Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Hoshi, M.; Takashima, A.; Noguchi, K.; Murayama, M.; Sato, M.; Kondo, S.; Saitoh, Y.; Ishiguro, K.; Hoshino, T.; Imahori, K.
    Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain (1996), Proc. Natl. Acad. Sci. USA, 93, 2719-2723.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Application

Application Comment Organism
medicine
-
 Rattus norvegicus
medicine TPKI/GSK-3beta plays a key role in the pathogenesis of Alzheimer disease, tau protein kinases I and II are candidate enzymes responsible for hyperphosphorylation of tau to induce formation of paired helical filaments Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
TPKI/GSK-3beta-interacting proteins from a human brain cDNA library in a yeast two-hybrid system Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Rattus norvegicus
-
 ADP + protein tau phosphate
-
 ?
ATP + protein tau Homo sapiens regulates PDH and participates in energy metabolism and acetylcholine synthesis ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
embryo
-
 Rattus norvegicus
-
fetus
-
 Homo sapiens
-
fetus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?
ATP + protein tau phosphorylates tau protein into Alzheimer disease-like forms, resulting in neuronal death Homo sapiens ADP + protein tau phosphate
-
 ?
ATP + protein tau regulates PDH and participates in energy metabolism and acetylcholine synthesis Homo sapiens ADP + protein tau phosphate
-
 ?
ATP + pyruvate dehydrogenase PDH is phosphorylated and inactivated in vitro and also in betaA-treated hippocampal cultures, resulting in mitochondrial dysfunction which will contribute to neuronal death Homo sapiens ADP + pyruvate dehydrogenase phosphate
-
 ?

Synonyms

Synonyms Comment Organism
tau protein kinase I/glycogen synthase kinase 3beta
-
 Homo sapiens
TPKI/GSK-3beta
-
 Homo sapiens