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Literature summary for 2.5.1.18 extracted from

  • Appiah-Opong, R.; Commandeur, J.N.; Istyastono, E.; Bogaards, J.J.; Vermeulen, N.P.
    Inhibition of human glutathione S-transferases by curcumin and analogues (2009), Xenobiotica, 39, 302-311.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-pentadiene-3-one curcumin derivative Homo sapiens
1,4-pentadiene-3-one curcumin derivative Rattus norvegicus
2,5-dibenzylidenecyclopentanone curcumin derivative Homo sapiens
2,5-dibenzylidenecyclopentanone curcumin derivative Rattus norvegicus
2,6-dibenzylidenecyclohexanone curcumin derivative Homo sapiens
2,6-dibenzylidenecyclohexanone curcumin derivative Rattus norvegicus
curcumin a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes Homo sapiens
curcumin
-
Rattus norvegicus
additional information construction of three series of curcumin derivatives, inhibitory potencies on GSt isozymes, overview Homo sapiens
additional information construction of three series of curcumin derivatives, inhibitory potencies on GSt isozymes, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes GSTA1-1, GSTM1-1, and GSTP1-1
-
Rattus norvegicus
-
isozymes GSTA1-1, GSTM1-1, and GSTP1-1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
Homo sapiens S-(2,4-dinitrophenyl)glutathione + HCl
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
-
Rattus norvegicus S-(2,4-dinitrophenyl)glutathione + HCl
-
?
additional information quantitative structure-activity relationship analyses, overview Homo sapiens ?
-
?
additional information quantitative structure-activity relationship analyses, overview Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
More quantitative structure-activity relationship analyses, calculation, overview Homo sapiens
More quantitative structure-activity relationship analyses, calculation, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
glutathione S-transferase
-
Homo sapiens
glutathione S-transferase
-
Rattus norvegicus
GST
-
Homo sapiens
GST
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
24
-
assay at Rattus norvegicus
24
-
aasay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Rattus norvegicus
6.5
-
aasay at Homo sapiens

General Information

General Information Comment Organism
physiological function GSTs are important phase II drug-metabolizing enzymes that play a major role in protecting cells from the toxic insults of electrophilic compounds Homo sapiens