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Literature summary for 2.7.11.26 extracted from

  • Wang, F.S.; Ko, J.Y.; Weng, L.H.; Yeh, D.W.; Ke, H.J.; Wu, S.L.
    Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss (2009), Life Sci., 85, 685-692.
    View publication on PubMed

Application

Application Comment Organism
medicine controlling GSK-3beta signaling in bone cells is a strategy for preventing glucocorticoid-induced osteopenia Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
6-bromoindirubin-3'-oxim
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MC3T3-E1 cell
-
Mus musculus
-
osteoblast
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin
-
Mus musculus ADP + phosphorylated beta-catenin
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Mus musculus
GSK-3beta
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
malfunction inhibition of GSK-3beta abrogates glucocorticoid-induced bone loss by increasing beta-catenin- and Runx2-mediated osteoblast differentiation Mus musculus