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Literature summary for 2.5.1.18 extracted from
- Characterization of an omega-class glutathione S-transferase from Schistosoma mansoni with glutaredoxin-like dehydroascorbate reductase and thiol transferase activities (2002), Eur. J. Biochem., 269, 5512-5521.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Schistosoma mansoni |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromosulfophthalein | - |
Schistosoma mansoni |  |
| Evan's blue | - |
Schistosoma mansoni | |
| Hematin | - |
Schistosoma mansoni | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.23 | - |
hydroxyethyldisulfide | - |
Schistosoma mansoni | |
| 0.32 | - |
glutathione | - |
Schistosoma mansoni | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RX + glutathione | Schistosoma mansoni | participates in detoxification | HX + R-S-glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Schistosoma mansoni |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1-chloro-2,4-dinitrobenzene | low activity towards the substrate | Schistosoma mansoni | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
| glutathione + ethacrynic acid | low activity towards substrate | Schistosoma mansoni | ? | - |
? | |
| glutathione + hydroxyethyldisulfide | - |
Schistosoma mansoni | ? | - |
? | |
| additional information | enzyme has glutathione-dependent dehydroascorbate reductase and thiol transferase activity | Schistosoma mansoni | ? | - |
? | |
| RX + glutathione | participates in detoxification | Schistosoma mansoni | HX + R-S-glutathione | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
phosphate buffer | Schistosoma mansoni |
| 8.7 | - |
Tris buffer | Schistosoma mansoni |
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Release 2023.1 (January 2023)
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