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Literature summary for 2.5.1.18 extracted from

  • Sanchez-Gomez, F.J.; Gayarre, J.; Avellano, M.I.; Perez-Sala, D.
    Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival (2007), Arch. Biochem. Biophys., 457, 150-159.
    View publication on PubMed
Search for more literature for 2.5.1.18

Application

Application Comment Organism
drug development the enzyme is a target for development of irreversible GST inhibitors as anticancer agents based on prostaglandins Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Prostaglandins isozyme GST P1-1 forms covalent complexes with cyclopentenone prostaglandins, i.e. cyPG 15-deoxy-DELTA12,14-PGJ2 and biotinylated 15d-PGJ2, mass spectrometry analysis, overview, irreversible inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme GST P1-1
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant glutathione-S-transferase P1-1 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens chloride + 2,4-dinitrophenyl-glutathione
-
 ?

Synonyms

Synonyms Comment Organism
glutathione-S-transferase
-
 Homo sapiens
GST
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens