Reference on EC 2.7.11.26 - tau-protein kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lepage, T.; Gache, C.
Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo
EMBO J.
9
3003-3012
1990
Rattus norvegicus (P18265)
Theologis, A.; Ecker, J.R.; Palm, C.J.; et al.
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana
Nature
408
816-820
2000
Arabidopsis thaliana (Q39010), Arabidopsis thaliana (Q39012), Arabidopsis thaliana (Q39019)
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P18431)
Tabata, S.; Kaneko, T.; Nakamura, Y.; Kotani, H.; Kato, T.; et al.
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana
Nature
408
823-826
2000
Arabidopsis thaliana (P43288)
Ishiguro, K.; Takamatsu, M.; Tomizawa, K.; Omori, A.; Takahashi, M.; Arioka, M.; Uchida, T.; Imahori, K.
Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments
J. Biol. Chem.
267
10897-10901
1992
Bos taurus
Delcommenne, M.; Tan, C.; Gray, V.; Rue, L.; Woodgett, J.; Dedhar, S.
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Proc. Natl. Acad. Sci. USA
95
11211-11216
1998
Homo sapiens (P49841)
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (Q10452)
Mayer, K.; Schuller, C.; Wambutt, R.; Murphy, G.; et al.
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Nature
402
769-777
1999
Arabidopsis thaliana (Q39011), Arabidopsis thaliana (Q96287)
Salanoubat, M.; Lemcke, K.; Rieger, M.; Ansorge, W.; Unseld, M.; et al.
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana
Nature
408
820-822
2000
Arabidopsis thaliana (O23145), Arabidopsis thaliana (P43289)
Benos, P.V.; Gatt, M.K.; Ashburner, M.; Murphy, L.; Harris, D.; et al.
From sequence to chromosome: the tip of the X chromosome of D. melanogaster
Science
287
2220-2222
2000
Drosophila melanogaster (P18431)
Bourouis, M.; Moore, P.; Ruel, L.; Grau, Y.; Heitzler, P.; Simpson, P.
An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily
EMBO J.
9
2877-2884
1990
Drosophila melanogaster (P18431)
Hughes, K.; Nikolakaki, E.; Plyte, S.E.; Totty, N.F.; Woodgett, J.R.
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
EMBO J.
12
803-808
1993
Rattus norvegicus (P18265), Rattus norvegicus (P18266), Drosophila melanogaster (P18431), Drosophila melanogaster
Ishiguro, K.; Shiratsuchi, A.; Sato, S.; Omori, A.; Arioka, M.; Kobayashi, S.; Uchida, T.; Imahori, K.
Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments
FEBS Lett.
325
167-172
1993
Rattus norvegicus (P18266)
Lau, K.F.; Miller, C.C.; Anderton, B.H.; Shaw, P.C.
Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter
Genomics
60
121-128
1999
Homo sapiens (P49841)
Peifer, M.; Pai, L.M.; Casey, M.
Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase
Dev. Biol.
166
543-556
1994
Drosophila melanogaster (P18431)
Rhoads, A.R.; Karkera, J.D.; Detera-Wadleigh, S.D.
Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway
Mol. Psychiatry
4
437-442
1999
Homo sapiens (P49841)
Ruel, L.; Pantesco, V.; Lutz, Y.; Simpson, P.; Bourouis, M.
Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila
EMBO J.
12
1657-1669
1993
Drosophila melanogaster (P18431)
Siegfried, E.; Perkins, L.A.; Capaci, T.M.; Perrimon, N.
Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3
Nature
345
825-829
1990
Drosophila melanogaster (P18431)
Siegfried, E.; Chou, T.B.; Perrimon, N.
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
Cell
71
1167-1179
1992
Drosophila melanogaster (P18431)
Stambolic, V.; Woodgett, J.R.
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation
Biochem. J.
303
701-704
1994
Homo sapiens (P49841)
Woodgett, J.R.
Molecular cloning and expression of glycogen synthase kinase-3/factor A
EMBO J.
9
2431-2438
1990
Rattus norvegicus (P18266)
Tichtinsky, G.; Tavares, R.; Takvorian, A.; Schwebel-Dugue, N.; Twell, D.; Kreis, M.
An evolutionary conserved group of plant GSK-3/shaggy-like protein kinase genes preferentially expressed in developing pollen
Biochim. Biophys. Acta
1442
261-273
1998
Brassica napus (O04160), Brassica napus, Arabidopsis thaliana (O23145), Arabidopsis thaliana
Tavares, R.; Aubourg, S.; Lecharny, A.; Kreis, M.
Organization and structural evolution of four multigene families in Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2
Plant Mol. Biol.
42
703-717
2000
Arabidopsis thaliana (O23145)
Maurer, K.C.; Urbanus, J.H.; Planta, R.J.
Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene
Yeast
11
1303-1310
1995
Saccharomyces cerevisiae (P21965)
Maftahi, M.; Nicaud, J.M.; Levesque, H.; Gaillardin, C.
Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames
Yeast
11
1077-1085
1995
Saccharomyces cerevisiae (P21965)
Shero, J.H.; Hieter, P.
A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1)
Genes Dev.
5
549-560
1991
Saccharomyces cerevisiae (P21965)
Neigeborn, L.; Mitchell, A.P.
The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression
Genes Dev.
5
533-548
1991
Saccharomyces cerevisiae (P21965)
Dailey, D.; Schieven, G.L.; Lim, M.Y.; Marquardt, H.; Gilmore, T.; Thorner, J.; Martin, G.S.
Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity
Mol. Cell. Biol.
10
6244-6256
1990
Saccharomyces cerevisiae (P21965)
Zhan, X.L.; Hong, Y.; Zhu, T.; Mitchell, A.P.; Deschenes, R.J.; Guan, K.L.
Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation
Mol. Biol. Cell
11
663-676
2000
Saccharomyces cerevisiae (P38615)
Puziss, J.W.; Hardy, T.A.; Johnson, R.B.; Roach, P.J.; Hieter, P.
MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3
Mol. Cell. Biol.
14
831-839
1994
Saccharomyces cerevisiae (P38615)
Bowdish, K.S.; Yuan, H.E.; Mitchell, A.P.
Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1
Mol. Cell. Biol.
14
7909-7919
1994
Saccharomyces cerevisiae (P38615)
Bianchi, M.W.; Plyte, S.E.; Kreis, M.; Woodgett, J.R.
A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product
Gene
134
51-56
1993
Saccharomyces cerevisiae (P38615)
Bianchi, M.W.; Guivarc'h, D.; Thomas, M.; Woodgett, J.R.; Kreis, M.
Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli
Mol. Gen. Genet.
242
337-345
1994
Arabidopsis thaliana (P43288), Arabidopsis thaliana (P43289)
Dornelas, M.C.; Lejeune, B.; Dron, M.; Kreis, M.
The Arabidopsis SHAGGY-related protein kinase (ASK) gene family: structure, organization and evolution
Gene
212
249-257
1998
Arabidopsis thaliana (P43289), Arabidopsis thaliana (Q39011), Arabidopsis thaliana (Q96287)
Hardy, T.A.; Wu, D.; Roach, P.J.
Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy
Biochem. Biophys. Res. Commun.
208
728-734
1995
Saccharomyces cerevisiae (P50873)
Harwood, A.J.; Plyte, S.E.; Woodgett, J.; Strutt, H.; Kay, R.R.
Glycogen synthase kinase 3 regulates cell fate in Dictyostelium
Cell
80
139-148
1995
Dictyostelium discoideum (P51136)
Pay, A.; Jonak, C.; Bogre, L.; Meskiene, I.; Mairinger, T.; Szalay, A.; Heberle-Bors, E.; Hirt, H.
The MsK family of alfalfa protein kinase genes encodes homologues of shaggy/glycogen synthase kinase-3 and shows differential expression patterns in plant organs and development
Plant J.
3
847-856
1993
Medicago sativa (P51137), Medicago sativa (P51138), Medicago sativa (P51139)
Plyte, S.E.; Feoktistova, A.; Burke, J.D.; Woodgett, J.R.; Gould, K.L.
Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant
Mol. Cell. Biol.
16
179-191
1996
Schizosaccharomyces pombe (Q10452), Schizosaccharomyces pombe
Lin, X.; Kaul, S.; Rounsley, S.; Shea, T.P.; Benito, M.I.; Town, C.D.; Fujii, C.Y.; Mason, T.; Bowman, C.L.; Barnstead, M.; Feldblyum, T.V.; Buell, C.R.; Ketchum, K.A.; Lee, J.; Ronning, C.M.; Koo, H.L.; Moffat, K.S.; Cronin, L.A.; Shen, M.; Pai, G.; Van Aken, S.; Umayam, L.; Tallon, L.J.; Gill, J.E.; Venter, J.C.; et al.
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana
Nature
402
761-768
1999
Arabidopsis thaliana (Q39010)
Jonak, C.; Heberle-Bors, E.; Hirt, H.
Inflorescence-specific expression of AtK-1, a novel Arabidopsis thaliana homologue of shaggy/glycogen synthase kinase-3
Plant Mol. Biol.
27
217-221
1995
Arabidopsis thaliana (Q39019), Arabidopsis thaliana
Einzenberger, E.; Eller, N.; Heberle-Bors, E.; Vicente, O.
Isolation and expression during pollen development of a tobacco cDNA clone encoding a protein kinase homologous to shaggy/glycogen synthase kinase-3
Biochim. Biophys. Acta
1260
315-319
1995
Nicotiana tabacum (Q40518), Nicotiana tabacum
Ali, A.; Hoeflich, K.P.; Woodgett, J.R.
Glycogen synthase kinase-3: properties, functions, and regulation
Chem. Rev.
101
2527-2540
2001
Homo sapiens (P49841)
Ishiguro, K.; Ihara, Y.; Uchida, T.; Imahori, K.
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau
J. Biochem.
104
319-321
1988
Rattus norvegicus
Bush, M.L.; Miyashiro, J.S.; Ingram, V.M.
Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells
Proc. Natl. Acad. Sci. USA
92
1861-1865
1995
Rattus norvegicus
Song, J.S.; Yang, S.D.
tau Protein kinase I/GSK-3b/kinase FA in heparin phosphorylates Tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain
J. Protein Chem.
14
95-105
1995
Homo sapiens
Takahashi, M.; Tomizawa, K.; Ishiguro, K.; Takamatsu, M.; Fujita, S.C.; Imahori, K.
Involvement of tau protein kinase I in paired helical filament-like phosphorylation of the juvenile tau in rat brain
J. Neurochem.
64
1759-1768
1995
Rattus norvegicus, Rattus norvegicus Wistar
Takahashi, M.; Tomizawa, K.; Sato, K.; Ohtake, A.; Omori, A.
A novel tau-tubulin kinase from bovine brain
FEBS Lett.
372
59-64
1995
Bos taurus
Hoshi, M.; Takashima, A.; Noguchi, K.; Murayama, M.; Sato, M.; Kondo, S.; Saitoh, Y.; Ishiguro, K.; Hoshino, T.; Imahori, K.
Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain
Proc. Natl. Acad. Sci. USA
93
2719-2723
1996
Homo sapiens, Rattus norvegicus
Imahori, K.; Uchida, T.
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease
J. Biochem.
121
179-188
1997
Homo sapiens, Rattus norvegicus
Alvarez, A.; Toro, R.; Caceres, A.; Maccioni, R.B.
Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death
FEBS Lett.
459
421-426
1999
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Aoki, M.; Iwamoto-Sugai, M.; Sugiura, I.; Sasaki, C.; Hasegawa, T.; Okumura, C.; Sugio, S.; Kohno, T.; Matsuzaki, T.
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta
Acta Crystallogr. Sect. D
56
1464-1465
2000
Homo sapiens
Evans, D.B.; Rank, K.B.; Bhattacharya, K.; Thomsen, D.R.; Gurney, M.E.; Sharma, S.K.
tau Phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly
J. Biol. Chem.
275
24977-24983
2000
Homo sapiens
Lund, E.T.; McKenna, R.; Evans, D.B.; Sharma, S.K.; Mathews, W.R.
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry
J. Neurochem.
76
1221-1232
2001
Homo sapiens
Tomizawa, K.; Omori, A.; Ohtake, A.; Sato, K.; Takahashi, M.
tau-Tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau
FEBS Lett.
492
221-227
2001
Bos taurus, Mus musculus, Mus musculus (Q3UVR3), Rattus norvegicus, Rattus norvegicus Wistar
Mukai, F.; Ishiguro, K.; Sano, Y.; Fujita, S.C.
Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta
J. Neurochem.
81
1073-1083
2002
Homo sapiens, Mus musculus, Rattus norvegicus
Rank, K.B.; Pauley, A.M.; Bhattacharya, K.; Wang, Z.; Evans, D.B.; Fleck, T.J.; Johnston, J.A.; Sharma, S.K.
Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II
FEBS Lett.
514
263-268
2002
Homo sapiens
Aoki, M.; Yokota, T.; Sugiura, I.; Sasaki, C.; Hasegawa, T.; Okumura, C.; Ishiguro, K.; Kohno, T.; Sugio, S.; Matsuzaki, T.
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta
Acta Crystallogr. Sect. D
60
439-446
2004
Homo sapiens
Okawa, Y.; Ishiguro, K.; Fujita, S.C.
Stress-induced hyperphosphorylation of tau in the mouse brain
FEBS Lett.
535
183-189
2003
Mus musculus
Takahashi, S.; Saito, T.; Hisanaga, S.; Pant, H.C.; Kulkarni, A.B.
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
J. Biol. Chem.
278
10506-10515
2003
Mus musculus
Agarwal-Mawal, A.; Qureshi, H.Y.; Cafferty, P.W.; Yuan, Z.; Han, D.; Lin, R.; Paudel, H.K.
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex
J. Biol. Chem.
278
12722-12728
2003
Bos taurus
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
J. Biol. Chem.
278
187-193
2003
Homo sapiens
Hamdane, M.; Sambo, A.V.; Delobel, P.; Begard, S.; Violleau, A.; Delacourte, A.; Bertrand, P.; Benavides, J.; Buee, L.
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex
J. Biol. Chem.
278
34026-34034
2003
Homo sapiens
Hernandez, F.; Perez, M.; Lucas, J.J.; Mata, A.M.; Bhat, R.; Avila, J.
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease
J. Biol. Chem.
279
3801-3806
2004
Homo sapiens
Harris, F.M.; Brecht, W.J.; Xu, Q.; Mahley, R.W.; Huang, Y.
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
J. Biol. Chem.
279
44795-44801
2004
Mus musculus
Liu, S.J.; Zhang, J.Y.; Li, H.L.; Fang, Z.Y.; Wang, Q.; Deng, H.M.; Gong, C.X.; Grundke-Iqbal, I.; Iqbal, K.; Wang, J.Z.
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
J. Biol. Chem.
279
50078-50088
2004
Rattus norvegicus
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ
J. Biol. Chem.
279
54716-54723
2004
Homo sapiens
Stoothoff, W.H.; Cho, J.H.; McDonald, R.P.; Johnson, G.V.
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation
J. Biol. Chem.
280
270-276
2005
Homo sapiens
Li, X.; Lu, F.; Tian, Q.; Yang, Y.; Wang, Q.; Wang, J.Z.
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture
J. Neural Transm.
113
93-102
2006
Rattus norvegicus
Zhang, Y.; Li, H.L.; Wang, D.L.; Liu, S.J.; Wang, J.Z.
A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology
J. Neural Transm.
2
1-11
2006
Homo sapiens
Darios, F.; Muriel, M.P.; Khondiker, M.E.; Brice, A.; Ruberg, M.
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau
J. Neurosci.
25
4159-4168
2005
Rattus norvegicus
Shelton, S.B.; Krishnamurthy, P.; Johnson, G.V.
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells
J. Neurosci. Res.
76
110-120
2004
Mus musculus
Ma, Q.L.; Lim, G.P.; Harris-White, M.E.; Yang, F.; Ambegaokar, S.S.; Ubeda, O.J.; Glabe, C.G.; Teter, B.; Frautschy, S.A.; Cole, G.M.
