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Literature summary for 2.5.1.18 extracted from
- Glutathione S-transferases (rat and human) (1981), Methods Enzymol., 77, 218-231.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | 49000 | - |
Homo sapiens |
| 45000 | 49000 | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RX + glutathione | Homo sapiens | first step in mercapturic acid synthesis | HX + R-S-glutathione | - |
? |  |
| RX + glutathione | Rattus norvegicus | first step in mercapturic acid synthesis | HX + R-S-glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| forms: alpha, beta, gamma, delta, epsilon and a species with a very low isoelectric point | Homo sapiens |
| isoenzyme A, AA, B, C and E | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.81 | - |
isoenzyme B | Rattus norvegicus |
| 2 | - |
isoenzyme C | Rattus norvegicus |
| 4.1 | - |
isoenzyme A | Rattus norvegicus |
| 14 | - |
isoenzyme AA | Rattus norvegicus |
| 16 | - |
isoenzyme beta | Homo sapiens |
| 17 | - |
isoenzyme gamma | Homo sapiens |
| 29.2 | - |
isoenzyme E | Rattus norvegicus |
| 34 | - |
isoenzyme epsilon | Homo sapiens |
| 37 | - |
isoenzyme delta | Homo sapiens |
| 66 | - |
species with very low isoelectric point from erythrocytes | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for several months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-dichloro-4-nitrobenzene | - |
Homo sapiens | ? | - |
? | |
| glutathione + 1,2-dichloro-4-nitrobenzene | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane | isoenzyme E | Rattus norvegicus | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
| additional information | any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible | Homo sapiens | ? | - |
? | |
| additional information | any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible | Rattus norvegicus | ? | - |
? | |
| RX + glutathione | first step in mercapturic acid synthesis | Homo sapiens | HX + R-S-glutathione | - |
? | |
| RX + glutathione | first step in mercapturic acid synthesis | Rattus norvegicus | HX + R-S-glutathione | - |
? | |
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