Literature summary for 2.7.11.26 extracted from

Ma, Q.L.; Lim, G.P.; Harris-White, M.E.; Yang, F.; Ambegaokar, S.S.; Ubeda, O.J.; Glabe, C.G.; Teter, B.; Frautschy, S.A.; Cole, G.M.
Antibodies against beta-amyloid reduce abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro (2006), J. Neurosci. Res., 83, 374-384.

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Activating Compound

Activating Compound	Comment	Organism	Structure
soluble beta-amyloid oligomers	activate GSK-3beta mediated tau phosphorylation and increase toxicity, reduced content of soluble, not insoluble, amyloid oligomers reduces the tau phosphorylation activity, specific antibodies can inhibit the activation, overview	Mus musculus
soluble beta-amyloid oligomers	activate GSK-3beta mediated tau phosphorylation and increase toxicity, reduced content of soluble, not insoluble, amyloid oligomers reduces the tau phosphorylation activity, specific antibodies can inhibit the activation, overview	Homo sapiens

Application

Application	Comment	Organism
pharmacology	anti-bodies highly specific for toxic amyloid oligomer subspecies may reduce toxicity via reduction of GSK-3beta amount in Alzheimer's disease therapeutic strategy	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Mus musculus
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [tau-protein]	Mus musculus	tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	Homo sapiens	tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview	ADP + O-phospho-[tau-protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	transgenic APP TG2576 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Mus musculus	-
SH-SY5Y cell	neuroblastoma cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [tau-protein]	-	Mus musculus	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	-	Homo sapiens	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview	Mus musculus	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview	Homo sapiens	ADP + O-phospho-[tau-protein]	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Mus musculus
glycogen synthase kinase-3beta	-	Homo sapiens
GSK-3beta	-	Mus musculus
GSK-3beta	-	Homo sapiens
tau kinase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)