Antibodies against beta-amyloid reduce abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
J. Neurosci. Res.
83
374-384
2006
Homo sapiens, Mus musculus
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Chun, J.; Kwon, T.; Lee, E.J.; Kim, C.H.; Han, Y.S.; Hong, S.K.; Hyun, S.; Kang, S.S.
14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1
Mol. Cells
18
360-368
2004
Homo sapiens
Hanger, D.P.; Byers, H.L.; Wray, S.; Leung, K.Y.; Saxton, M.J.; Seereeram, A.; Reynolds, C.H.; Ward, M.A.; Anderton, B.H.
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
J. Biol. Chem.
282
23645-23654
2007
Homo sapiens
Kitano-Takahashi, M.; Morita, H.; Kondo, S.; Tomizawa, K.; Kato, R.; Tanio, M.; Shirota, Y.; Takahashi, H.; Sugio, S.; Kohno, T.
Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein
Acta Crystallogr. Sect. F
63
602-604
2007
Homo sapiens
Li, T.; Paudel, H.K.
Glycogen synthase kinase 3beta phosphorylates Alzheimers disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism
Biochemistry
45
3125-3133
2006
Bos taurus
Guerra-Araiza, C.; Amorim, M.A.; Camacho-Arroyo, I.; Garcia-Segura, L.M.
Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum
Dev. Neurobiol.
67
510-520
2007
Rattus norvegicus
Ikeda, Y.; Ishiguro, K.; Fujita, S.C.
Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain
FEBS Lett.
581
891-897
2007
Mus musculus
Plattner, F.; Angelo, M.; Giese, K.P.
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
J. Biol. Chem.
281
25457-25465
2006
Mus musculus
Lin, Y.T.; Cheng, J.T.; Liang, L.C.; Ko, C.Y.; Lo, Y.K.; Lu, P.J.
The binding and phosphorylation of Thr231 is critical for Taus hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta
J. Neurochem.
103
802-813
2007
Mus musculus
Sato, S.; Cerny, R.L.; Buescher, J.L.; Ikezu, T.
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation
J. Neurochem.
98
1573-1584
2006
Homo sapiens, Mus musculus
Blard, O.; Frebourg, T.; Campion, D.; Lecourtois, M.
Inhibition of proteasome and Shaggy/Glycogen synthase kinase-3beta kinase prevents clearance of phosphorylated tau in Drosophila
J. Neurosci. Res.
84
1107-1115
2006
Drosophila sp. (in: flies)
Fujio, J.; Hosono, H.; Ishiguro, K.; Ikegami, S.; Fujita, S.C.
Tau phosphorylation in the mouse brain during aversive conditioning
Neurochem. Int.
51
200-208
2007
Mus musculus, Mus musculus C57BL/6Njcl
Lebouvier, T.; Scales, T.M.; Hanger, D.P.; Geahlen, R.L.; Lardeux, B.; Reynolds, C.H.; Anderton, B.H.; Derkinderen, P.
The microtubule-associated protein tau is phosphorylated by Syk
Biochim. Biophys. Acta
1783
188-192
2008
Homo sapiens
Kotliarova, S.; Pastorino, S.; Kovell, L.C.; Kotliarov, Y.; Song, H.; Zhang, W.; Bailey, R.; Maric, D.; Zenklusen, J.C.; Lee, J.; Fine, H.A.
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation
Cancer Res.
68
6643-6651
2008
Homo sapiens
Chatterjee, S.; Sang, T.K.; Lawless, G.M.; Jackson, G.R.
Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK, and Cdk5 in a Drosophila model
Hum. Mol. Genet.
18
164-177
2008
Drosophila melanogaster
Meske, V.; Albert, F.; Ohm, T.G.
Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3-dependent phosphorylation of Tau
J. Biol. Chem.
283
100-109
2008
Mus musculus (Q9WV60)
Shi, H.R.; Zhu, L.Q.; Wang, S.H.; Liu, X.A.; Tian, Q.; Zhang, Q.; Wang, Q.; Wang, J.Z.
17beta-Estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner
J. Neural Transm.
115
879-888
2008
Mus musculus
Hu, M.; Waring, J.F.; Gopalakrishnan, M.; Li, J.
Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells
J. Neurochem.
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2008
Rattus norvegicus
Wen, Y.; Planel, E.; Herman, M.; Figueroa, H.Y.; Wang, L.; Liu, L.; Lau, L.F.; Yu, W.H.; Duff, K.E.
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
J. Neurosci.
28
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2008
Mus musculus
Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R.
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation
J. Neurosci. Res.
86
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2008
Rattus norvegicus
Mercado-Gomez, O.; Hernandez-Fonseca, K.; Villavicencio-Queijeiro, A.; Massieu, L.; Chimal-Monroy, J.; Arias, C.
Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation
Neurochem. Res.
33
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2008
Rattus norvegicus (P18266)
Yamauchi, K.; Kurosaka, A.
Expression and function of glycogen synthase kinase-3 in human hair follicles
Arch. Dermatol. Res.
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2010
Homo sapiens
Najafi, S.M.
Activators of G proteins inhibit GSK-3beta and stabilize beta-catenin in Xenopus oocytes
Biochem. Biophys. Res. Commun.
382
365-369
2009
Xenopus laevis
Suzuki, K.; Kawakami, F.; Sasaki, H.; Maruyama, H.; Ohtsuki, K.
Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain
Biochim. Biophys. Acta
1790
188-197
2009
Oryctolagus cuniculus
Boom, A.; Authelet, M.; Dedecker, R.; Frederick, C.; Van Heurck, R.; Daubie, V.; Leroy, K.; Pochet, R.; Brion, J.P.
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells
Biochim. Biophys. Acta
1793
1058-1067
2009
Homo sapiens
Kang, N.S.; Lee, G.N.; Kim, C.H.; Bae, M.A.; Kim, I.; Cho, Y.S.
Identification of small molecules that inhibit GSK-3beta through virtual screening
Bioorg. Med. Chem. Lett.
19
533-537
2009
Homo sapiens (P49841)
Saitoh, M.; Kunitomo, J.; Kimura, E.; Hayase, Y.; Kobayashi, H.; Uchiyama, N.; Kawamoto, T.; Tanaka, T.; Mol, C.D.; Dougan, D.R.; Textor, G.S.; Snell, G.P.; Itoh, F.
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg. Med. Chem.
17
2017-2029
2009
Homo sapiens (P49841)
Ye, Q.; Xu, G.; Lv, D.; Cheng, Z.; Li, J.; Hu, Y.
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3beta (GSK-3beta) inhibitors
Bioorg. Med. Chem.
17
4302-4312
2009
Homo sapiens
Martin, L.; Magnaudeix, A.; Esclaire, F.; Yardin, C.; Terro, F.
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A
Brain Res.
1252
66-75
2009
Rattus norvegicus
Lomoio, S.; Scherini, E.; Necchi, D.
beta-Amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice
Brain Res.
1297
198-206
2009
Mus musculus
Song, S.; Mazurek, N.; Liu, C.; Sun, Y.; Ding, Q.Q.; Liu, K.; Hung, M.C.; Bresalier, R.S.
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity
Cancer Res.
69
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2009
Homo sapiens
Kandasamy, A.D.; Schulz, R.
Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts
Cardiovasc. Res.
83
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2009
Rattus norvegicus
Miura, T.; Miki, T.
GSK-3beta, a therapeutic target for cardiomyocyte protection
Circ. J.
73
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2009
Rattus norvegicus
Collino, M.; Aragno, M.; Castiglia, S.; Tomasinelli, C.; Thiemermann, C.; Boccuzzi, G.; Fantozzi, R.
Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta
Diabetes
58
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2009
Rattus norvegicus
Koh, S.H.; Kim, S.H.; Kim, H.T.
Role of glycogen synthase kinase-3 in L-DOPA-induced neurotoxicity
Expert. Opin. Drug Metab. Toxicol.
5
1359-1368
2009
Homo sapiens
Sluchanko, N.N.; Seit-Nebi, A.S.; Gusev, N.B.
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta
FEBS Lett.
583
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2009
Mus musculus
Park, H.J.; Kim, H.J.; Bae, G.S.; Seo, S.W.; Kim, D.Y.; Jung, W.S.; Kim, M.S.; Song, M.Y.; Kim, E.K.; Kwon, K.B.; Hwang, S.Y.; Song, H.J.; Park, C.S.; Park, R.K.; Chong, M.S.; Park, S.J.
Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells
Hear. Res.
257
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2009
Mus musculus
Crespo-Biel, N.; Camins, A.; Gutierrez-Cuesta, J.; Melchiorri, D.; Nicoletti, F.; Pallas, M.; Canudas, A.M.
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model
Hippocampus
20
962-970
2010
Mus musculus
Hong, X.P.; Peng, C.X.; Wei, W.; Tian, Q.; Liu, Y.H.; Yao, X.Q.; Zhang, Y.; Cao, F.Y.; Wang, Q.; Wang, J.Z.
Essential role of tau phosphorylation in adult hippocampal neurogenesis
Hippocampus
20
1339-1349
2010
Rattus norvegicus
Gao, H.K.; Yin, Z.; Zhang, R.Q.; Zhang, J.; Gao, F.; Wang, H.C.
GSK-3beta inhibitor modulates TLR2/NF-kappaB signaling following myocardial ischemia-reperfusion
Inflamm. Res.
58
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2009
Rattus norvegicus
Xingi, E.; Smirlis, D.; Myrianthopoulos, V.; Magiatis, P.; Grant, K.M.; Meijer, L.; Mikros, E.; Skaltsounis, A.L.; Soteriadou, K.
6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis
Int. J. Parasitol.
39
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2009
Leishmania donovani, Leishmania donovani LG13
Yotsumoto, K.; Saito, T.; Asada, A.; Oikawa, T.; Kimura, T.; Uchida, C.; Ishiguro, K.; Uchida, T.; Hasegawa, M.; Hisanaga, S.
Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau
J. Biol. Chem.
284
16840-16847
2009
Rattus norvegicus
Gimenez-Cassina, A.; Lim, F.; Cerrato, T.; Palomo, G.M.; Diaz-Nido, J.
Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3
J. Biol. Chem.
284
3001-3011
2009
Homo sapiens
Cho, J.; Rameshwar, P.; Sadoshima, J.
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells
J. Biol. Chem.
284
36647-36658
2009
Mus musculus
Wu, C.H.; Yeh, S.H.; Tsay, Y.G.; Shieh, Y.H.; Kao, C.L.; Chen, Y.S.; Wang, S.H.; Kuo, T.J.; Chen, D.S.; Chen, P.J.
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication
J. Biol. Chem.
284
5229-5239
2009
Homo sapiens
Dobocan, M.C.; Sadvakassova, G.; Congote, L.F.
