Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AT7519 | 0.0005 mM AT7519 inhibits glycogen synthase kinase 3beta phosphorylation, AT7519 dephosphorylates GSK-3beta independent of inhibition of transcription | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | GSK-3beta is a therapeutic target in cancer treatment | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | Homo sapiens | - |
ADP + phosphorylated beta-catenin | - |
? | |
ATP + c-Myc | Homo sapiens | - |
ADP + phosphorylated c-Myc | - |
? | |
ATP + cyclin D | Homo sapiens | - |
ADP + phosphorylated cyclin D | - |
? | |
ATP + cyclin E | Homo sapiens | - |
ADP + phosphorylated cyclin E | - |
? | |
ATP + glycogen synthase | Homo sapiens | - |
ADP + glycogen synthase phosphate | - |
? | |
ATP + nuclear factor-kappaB | Homo sapiens | - |
ADP + phosphorylated nuclear factor-kappaB | - |
? | |
ATP + p53 | Homo sapiens | - |
ADP + phosphorylated p53 | - |
? | |
ATP + protein tau | Homo sapiens | - |
ADP + protein tau phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | GSK-3beta is activated via phosphorylation at Ser9 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MM1-S cell | - |
Homo sapiens | - |
multiple myeloma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Homo sapiens | ADP + phosphorylated beta-catenin | - |
? | |
ATP + c-Myc | - |
Homo sapiens | ADP + phosphorylated c-Myc | - |
? | |
ATP + cyclin D | - |
Homo sapiens | ADP + phosphorylated cyclin D | - |
? | |
ATP + cyclin E | - |
Homo sapiens | ADP + phosphorylated cyclin E | - |
? | |
ATP + glycogen synthase | - |
Homo sapiens | ADP + glycogen synthase phosphate | - |
? | |
ATP + nuclear factor-kappaB | - |
Homo sapiens | ADP + phosphorylated nuclear factor-kappaB | - |
? | |
ATP + p53 | - |
Homo sapiens | ADP + phosphorylated p53 | - |
? | |
ATP + protein tau | - |
Homo sapiens | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Homo sapiens |
GSK-3beta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |