant expression of wild-type and mutants as His6-tagged enzymes
-
sequence comparisons and phylogenetic analysis
subcloning in Escherichia coli strain DH5alpha, expression in Escherichia coli strain BL21(DE3)
tau class GST gene OsGSTU17, DNA and amino acid sequence determination and analysis, overexpression of His6-tagged GSTU17 in Escherichia coli strain Bl21
the catalytically active antibody fragment ScFv2F3 is expressed in Escherichia coli
-
the Epsilon GST class in Aedes aegypti consists of eight sequentially arranged genes spanning 53645 bp on super contig 1.291, which maps to chromosome 2, quantitative RT-PCR isozyme GSTE1-GSTE8 expression analysis in different strains, overview. Overexpression of N-terminally His6-tagged Epsilon GST isozymmes GSTe1, GSTe2, GSTe8, GSTe5, and GSTe7, in Escherichia coli strain BL21 Star (DE3)
-
transient expression of His6-tagged wild-type hGSTZ1-1 and mutant seleno-hGSTZ1-1 in HEK-293T cells, expression of GSTZ1-1 in Escherichia coli strain M15
-
wild-type and mutant bmGST expression in Escherichia coli strain Rosetta (DE3)pLysS
-
wild-type and mutant enzymes
-