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3
J. Cell. Physiol.
219
470-476
2009
Homo sapiens
Goodarzi, M.; Freitas, M.P.; Jensen, R.
Feature selection and linear/nonlinear regression methods for the accurate prediction of glycogen synthase kinase-3beta inhibitory activities
J. Chem. Inf. Model.
49
824-832
2009
Homo sapiens
Lin, J.L.; Lin, P.L.; Gu, S.H.
Phosphorylation of glycogen synthase kinase-3beta in relation to diapause processing in the silkworm, Bombyx mori
J. Insect Physiol.
55
593-598
2009
Bombyx mori
Chan, M.M.; Cheung, B.K.; Li, J.C.; Chan, L.L.; Lau, A.S.
A role for glycogen synthase kinase-3 in antagonizing mycobacterial immune evasion by negatively regulating IL-10 induction
J. Leukoc. Biol.
86
283-291
2009
Homo sapiens
Kim, K.H.; Gaisina, I.; Gallier, F.; Holzle, D.; Blond, S.Y.; Mesecar, A.; Kozikowski, A.P.
Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors
J. Mol. Model.
15
1463-1479
2009
Homo sapiens (P49841)
Cheenpracha, S.; Zhang, H.; Mar, A.M.; Foss, A.P.; Foo, S.H.; Lai, N.S.; Jee, J.M.; Seow, H.F.; Ho, C.C.; Chang, L.C.
Yeast glycogen synthase kinase-3beta pathway inhibitors from an organic extract of Streptomyces sp.
J. Nat. Prod.
72
1520-1523
2009
Homo sapiens
McCulloch, M.W.; Bugni, T.S.; Concepcion, G.P.; Coombs, G.S.; Harper, M.K.; Kaur, S.; Mangalindan, G.C.; Mutizwa, M.M.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M.
Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.
J. Nat. Prod.
72
1651-1656
2009
Oryctolagus cuniculus
van Eersel, J.; Bi, M.; Ke, Y.D.; Hodges, J.R.; Xuereb, J.H.; Gregory, G.C.; Halliday, G.M.; Goetz, J.; Kril, J.J.; Ittner, L.M.
Phosphorylation of soluble tau differs in Picks disease and Alzheimers disease brains
J. Neural Transm.
116
1243-1251
2009
Homo sapiens
Burgos-Ramos, E.; Martos-Moreno, G.A.; Lopez, M.G.; Herranz, R.; Aguado-Llera, D.; Egea, J.; Frechilla, D.; Cenarruzabeitia, E.; Leon, R.; Arilla-Ferreiro, E.; Argente, J.; Barrios, V.
The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3beta modulation
J. Neurochem.
109
360-370
2009
Rattus norvegicus
Espada, S.; Rojo, A.I.; Salinas, M.; Cuadrado, A.
The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection
J. Neurochem.
110
1107-1119
2009
Rattus norvegicus
Castano, Z.; Gordon-Weeks, P.R.; Kypta, R.M.
The neuron-specific isoform of GSK-3beta is required for axon growth
J. Neurochem.
113
117-130
2010
Homo sapiens
LaPointe, N.E.; Morfini, G.; Pigino, G.; Gaisina, I.N.; Kozikowski, A.P.; Binder, L.I.; Brady, S.T.
The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity
J. Neurosci. Res.
87
440-451
2009
Homo sapiens
Miao, Y.; Chen, J.; Zhang, Q.; Sun, A.
Deletion of tau attenuates heat shock-induced injury in cultured cortical neurons
J. Neurosci. Res.
88
102-110
2010
Mus musculus
Tackenberg, C.; Brandt, R.
Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau
J. Neurosci.
29
14439-14450
2009
Mus musculus
Miura, T.; Nishihara, M.; Miki, T.
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury
J. Pharmacol. Sci.
109
162-167
2009
Homo sapiens
Osakada, F.; Takahashi, M.
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: targeting the Wnt pathway and transplantation therapy as strategies for retinal repair
J. Pharmacol. Sci.
109
168-173
2009
Homo sapiens
Takashima, A.
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain
J. Pharmacol. Sci.
109
174-178
2009
Mus musculus
Takahashi-Yanaga, F.; Sasaguri, T.
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: Inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs
J. Pharmacol. Sci.
109
179-183
2009
Homo sapiens
Deming, D.; Geiger, P.; Chen, H.; Kunnimalaiyaan, M.; Holen, K.
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines
J. Surg. Res.
161
28-32
2009
Homo sapiens
Jahnke, H.G.; Rothermel, A.; Sternberger, I.; Mack, T.G.; Kurz, R.G.; Paenke, O.; Striggow, F.; Robitzki, A.A.
An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells
Lab Chip
9
1422-1428
2009
Homo sapiens
Sul, D.; Kim, H.S.; Lee, D.; Joo, S.S.; Hwang, K.W.; Park, S.Y.
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation
Life Sci.
84
257-262
2009
Rattus norvegicus
Wang, F.S.; Ko, J.Y.; Weng, L.H.; Yeh, D.W.; Ke, H.J.; Wu, S.L.
Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss
Life Sci.
85
685-692
2009
Mus musculus
Voss, K.; Gamblin, T.C.
GSK-3beta phosphorylation of functionally distinct tau isoforms has differential, but mild effects
Mol. Neurodegener.
4
18
2009
Homo sapiens
Manceur, A.P.; Driscoll, B.D.; Sun, W.; Audet, J.
Selective enhancement of the uptake and bioactivity of a TAT-conjugated peptide inhibitor of glycogen synthase kinase-3
Mol. Ther.
17
500-507
2009
Homo sapiens, Mus musculus
Liu, Y.H.; Wei, W.; Yin, J.; Liu, G.P.; Wang, Q.; Cao, F.Y.; Wang, J.Z.
Proteasome inhibition increases tau accumulation independent of phosphorylation
Neurobiol. Aging
30
1949-1961
2009
Rattus norvegicus
Min, W.W.; Yuskaitis, C.J.; Yan, Q.; Sikorski, C.; Chen, S.; Jope, R.S.; Bauchwitz, R.P.
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential
Neuropharmacology
56
463-472
2009
Mus musculus
Greco, S.J.; Sarkar, S.; Casadesus, G.; Zhu, X.; Smith, M.A.; Ashford, J.W.; Johnston, J.M.; Tezapsidis, N.
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells
Neurosci. Lett.
455
191-194
2009
Homo sapiens
Pajak, B.; Songin, M.; Strosznajder, J.B.; Gajkowska, B.
Alzheimers disease genetic mutation evokes ultrastructural alterations: correlation to an intracellular Abeta deposition and the level of GSK-3beta-P(Y216) phosphorylated form
Neurotoxicology
30
581-588
2009
Rattus norvegicus
Santo, L.; Vallet, S.; Hideshima, T.; Cirstea, D.; Ikeda, H.; Pozzi, S.; Patel, K.; Okawa, Y.; Gorgun, G.; Perrone, G.; Calabrese, E.; Yule, M.; Squires, M.; Ladetto, M.; Boccadoro, M.; Richardson, P.G.; Munshi, N.C.; Anderson, K.C.; Raje, N.
AT7519, a novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition
Oncogene
29
2325-2336
2010
Homo sapiens
Petit-Paitel, A.; Brau, F.; Cazareth, J.; Chabry, J.
Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons
PLoS ONE
4
e5491
2009
Mus musculus
Thompson, A.J.; Williamson, R.; Schofield, E.; Stephenson, J.; Hanger, D.; Anderton, B.
Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts
Proteomics
9
3022-3035
2009
Homo sapiens
Nehme, H.; Chantepie, S.; Defert, J.; Morin, P.; Papy-Garcia, D.; Nehme, R.
New methods based on capillary electrophoresis for in vitro evaluation of protein tau phosphorylation by glycogen synthase kinase 3-beta
Anal. Bioanal. Chem.
407
2821-2828
2015
Homo sapiens (P49841)
Ye, Q.; Li, M.; Zhou, Y.B.; Cao, J.Y.; Xu, L.; Li, Y.J.; Han, L.; Gao, J.R.; Hu, Y.Z.; Li, J.
Design, synthesis, and evaluation of 3-aryl-4-pyrrolyl-maleimides as glycogen synthase kinase-3beta inhibitors
Arch. Pharm.
346
349-358
2013
Homo sapiens (P49841)
Saeki, K.; Machida, M.; Kinoshita, Y.; Takasawa, R.; Tanuma, S.
Glycogen synthase kinase-3beta2 has lower phosphorylation activity to tau than glycogen synthase kinase-3beta1
Biol. Pharm. Bull.
34
146-149
2011
Homo sapiens (P49841)
Liao, J.C.; Yang, T.T.; Weng, R.R.; Kuo, C.T.; Chang, C.W.
TTBK2: a tau protein kinase beyond tau phosphorylation
BioMed Res. Int.
2015
575170
2015
Mus musculus (Q3UVR3), Homo sapiens (Q6IQ55)
Lund, H.; Cowburn, R.F.; Gustafsson, E.; Stroemberg, K.; Svensson, A.; Dahllund, L.; Malinowsky, D.; Sunnemark, D.
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimers disease brain
Brain Pathol.
23
378-389
2012
Homo sapiens (Q5TCY1), Homo sapiens
Majd, S.; Power, J.H.; Koblar, S.A.; Grantham, H.J.
Early glycogen synthase kinase-3beta and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway
Eur. J. Neurosci.
44
1987-1997
2016
Rattus norvegicus (P18266), Rattus norvegicus Sprague-Dawley (P18266)
Xu, J.; Sato, S.; Okuyama, S.; Swan, R.J.; Jacobsen, M.T.; Strunk, E.; Ikezu, T.
Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice
FASEB J.
24
2904-2915
2010
Homo sapiens (Q5TCY1)
Hanger, D.P.; Noble, W.
Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation
Int. J. Alzheimers Dis.
2011
352805
2011
Homo sapiens (P49841)
Kumar Dasappa, J.; Nagendra, H.G.
Preferential selectivity of inhibitors with human tau protein kinase gsk3beta elucidates their potential roles for off-target Alzheimers therapy
Int. J. Alzheimers Dis.
2013
809386
2013
Homo sapiens (P49841), Homo sapiens
Buescher, J.L.; Phiel, C.J.
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity
J. Biol. Chem.
285
7957-7963
2010
Homo sapiens (P49840), Homo sapiens (P49841)
Soutar, M.P.; Kim, W.Y.; Williamson, R.; Peggie, M.; Hastie, C.J.; McLauchlan, H.; Snider, W.D.; Gordon-Weeks, P.R.; Sutherland, C.
