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Literature summary for 2.7.11.26 extracted from

  • McCulloch, M.W.; Bugni, T.S.; Concepcion, G.P.; Coombs, G.S.; Harper, M.K.; Kaur, S.; Mangalindan, G.C.; Mutizwa, M.M.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M.
    Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. (2009), J. Nat. Prod., 72, 1651-1656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Inhibitors

Inhibitors Comment Organism Structure
carteriosulfonic acid A low micromolar inhibitor of GSK-3beta Oryctolagus cuniculus
carteriosulfonic acid B low micromolar inhibitor of GSK-3beta Oryctolagus cuniculus
carteriosulfonic acid C low micromolar inhibitor of GSK-3beta Oryctolagus cuniculus
additional information desacyl-carteriosulfonic acid shows no GSK-3beta inhibitory activity at concentrations up to 0.05 mM Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin
-
 Oryctolagus cuniculus ADP + phosphorylated beta-catenin
-
 ?
ATP + RRRPASVPPSPSLSRHSpSHQRR
-
 Oryctolagus cuniculus ADP + ?
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
 Oryctolagus cuniculus
GSK-3beta
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0068
-
 at 37°C Oryctolagus cuniculus carteriosulfonic acid B
0.0068
-
 at 37°C Oryctolagus cuniculus carteriosulfonic acid C
0.0125
-
 at 37°C Oryctolagus cuniculus carteriosulfonic acid A