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain
J. Neurochem.
115
974-983
2010
Homo sapiens (P49840), Homo sapiens (P49841)
Koehler, C.; Dinekov, M.; Goetz, J.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
Neurobiol. Aging
34
1369-1379
2013
Mus musculus (Q2NL51), Mus musculus (Q9WV60), Mus musculus C57BL/6 (Q2NL51), Mus musculus C57BL/6 (Q9WV60)
Ranganadha Reddy, A.; Venkateswarulu, T.; John Babu, D.; Shyamala Devi, N.
Homology modeling, simulation and docking studies of Tau-protein kinase
Res. J. Pharm. Technol.
7
376-388
2014
Homo sapiens
-
Jiang, J.; Wang, Z.H.; Qu, M.; Gao, D.; Liu, X.P.; Zhu, L.Q.; Wang, J.Z.
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta
Sci. Rep.
5
11765
2015
Homo sapiens (P49841), Homo sapiens, Mus musculus (Q9WV60), Mus musculus
Domise, M.; Didier, S.; Marinangeli, C.; Zhao, H.; Chandakkar, P.; Buee, L.; Viollet, B.; Davies, P.; Marambaud, P.; Vingtdeux, V.
AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
Sci. Rep.
6
26758
2016
Mus musculus (Q5EG47), Mus musculus, Mus musculus C57BL6 (Q5EG47)
Qu, Z.S.; Li, L.; Sun, X.J.; Zhao, Y.W.; Zhang, J.; Geng, Z.; Fu, J.L.; Ren, Q.G.
Glycogen synthase kinase-3 regulates production of amyloid-beta peptides and tau phosphorylation in diabetic rat brain
ScientificWorldJournal
2014
878123
2014
Rattus norvegicus (P18266)
Marcotte, D.J.; Spilker, K.A.; Wen, D.; Hesson, T.; Patterson, T.A.; Kumar, P.R.; Chodaparambil, J.V.
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
Acta Crystallogr. Sect. F
76
103-108
2020
Homo sapiens (Q6IQ55), Homo sapiens
Ikezu, S.; Ingraham Dixie, K.L.; Koro, L.; Watanabe, T.; Kaibuchi, K.; Ikezu, T.
Tau-tubulin kinase 1 and amyloid-beta peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models
Acta Neuropathol. Commun.
8
12
2020
Homo sapiens (Q5TCY1), Homo sapiens
Fernius, J.; Starkenberg, A.; Pokrzywa, M.; Thor, S.
Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
Biol. Open
6
113-1023
2017
Drosophila melanogaster
Bao, C.; Bajrami, B.; Marcotte, D.J.; Chodaparambil, J.V.; Kerns, H.M.; Henderson, J.; Wei, R.; Gao, B.; Dillon, G.M.
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Cell. Mol. Neurobiol.
41
669-685
2021
Mus musculus (Q3UVR3), Mus musculus (Q6PCN3), Homo sapiens (Q5TCY1), Homo sapiens (Q6IQ55)
Nieding, K.; Matschke, V.; Meuth, S.G.; Lang, F.; Seebohm, G.; Strutz-Seebohm, N.
Tau tubulin kinase TTBK2 sensitivity of glutamate receptor GluK2
Cell. Physiol. Biochem.
39
1444-1452
2016
Homo sapiens (Q6IQ55), Homo sapiens
Nozal, V.; Martinez, A.
Tau tubulin kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases
Eur. J. Med. Chem.
161
39-47
2019
Homo sapiens (Q5TCY1)
Yao, X.; Xian, X.; Fang, M.; Fan, S.; Li, W.
Loss of miR-369 promotes tau phosphorylation by targeting the Fyn and serine/threonine-protein kinase 2 signaling pathways in Alzheimer s disease mice
Front. Aging Neurosci.
11
365
2019
Mus musculus
Qi, H.; Prabakaran, S.; Cantrelle, F.X.; Chambraud, B.; Gunawardena, J.; Lippens, G.; Landrieu, I.
Characterization of neuronal tau protein as a target of extracellular signal-regulated kinase
J. Biol. Chem.
291
7742-7753
2016
Rattus norvegicus
Jana, S.; Singh, S.K.
Identification of human tau-tubulin kinase 1 inhibitors an integrated e-pharmacophore-based virtual screening and molecular dynamics simulation
J. Biomol. Struct. Dyn.
38
886-900
2020
Homo sapiens (Q5TCY1), Homo sapiens
Cortes-Gomez, M.; Llorens-Alvarez, E.; Alom, J.; del Ser, T.; Avila, J.; Saez-Valero, J.; Garcia-Ayllon, M.
Tau phosphorylation by glycogen synthase kinase 3beta modulates enzyme acetylcholinesterase expression
J. Neurochem.
157
2091-2105
2020
Homo sapiens (P49841), Homo sapiens
Llorach-Pares, L.; Nonell-Canals, A.; Avila, C.; Sanchez-Martinez, M.
Kororamides, convolutamines, and indole derivatives as possible tau and dual-specificity kinase inhibitors for Alzheimer's disease A computational study
Mar. Drugs
16
386
2018
Homo sapiens (P48730), Homo sapiens (P49841)
Magley, R.A.; Rouhana, L.
Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms
Mol. Biol. Cell
30
2155-2170
2019
Schmidtea mediterranea
Bernatik, O.; Pejskova, P.; Vyslouzil, D.; Hanakova, K.; Zdrahal, Z.; Cajanek, L.
Phosphorylation of multiple proteins involved in ciliogenesis by tau tubulin kinase 2
Mol. Biol. Cell
31
1032-1046
2020
Homo sapiens (Q6IQ55), Homo sapiens
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